REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] 0.36[2] -1.30[3] -3.53[4] -2.07[5] 0.03[6] -2.19[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] -0.40[9] -0.90[10] -1.52[11] -0.13[12] -0.56[13] -0.60[14]
3 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 [15] -0.49[16] -1.01[17] -0.33[18] 0.00[19] -0.27[20] -0.54[21]
4 RPS6KB2 Ribosomal protein S6 kinase beta-2 [22] [23] [24] [25] [26] [27] [28]
5 BAD Bcl2-associated agonist of cell death [29] -2.15[30] -2.29[31] -2.78[32] -1.15[33] -1.20[34] -1.78[35]
6 AKT1S1 Proline-rich AKT1 substrate 1 [36] -0.94[37] -1.37[38] -0.56[39] -0.83[40] -0.66[41] -1.55[42]
7 CDKN1B Cyclin-dependent kinase inhibitor 1B [43] -0.56[44] -0.39[45] 0.26[46] -1.19[47] -1.18[48] -1.27[49]
8 AKT2 RAC-beta serine/threonine-protein kinase [50] 0.48[51] 0.49[52] 1.07[53] 0.78[54] 0.12[55] 0.77[56]
9 MLST8 Target of rapamycin complex subunit LST8 [57] -0.65[58] -0.59[59] 0.23[60] -1.06[61] -1.16[62] -0.92[63]
10 GSK3A Glycogen synthase kinase-3 alpha [64] 0.14[65] -0.39[66] 0.17[67] 0.00[68] 0.31[69] -2.19[70]
11 PRR5 Proline-rich protein 5 [71] -1.07[72] -1.28[73] -1.74[74] -2.37[75] -5.61[76] -1.14[77]
12 MDM2 E3 ubiquitin-protein ligase Mdm2 [78] 1.63[79] 2.78[80] 0.47[81] 0.43[82] 0.85[83] 1.80[84]
13 GSK3B Glycogen synthase kinase-3 beta [85] 0.79[86] 0.15[87] 1.18[88] 1.73[89] 1.11[90] 0.80[91]
14 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [92] 0.42[93] 1.37[94] 1.79[95] 0.57[96] 0.93[97] 1.16[98]
15 PDPK1 3-phosphoinositide-dependent protein kinase 1 [99] 1.85[100] 2.77[101] 1.94[102] 1.36[103] 1.30[104] 2.14[105]
16 MTOR Serine/threonine-protein kinase mTOR [106] 2.06[107] 2.80[108] 2.82[109] 2.60[110] 2.23[111] 3.09[112]
17 TSC2 Tuberin [113] 1.34[114] 0.59[115] 1.74[116] 1.12[117] 1.19[118] 1.72[119]
18 FOXO3 Forkhead box protein O3 [120] -0.02[121] -0.20[122] 0.89[123] 0.32[124] 1.10[125] 1.97[126]
19 CASP9 Caspase-9 [127] -0.32[128] 0.37[129] -0.06[130] 0.17[131] -0.97[132] -0.90[133]
20 CREB1 Cyclic AMP-responsive element-binding protein 1 [134] 1.24[135] 2.13[136] 3.08[137] 2.46[138] 1.95[139] 1.98[140]
21 FOXO1 Forkhead box protein O1 [141] 1.21[142] 0.61[143] 1.20[144] 1.09[145] 2.66[146] 2.73[147]
22 RICTOR Rapamycin-insensitive companion of mTOR [148] 0.25[149] 2.06[150] 3.19[151] 2.28[152] 2.02[153] 3.15[154]
23 FOXO4 Forkhead box protein O4 [155] 0.25[156] 0.38[157] 0.67[158] 0.08[159] -0.16[160] -1.05[161]
24 NR4A1 Nuclear receptor subfamily 4 group A member 1 [162] 0.74[163] 1.02[164] 1.61[165] 0.06[166] 0.71[167] 0.17[168]
25 AKT3 RAC-gamma serine/threonine-protein kinase [169] -2.32[170] -5.15[171] -4.00[172] 5.76[173] 4.26[174] 3.25[175]
26 FOXO6 Forkhead box protein O6 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[15]
ref_hepatocyte MAPKAP1
Mean 18.9
Standard deviation 8.4
Values 14 33 18 16 13
[16]
HepG2 MAPKAP1
Mean 41.3
Standard deviation 6.5
Values 37 46
[17]
HepG2.C3A MAPKAP1
Mean 31
Standard deviation 5.4
Values 27 35
[18]
HuH.7 MAPKAP1
Mean 34.6
Standard deviation 7.1
Values 38 26 40
[19]
SNU475 MAPKAP1
Mean 36.6
Standard deviation 8.3
Values 43 31
[20]
THLE MAPKAP1
Mean 46.7
Standard deviation 15
Values 36 57
[21]
liver MAPKAP1
Mean 23.6
Standard deviation 2.7
Values 23 26 20 25
[22]
ref_hepatocyte RPS6KB2
Mean 17
Standard deviation 4.8
Values 17 25 15 15 13
[23]
HepG2 RPS6KB2
Missing
[24]
HepG2.C3A RPS6KB2
Missing
[25]
HuH.7 RPS6KB2
Missing
[26]
SNU475 RPS6KB2
Missing
[27]
THLE RPS6KB2
Missing
[28]
liver RPS6KB2
Missing
[29]
ref_hepatocyte BAD
Mean 16.7
Standard deviation 11
Values 5.4 16 6.7 28 27
[30]
HepG2 BAD
Mean 11.6
Standard deviation 0.78
Values 11 12
[31]
HepG2.C3A BAD
Mean 11.3
Standard deviation 1.1
Values 10 12
[32]
HuH.7 BAD
Mean 5.61
Standard deviation 0.7
Values 5 6.4 5.5
[33]
SNU475 BAD
Mean 14.6
Standard deviation 2.5
Values 16 13
[34]
THLE BAD
Mean 21.6
Standard deviation 1.3
Values 21 23
[35]
liver BAD
Mean 8.85
Standard deviation 6.2
Values 16 3.7 12 3.7
[36]
ref_hepatocyte AKT1S1
Mean 16.3
Standard deviation 7.1
Values 9.3 9.6 22 25 16
[37]
HepG2 AKT1S1
Mean 26.1
Standard deviation 2.4
Values 24 28
[38]
HepG2.C3A AKT1S1
Mean 20.9
Standard deviation 0.11
Values 21 21
[39]
HuH.7 AKT1S1
Mean 25.6
Standard deviation 5
Values 30 20 27
[40]
SNU475 AKT1S1
Mean 17.8
Standard deviation 0.54
Values 18 17
[41]
THLE AKT1S1
Mean 30.7
Standard deviation 8
Values 25 36
[42]
liver AKT1S1
Mean 10.2
Standard deviation 7
Values 14 4.3 18 4.2
[43]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 23 13 7.5 10 15
