REACTOME_COMPLEMENT_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CRP | C-reactive protein | [1] | [2] | [3] | -13.58[4] | [5] | -11.88[6] | -0.25[7] |
2 | VTN | Vitronectin | [8] | -2.11[9] | -1.25[10] | 0.13[11] | -5.92[12] | -5.19[13] | -0.53[14] |
3 | C3 | Complement C3 | [15] | 2.48[16] | 2.37[17] | 0.22[18] | -2.00[19] | 1.66[20] | 1.07[21] |
4 | CFB | Complement factor B | [22] | -1.17[23] | -0.54[24] | -2.08[25] | -0.25[26] | -1.02[27] | -0.22[28] |
5 | CLU | Clusterin | [29] | -1.19[30] | 0.09[31] | 1.83[32] | 1.30[33] | -2.91[34] | -0.17[35] |
6 | SERPING1 | Plasma protease C1 inhibitor | [36] | -3.29[37] | -12.96[38] | -4.26[39] | -5.39[40] | -0.37[41] | -0.52[42] |
7 | C1S | Complement C1s subcomponent | [43] | -1.66[44] | -4.40[45] | -3.27[46] | 1.75[47] | 1.02[48] | 0.13[49] |
8 | CFHR1 | Complement factor H-related protein 1 | [50] | -14.53[51] | -14.96[52] | -4.27[53] | -4.45[54] | -10.40[55] | -2.79[56] |
9 | C1R | Complement C1r subcomponent | [57] | -3.57[58] | -7.84[59] | -4.98[60] | 0.15[61] | 0.65[62] | -0.38[63] |
10 | F2 | Prothrombin | [64] | 1.60[65] | 1.32[66] | 2.08[67] | -5.17[68] | -5.85[69] | 0.05[70] |
11 | C4BPA | C4b-binding protein alpha chain | [71] | -1.97[72] | -0.97[73] | -1.07[74] | -6.46[75] | -8.29[76] | 0.21[77] |
12 | C9 | Complement component C9 | [78] | [79] | -13.94[80] | -12.10[81] | -7.90[82] | -11.22[83] | 0.62[84] |
13 | CFHR2 | Complement factor H-related protein 2 | [85] | -11.80[86] | -12.64[87] | -6.00[88] | [89] | [90] | -2.01[91] |
14 | CFI | Complement factor I | [92] | 0.98[93] | 0.88[94] | -0.29[95] | 2.18[96] | 0.13[97] | -0.39[98] |
15 | C4A | Complement C4-A | [99] | [100] | [101] | [102] | [103] | [104] | [105] |
16 | CFH | Complement factor H | [106] | -7.98[107] | -8.63[108] | 1.71[109] | 2.18[110] | 1.70[111] | 1.43[112] |
17 | CPB2 | Carboxypeptidase B2 | [113] | -1.65[114] | 0.30[115] | -0.19[116] | -6.98[117] | -7.42[118] | 0.19[119] |
18 | CD81 | CD81 antigen | [120] | -6.37[121] | -8.30[122] | 0.42[123] | 3.27[124] | 2.41[125] | -2.20[126] |
19 | C4BPB | C4b-binding protein beta chain | [127] | -0.30[128] | -0.05[129] | -3.22[130] | -4.84[131] | -5.41[132] | -1.44[133] |
20 | C2 | Complement C2 | [134] | 1.77[135] | 1.97[136] | 0.18[137] | 1.65[138] | -2.77[139] | -0.05[140] |
21 | C8G | Complement component C8 gamma chain | [141] | -3.68[142] | -1.49[143] | -4.64[144] | -6.17[145] | -7.50[146] | -0.56[147] |
22 | C8B | Complement component C8 beta chain | [148] | -2.95[149] | -4.85[150] | 0.32[151] | -5.80[152] | -8.29[153] | 0.11[154] |
23 | C8A | Complement component C8 alpha chain | [155] | -2.29[156] | -3.10[157] | 1.17[158] | -5.17[159] | -7.11[160] | 0.24[161] |
24 | C4B | Complement C4-B | [162] | [163] | [164] | [165] | [166] | [167] | [168] |
25 | C6 | Complement component C6 | [169] | -5.23[170] | -8.23[171] | -5.95[172] | [173] | -9.76[174] | 1.65[175] |
26 | MASP2 | Mannan-binding lectin serine protease 2 | [176] | -1.18[177] | -0.11[178] | -3.68[179] | -1.89[180] | -3.08[181] | 0.02[182] |
27 | CFHR3 | Complement factor H-related protein 3 | [183] | -10.56[184] | [185] | -3.67[186] | -2.26[187] | -3.70[188] | -0.38[189] |
28 | C5 | Complement C5 | [190] | 2.78[191] | 2.78[192] | 4.38[193] | -0.59[194] | -0.56[195] | 2.40[196] |
