REACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSP90AA1 Heat shock protein HSP 90-alpha [1] -0.41[2] 0.02[3] -0.39[4] -0.20[5] -0.18[6] -0.31[7]
2 CDC37 Hsp90 co-chaperone Cdc37 [8] -0.52[9] -1.72[10] -0.98[11] -2.09[12] -1.19[13] -1.04[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 1.43[16] 0.72[17] 1.21[18] 0.27[19] 0.51[20] 1.24[21]
4 SHC1 SHC-transforming protein 1 [22] 1.40[23] 1.07[24] 1.51[25] 2.36[26] 2.18[27] 1.72[28]
5 NRAS GTPase NRas [29] 0.87[30] 0.75[31] 1.53[32] 0.71[33] 0.61[34] 0.69[35]
6 HRAS GTPase HRas [36] -0.77[37] -2.02[38] -2.45[39] -1.23[40] -1.12[41] -1.72[42]
7 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 [43] 1.02[44] 0.85[45] 0.18[46] 1.47[47] 0.88[48] 0.49[49]
8 KRAS GTPase KRas [50] -0.28[51] -0.84[52] 1.12[53] 0.52[54] 0.50[55] 1.62[56]
9 SOS1 Son of sevenless homolog 1 [57] 0.14[58] 1.12[59] 0.99[60] 0.56[61] 0.12[62] 1.48[63]
10 ERBB2 Receptor tyrosine-protein kinase erbB-2 [64] 2.61[65] 0.88[66] 2.42[67] 0.97[68] 0.90[69] 1.10[70]
11 ERBIN Erbin [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[2]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[3]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[4]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[5]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[6]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[7]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[8]
ref_hepatocyte CDC37
Mean 77.7
Standard deviation 56
Values 42 1.3e+02 1.5e+02 40 29
[9]
HepG2 CDC37
Mean 102
Standard deviation 8.8
Values 1.1e+02 95
[10]
HepG2.C3A CDC37
Mean 57.6
Standard deviation 0.71
Values 57 58
[11]
HuH.7 CDC37
Mean 71.5
Standard deviation 19
Values 75 51 88
[12]
SNU475 CDC37
Mean 40.8
Standard deviation 3.1
Values 39 43
[13]
THLE CDC37
Mean 68.3
Standard deviation 6.1
Values 64 73
[14]
liver CDC37
Mean 28
Standard deviation 16
Values 40 14 45 13
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[23]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[24]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[25]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[26]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[27]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[28]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte PTPN12
Mean 9.2
Standard deviation 4.5
Values 11 14 12 5.3 3.4
[44]
HepG2 PTPN12
Mean 35
Standard deviation 1.2
Values 34 36
[45]
HepG2.C3A PTPN12
Mean 40.5
Standard deviation 2.5
Values 42 39
[46]
HuH.7 PTPN12
Mean 18.9
Standard deviation 1.1
Values 19 18 20
[47]
SNU475 PTPN12
Mean 57
Standard deviation 14
Values 47 67
[48]
THLE PTPN12
Mean 33.7
Standard deviation 3.5
Values 36 31
[49]
liver PTPN12
Mean 9.55
Standard deviation 3.7
Values 15 9.1 6.7 7.5
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[57]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[58]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[59]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[60]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[61]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[62]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[63]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[64]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[65]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[66]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[67]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[68]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[69]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[70]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[71]
ref_hepatocyte ERBIN
Missing
[72]
HepG2 ERBIN
Missing
[73]
HepG2.C3A ERBIN
Missing
[74]
HuH.7 ERBIN
Missing
[75]
SNU475 ERBIN
Missing
[76]
THLE ERBIN
Missing
[77]
liver ERBIN
Missing