REACTOME_CONSTITUTIVE_SIGNALING_BY_LIGAND_RESPONSIVE_EGFR_CANCER_VARIANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.76[2] -1.26[3] -1.03[4] -1.51[5] -0.95[6] -0.34[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.32[16] -0.50[17] -0.66[18] -0.65[19] -0.58[20] 0.11[21]
4 HSP90AA1 Heat shock protein HSP 90-alpha [22] 0.79[23] 1.47[24] 0.78[25] 1.36[26] 1.14[27] 0.28[28]
5 CDC37 Hsp90 co-chaperone Cdc37 [29] 0.68[30] -0.26[31] 0.18[32] -0.53[33] 0.14[34] -0.44[35]
6 UBA52 Ubiquitin-60S ribosomal protein L40 [36] 2.12[37] 1.73[38] 2.85[39] 0.74[40] 1.65[41] 0.88[42]
7 GRB2 Growth factor receptor-bound protein 2 [43] 2.63[44] 2.18[45] 2.38[46] 1.83[47] 1.84[48] 1.84[49]
8 SHC1 SHC-transforming protein 1 [50] 2.60[51] 2.53[52] 2.68[53] 3.92[54] 3.50[55] 2.32[56]
9 NRAS GTPase NRas [57] 2.07[58] 2.20[59] 2.69[60] 2.27[61] 1.94[62] 1.29[63]
10 HRAS GTPase HRas [64] 0.43[65] -0.57[66] -1.28[67] 0.32[68] 0.20[69] -1.12[70]
11 KRAS GTPase KRas [71] 0.92[72] 0.61[73] 2.29[74] 2.07[75] 1.83[76] 2.21[77]
12 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [78] 0.96[79] 0.79[80] 1.96[81] 3.34[82] 2.94[83] 4.54[84]
13 SOS1 Son of sevenless homolog 1 [85] 1.34[86] 2.57[87] 2.16[88] 2.12[89] 1.44[90] 2.08[91]
14 EGFR Epidermal growth factor receptor [92] 0.74[93] 0.07[94] 3.03[95] 1.71[96] 2.42[97] 4.19[98]
15 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 4.93[99] 4.25[100] 3.66[101] 4.09[102] 3.68[103] 1.88[104]
16 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.06[105] 2.40[106] 2.67[107] 2.40[108] 2.70[109] 3.45[110]
17 GAB1 GRB2-associated-binding protein 1 [111] 2.74[112] 3.53[113] 3.73[114] 3.20[115] 3.16[116] 4.41[117]
18 CBL E3 ubiquitin-protein ligase CBL [118] 5.88[119] 4.54[120] 4.84[121] 6.41[122] 5.98[123] 5.30[124]
19 EGF Pro-epidermal growth factor [125] 3.40[126] 4.90[127] 8.59[128] 10.30[129] 7.81[130] 3.12[131]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[23]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[24]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[25]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[26]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[27]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[28]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[29]
ref_hepatocyte CDC37
Mean 77.7
Standard deviation 56
Values 42 1.3e+02 1.5e+02 40 29
[30]
HepG2 CDC37
Mean 102
Standard deviation 8.8
Values 1.1e+02 95
[31]
HepG2.C3A CDC37
Mean 57.6
Standard deviation 0.71
Values 57 58
[32]
HuH.7 CDC37
Mean 71.5
Standard deviation 19
Values 75 51 88
[33]
SNU475 CDC37
Mean 40.8
Standard deviation 3.1
Values 39 43
[34]
THLE CDC37
Mean 68.3
Standard deviation 6.1
Values 64 73
[35]
liver CDC37
Mean 28
Standard deviation 16
Values 40 14 45 13
[36]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[37]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[38]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[39]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[40]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[41]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[42]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[43]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[44]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[45]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[46]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[47]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[48]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[49]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[50]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[51]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[52]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[53]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[54]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[55]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[56]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[57]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[58]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[59]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[60]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[61]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[62]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[63]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[64]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[65]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[66]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[67]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[68]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[69]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[70]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[71]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[72]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[73]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[74]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[75]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[76]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[77]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[78]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[79]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[80]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[81]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[82]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[83]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[84]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[85]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[86]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[87]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[88]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[89]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[90]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[91]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[92]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[93]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[94]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[95]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[96]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[97]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[98]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[99]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[100]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[101]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[102]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[103]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[104]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[105]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[106]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[107]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[108]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[109]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[110]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[111]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[112]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[113]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[114]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[115]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[116]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[117]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[118]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[119]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[120]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[121]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[122]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[123]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[124]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[125]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[126]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14
[127]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[128]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[129]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[130]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[131]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[132]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[133]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013