REACTOME_CLEC7A_DECTIN_1_SIGNALING |
Return to index |
|
|
|
|
|
Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
UBB |
Polyubiquitin-B |
[1] |
-1.28[2] |
-1.39[3] |
-1.16[4] |
-1.57[5] |
-1.22[6] |
-0.69[7] |
2 |
RPS27A |
Ubiquitin-40S ribosomal protein S27a |
[8] |
[9] |
[10] |
[11] |
[12] |
[13] |
[14] |
3 |
UBC |
Polyubiquitin-C |
[15] |
-0.83[16] |
-0.64[17] |
-0.79[18] |
-0.71[19] |
-0.84[20] |
-0.23[21] |
4 |
PSME1 |
Proteasome activator complex subunit 1 |
[22] |
-0.60[23] |
-2.23[24] |
-1.76[25] |
-1.43[26] |
-2.06[27] |
-1.19[28] |
5 |
PSME2 |
Proteasome activator complex subunit 2 |
[29] |
-0.42[30] |
-1.85[31] |
-1.85[32] |
-1.22[33] |
-1.60[34] |
-0.81[35] |
6 |
PSMA7 |
Proteasome subunit alpha type-7 |
[36] |
0.54[37] |
0.62[38] |
-0.61[39] |
0.41[40] |
-0.12[41] |
0.21[42] |
7 |
PSMB1 |
Proteasome subunit beta type-1 |
[43] |
0.08[44] |
0.17[45] |
-0.80[46] |
-0.84[47] |
-0.16[48] |
0.05[49] |
8 |
PSMB3 |
Proteasome subunit beta type-3 |
[50] |
-0.40[51] |
-1.21[52] |
-0.08[53] |
-0.86[54] |
-1.07[55] |
-0.25[56] |
9 |
PSMB4 |
Proteasome subunit beta type-4 |
[57] |
-0.16[58] |
-0.01[59] |
0.22[60] |
0.57[61] |
0.47[62] |
-0.57[63] |
10 |
PSMB7 |
Proteasome subunit beta type-7 |
[64] |
-1.10[65] |
-1.11[66] |
-0.88[67] |
-1.20[68] |
-0.85[69] |
-1.01[70] |
11 |
PSMB5 |
Proteasome subunit beta type-5 |
[71] |
1.30[72] |
-0.15[73] |
-0.12[74] |
-0.48[75] |
-0.29[76] |
-0.54[77] |
12 |
PSMA6 |
Proteasome subunit alpha type-6 |
[78] |
1.43[79] |
0.13[80] |
0.16[81] |
0.05[82] |
-0.02[83] |
-0.46[84] |
13 |
NFKBIA |
NF-kappa-B inhibitor alpha |
[85] |
-0.13[86] |
-1.84[87] |
-2.14[88] |
-2.31[89] |
-0.53[90] |
0.05[91] |
14 |
PSMA4 |
Proteasome subunit alpha type-4 |
[92] |
-0.50[93] |
0.14[94] |
0.04[95] |
0.35[96] |
0.09[97] |
-0.54[98] |
15 |
SKP1 |
S-phase kinase-associated protein 1 |
[99] |
-0.06[100] |
0.42[101] |
-0.37[102] |
0.71[103] |
0.82[104] |
0.50[105] |
16 |
PSMC3 |
26S proteasome regulatory subunit 6A |
[106] |
-0.54[107] |
-0.62[108] |
0.10[109] |
-0.85[110] |
-0.74[111] |
-0.07[112] |
17 |
PSMA3 |
Proteasome subunit alpha type-3 |
[113] |
-1.12[114] |
-0.14[115] |
-0.71[116] |
-0.10[117] |
-0.64[118] |
-0.29[119] |
18 |
PSMB6 |
Proteasome subunit beta type-6 |
[120] |
-0.57[121] |
-0.44[122] |
-0.19[123] |
-0.65[124] |
-1.00[125] |
-0.13[126] |
19 |
PSMA2 |
Proteasome subunit alpha type-2 |
[127] |
-0.66[128] |
0.28[129] |
0.72[130] |
-0.15[131] |
0.13[132] |
0.09[133] |
20 |
PSMD4 |
26S proteasome non-ATPase regulatory subunit 4 |
[134] |
-0.14[135] |
-0.14[136] |
0.16[137] |
0.55[138] |
-0.07[139] |
-0.23[140] |
21 |
PSMD7 |
26S proteasome non-ATPase regulatory subunit 7 |
[141] |
-0.22[142] |
