REACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSP90AA1 | Heat shock protein HSP 90-alpha | [1] | -0.44[2] | -0.01[3] | -0.44[4] | -0.28[5] | -0.29[6] | -0.77[7] |
2 | CDC37 | Hsp90 co-chaperone Cdc37 | [8] | -0.55[9] | -1.74[10] | -1.04[11] | -2.18[12] | -1.29[13] | -1.49[14] |
3 | GRB2 | Growth factor receptor-bound protein 2 | [15] | 1.40[16] | 0.70[17] | 1.15[18] | 0.18[19] | 0.40[20] | 0.79[21] |
4 | SHC1 | SHC-transforming protein 1 | [22] | 1.37[23] | 1.05[24] | 1.46[25] | 2.28[26] | 2.07[27] | 1.27[28] |
5 | NRAS | GTPase NRas | [29] | 0.83[30] | 0.73[31] | 1.47[32] | 0.62[33] | 0.50[34] | 0.24[35] |
6 | HRAS | GTPase HRas | [36] | -0.80[37] | -2.05[38] | -2.51[39] | -1.32[40] | -1.23[41] | -2.17[42] |
7 | KRAS | GTPase KRas | [43] | -0.31[44] | -0.87[45] | 1.06[46] | 0.43[47] | 0.39[48] | 1.16[49] |
8 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [50] | -0.27[51] | -0.69[52] | 0.74[53] | 1.69[54] | 1.50[55] | 3.49[56] |
9 | SOS1 | Son of sevenless homolog 1 | [57] | 0.10[58] | 1.09[59] | 0.94[60] | 0.47[61] | 0.01[62] | 1.03[63] |
10 | EGFR | Epidermal growth factor receptor | [64] | -0.49[65] | -1.41[66] | 1.81[67] | 0.06[68] | 0.99[69] | 3.14[70] |
11 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.69[71] | 2.77[72] | 2.44[73] | 2.45[74] | 2.25[75] | 0.83[76] | |
12 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.18[77] | 0.92[78] | 1.45[79] | 0.76[80] | 1.27[81] | 2.40[82] | |
13 | GAB1 | GRB2-associated-binding protein 1 | [83] | 1.51[84] | 2.05[85] | 2.51[86] | 1.56[87] | 1.73[88] | 3.36[89] |
14 | CBL | E3 ubiquitin-protein ligase CBL | [90] | 4.65[91] | 3.06[92] | 3.61[93] | 4.76[94] | 4.55[95] | 4.25[96] |
15 | EGF | Pro-epidermal growth factor | [97] | 2.17[98] | 3.42[99] | 7.37[100] | 8.65[101] | 6.38[102] | 2.07[103] |