REACTOME_COLLAGEN_DEGRADATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CTSB | Cathepsin B | [1] | -0.11[2] | -0.03[3] | -1.39[4] | -3.00[5] | -1.69[6] | -0.94[7] |
2 | CTSD | Cathepsin D | [8] | -0.64[9] | -0.65[10] | -0.93[11] | -1.47[12] | -2.92[13] | -0.36[14] |
3 | COL18A1 | Collagen alpha-1(XVIII) chain | [15] | -0.12[16] | -0.20[17] | -0.26[18] | -1.16[19] | -4.40[20] | 0.28[21] |
4 | FURIN | Furin | [22] | 0.99[23] | -2.10[24] | -0.25[25] | -2.85[26] | -1.92[27] | 0.73[28] |
5 | ADAM9 | Disintegrin and metalloproteinase domain-containing protein 9 | [29] | 0.72[30] | 1.86[31] | 1.42[32] | 0.45[33] | 1.24[34] | -1.26[35] |
6 | TMPRSS6 | Transmembrane protease serine 6 | [36] | -2.42[37] | -0.70[38] | -5.87[39] | -11.06[40] | -8.76[41] | -0.05[42] |
7 | MMP1 | Interstitial collagenase | [43] | -5.80[44] | -8.92[45] | [46] | -3.33[47] | -3.32[48] | -13.06[49] |
8 | MMP3 | Stromelysin-1 | [50] | -5.15[51] | -9.41[52] | -12.10[53] | -3.32[54] | -5.91[55] | -9.25[56] |
9 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [57] | 0.35[58] | 1.48[59] | 1.20[60] | -0.30[61] | 0.57[62] | -0.13[63] |
10 | MMP15 | Matrix metalloproteinase-15 | [64] | 1.09[65] | 1.82[66] | 1.28[67] | -1.99[68] | -0.99[69] | -0.34[70] |
11 | COL9A3 | Collagen alpha-3(IX) chain | [71] | 2.18[72] | 1.82[73] | -2.57[74] | -5.33[75] | -6.77[76] | -6.07[77] |
12 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [78] | 0.04[79] | 0.58[80] | 0.00[81] | 0.16[82] | -0.24[83] | -0.85[84] |
13 | MMP10 | Stromelysin-2 | [85] | -6.95[86] | -10.72[87] | [88] | -9.76[89] | [90] | [91] |
14 | MMP14 | Matrix metalloproteinase-14 | [92] | 0.42[93] | 0.49[94] | 2.17[95] | -0.86[96] | 4.14[97] | -1.43[98] |
15 | COL6A1 | Collagen alpha-1(VI) chain | [99] | -0.39[100] | -1.64[101] | 1.51[102] | 1.89[103] | 2.83[104] | 1.94[105] |
16 | COL16A1 | Collagen alpha-1(XVI) chain | [106] | 1.14[107] | 1.05[108] | -7.63[109] | -2.20[110] | -1.25[111] | -2.52[112] |
17 | MMP19 | Matrix metalloproteinase-19 | [113] | -3.34[114] | -4.07[115] | -5.25[116] | -3.43[117] | -0.67[118] | -2.27[119] |
18 | MMP12 | Macrophage metalloelastase | [120] | [121] | [122] | [123] | -3.30[124] | -10.93[125] | -6.62[126] |
19 | COL4A5 | Collagen alpha-5(IV) chain | [127] | 2.63[128] | -6.01[129] | -0.53[130] | 1.13[131] | 2.88[132] | -1.59[133] |
20 | COL5A2 | Collagen alpha-2(V) chain | [134] | -1.85[135] | -1.15[136] | 6.48[137] | 5.22[138] | 4.97[139] | 2.00[140] |
21 | COL9A2 | Collagen alpha-2(IX) chain | [141] | 3.14[142] | 3.23[143] | 2.08[144] | -0.71[145] | -3.57[146] | -4.32[147] |
22 | COL5A3 | Collagen alpha-3(V) chain | [148] | -4.66[149] | -4.29[150] | -0.14[151] | -3.29[152] | -4.93[153] | 0.11[154] |
23 | COL6A2 | Collagen alpha-2(VI) chain | [155] | -1.18[156] | -3.50[157] | 1.41[158] | 3.46[159] | 4.06[160] | 3.16[161] |
24 | MMP9 | Matrix metalloproteinase-9 | [162] | -3.35[163] | -3.75[164] | -6.46[165] | -3.01[166] | -5.11[167] | -1.07[168] |
25 | COL4A2 | Collagen alpha-2(IV) chain | [169] | -0.70[170] | 0.27[171] | -2.74[172] | 5.61[173] | 5.98[174] | 4.23[175] |
26 | COL3A1 | Collagen alpha-1(III) chain | [176] | -1.63[177] | -2.58[178] | -0.50[179] | 8.38[180] | 7.06[181] | 6.68[182] |
27 | COL1A1 | Collagen alpha-1(I) chain | [183] | 4.10[184] | -2.75[185] | -1.25[186] | 5.43[187] | 7.43[188] | 5.43[189] |
28 | COL7A1 | Collagen alpha-1(VII) chain | [190] | 2.25[191] | 5.88[192] | 2.60[193] | 4.21[194] | 3.63[195] | -0.65[196] |
29 | COL1A2 | Collagen alpha-2(I) chain | [197] | -6.79[198] | -6.06[199] | -3.88[200] | 3.40[201] | 3.90[202] | 5.50[203] |
30 | MMP11 | Stromelysin-3 | [204] | 2.22[205] | 3.83[206] | 4.38[207] | 0.39[208] | -1.01[209] | -1.81[210] |
31 | COL4A1 | Collagen alpha-1(IV) chain | [211] | -3.37[212] | -3.70[213] | -2.66[214] | 5.81[215] | 6.05[216] | 5.14[217] |