29 | PROS1 | Vitamin K-dependent protein S | [197] | 2.13[198] | 1.99[199] | 4.26[200] | 0.91[201] | 2.79[202] | 1.05[203] |
30 | CPN2 | Carboxypeptidase N subunit 2 | [204] | 2.52[205] | 0.39[206] | 0.33[207] | -6.38[208] | -5.90[209] | 0.97[210] |
31 | CFHR5 | Complement factor H-related protein 5 | [211] | -10.07[212] | -10.36[213] | -4.36[214] | -6.30[215] | -9.46[216] | 0.15[217] |
32 | CFHR4 | Complement factor H-related protein 4 | [218] | [219] | [220] | -2.67[221] | -5.12[222] | [223] | -0.05[224] |
33 | CD59 | CD59 glycoprotein | [225] | 4.90[226] | 3.51[227] | 2.30[228] | 5.86[229] | 6.38[230] | 0.79[231] |
34 | C1QB | Complement C1q subcomponent subunit B | [232] | [233] | [234] | [235] | [236] | [237] | -0.08[238] |
35 | CD46 | Membrane cofactor protein | [239] | 4.25[240] | 4.94[241] | 5.07[242] | 6.58[243] | 5.79[244] | 1.26[245] |
36 | MBL2 | Mannose-binding protein C | [246] | 0.85[247] | 1.45[248] | 3.15[249] | -5.29[250] | -5.35[251] | 2.15[252] |
37 | CPN1 | Carboxypeptidase N catalytic chain | [253] | -1.04[254] | 1.55[255] | 1.62[256] | -7.18[257] | -6.17[258] | -0.05[259] |
38 | C1QA | Complement C1q subcomponent subunit A | [260] | [261] | [262] | [263] | -8.76[264] | [265] | -0.45[266] |
39 | C1QC | Complement C1q subcomponent subunit C | [267] | [268] | [269] | [270] | [271] | [272] | -0.24[273] |
40 | CD55 | Complement decay-accelerating factor | [274] | 2.57[275] | 1.38[276] | 2.26[277] | 4.71[278] | 5.87[279] | -1.42[280] |
41 | FCN3 | Ficolin-3 | [281] | [282] | [283] | -9.23[284] | -4.12[285] | -5.80[286] | 1.69[287] |
42 | MASP1 | Mannan-binding lectin serine protease 1 | [288] | 4.18[289] | 4.28[290] | 6.62[291] | -1.09[292] | -1.60[293] | 2.66[294] |
43 | FCN2 | Ficolin-2 | [295] | [296] | [297] | [298] | -5.78[299] | [300] | 3.11[301] |
44 | CFP | Properdin | [302] | -6.95[303] | [304] | -2.54[305] | -0.48[306] | -0.44[307] | -0.03[308] |
45 | FCN1 | Ficolin-1 | [309] | [310] | [311] | [312] | [313] | [314] | -1.94[315] |
46 | CFD | Complement factor D | [316] | 3.88[317] | 3.47[318] | 3.58[319] | 3.72[320] | 1.13[321] | -0.30[322] |
47 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | [323] | 1.22[324] | 1.69[325] | -0.41[326] | 1.19[327] | 0.32[328] | -0.34[329] |
48 | COLEC11 | Collectin-11 | [330] | 2.42[331] | 1.94[332] | 1.75[333] | 0.22[334] | 0.64[335] | 3.83[336] |
49 | C3AR1 | C3a anaphylatoxin chemotactic receptor | [337] | -2.23[338] | [339] | -4.91[340] | 3.32[341] | 5.63[342] | 0.77[343] |
50 | C7 | Complement component C7 | [344] | 3.36[345] | 0.40[346] | 2.79[347] | 0.01[348] | 1.73[349] | 7.58[350] |
51 | GZMM | Granzyme M | [351] | -0.04[352] | -1.62[353] | 1.50[354] | 1.36[355] | 3.64[356] | -1.22[357] |
52 | CR1 | Complement receptor type 1 | [358] | 1.29[359] | 1.07[360] | 1.83[361] | 3.27[362] | 2.36[363] | 4.77[364] |
53 | CD19 | B-lymphocyte antigen CD19 | [365] | 5.96[366] | 6.89[367] | 2.43[368] | 3.92[369] | [370] | 0.79[371] |
54 | COLEC10 | Collectin-10 | [372] | [373] | [374] | -1.23[375] | 6.40[376] | 3.53[377] | 7.82[378] |
55 | ELANE | Neutrophil elastase | [379] | [380] | [381] | 1.01[382] | 3.73[383] | 0.81[384] | 1.78[385] |
