REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MMADHC Methylmalonic aciduria and homocystinuria type D protein, mitochondrial -1.14[1] -0.37[2] -0.27[3] -0.21[4] -0.08[5] -0.65[6]
2 AMN Protein amnionless [7] -3.22[8] -2.45[9] -3.22[10] -9.83[11] -9.77[12] -3.72[13]
3 LMBRD1 Probable lysosomal cobalamin transporter [14] -1.23[15] -0.39[16] -0.59[17] -1.07[18] -0.61[19] 0.72[20]
4 CD320 CD320 antigen [21] 1.05[22] 0.73[23] 0.17[24] -0.88[25] 0.41[26] -2.07[27]
5 PRSS3 Trypsin-3 [28] -11.34[29] -9.65[30] -1.89[31] -11.71[32] -3.67[33] -3.74[34]
6 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial [35] -1.64[36] 1.26[37] 0.96[38] -1.55[39] -1.51[40] 1.09[41]
7 MTRR Methionine synthase reductase [42] 0.40[43] 1.00[44] 2.08[45] 1.07[46] 2.07[47] 1.36[48]
8 ABCD4 ATP-binding cassette sub-family D member 4 [49] 0.10[50] 1.37[51] 0.48[52] 0.68[53] 0.52[54] 0.89[55]
9 MMAA Methylmalonic aciduria type A protein, mitochondrial [56] -2.46[57] -1.56[58] -0.65[59] -0.18[60] 0.21[61] 2.46[62]
10 MMACHC Methylmalonic aciduria and homocystinuria type C protein [63] 0.25[64] 0.79[65] 0.96[66] -0.76[67] 0.19[68] 1.83[69]
11 TCN2 Transcobalamin-2 [70] -1.17[71] -2.99[72] -0.32[73] 1.80[74] 1.43[75] 1.73[76]
12 ABCC1 Multidrug resistance-associated protein 1 [77] 5.41[78] 2.54[79] 1.97[80] 4.93[81] 3.70[82] 0.92[83]
13 MTR Methionine synthase [84] 2.43[85] 3.06[86] 3.55[87] 3.66[88] 3.33[89] 3.50[90]
14 TCN1 Transcobalamin-1 [91] 0.70[92] -4.38[93] 1.13[94] -1.94[95] -3.42[96] -1.78[97]
15 CUBN Cubilin [98] 1.39[99] 2.83[100] 1.43[101] 5.82[102] 4.61[103] 4.85[104]
16 CBLIF [105] [106] [107] [108] [109] [110] [111]
17 CTRC Chymotrypsin-C [112] [113] [114] [115] [116] [117] [118]
18 PRSS1 Trypsin-1 [119] [120] [121] [122] [123] [124] [125]
19 MMUT [126] [127] [128] [129] [130] [131] [132]
20 CTRB2 Chymotrypsinogen B2 [133] [134] [135] [136] [137] [138] [139]
21 CTRB1 Chymotrypsinogen B [140] [141] [142] [143] [144] [145] [146]
[1]
ref_hepatocyte MMADHC
Mean 53.2
Standard deviation 26
Values 71 81 15 48 51
[2]
HepG2 MMADHC
Mean 47.4
Standard deviation 7.3
Values 42 53
[3]
HepG2.C3A MMADHC
Mean 75.4
Standard deviation 22
Values 60 91
[4]
HuH.7 MMADHC
Mean 60.8
Standard deviation 4
Values 65 57 60
[5]
SNU475 MMADHC
Mean 59.1
Standard deviation 1.5
Values 58 60
[6]
THLE MMADHC
Mean 57.6
Standard deviation 10
Values 50 65
[7]
liver MMADHC
Mean 43.5
Standard deviation 21
Values 63 28 61 22
[8]
ref_hepatocyte AMN
Mean 35.6
Standard deviation 50
Values 14 0.23 2.6 40 1.2e+02
[9]
HepG2 AMN
Mean 7.5
Standard deviation 1.1
Values 8.2 6.7
[10]
HepG2.C3A AMN
Mean 11.9
Standard deviation 6.3
Values 16 7.5
[11]
HuH.7 AMN
Mean 5.27
Standard deviation 1.7
Values 3.8 7.1 4.9
[12]
SNU475 AMN
Mean 0.0503
Standard deviation 0.058
Values 0.0093 0.091
[13]
THLE AMN
Mean 0.0467
Standard deviation 0.024
Values 0.03 0.064
[14]
liver AMN
Mean 3.47
Standard deviation 4.8