0.13[143] |
0.09[144] |
-0.54[145] |
-0.15[146] |
-0.41[147] |
22 |
PSMD8 |
26S proteasome non-ATPase regulatory subunit 8 |
[148] |
-0.06[149] |
0.17[150] |
0.41[151] |
-0.26[152] |
0.42[153] |
-0.38[154] |
23 |
PSMD2 |
26S proteasome non-ATPase regulatory subunit 2 |
[155] |
1.47[156] |
0.64[157] |
0.81[158] |
0.85[159] |
2.06[160] |
0.66[161] |
24 |
PSMC1 |
26S proteasome regulatory subunit 4 |
[162] |
-0.20[163] |
-0.15[164] |
-0.70[165] |
1.03[166] |
0.47[167] |
-0.18[168] |
25 |
PSMA1 |
Proteasome subunit alpha type-1 |
[169] |
-0.02[170] |
0.36[171] |
0.52[172] |
0.61[173] |
0.03[174] |
0.30[175] |
26 |
UBA52 |
Ubiquitin-60S ribosomal protein L40 |
[176] |
1.60[177] |
1.60[178] |
2.72[179] |
0.68[180] |
1.39[181] |
0.53[182] |
27 |
PSMC5 |
26S proteasome regulatory subunit 8 |
[183] |
0.30[184] |
0.18[185] |
0.36[186] |
0.02[187] |
0.35[188] |
0.07[189] |
28 |
PSMD3 |
26S proteasome non-ATPase regulatory subunit 3 |
[190] |
0.70[191] |
0.17[192] |
0.87[193] |
0.55[194] |
0.69[195] |
-0.21[196] |
29 |
PSMB8 |
Proteasome subunit beta type-8 |
[197] |
-1.70[198] |
-2.31[199] |
-9.42[200] |
0.52[201] |
-0.87[202] |
-0.90[203] |
30 |
PSMD14 |
26S proteasome non-ATPase regulatory subunit 14 |
[204] |
-0.13[205] |
0.46[206] |
0.82[207] |
0.41[208] |
0.36[209] |
-0.36[210] |
31 |
PSMC4 |
26S proteasome regulatory subunit 6B |
[211] |
0.30[212] |
0.31[213] |
0.35[214] |
0.04[215] |
0.07[216] |
0.12[217] |
32 |
PSMD6 |
26S proteasome non-ATPase regulatory subunit 6 |
[218] |
-0.85[219] |
-0.39[220] |
-1.37[221] |
-0.59[222] |
0.14[223] |
-0.47[224] |
33 |
PSMD13 |
26S proteasome non-ATPase regulatory subunit 13 |
[225] |
0.34[226] |
0.44[227] |
1.04[228] |
0.47[229] |
-0.10[230] |
-0.28[231] |
34 |
PSMD12 |
26S proteasome non-ATPase regulatory subunit 12 |
[232] |
-0.48[233] |
-0.41[234] |
-0.62[235] |
0.09[236] |
0.08[237] |
-0.36[238] |
35 |
PSMC6 |
26S proteasome regulatory subunit 10B |
[239] |
-0.18[240] |
1.38[241] |
0.30[242] |
0.45[243] |
0.30[244] |
0.29[245] |
36 |
PSMD11 |
26S proteasome non-ATPase regulatory subunit 11 |
[246] |
0.70[247] |
0.30[248] |
0.99[249] |
0.86[250] |
0.93[251] |
1.12[252] |
37 |
UBE2V1 |
Ubiquitin-conjugating enzyme E2 variant 1 |
[253] |
-2.95[254] |
-3.06[255] |
-2.83[256] |
-2.68[257] |
-3.43[258] |
-3.82[259] |
38 |
PSMC2 |
26S proteasome regulatory subunit 7 |
[260] |
0.46[261] |
0.84[262] |
0.72[263] |
1.25[264] |
1.00[265] |
1.17[266] |
39 |
CALM1 |
Calmodulin-1 |
[267] |
1.00[268] |
1.12[269] |
1.66[270] |
2.80[271] |
1.96[272] |
2.81[273] |
40 |
PSME3 |
Proteasome activator complex subunit 3 |
[274] |
1.68[275] |
1.39[276] |
1.17[277] |
1.28[278] |
1.46[279] |
0.74[280] |
41 |
CDC34 |