[44]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 31 26
[45]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 34 36
[46]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 35 42 37
[47]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 14 9.7
[48]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[49]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 9.9 14 5.8 12
[50]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[51]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[52]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[53]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[54]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[55]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[56]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[57]
ref_hepatocyte MLST8
Mean 10
Standard deviation 3.8
Values 7 5.5 14 14 10
[58]
HepG2 MLST8
Mean 19.6
Standard deviation 1.4
Values 21 19
[59]
HepG2.C3A MLST8
Mean 22
Standard deviation 3.6
Values 24 19
[60]
HuH.7 MLST8
Mean 27.2
Standard deviation 3.6
Values 28 23 30
[61]
SNU475 MLST8
Mean 9.36
Standard deviation 0.84
Values 9.9 8.8
[62]
THLE MLST8
Mean 13.3
Standard deviation 1.9
Values 12 15
[63]
liver MLST8
Mean 9.64
Standard deviation 7.6
Values 17 2.5 15 3.8
[64]
ref_hepatocyte GSK3A
Mean 9.38
Standard deviation 5.1
Values 7.5 3.9 17 12 6.4
[65]
HepG2 GSK3A
Mean 31.9
Standard deviation 3.3
Values 34 30
[66]
HepG2.C3A GSK3A
Mean 23.7
Standard deviation 0.26
Values 24 24
[67]
HuH.7 GSK3A
Mean 24.3
Standard deviation 3.3
Values 26 21 26
[68]
SNU475 GSK3A
Mean 18.2
Standard deviation 1.9
Values 17 20
[69]
THLE GSK3A
Mean 34.6
Standard deviation 4.3
Values 32 38
[70]
liver GSK3A
Mean 3.74
Standard deviation 0.84
Values 4.7 3.1 3 4.2
[71]
ref_hepatocyte PRR5
Mean 7.43
Standard deviation 4.5
Values 11 2 3.1 10 11
[72]
HepG2 PRR5
Mean 10.9
Standard deviation 2.6
Values 13 9.1
[73]
HepG2.C3A PRR5
Mean 10.1
Standard deviation 0.29
Values 10 9.9
[74]
HuH.7 PRR5
Mean 5.13
Standard deviation 0.59
Values 4.7 4.9 5.8
[75]
SNU475 PRR5
Mean 2.8
Standard deviation 0.093
Values 2.7 2.9
[76]
THLE PRR5
Mean 0.452
Standard deviation 0.2
Values 0.31 0.59
[77]
liver PRR5
Mean 6.15
Standard deviation 3.4
Values 7.7 2.9 10 3.9
[78]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 11 7.6 5 3.6 4.8
[79]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 51 70
[80]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.1e+02 1.8e+02
[81]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 21 20 20
[82]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 18 15
[83]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[84]
liver MDM2
Mean 40.5
Standard deviation 11
Values 29 54 35 45
[85]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 5.2 5.9 4.9 2.7 2.1
[86]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 18 26
[87]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 14 17
[88]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 24 26 15
[89]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 29 25
[90]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[91]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 14 15 8.6 16
[92]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[93]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[94]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[95]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[96]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[97]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[98]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[99]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 6.9 3.4 3.6 1.8 2
[100]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 35 43
[101]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 89 71
[102]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 35 33 26
[103]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 17 18
[104]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[105]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 34 27 22 31
[106]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 2.6 3.1 4.3 3.5 3.2
[107]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 38 47
[108]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 89 65
[109]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 73 50 41
[110]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 39 40
[111]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[112]
liver MTOR
Mean 51.8