Values 11 1.6 0.95 0.74
[15]
ref_hepatocyte LMBRD1
Mean 15.7
Standard deviation 6.8
Values 15 14 6.8 17 26
[16]
HepG2 LMBRD1
Mean 13.1
Standard deviation 1.1
Values 12 14
[17]
HepG2.C3A LMBRD1
Mean 22
Standard deviation 0.015
Values 22 22
[18]
HuH.7 LMBRD1
Mean 14.4
Standard deviation 3.1
Values 13 18 12
[19]
SNU475 LMBRD1
Mean 9.65
Standard deviation 3.6
Values 12 7.1
[20]
THLE LMBRD1
Mean 11.8
Standard deviation 1
Values 11 13
[21]
liver LMBRD1
Mean 33.3
Standard deviation 16
Values 52 25 41 16
[22]
ref_hepatocyte CD320
Mean 15.2
Standard deviation 13
Values 8.4 9.5 38 12 7.7
[23]
HepG2 CD320
Mean 61.9
Standard deviation 11
Values 69 54
[24]
HepG2.C3A CD320
Mean 46.2
Standard deviation 6.6
Values 42 51
[25]
HuH.7 CD320
Mean 23.6
Standard deviation 10
Values 27 12 32
[26]
SNU475 CD320
Mean 10.7
Standard deviation 0.022
Values 11 11
[27]
THLE CD320
Mean 23.2
Standard deviation 0.08
Values 23 23
[28]
liver CD320
Mean 4.65
Standard deviation 3.5
Values 7.5 1.9 7.9 1.3
[29]
ref_hepatocyte PRSS3
Mean 13.2
Standard deviation 22
Values 0.59 4.1 53 4.1 4.6
[30]
HepG2 PRSS3
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[31]
HepG2.C3A PRSS3
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[32]
HuH.7 PRSS3
Mean 4.94
Standard deviation 1.3
Values 3.7 6.3 4.8
[33]
SNU475 PRSS3
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[34]
THLE PRSS3
Mean 1.19
Standard deviation 0.27
Values 1 1.4
[35]
liver PRSS3
Mean 1.27
Standard deviation 1.4
Values 2.9 0.3 1.8 0.013
[36]
ref_hepatocyte MMAB
Mean 11.5
Standard deviation 12
Values 6.1 2.6 1.9 18 29
[37]
HepG2 MMAB
Mean 7.28
Standard deviation 1.8
Values 6 8.5
[38]
HepG2.C3A MMAB
Mean 50.5
Standard deviation 17
Values 62 39
[39]
HuH.7 MMAB
Mean 31
Standard deviation 2.8
Values 29 30 34
[40]
SNU475 MMAB
Mean 5.06
Standard deviation 1.2
Values 5.9 4.2
[41]
THLE MMAB
Mean 4.65
Standard deviation 0.9
Values 4 5.3
[42]
liver MMAB
Mean 31.6
Standard deviation 24
Values 43 10 61 13
[43]
ref_hepatocyte MTRR
Mean 6.08
Standard deviation 1.7
Values 3.7 7.4 5.1 8 6.2
[44]
HepG2 MTRR
Mean 15.8
Standard deviation 4.2
Values 13 19
[45]
HepG2.C3A MTRR
Mean 22.3
Standard deviation 4.3
Values 19 25
[46]
HuH.7 MTRR
Mean 35.5
Standard deviation 8.3
Values 42 26 38
[47]
SNU475 MTRR
Mean 16.4
Standard deviation 3.1
Values 14 19
[48]
THLE MTRR
Mean 29.4
Standard deviation 7.2
Values 34 24
[49]
liver MTRR
Mean 20.1
Standard deviation 4.3
Values 21 20 25 14
[50]
ref_hepatocyte ABCD4
Mean 5.56
Standard deviation 3.4
Values 3.8 2.3 3.4 8.6 9.7
[51]
HepG2 ABCD4
Mean 11.7
Standard deviation 1.2
Values 13 11
[52]
HepG2.C3A ABCD4
Mean 26.3
Standard deviation 6.6
Values 31 22
[53]
HuH.7 ABCD4
Mean 10.7
Standard deviation 2
Values 10 9 13
[54]
SNU475 ABCD4
Mean 11.5
Standard deviation 0.23
Values 12 11
[55]
THLE ABCD4
Mean 9.15
Standard deviation 0.94
Values 9.8 8.5
[56]
liver ABCD4
Mean 13.3
Standard deviation 4.7