32 | COL4A6 | Collagen alpha-6(IV) chain | [218] | 3.85[219] | -4.78[220] | -4.54[221] | -0.17[222] | 4.07[223] | -2.55[224] |
33 | MMP7 | Matrilysin | [225] | -0.21[226] | -2.34[227] | [228] | 0.97[229] | -3.83[230] | -0.21[231] |
34 | MMP2 | 72 kDa type IV collagenase | [232] | 2.80[233] | -3.53[234] | -2.57[235] | 5.86[236] | 5.88[237] | 3.01[238] |
35 | CTSK | Cathepsin K | [239] | 0.34[240] | 2.99[241] | 2.22[242] | 1.50[243] | 1.83[244] | 2.19[245] |
36 | COL17A1 | Collagen alpha-1(XVII) chain | [246] | 1.02[247] | -3.13[248] | -2.93[249] | -2.63[250] | -0.66[251] | -1.26[252] |
37 | COL15A1 | Collagen alpha-1(XV) chain | [253] | -2.00[254] | -5.48[255] | [256] | 1.62[257] | -1.96[258] | -0.03[259] |
38 | COL2A1 | Collagen alpha-1(II) chain | [260] | -0.05[261] | 3.38[262] | 5.54[263] | -3.93[264] | -3.74[265] | [266] |
39 | COL12A1 | Collagen alpha-1(XII) chain | [267] | -0.22[268] | -1.90[269] | 4.96[270] | 9.22[271] | 6.49[272] | 4.28[273] |
40 | COL6A3 | Collagen alpha-3(VI) chain | [274] | -0.50[275] | -2.41[276] | -3.14[277] | 5.83[278] | 6.96[279] | 6.88[280] |
41 | COL14A1 | Collagen alpha-1(XIV) chain | [281] | -0.83[282] | 0.18[283] | 9.62[284] | 3.51[285] | -0.77[286] | 6.37[287] |
42 | COL25A1 | Collagen alpha-1(XXV) chain | [288] | [289] | -2.33[290] | [291] | -7.16[292] | -1.40[293] | 3.37[294] |
43 | COL4A3 | Collagen alpha-3(IV) chain | [295] | -3.93[296] | -3.03[297] | -1.93[298] | 4.56[299] | -2.19[300] | 2.59[301] |
44 | COL4A4 | Collagen alpha-4(IV) chain | [302] | -2.02[303] | -4.20[304] | -0.28[305] | 6.76[306] | 2.83[307] | 5.08[308] |
45 | ELANE | Neutrophil elastase | [309] | [310] | [311] | -2.74[312] | -3.24[313] | -5.36[314] | 1.13[315] |
46 | COL13A1 | Collagen alpha-1(XIII) chain | [316] | -3.45[317] | [318] | -4.69[319] | -0.98[320] | 2.54[321] | 0.05[322] |
47 | COL5A1 | Collagen alpha-1(V) chain | [323] | 2.79[324] | -0.17[325] | 0.81[326] | 9.52[327] | 9.03[328] | 6.18[329] |
48 | COL11A2 | Collagen alpha-2(XI) chain | [330] | 0.81[331] | 3.03[332] | 2.16[333] | 3.31[334] | 1.47[335] | 1.93[336] |
49 | MMP8 | Neutrophil collagenase | [337] | [338] | [339] | [340] | [341] | -3.15[342] | 2.13[343] |
50 | COL9A1 | Collagen alpha-1(IX) chain | [344] | -3.19[345] | [346] | [347] | -5.17[348] | [349] | -2.01[350] |
51 | MMP20 | Matrix metalloproteinase-20 | [351] | 3.68[352] | 4.35[353] | [354] | -2.19[355] | -4.20[356] | -3.32[357] |
52 | COL11A1 | Collagen alpha-1(XI) chain | [358] | -0.24[359] | [360] | -1.15[361] | 4.64[362] | 2.41[363] | -0.65[364] |
53 | COL8A1 | Collagen alpha-1(VIII) chain | [365] | -1.38[366] | 0.06[367] | 0.57[368] | 3.32[369] | 9.84[370] | 5.13[371] |
54 | COL23A1 | Collagen alpha-1(XXIII) chain | [372] | -0.93[373] | [374] | [375] | -3.49[376] | [377] | 2.88[378] |
55 | COL8A2 | Collagen alpha-2(VIII) chain | [379] | 5.17[380] | 3.99[381] | 4.98[382] | 2.90[383] | 5.10[384] | 3.88[385] |
56 | COL19A1 | Collagen alpha-1(XIX) chain | [386] | -0.96[387] | [388] | 4.41[389] | 0.68[390] | -0.29[391] | 4.82[392] |
57 | MMP13 | Collagenase 3 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | [400] | [401] | [402] | [403] | [404] | [405] | [406] |
59 | COL6A5 | Collagen alpha-5(VI) chain | [407] | [408] | [409] | [410] | [411] | [412] | [413] |
60 | PRSS2 | Trypsin-2 | [414] | [415] | [416] | [417] | [418] | [419] | [420] |
61 | CTSL | Cathepsin L1 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |
62 | COL26A1 | Collagen alpha-1(XXVI) chain | [428] | [429] | [430] | [431] | [432] | [433] | [434] |
63 | COL6A6 | Collagen alpha-6(VI) chain | [435] | [436] | [437] | [438] | [439] | [440] | [441] |
64 | COL10A1 | Collagen alpha-1(X) chain | [442] | [443] | [444] | [445] | [446] | [447] | [448] |