REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
CDC42 |
Cell division control protein 42 homolog |
[1] |
-0.89[2] |
-0.41[3] |
-1.21[4] |
-0.70[5] |
-1.33[6] |
-2.28[7] |
2 |
RAC1 |
Ras-related C3 botulinum toxin substrate 1 |
[8] |
-0.46[9] |
-1.02[10] |
-0.11[11] |
-0.15[12] |
-0.08[13] |
-1.17[14] |
3 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[15] |
0.02[16] |
-0.45[17] |
-1.33[18] |
-0.21[19] |
-0.10[20] |
-0.44[21] |
4 |
TRIB3 |
Tribbles homolog 3 |
[22] |
0.84[23] |
0.90[24] |
-0.01[25] |
-2.18[26] |
-1.58[27] |
-0.62[28] |
5 |
HLA-DRA |
HLA class II histocompatibility antigen, DR alpha chain |
[29] |
-13.33[30] |
[31] |
-14.37[32] |
-5.91[33] |
-7.75[34] |
-0.77[35] |
6 |
PPP2R1A |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A alpha isoform |
0.74[36] |
0.32[37] |
0.45[38] |
1.04[39] |
0.46[40] |
-0.05[41] |
7 |
PPP2CA |
Serine/threonine-protein phosphatase
2A catalytic subunit alpha isoform |
0.21[42] |
0.07[43] |
-0.37[44] |
0.58[45] |
0.78[46] |
-0.30[47] |
8 |
PPP2CB |
Serine/threonine-protein phosphatase
2A catalytic subunit beta isoform |
-0.46[48] |
-1.03[49] |
-0.75[50] |
-0.62[51] |
-0.63[52] |
-1.19[53] |
9 |
PTPN11 |
Tyrosine-protein phosphatase non-receptor type 11 |
[54] |
0.38[55] |
0.58[56] |
0.73[57] |
0.72[58] |
1.45[59] |
1.06[60] |
10 |
GRB2 |
Growth factor receptor-bound protein 2 |
[61] |
1.13[62] |
0.73[63] |
1.06[64] |
0.39[65] |
0.39[66] |
0.10[67] |
11 |
YES1 |
Tyrosine-protein kinase Yes |
[68] |
-0.93[69] |
0.33[70] |
0.75[71] |
0.29[72] |
-0.16[73] |
-0.08[74] |
12 |
HLA-DRB1 |
HLA class II histocompatibility antigen, DRB1-15 beta chain |
[75] |
-8.50[76] |
[77] |
[78] |
-6.27[79] |
-11.25[80] |
-1.86[81] |
13 |
MAPKAP1 |
Target of rapamycin complex 2 subunit MAPKAP1 |
[82] |
-0.08[83] |
-0.56[84] |
-0.14[85] |
-0.08[86] |
0.19[87] |
-0.38[88] |
14 |
CD4 |
T-cell surface glycoprotein CD4 |
[89] |
-5.82[90] |
-3.87[91] |
-6.30[92] |
-7.62[93] |
-9.58[94] |
-0.28[95] |
15 |
PPP2R5A |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit alpha isoform |
-1.19[96] |
-0.53[97] |
0.39[98] |
-0.41[99] |
-1.45[100] |
0.44[101] |
16 |
PPP2R5C |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit gamma isoform |
-0.37[102] |
0.27[103] |
0.17[104] |
0.78[105] |
0.67[106] |
-0.40[107] |
17 |
PPP2R1B |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A beta isoform |
0.39[108] |
-0.37[109] |
0.24[110] |
0.11[111] |
-0.02[112] |
2.73[113] |
18 |
PAK2 |
Serine/threonine-protein kinase PAK 2 |
[114] |
1.38[115] |
0.89[116] |
1.39[117] |
0.59[118] |
1.22[119] |
1.16[120] |
19 |
AKT2 |
RAC-beta serine/threonine-protein kinase |
[121] |
0.89[122] |
0.93[123] |
1.27[124] |
0.69[125] |
0.57[126] |
0.93[127] |
20 |
CSK |
Tyrosine-protein kinase CSK |
[128] |
0.31[129] |
-0.43[130] |
0.15[131] |
-0.18[132] |
-0.49[133] |
-1.06[134] |
21 |
MLST8 |
Target of rapamycin complex subunit LST8 |
[135] |
-0.24[136] |
-0.15[137] |
0.43[138] |
-1.14[139] |
-0.70[140] |
-0.76[141] |
22 |
TNFRSF14 |
Tumor necrosis factor receptor superfamily member 14 |
[142] |
-1.10[143] |
-0.57[144] |
-7.40[145] |
-4.06[146] |
-3.50[147] |
-0.73[148] |
23 |
PPP2R5D |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit delta isoform |
1.19[149] |
0.71[150] |
0.47[151] |
1.13[152] |
1.10[153] |
-0.47[154] |
24 |
PIK3R1 |
Phosphatidylinositol 3-kinase regulatory subunit alpha |
[155] |
-0.54[156] |