Ubiquitin-conjugating enzyme E2 R1 |
[281] |
0.71[282] |
0.96[283] |
0.29[284] |
-0.32[285] |
-0.66[286] |
-1.06[287] |
42 |
PSMD1 |
26S proteasome non-ATPase regulatory subunit 1 |
[288] |
1.44[289] |
1.75[290] |
1.73[291] |
2.08[292] |
2.01[293] |
1.92[294] |
43 |
IKBKG |
NF-kappa-B essential modulator |
[295] |
0.03[296] |
0.27[297] |
-1.90[298] |
0.36[299] |
-0.96[300] |
0.59[301] |
44 |
PSMB10 |
Proteasome subunit beta type-10 |
[302] |
-1.28[303] |
-0.70[304] |
-2.49[305] |
-0.13[306] |
-1.37[307] |
-0.22[308] |
45 |
AHCYL1 |
S-adenosylhomocysteine hydrolase-like protein 1 |
[309] |
1.16[310] |
1.34[311] |
1.99[312] |
2.23[313] |
1.99[314] |
1.49[315] |
46 |
PSMA5 |
Proteasome subunit alpha type-5 |
[316] |
1.77[317] |
2.18[318] |
1.85[319] |
2.14[320] |
1.62[321] |
1.76[322] |
47 |
PSMF1 |
Proteasome inhibitor PI31 subunit |
[323] |
2.15[324] |
2.18[325] |
1.09[326] |
1.14[327] |
0.82[328] |
1.71[329] |
48 |
UBE2N |
Ubiquitin-conjugating enzyme E2 N |
[330] |
1.61[331] |
2.17[332] |
1.08[333] |
1.53[334] |
1.31[335] |
0.47[336] |
49 |
UBE2M |
NEDD8-conjugating enzyme Ubc12 |
[337] |
0.27[338] |
0.08[339] |
0.83[340] |
0.75[341] |
0.55[342] |
-1.50[343] |
50 |
NFKB2 |
Nuclear factor NF-kappa-B p100 subunit |
[344] |
0.16[345] |
0.54[346] |
1.07[347] |
-0.17[348] |
0.57[349] |
-1.83[350] |
51 |
PSMB2 |
Proteasome subunit beta type-2 |
[351] |
1.93[352] |
1.65[353] |
2.14[354] |
2.44[355] |
2.34[356] |
2.25[357] |
52 |
RELA |
Transcription factor p65 |
[358] |
1.06[359] |
0.64[360] |
0.86[361] |
1.16[362] |
0.96[363] |
0.31[364] |
53 |
PSMB9 |
Proteasome subunit beta type-9 |
[365] |
-2.07[366] |
-4.71[367] |
-6.92[368] |
1.69[369] |
-0.66[370] |
-0.64[371] |
54 |
PSMD9 |
26S proteasome non-ATPase regulatory subunit 9 |
[372] |
0.31[373] |
0.78[374] |
-0.10[375] |
0.32[376] |
0.67[377] |
0.58[378] |
55 |
CUL1 |
Cullin-1 |
[379] |
0.54[380] |
1.30[381] |
0.94[382] |
1.79[383] |
1.34[384] |
1.94[385] |
56 |
PPP3R1 |
Calcineurin subunit B type 1 |
[386] |
1.11[387] |
1.38[388] |
1.37[389] |
1.92[390] |
1.57[391] |
0.04[392] |
57 |
UBE2D2 |
Ubiquitin-conjugating enzyme E2 D2 |
[393] |
1.92[394] |
2.05[395] |
1.41[396] |
2.01[397] |
2.10[398] |
1.15[399] |
58 |
UBA3 |
NEDD8-activating enzyme E1 catalytic subunit |
[400] |
0.65[401] |
1.29[402] |
0.46[403] |
1.40[404] |
1.91[405] |
1.01[406] |
59 |
PSMD10 |
26S proteasome non-ATPase regulatory subunit 10 |
[407] |
0.86[408] |
1.17[409] |
1.29[410] |
1.99[411] |
1.22[412] |
0.56[413] |
60 |
TAB2 |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
[414] |
1.29[415] |
1.54[416] |
1.89[417] |
2.91[418] |
2.26[419] |
1.43[420] |
61 |
CASP8 |
Caspase-8 |
[421] |
0.94[422] |
1.60[423] |
0.85[424] |
