REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial [1] -1.12[2] -1.57[3] -0.96[4] -1.68[5] -2.94[6] -0.24[7]
2 MDH2 Malate dehydrogenase, mitochondrial [8] -0.19[9] -0.77[10] -0.13[11] -0.41[12] -0.91[13] -0.40[14]
3 SDHB Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial -1.14[15] -0.54[16] -1.21[17] -1.25[18] -1.03[19] -0.45[20]
4 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial -0.33[21] -0.65[22] -0.61[23] -0.69[24] -0.06[25] 0.13[26]
5 SDHD Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial -0.53[27] -0.52[28] -1.01[29] -0.07[30] -0.27[31] 0.31[32]
6 SUCLG2 Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial [33] -1.18[34] -0.76[35] -0.95[36] -1.71[37] -0.97[38] -0.04[39]
7 SUCLG1 Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial -0.80[40] -0.33[41] 0.74[42] -1.00[43] -0.65[44] -0.54[45]
8 FH Fumarate hydratase, mitochondrial [46] -0.66[47] -0.53[48] -0.16[49] 0.32[50] -0.12[51] 0.19[52]
9 DLD Dihydrolipoyl dehydrogenase, mitochondrial [53] -0.23[54] 0.39[55] 0.38[56] 0.87[57] 0.41[58] 0.15[59]
10 SDHC Succinate dehydrogenase cytochrome b560 subunit, mitochondrial [60] 1.19[61] 1.13[62] 0.87[63] 1.58[64] 1.25[65] -0.70[66]
11 IDH3B Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [67] 0.71[68] 0.85[69] 0.18[70] 0.18[71] 0.33[72] -0.76[73]
12 FAHD1 Acylpyruvase FAHD1, mitochondrial [74] -0.43[75] -0.37[76] -0.53[77] -1.89[78] -0.52[79] -0.48[80]
13 NNT NAD(P) transhydrogenase, mitochondrial [81] -0.24[82] 0.33[83] -0.10[84] 0.12[85] 0.47[86] 1.90[87]
14 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 1.36[88] 1.78[89] 0.87[90] 1.44[91] 1.63[92] -0.50[93]
15 ACO2 Aconitate hydratase, mitochondrial [94] 0.69[95] 0.66[96] 0.95[97] 0.11[98] 0.35[99] 0.29[100]
16 CS Citrate synthase, mitochondrial [101] 3.24[102] 2.92[103] 2.54[104] 2.36[105] 2.50[106] 0.37[107]
17 IDH3G Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial [108] -0.30[109] -0.21[110] 0.13[111] 0.80[112] 0.48[113] -0.31[114]
18 SUCLA2 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [115] 0.05[116] 1.09[117] 0.25[118] 0.22[119] 0.93[120] -0.18[121]
19 OGDH 2-oxoglutarate dehydrogenase, mitochondrial [122] 1.65[123] 0.95[124] 2.01[125] 2.18[126] 2.19[127] 1.34[128]
20 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [129] 0.47[130] 0.90[131] 0.07[132] 1.38[133] 1.83[134] 0.81[135]
21 ME2 NAD-dependent malic enzyme, mitochondrial [136] 1.77[137] 1.55[138] 2.21[139] 3.05[140] 3.48[141] 1.26[142]
22 ME3 NADP-dependent malic enzyme, mitochondrial [143] -3.00[144] -5.07[145] -2.15[146] 2.63[147] 2.02[148] 1.04[149]
[1]
ref_hepatocyte IDH2
Mean 157
Standard deviation 1.1e+02
