REACTOME_CREATINE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GATM Glycine amidinotransferase, mitochondrial [1] -8.25[2] -3.33[3] -4.19[4] -8.10[5] -9.11[6] 0.16[7]
2 GAMT Guanidinoacetate N-methyltransferase [8] -0.65[9] -0.16[10] -0.38[11] -0.14[12] -0.46[13] -0.46[14]
3 SLC6A12 Sodium- and chloride-dependent betaine transporter [15] -0.25[16] -2.08[17] -1.20[18] -1.21[19] -4.94[20] 0.39[21]
4 CKB Creatine kinase B-type [22] 5.04[23] 3.89[24] 5.87[25] 5.81[26] 4.38[27] -0.43[28]
5 SLC6A11 Sodium- and chloride-dependent GABA transporter 3 [29] 2.14[30] 2.02[31] 1.98[32] -4.76[33] -3.92[34] -8.64[35]
6 SLC6A8 Sodium- and chloride-dependent creatine transporter 1 [36] 5.51[37] 5.82[38] 2.55[39] 3.80[40] 6.07[41] -3.39[42]
7 CKMT2 Creatine kinase S-type, mitochondrial [43] 2.64[44] 3.82[45] -1.10[46] 1.75[47] 1.51[48] 1.88[49]
8 CKMT1B [50] 1.51[51] 0.67[52] [53] 2.45[54] 0.70[55] [56]
9 CKMT1A Creatine kinase U-type, mitochondrial [57] -0.44[58] -1.75[59] 1.71[60] 0.97[61] 1.96[62] [63]
10 CKM Creatine kinase M-type [64] 6.29[65] 5.22[66] 0.16[67] 1.67[68] 0.40[69] -1.29[70]
11 SLC6A7 Sodium-dependent proline transporter [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte GATM
Mean 270
Standard deviation 4.7e+02
Values 0.68 50 12 1.9e+02 1.1e+03
[2]
HepG2 GATM
Mean 0.609
Standard deviation 0.19
Values 0.48 0.74
[3]
HepG2.C3A GATM
Mean 18.3
Standard deviation 1.2
Values 17 19
[4]
HuH.7 GATM
Mean 12.8
Standard deviation 4.6
Values 14 7.8 17
[5]
SNU475 GATM
Mean 0.101
Standard deviation 0.065
Values 0.056 0.15
[6]
THLE GATM
Mean 0.0721
Standard deviation 0.018
Values 0.059 0.085
[7]
liver GATM
Mean 474
Standard deviation 2.1e+02
Values 7.7e+02 3.2e+02 4.5e+02 3.5e+02
[8]
ref_hepatocyte GAMT
Mean 94.4
Standard deviation 1.2e+02
Values 15 6 11 1.8e+02 2.6e+02
[9]
HepG2 GAMT
Mean 41.4
Standard deviation 4.1
Values 44 38
[10]
HepG2.C3A GAMT
Mean 57.7
Standard deviation 8.1
Values 63 52
[11]
HuH.7 GAMT
Mean 62.6
Standard deviation 22
Values 72 38 78
[12]
SNU475 GAMT
Mean 8.87
Standard deviation 1.8
Values 10 7.6
[13]
THLE GAMT
Mean 10.1
Standard deviation 0.71
Values 11 9.6
[14]
liver GAMT
Mean 108
Standard deviation 90
Values 2e+02 31 1.7e+02 32
[15]
ref_hepatocyte SLC6A12
Mean 6.4
Standard deviation 8.3
Values 2 0.55 0.4 9.2 20
[16]
HepG2 SLC6A12
Mean 3.71
Standard deviation 0.83
Values 3.1 4.3
[17]
HepG2.C3A SLC6A12
Mean 1.03
Standard deviation 0.4
Values 0.75 1.3
[18]
HuH.7 SLC6A12
Mean 2.4
Standard deviation 0.86
Values 2.1 3.4 1.8
[19]
SNU475 SLC6A12
Mean 0.285
Standard deviation 0.14
Values 0.19 0.39
[20]
THLE SLC6A12
Mean 0.0307
Standard deviation 0.0017
Values 0.03 0.032
[21]
liver SLC6A12
Mean 13.3
Standard deviation 4.9
Values 20 9.9 12 10
[22]
ref_hepatocyte CKB
Mean 4.4
Standard deviation 5.3
Values 13 1 4.9 1.8 0.89
[23]
HepG2 CKB
Mean 99.7
Standard deviation 12
Values 1.1e+02 91
[24]
HepG2.C3A CKB
Mean 44.6
Standard deviation 6.7
Values 40 49
[25]
HuH.7 CKB
Mean 222
Standard deviation 17
Values 2.1e+02 2.1e+02 2.4e+02
[26]
SNU475 CKB
Mean 25.4
Standard deviation 1.2
Values 26 25
[27]
THLE CKB
Mean 13.5
Standard deviation 1.3
Values 14 13
[28]
liver CKB
Mean 5.14
Standard deviation 6.3
Values 14 0.56 4.3 1.5
[29]
ref_hepatocyte SLC6A11
Mean 3.81
Standard deviation 8.5
Values 19 0 0 0.069 0
[30]
HepG2 SLC6A11
Mean 11.6
Standard deviation 1.9
Values 10 13
[31]
HepG2.C3A SLC6A11