1.13[425] |
0.28[426] |
-0.23[427] |
62 |
MAP3K7 |
Mitogen-activated protein kinase kinase kinase 7 |
[428] |
0.82[429] |
1.98[430] |
1.93[431] |
1.70[432] |
1.77[433] |
1.44[434] |
63 |
PSME4 |
Proteasome activator complex subunit 4 |
[435] |
2.39[436] |
3.29[437] |
3.39[438] |
2.54[439] |
2.42[440] |
2.83[441] |
64 |
TAB3 |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
[442] |
0.98[443] |
3.01[444] |
3.19[445] |
1.56[446] |
2.65[447] |
2.02[448] |
65 |
NFKB1 |
Nuclear factor NF-kappa-B p105 subunit |
[449] |
1.59[450] |
1.36[451] |
1.23[452] |
0.97[453] |
1.77[454] |
1.64[455] |
66 |
PSMD5 |
26S proteasome non-ATPase regulatory subunit 5 |
[456] |
1.28[457] |
0.82[458] |
2.48[459] |
2.37[460] |
2.37[461] |
2.01[462] |
67 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[463] |
1.84[464] |
3.38[465] |
1.92[466] |
1.22[467] |
1.25[468] |
5.06[469] |
68 |
FBXW11 |
F-box/WD repeat-containing protein 11 |
[470] |
2.30[471] |
2.29[472] |
3.13[473] |
2.73[474] |
2.54[475] |
2.14[476] |
69 |
PPP3CB |
Serine/threonine-protein phosphatase
2B catalytic subunit beta isoform |
1.41[477] |
2.29[478] |
1.88[479] |
1.97[480] |
1.61[481] |
1.04[482] |
70 |
NFATC3 |
Nuclear factor of activated T-cells, cytoplasmic 3 |
[483] |
2.39[484] |
3.25[485] |
3.23[486] |
2.07[487] |
2.34[488] |
3.59[489] |
71 |
RELB |
Transcription factor RelB |
[490] |
0.64[491] |
0.30[492] |
0.63[493] |
0.20[494] |
1.31[495] |
-1.32[496] |
72 |
CHUK |
Inhibitor of nuclear factor kappa-B kinase subunit alpha |
[497] |
1.83[498] |
3.13[499] |
3.17[500] |
1.86[501] |
2.57[502] |
2.71[503] |
73 |
SRC |
Proto-oncogene tyrosine-protein kinase Src |
[504] |
3.95[505] |
4.02[506] |
3.10[507] |
3.61[508] |
2.68[509] |
0.34[510] |
74 |
TAB1 |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
[511] |
1.57[512] |
2.30[513] |
2.46[514] |
1.22[515] |
1.45[516] |
1.41[517] |
75 |
PRKCD |
Protein kinase C delta type |
[518] |
2.02[519] |
2.36[520] |
1.91[521] |
0.71[522] |
1.76[523] |
0.12[524] |
76 |
PDPK1 |
3-phosphoinositide-dependent protein kinase 1 |
[525] |
3.26[526] |
4.53[527] |
3.32[528] |
2.65[529] |
2.93[530] |
3.69[531] |
77 |
IKBKB |
Inhibitor of nuclear factor kappa-B kinase subunit beta |
[532] |
1.44[533] |
1.59[534] |
1.77[535] |
1.47[536] |
1.45[537] |
2.37[538] |
78 |
PPP3CA |
Serine/threonine-protein phosphatase
2B catalytic subunit alpha isoform |
1.65[539] |
1.50[540] |
1.38[541] |
3.16[542] |
2.79[543] |
3.00[544] |
79 |
IL1B |
Interleukin-1 beta |
[545] |
-7.77[546] |
-7.55[547] |
-3.15[548] |
-2.38[549] |
3.10[550] |
-4.01[551] |
80 |
BCL10 |
B-cell lymphoma/leukemia 10 |
[552] |
1.01[553] |
0.60[554] |
1.67[555] |
1.75[556] |
1.68[557] |
1.72[558] |
81 |