56 | CR2 | Complement receptor type 2 | [386] | 0.72[387] | [388] | [389] | 3.93[390] | 1.91[391] | 1.88[392] |
57 | IGLV1-51 | Immunoglobulin lambda variable 1-51 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | IGLV2-8 | Immunoglobulin lambda variable 2-8 | [400] | [401] | [402] | [403] | [404] | [405] | [406] |
59 | IGHG2 | Immunoglobulin heavy constant gamma 2 | [407] | [408] | [409] | [410] | [411] | [412] | [413] |
60 | IGHV3-7 | Immunoglobulin heavy variable 3-7 | [414] | [415] | [416] | [417] | [418] | [419] | [420] |
61 | IGKV2D-2 | Immunoglobulin kappa variable 2D-28 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |
62 | IGLV2-23 | Immunoglobulin lambda variable 2-23 | [428] | [429] | [430] | [431] | [432] | [433] | [434] |
63 | IGKV2D-3 | Immunoglobulin kappa variable 2D-30 | [435] | [436] | [437] | [438] | [439] | [440] | [441] |
64 | C4B_2 | [442] | [443] | [444] | [445] | [446] | [447] | [448] | |
65 | IGKV1-12 | Immunoglobulin kappa variable 1-12 | [449] | [450] | [451] | [452] | [453] | [454] | [455] |
66 | IGHV2-5 | Immunoglobulin heavy variable 2-5 | [456] | [457] | [458] | [459] | [460] | [461] | [462] |
67 | IGLV6-57 | Immunoglobulin lambda variable 6-57 | [463] | [464] | [465] | [466] | [467] | [468] | [469] |
68 | IGLV3-25 | Immunoglobulin lambda variable 3-25 | [470] | [471] | [472] | [473] | [474] | [475] | [476] |
69 | IGLV3-19 | Immunoglobulin lambda variable 3-19 | [477] | [478] | [479] | [480] | [481] | [482] | [483] |
70 | IGHV3-33 | Immunoglobulin heavy variable 3-33 | [484] | [485] | [486] | [487] | [488] | [489] | [490] |
71 | IGHV4-59 | Immunoglobulin heavy variable 4-59 | [491] | [492] | [493] | [494] | [495] | [496] | [497] |
72 | IGHV3-13 | Immunoglobulin heavy variable 3-13 | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | IGKV1D-3 | Immunoglobulin kappa variable 1D-39 | [505] | [506] | [507] | [508] | [509] | [510] | [511] |
74 | IGKV2D-4 | Immunoglobulin kappa variable 2D-40 | [512] | [513] | [514] | [515] | [516] | [517] | [518] |
75 | IGLV2-14 | Immunoglobulin lambda variable 2-14 | [519] | [520] | [521] | [522] | [523] | [524] | [525] |
76 | IGLV1-47 | Immunoglobulin lambda variable 1-47 | [526] | [527] | [528] | [529] | [530] | [531] | [532] |
77 | IGHV1-69 | Immunoglobulin heavy variable 1-69 | [533] | [534] | [535] | [536] | [537] | [538] | [539] |
78 | IGHG1 | Immunoglobulin heavy constant gamma 1 | [540] | [541] | [542] | [543] | [544] | [545] | [546] |
79 | IGHV3-23 | Immunoglobulin heavy variable 3-23 | [547] | [548] | [549] | [550] | [551] | [552] | [553] |
80 | IGKV1-17 | Immunoglobulin kappa variable 1-17 | [554] | [555] | [556] | [557] | [558] | [559] | [560] |
81 | IGKV3-11 | Immunoglobulin kappa variable 3-11 | [561] | [562] | [563] | [564] | [565] | [566] | [567] |
82 | IGHV3-30 | Immunoglobulin heavy variable 3-30 | [568] | [569] | [570] | [571] | [572] | [573] | [574] |
83 | IGLV1-40 | Immunoglobulin lambda variable 1-40 | [575] | [576] | [577] | [578] | [579] | [580] | [581] |
84 | IGKV3D-2 | Immunoglobulin kappa variable 3D-20 | [582] | [583] | [584] | [585] | [586] | [587] | [588] |
85 | IGKV1D-1 | Immunoglobulin kappa variable 1D-16 (Fragment) | [589] | [590] | [591] | [592] | [593] | [594] | [595] |