Values 18 8.8 17 9.6
[57]
ref_hepatocyte MMAA
Mean 2.58
Standard deviation 1.4
Values 0.53 1.6 3.4 3.7 3.6
[58]
HepG2 MMAA
Mean 0.922
Standard deviation 0.37
Values 0.66 1.2
[59]
HepG2.C3A MMAA
Mean 1.6
Standard deviation 0.69
Values 1.1 2.1
[60]
HuH.7 MMAA
Mean 2.27
Standard deviation 0.28
Values 2.6 2.3 2
[61]
SNU475 MMAA
Mean 2.93
Standard deviation 0.84
Values 3.5 2.3
[62]
THLE MMAA
Mean 3.42
Standard deviation 0.2
Values 3.3 3.6
[63]
liver MMAA
Mean 18.2
Standard deviation 6.6
Values 24 14 23 11
[64]
ref_hepatocyte MMACHC
Mean 2.46
Standard deviation 2.5
Values 1.2 0.4 0.38 5.1 5.2
[65]
HepG2 MMACHC
Mean 5.75
Standard deviation 1.4
Values 4.8 6.7
[66]
HepG2.C3A MMACHC
Mean 7.79
Standard deviation 1.7
Values 6.6 9
[67]
HuH.7 MMACHC
Mean 6.61
Standard deviation 1.3
Values 7.9 5.3 6.6
[68]
SNU475 MMACHC
Mean 1.87
Standard deviation 0.26
Values 1.7 2.1
[69]
THLE MMACHC
Mean 3.23
Standard deviation 0.96
Values 2.5 3.9
[70]
liver MMACHC
Mean 11.3
Standard deviation 3.2
Values 15 7.2 11 11
[71]
ref_hepatocyte TCN2
Mean 1.75
Standard deviation 1.6
Values 0.3 1.1 0.65 2.6 4
[72]
HepG2 TCN2
Mean 1.53
Standard deviation 0.2
Values 1.4 1.7
[73]
HepG2.C3A TCN2
Mean 0.402
Standard deviation 0.16
Values 0.52 0.29
[74]
HuH.7 TCN2
Mean 1.94
Standard deviation 0.14
Values 2.1 1.9 1.9
[75]
SNU475 TCN2
Mean 7.84
Standard deviation 2.8
Values 9.8 5.9
[76]
THLE TCN2
Mean 5.39
Standard deviation 1.5
Values 4.3 6.5
[77]
liver TCN2
Mean 7.47
Standard deviation 4.1
Values 13 4.5 8.3 4.1
[78]
ref_hepatocyte ABCC1
Mean 1.64
Standard deviation 2.8
Values 6.7 0.55 0.55 0.18 0.21
[79]
HepG2 ABCC1
Mean 138
Standard deviation 32
Values 1.6e+02 1.2e+02
[80]
HepG2.C3A ABCC1
Mean 17.5
Standard deviation 0.7
Values 18 17
[81]
HuH.7 ABCC1
Mean 8.92
Standard deviation 1.5
Values 11 8.1 8.1
[82]
SNU475 ABCC1
Mean 64.4
Standard deviation 27
Values 83 45
[83]
THLE ABCC1
Mean 24.5
Standard deviation 8.1
Values 19 30
[84]
liver ABCC1
Mean 4
Standard deviation 2.2
Values 2.8 4.5 1.8 6.8
[85]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 2.9 2.1 1.2 0.53 0.48
[86]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 12 18
[87]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 22 21
[88]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 29 21 20
[89]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 29 18
[90]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[91]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 12 34 14 24
[92]
ref_hepatocyte TCN1
Mean 0.0552
Standard deviation 0.12
Values 0 0 0 0.28 0
[93]
HepG2 TCN1
Mean 0.176
Standard deviation 0.054
Values 0.14 0.21
[94]
HepG2.C3A TCN1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 TCN1
Mean 0.167
Standard deviation 0.095
Values 0.082 0.27 0.15
[96]
SNU475 TCN1
Mean 0.0186
Standard deviation 0.026
Values 0.037 0
[97]
THLE TCN1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[98]
liver TCN1