Standard deviation 18
Values 34 72 39 62
[113]
ref_hepatocyte TSC2
Mean 3.2
Standard deviation 0.13
Values 3.1 3.1 3.2 3.2 3.4
[114]
HepG2 TSC2
Mean 24.9
Standard deviation 3.4
Values 27 22
[115]
HepG2.C3A TSC2
Mean 16
Standard deviation 4.7
Values 19 13
[116]
HuH.7 TSC2
Mean 24.6
Standard deviation 4
Values 29 24 21
[117]
SNU475 TSC2
Mean 13.5
Standard deviation 5
Values 17 10
[118]
THLE TSC2
Mean 21.8
Standard deviation 1.7
Values 21 23
[119]
liver TSC2
Mean 19.2
Standard deviation 2.2
Values 17 19 18 22
[120]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 3.3 2.7 2.3 2.8 2.9
[121]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 7.7 9.2
[122]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 9.7 6.3
[123]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 13 15 7.9
[124]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 7.3 6.2
[125]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[126]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 24 21 12 23
[127]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 1.9 1.9 2 2.7 4.4
[128]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 5.8 7
[129]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[130]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.7 4.1 6.6
[131]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 6.3 5
[132]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[133]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 2.4 1.9 4.2 1.6
[134]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 3.7 2.1 1.5 0.96 0.81
[135]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 11 15
[136]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 24 28
[137]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 38 36 31
[138]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[139]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[140]
liver CREB1
Mean 13
Standard deviation 3.1
Values 12 16 9.3 15
[141]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 0.71 1.7 2 1.9 2.6
[142]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 11 14
[143]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 10 7.9
[144]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 10 10 7.6
[145]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 8.6 6
[146]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[147]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 25 19 13 29
[148]
ref_hepatocyte RICTOR
Mean 1.67
Standard deviation 0.88
Values 2.2 2.1 2.6 0.49 1
[149]
HepG2 RICTOR
Mean 6.11
Standard deviation 1
Values 5.4 6.8
[150]
HepG2.C3A RICTOR
Mean 23
Standard deviation 1
Values 22 24
[151]
HuH.7 RICTOR
Mean 35.2
Standard deviation 17
Values 31 54 21
[152]
SNU475 RICTOR
Mean 15.7
Standard deviation 0.97
Values 16 15
[153]
THLE RICTOR
Mean 20.3
Standard deviation 7.9
Values 26 15
[154]
liver RICTOR
Mean 27.1
Standard deviation 8.5
Values 24 35 17 33
[155]
ref_hepatocyte FOXO4
Mean 1.56
Standard deviation 0.85
Values 2.8 1.6 0.42 1.7 1.3
[156]
HepG2 FOXO4
Mean 5.71
Standard deviation 1.3
Values 6.6 4.8
[157]
HepG2.C3A FOXO4
Mean 6.69
Standard deviation 3.6
Values 9.2 4.2
[158]
HuH.7 FOXO4
Mean 5.72
Standard deviation 1.5
Values 5.1 7.5 4.6
[159]
SNU475 FOXO4
Mean 3.21
Standard deviation 1.1
Values 4 2.4
[160]
THLE FOXO4
Mean 4.17
Standard deviation 0.02
Values 4.2 4.2
[161]
liver FOXO4
Mean 1.37
Standard deviation 1.1
Values 0.54 2 0.33 2.6
[162]
ref_hepatocyte NR4A1
Mean 0.973
Standard deviation 0.84
Values 0.53 0.14 1.1 2.3 0.73
[163]
HepG2 NR4A1
Mean 4.99
Standard deviation 1.2
Values 5.9 4.1
[164]
HepG2.C3A NR4A1
Mean 6.51
Standard deviation 3.5
Values 9 4
[165]
HuH.7 NR4A1
Mean 6.85
Standard deviation 0.31
Values 7 6.5 7.1
[166]
SNU475 NR4A1
Mean 1.97
Standard deviation 1.2
Values 1.1 2.8
[167]
THLE NR4A1
Mean 4.73
Standard deviation 1.4
Values 5.7 3.7
[168]
liver NR4A1
Mean 1.99
Standard deviation 2
Values 5 0.9 1.2 0.85
[169]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[170]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[171]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[172]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[173]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[174]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[175]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[176]
ref_hepatocyte FOXO6
Missing
[177]
HepG2 FOXO6
Missing
[178]
HepG2.C3A FOXO6
Missing
[179]
HuH.7 FOXO6
Missing
[180]
SNU475 FOXO6
Missing
[181]
THLE FOXO6
Missing
[182]
liver FOXO6
Missing