-0.65[157] |
0.64[158] |
1.90[159] |
1.49[160] |
2.80[161] |
25 |
PRR5 |
Proline-rich protein 5 |
[162] |
-0.66[163] |
-0.83[164] |
-1.55[165] |
-2.45[166] |
-5.16[167] |
-0.98[168] |
26 |
HLA-DPA1 |
HLA class II histocompatibility antigen, DP alpha 1 chain |
[169] |
-7.00[170] |
-10.74[171] |
[172] |
-5.26[173] |
-7.03[174] |
-0.48[175] |
27 |
HLA-DRB5 |
HLA class II histocompatibility antigen, DR beta 5 chain |
[176] |
-11.15[177] |
[178] |
[179] |
-8.52[180] |
[181] |
-6.05[182] |
28 |
PPP2R5E |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit epsilon isoform |
0.05[183] |
-0.01[184] |
-0.27[185] |
0.70[186] |
0.57[187] |
-0.01[188] |
29 |
LYN |
Tyrosine-protein kinase Lyn |
[189] |
-0.93[190] |
-1.34[191] |
-0.61[192] |
0.89[193] |
-0.26[194] |
-0.18[195] |
30 |
PTPN6 |
Tyrosine-protein phosphatase non-receptor type 6 |
[196] |
-0.53[197] |
-0.57[198] |
0.21[199] |
-7.30[200] |
-2.20[201] |
-0.38[202] |
31 |
PIK3R2 |
Phosphatidylinositol 3-kinase regulatory subunit beta |
[203] |
1.81[204] |
1.80[205] |
2.61[206] |
0.54[207] |
1.19[208] |
-0.49[209] |
32 |
SRC |
Proto-oncogene tyrosine-protein kinase Src |
[210] |
2.96[211] |
2.71[212] |
1.91[213] |
2.24[214] |
1.50[215] |
-1.05[216] |
33 |
PDPK1 |
3-phosphoinositide-dependent protein kinase 1 |
[217] |
2.27[218] |
3.22[219] |
2.13[220] |
1.27[221] |
1.76[222] |
2.30[223] |
34 |
MTOR |
Serine/threonine-protein kinase mTOR |
[224] |
2.47[225] |
3.25[226] |
3.02[227] |
2.52[228] |
2.69[229] |
3.25[230] |
35 |
HLA-DPB1 |
HLA class II histocompatibility antigen, DP beta 1 chain |
[231] |
-9.10[232] |
-10.41[233] |
[234] |
-4.10[235] |
-2.02[236] |
0.31[237] |
36 |
PAK1 |
Serine/threonine-protein kinase PAK 1 |
[238] |
-0.08[239] |
-1.07[240] |
1.54[241] |
-2.02[242] |
1.85[243] |
0.07[244] |
37 |
PPP2R5B |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit beta isoform |
0.71[245] |
0.24[246] |
-0.20[247] |
0.13[248] |
1.38[249] |
-0.10[250] |
38 |
FYN |
Tyrosine-protein kinase Fyn |
[251] |
0.88[252] |
-7.96[253] |
0.81[254] |
1.31[255] |
2.92[256] |
0.77[257] |
39 |
HLA-DQA1 |
HLA class II histocompatibility antigen, DQ alpha 1 chain |
[258] |
[259] |
[260] |
[261] |
-6.94[262] |
-10.49[263] |
-1.07[264] |
40 |
MAP3K14 |
Mitogen-activated protein kinase kinase kinase 14 |
[265] |
-0.46[266] |
-0.24[267] |
-1.21[268] |
1.91[269] |
0.98[270] |
0.68[271] |
41 |
PIK3CA |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
-0.44[272] |
0.96[273] |
1.35[274] |
0.97[275] |
1.26[276] |
1.71[277] |
42 |
THEM4 |
Acyl-coenzyme A thioesterase THEM4 |
[278] |
0.58[279] |
0.79[280] |
1.54[281] |
1.84[282] |
1.35[283] |
0.88[284] |
43 |
HLA-DQB1 |
HLA class II histocompatibility antigen, DQ beta 1 chain |
[285] |
-5.02[286] |
[287] |
[288] |
-3.95[289] |
[290] |
-1.16[291] |
44 |
MAP3K8 |
Mitogen-activated protein kinase kinase kinase 8 |
[292] |
1.68[293] |
1.45[294] |
0.84[295] |
-0.06[296] |
1.35[297] |
0.29[298] |
45 |
RICTOR |
Rapamycin-insensitive companion of mTOR |
[299] |
0.66[300] |
2.51[301] |
3.38[302] |
2.19[303] |
2.48[304] |
3.31[305] |
46 |
HLA-DQA2 |
HLA class II histocompatibility antigen, DQ alpha 2 chain |
[306] |
[307] |
[308] |
[309] |
-8.90[310] |
[311] |
-3.67[312] |
47 |
ICOSLG |
ICOS ligand |
[313] |
1.22[314] |
0.84[315] |
1.40[316] |
0.65[317] |
-1.12[318] |
0.03[319] |
48 |
CD3E |
T-cell surface glycoprotein CD3 epsilon chain |
[320] |