Mean 0.0206
Standard deviation 0.024
Values 0 0.043 0 0.04
[99]
ref_hepatocyte CUBN
Mean 0.0112
Standard deviation 0.0085
Values 0.021 0.018 0 0.0086 0.0081
[100]
HepG2 CUBN
Mean 0.058
Standard deviation 0.009
Values 0.052 0.064
[101]
HepG2.C3A CUBN
Mean 0.146
Standard deviation 0.055
Values 0.18 0.11
[102]
HuH.7 CUBN
Mean 0.0417
Standard deviation 0.0065
Values 0.049 0.039 0.037
[103]
SNU475 CUBN
Mean 0.813
Standard deviation 0.66
Values 0.34 1.3
[104]
THLE CUBN
Mean 0.313
Standard deviation 0.059
Values 0.35 0.27
[105]
liver CUBN
Mean 0.416
Standard deviation 0.32
Values 0.12 0.61 0.18 0.75
[106]
ref_hepatocyte CBLIF
Missing
[107]
HepG2 CBLIF
Missing
[108]
HepG2.C3A CBLIF
Missing
[109]
HuH.7 CBLIF
Missing
[110]
SNU475 CBLIF
Missing
[111]
THLE CBLIF
Missing
[112]
liver CBLIF
Missing
[113]
ref_hepatocyte CTRC
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 CTRC
Mean 0.0258
Standard deviation 0.012
Values 0.034 0.017
[115]
HepG2.C3A CTRC
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 CTRC
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[117]
SNU475 CTRC
Mean 0.0234
Standard deviation 0.026
Values 0.042 0.0051
[118]
THLE CTRC
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[119]
liver CTRC
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[120]
ref_hepatocyte PRSS1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 PRSS1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[122]
HepG2.C3A PRSS1
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 PRSS1
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 PRSS1
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE PRSS1
Mean 0
Standard deviation 0
Values 0 0
[126]
liver PRSS1
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[127]
ref_hepatocyte MMUT
Missing
[128]
HepG2 MMUT
Missing
[129]
HepG2.C3A MMUT
Missing
[130]
HuH.7 MMUT
Missing
[131]
SNU475 MMUT
Missing
[132]
THLE MMUT
Missing
[133]
liver MMUT
Missing
[134]
ref_hepatocyte CTRB2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 CTRB2
Mean 0.0415
Standard deviation 0.047
Values 0.074 0.0086
[136]
HepG2.C3A CTRB2
Mean 0.0399
Standard deviation 0.026
Values 0.058 0.021
[137]
HuH.7 CTRB2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[138]
SNU475 CTRB2
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[139]
THLE CTRB2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[140]
liver CTRB2
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte CTRB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 CTRB1
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[143]
HepG2.C3A CTRB1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[144]
HuH.7 CTRB1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[145]
SNU475 CTRB1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[146]
THLE CTRB1
Mean 0.0148
Standard deviation 0.021
Values 0.03 0
[147]
liver CTRB1
Mean 0
Standard deviation 0
Values 0 0 0 0