PYCARD |
Apoptosis-associated speck-like protein containing a CARD |
[559] |
0.98[560] |
1.25[561] |
-7.73[562] |
-7.03[563] |
1.44[564] |
0.36[565] |
82 |
UBE2D1 |
Ubiquitin-conjugating enzyme E2 D1 |
[566] |
1.72[567] |
2.67[568] |
3.10[569] |
2.73[570] |
2.39[571] |
1.69[572] |
83 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[573] |
6.22[574] |
5.15[575] |
3.72[576] |
3.56[577] |
5.63[578] |
1.42[579] |
84 |
BTRC |
F-box/WD repeat-containing protein 1A |
[580] |
2.34[581] |
3.21[582] |
2.91[583] |
1.97[584] |
2.40[585] |
2.54[586] |
85 |
MALT1 |
Mucosa-associated lymphoid tissue
lymphoma translocation protein 1 |
3.78[587] |
3.71[588] |
3.21[589] |
3.25[590] |
2.43[591] |
3.45[592] |
86 |
MAP3K14 |
Mitogen-activated protein kinase kinase kinase 14 |
[593] |
0.53[594] |
1.07[595] |
-0.02[596] |
3.29[597] |
2.16[598] |
2.07[599] |
87 |
CLEC7A |
C-type lectin domain family 7 member A |
[600] |
-3.79[601] |
-2.45[602] |
-2.06[603] |
-1.26[604] |
-3.49[605] |
2.21[606] |
88 |
PLCG2 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-2 |
-0.36[607] |
-6.02[608] |
1.51[609] |
-1.52[610] |
-0.48[611] |
3.91[612] |
89 |
TRAF6 |
TNF receptor-associated factor 6 |
[613] |
2.01[614] |
1.99[615] |
2.64[616] |
2.87[617] |
2.22[618] |
4.10[619] |
90 |
NFATC1 |
Nuclear factor of activated T-cells, cytoplasmic 1 |
[620] |
-1.03[621] |
-3.46[622] |
3.22[623] |
-4.76[624] |
3.54[625] |
1.91[626] |
91 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[627] |
4.06[628] |
4.03[629] |
5.27[630] |
4.06[631] |
4.82[632] |
5.84[633] |
92 |
NFATC2 |
Nuclear factor of activated T-cells, cytoplasmic 2 |
[634] |
3.51[635] |
4.85[636] |
4.34[637] |
1.39[638] |
2.24[639] |
4.48[640] |
93 |
SYK |
Tyrosine-protein kinase SYK |
[641] |
-7.24[642] |
-1.28[643] |
-4.22[644] |
1.31[645] |
-2.31[646] |
4.55[647] |
94 |
CCL22 |
C-C motif chemokine 22 |
[648] |
-0.45[649] |
-0.21[650] |
-1.47[651] |
-0.95[652] |
-1.12[653] |
-1.49[654] |
95 |
CARD9 |
Caspase recruitment domain-containing protein 9 |
[655] |
4.63[656] |
4.88[657] |
0.47[658] |
-0.30[659] |
-0.33[660] |
1.84[661] |
96 |
CARD11 |
Caspase recruitment domain-containing protein 11 |
[662] |
2.06[663] |
-4.37[664] |
-5.06[665] |
2.46[666] |
6.86[667] |
3.47[668] |
97 |
CCL17 |
C-C motif chemokine 17 |
[669] |
[670] |
-2.32[671] |
-1.81[672] |
[673] |
[674] |
-1.89[675] |
98 |
SEM1 |
Putative protein SEM1, isoform 2 |
[676] |
[677] |
[678] |
[679] |
[680] |
[681] |
[682] |
99 |
PSMA8 |
Proteasome subunit alpha type-7-like |
[683] |
[684] |
[685] |
[686] |
[687] |
[688] |
[689] |
100 |
PSMB11 |
Proteasome subunit beta type-11 |
[690] |
[691] |
[692] |
[693] |
[694] |
[695] |
[696] |
|
|
|
|
|
|
|
|
|
|