Mean 10.5
Standard deviation 1.4
Values 9.5 12
[32]
HuH.7 SLC6A11
Mean 13
Standard deviation 2.5
Values 16 11 12
[33]
SNU475 SLC6A11
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[34]
THLE SLC6A11
Mean 0.0373
Standard deviation 0.023
Values 0.053 0.021
[35]
liver SLC6A11
Mean 0.0151
Standard deviation 0.022
Values 0.047 0 0 0.013
[36]
ref_hepatocyte SLC6A8
Mean 3.27
Standard deviation 6.6
Values 15 0.3 0.47 0.36 0.19
[37]
HepG2 SLC6A8
Mean 103
Standard deviation 1.1
Values 1e+02 1e+02
[38]
HepG2.C3A SLC6A8
Mean 126
Standard deviation 37
Values 1.5e+02 1e+02
[39]
HuH.7 SLC6A8
Mean 16.4
Standard deviation 14
Values 8.9 32 8
[40]
SNU475 SLC6A8
Mean 4.71
Standard deviation 0.22
Values 4.6 4.9
[41]
THLE SLC6A8
Mean 32.5
Standard deviation 2.5
Values 31 34
[42]
liver SLC6A8
Mean 0.492
Standard deviation 0.11
Values 0.35 0.59 0.46 0.57
[43]
ref_hepatocyte CKMT2
Mean 0.174
Standard deviation 0.31
Values 0.72 0 0 0.095 0.057
[44]
HepG2 CKMT2
Mean 0.746
Standard deviation 0.05
Values 0.71 0.78
[45]
HepG2.C3A CKMT2
Mean 1.68
Standard deviation 0.29
Values 1.5 1.9
[46]
HuH.7 CKMT2
Mean 0.0703
Standard deviation 0.059
Values 0.057 0.13 0.019
[47]
SNU475 CKMT2
Mean 0.0608
Standard deviation 0.0072
Values 0.056 0.066
[48]
THLE CKMT2
Mean 0.073
Standard deviation 0.0055
Values 0.077 0.069
[49]
liver CKMT2
Mean 1.01
Standard deviation 0.86
Values 0.24 1.7 0.31 1.8
[50]
ref_hepatocyte CKMT1B
Mean 0.048
Standard deviation 0.055
Values 0.13 0.067 0 0 0.041
[51]
HepG2 CKMT1B
Mean 0.0937
Standard deviation 0.068
Values 0.046 0.14
[52]
HepG2.C3A CKMT1B
Mean 0.0521
Standard deviation 0.032
Values 0.029 0.075
[53]
HuH.7 CKMT1B
Mean 0
Standard deviation 0
Values 0 0 0
[54]
SNU475 CKMT1B
Mean 0.027
Standard deviation 0.012
Values 0.019 0.035
[55]
THLE CKMT1B
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[56]
liver CKMT1B
Mean 0
Standard deviation 0
Values 0 0 0 0
[57]
ref_hepatocyte CKMT1A
Mean 0.048
Standard deviation 0.055
Values 0.13 0.067 0 0 0.041
[58]
HepG2 CKMT1A
Mean 0.0243
Standard deviation 0.002
Values 0.023 0.026
[59]
HepG2.C3A CKMT1A
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[60]
HuH.7 CKMT1A
Mean 0.136
Standard deviation 0.082
Values 0.16 0.045 0.21
[61]
SNU475 CKMT1A
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[62]
THLE CKMT1A
Mean 0.0275
Standard deviation 0.014
Values 0.018 0.037
[63]
liver CKMT1A
Mean 0
Standard deviation 0
Values 0 0 0 0
[64]
ref_hepatocyte CKM
Mean 0.0455
Standard deviation 0.065
Values 0.14 0 0 0.086 0
[65]
HepG2 CKM
Mean 2.45
Standard deviation 2
Values 3.9 1
[66]
HepG2.C3A CKM
Mean 1.16
Standard deviation 0.28
Values 0.96 1.4
[67]
HuH.7 CKM
Mean 0.0437
Standard deviation 0.0097
Values 0.033 0.051 0.047
[68]
SNU475 CKM
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[69]
THLE CKM
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[70]
liver CKM
Mean 0.0294
Standard deviation 0.034
Values 0 0 0.051 0.066
[71]
ref_hepatocyte SLC6A7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[72]
HepG2 SLC6A7
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A SLC6A7
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 SLC6A7
Mean 0.0168
Standard deviation 0.019
Values 0 0.013 0.037
[75]
SNU475 SLC6A7
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE SLC6A7
Mean 0
Standard deviation 0
Values 0 0
[77]
liver SLC6A7
Mean 0
Standard deviation 0
Values 0 0 0 0