86 | IGHV3-48 | Immunoglobulin heavy variable 3-48 | [596] | [597] | [598] | [599] | [600] | [601] | [602] |
87 | IGHG4 | Immunoglobulin heavy constant gamma 4 | [603] | [604] | [605] | [606] | [607] | [608] | [609] |
88 | IGKV1-5 | Immunoglobulin kappa variable 1-5 | [610] | [611] | [612] | [613] | [614] | [615] | [616] |
89 | IGKV3-15 | Immunoglobulin kappa variable 3-15 | [617] | [618] | [619] | [620] | [621] | [622] | [623] |
90 | IGHV1-46 | Immunoglobulin heavy variable 1-46 | [624] | [625] | [626] | [627] | [628] | [629] | [630] |
91 | IGKV4-1 | Immunoglobulin kappa variable 4-1 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |
92 | C5AR2 | C5a anaphylatoxin chemotactic receptor 2 | [638] | [639] | [640] | [641] | [642] | [643] | [644] |
93 | IGHV4-39 | Immunoglobulin heavy variable 4-39 | [645] | [646] | [647] | [648] | [649] | [650] | [651] |
94 | IGHV3-53 | Immunoglobulin heavy variable 3-53 | [652] | [653] | [654] | [655] | [656] | [657] | [658] |
95 | IGLV3-21 | Immunoglobulin lambda variable 3-21 | [659] | [660] | [661] | [662] | [663] | [664] | [665] |
96 | IGKV1-33 | Immunoglobulin kappa variable 1-33 | [666] | [667] | [668] | [669] | [670] | [671] | [672] |
97 | IGHV4-34 | Immunoglobulin heavy variable 4-34 | [673] | [674] | [675] | [676] | [677] | [678] | [679] |
98 | IGLV2-11 | Immunoglobulin lambda variable 2-11 | [680] | [681] | [682] | [683] | [684] | [685] | [686] |
99 | IGKV1-39 | Immunoglobulin kappa variable 1-39 | [687] | [688] | [689] | [690] | [691] | [692] | [693] |
100 | IGKV3-20 | Immunoglobulin kappa variable 3-20 | [694] | [695] | [696] | [697] | [698] | [699] | [700] |
101 | IGLV1-44 | Immunoglobulin lambda variable 1-44 | [701] | [702] | [703] | [704] | [705] | [706] | [707] |
102 | IGLV7-43 | Immunoglobulin lambda variable 7-43 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |
103 | IGKV1D-1 | Immunoglobulin kappa variable 1D-12 | [715] | [716] | [717] | [718] | [719] | [720] | [721] |
104 | IGLV3-27 | Immunoglobulin lambda variable 3-27 | [722] | [723] | [724] | [725] | [726] | [727] | [728] |
105 | IGKV2-30 | Immunoglobulin kappa variable 2-30 | [729] | [730] | [731] | [732] | [733] | [734] | [735] |
106 | IGKV1D-3 | Immunoglobulin kappa variable 1D-33 | [736] | [737] | [738] | [739] | [740] | [741] | [742] |
107 | IGHV1-2 | Immunoglobulin heavy variable 1-2 | [743] | [744] | [745] | [746] | [747] | [748] | [749] |
108 | IGKV5-2 | Immunoglobulin kappa variable 5-2 | [750] | [751] | [752] | [753] | [754] | [755] | [756] |
109 | IGLC3 | Immunoglobulin lambda constant 3 | [757] | [758] | [759] | [760] | [761] | [762] | [763] |
110 | IGHV3-11 | Immunoglobulin heavy variable 3-11 | [764] | [765] | [766] | [767] | [768] | [769] | [770] |
111 | IGLV3-1 | Immunoglobulin lambda variable 3-1 | [771] | [772] | [773] | [774] | [775] | [776] | [777] |
112 | IGKV2-28 | Immunoglobulin kappa variable 2-28 | [778] | [779] | [780] | [781] | [782] | [783] | [784] |
113 | IGHV2-70 | Immunoglobulin heavy variable 2-70 | [785] | [786] | [787] | [788] | [789] | [790] | [791] |
114 | IGLC2 | Immunoglobulin lambda constant 2 | [792] | [793] | [794] | [795] | [796] | [797] | [798] |
115 | IGKV1-16 | Immunoglobulin kappa variable 1-16 | [799] | [800] | [801] | [802] | [803] | [804] | [805] |