-8.93[321] |
[322] |
-5.49[323] |
[324] |
[325] |
-0.81[326] |
49 |
CD274 |
Programmed cell death 1 ligand 1 |
[327] |
-3.21[328] |
-4.71[329] |
-5.95[330] |
-0.41[331] |
4.08[332] |
0.45[333] |
50 |
VAV1 |
Proto-oncogene vav |
[334] |
-8.56[335] |
-3.97[336] |
-5.48[337] |
-6.25[338] |
-7.42[339] |
0.98[340] |
51 |
PIK3R3 |
Phosphatidylinositol 3-kinase regulatory subunit gamma |
[341] |
1.66[342] |
1.43[343] |
2.48[344] |
3.00[345] |
2.11[346] |
2.48[347] |
52 |
CD86 |
T-lymphocyte activation antigen CD86 |
[348] |
[349] |
[350] |
-4.81[351] |
-4.26[352] |
-6.19[353] |
1.15[354] |
53 |
AKT3 |
RAC-gamma serine/threonine-protein kinase |
[355] |
-1.91[356] |
-4.70[357] |
-3.81[358] |
5.68[359] |
4.72[360] |
3.41[361] |
54 |
CD247 |
T-cell surface glycoprotein CD3 zeta chain |
[362] |
-4.93[363] |
-5.84[364] |
-7.14[365] |
-3.68[366] |
-4.97[367] |
-0.22[368] |
55 |
CD3D |
T-cell surface glycoprotein CD3 delta chain |
[369] |
1.33[370] |
-0.91[371] |
-3.08[372] |
-6.67[373] |
-4.58[374] |
-0.53[375] |
56 |
LCK |
Tyrosine-protein kinase Lck |
[376] |
2.71[377] |
2.56[378] |
-7.24[379] |
-5.25[380] |
-5.36[381] |
1.03[382] |
57 |
CD3G |
T-cell surface glycoprotein CD3 gamma chain |
[383] |
-3.66[384] |
-3.14[385] |
-4.00[386] |
-4.78[387] |
-4.10[388] |
-0.54[389] |
58 |
PDCD1LG2 |
Programmed cell death 1 ligand 2 |
[390] |
-6.56[391] |
[392] |
[393] |
-0.59[394] |
4.11[395] |
1.30[396] |
59 |
HLA-DQB2 |
HLA class II histocompatibility antigen, DQ beta 2 chain |
[397] |
[398] |
[399] |
[400] |
-3.57[401] |
[402] |
-3.16[403] |
60 |
CD28 |
T-cell-specific surface glycoprotein CD28 |
[404] |
-4.07[405] |
-3.43[406] |
-3.20[407] |
-2.51[408] |
-2.48[409] |
0.92[410] |
61 |
PAK3 |
Serine/threonine-protein kinase PAK 3 |
[411] |
-6.47[412] |
[413] |
[414] |
-1.76[415] |
0.04[416] |
0.59[417] |
62 |
GRAP2 |
GRB2-related adapter protein 2 |
[418] |
-5.91[419] |
[420] |
-2.33[421] |
-2.14[422] |
-1.01[423] |
0.64[424] |
63 |
CD80 |
T-lymphocyte activation antigen CD80 |
[425] |
[426] |
[427] |
-5.36[428] |
-1.32[429] |
-2.29[430] |
2.42[431] |
64 |
BTLA |
B- and T-lymphocyte attenuator |
[432] |
[433] |
-2.20[434] |
-1.11[435] |
-1.23[436] |
-0.64[437] |
2.23[438] |
65 |
ICOS |
Inducible T-cell costimulator |
[439] |
[440] |
-3.67[441] |
[442] |
[443] |
[444] |
-0.76[445] |
66 |
PDCD1 |
Programmed cell death protein 1 |
[446] |
4.77[447] |
1.22[448] |
[449] |
-0.40[450] |
[451] |
2.42[452] |
67 |
TRAV8-4 |
T-cell receptor alpha variable 8-4 (Fragment) |
[453] |
[454] |
[455] |
[456] |
[457] |
[458] |
[459] |
68 |
TRBV7-9 |
T-cell receptor beta variable 7-9 (Fragment) |
[460] |
[461] |
[462] |
[463] |
[464] |
[465] |
[466] |
69 |
TRBV12-3 |
T-cell receptor beta chain V region YT35 |
[467] |
[468] |
[469] |
[470] |
[471] |
[472] |
[473] |
70 |
TRAV29DV5 |
[474] |
[475] |
[476] |
[477] |
[478] |
[479] |
[480] |
71 |
TRAV19 |
T-cell receptor alpha variable 19 (Fragment) |
[481] |
[482] |
[483] |
[484] |
[485] |
[486] |
[487] |
72 |
HLA-DRB3 |
HLA class II histocompatibility antigen, DR beta 3 chain |
[488] |
[489] |
[490] |
[491] |
[492] |
[493] |
[494] |
73 |
CTLA4 |
Cytotoxic T-lymphocyte protein 4 |
[495] |
[496] |
[497] |
[498] |
[499] |
[500] |
[501] |
74 |
HLA-DRB4 |
HLA class II histocompatibility antigen, DR beta 4 chain |
[502] |
[503] |
[504] |
[505] |
[506] |
[507] |
[508] |
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