Values 2e+02 52 30 2.6e+02 2.4e+02
[2]
HepG2 IDH2
Mean 85
Standard deviation 1.2
Values 86 84
[3]
HepG2.C3A IDH2
Mean 59.2
Standard deviation 12
Values 68 51
[4]
HuH.7 IDH2
Mean 77.5
Standard deviation 6.5
Values 83 70 79
[5]
SNU475 IDH2
Mean 40.8
Standard deviation 22
Values 56 26
[6]
THLE IDH2
Mean 18.2
Standard deviation 1.2
Values 17 19
[7]
liver IDH2
Mean 181
Standard deviation 68
Values 2.1e+02 1.1e+02 2.6e+02 1.4e+02
[8]
ref_hepatocyte MDH2
Mean 104
Standard deviation 75
Values 38 53 77 2.2e+02 1.3e+02
[9]
HepG2 MDH2
Mean 107
Standard deviation 16
Values 1.2e+02 96
[10]
HepG2.C3A MDH2
Mean 67.7
Standard deviation 5.8
Values 72 64
[11]
HuH.7 MDH2
Mean 91.1
Standard deviation 31
Values 1.2e+02 57 98
[12]
SNU475 MDH2
Mean 64.7
Standard deviation 14
Values 74 55
[13]
THLE MDH2
Mean 49
Standard deviation 8.8
Values 43 55
[14]
liver MDH2
Mean 107
Standard deviation 92
Values 1.7e+02 26 2e+02 29
[15]
ref_hepatocyte SDHB
Mean 81.4
Standard deviation 76
Values 14 23 43 1.7e+02 1.6e+02
[16]
HepG2 SDHB
Mean 43.4
Standard deviation 2.6
Values 42 45
[17]
HepG2.C3A SDHB
Mean 62.7
Standard deviation 9.9
Values 56 70
[18]
HuH.7 SDHB
Mean 33.9
Standard deviation 12
Values 34 22 46
[19]
SNU475 SDHB
Mean 28.4
Standard deviation 0.73
Values 29 28
[20]
THLE SDHB
Mean 35.4
Standard deviation 4.1
Values 33 38
[21]
liver SDHB
Mean 81
Standard deviation 60
Values 1.4e+02 36 1.3e+02 23
[22]
ref_hepatocyte SDHA
Mean 64.8
Standard deviation 32
Values 47 43 36 93 1.1e+02
[23]
HepG2 SDHA
Mean 60.8
Standard deviation 7
Values 56 66
[24]
HepG2.C3A SDHA
Mean 46
Standard deviation 2.9
Values 48 44
[25]
HuH.7 SDHA
Mean 40.8
Standard deviation 11
Values 48 28 47
[26]
SNU475 SDHA
Mean 33.3
Standard deviation 7.3
Values 38 28
[27]
THLE SDHA
Mean 55.2
Standard deviation 3.8
Values 53 58
[28]
liver SDHA
Mean 96.7
Standard deviation 39
Values 97 78 1.5e+02 61
[29]
ref_hepatocyte SDHD
Mean 63.7
Standard deviation 69
Values 12 21 21 92 1.7e+02
[30]
HepG2 SDHD
Mean 51.9
Standard deviation 13
Values 42 61
[31]
HepG2.C3A SDHD
Mean 49.6
Standard deviation 13
Values 40 59
[32]
HuH.7 SDHD
Mean 30.4
Standard deviation 8.6
Values 30 22 39
[33]
SNU475 SDHD
Mean 50.5
Standard deviation 13
Values 59 42
[34]
THLE SDHD
Mean 46.9
Standard deviation 3.1
Values 45 49
[35]
liver SDHD
Mean 107
Standard deviation 77
Values 1.6e+02 50 1.8e+02 32
[36]
ref_hepatocyte SUCLG2
Mean 52.6
Standard deviation 48
Values 15 33 14 71 1.3e+02
[37]
HepG2 SUCLG2
Mean 27.4
Standard deviation 5.7
Values 23 31
[38]
HepG2.C3A SUCLG2
Mean 34.7
Standard deviation 8.9
Values 28 41
[39]
HuH.7 SUCLG2
Mean 26.2
Standard deviation 0.91
Values 27 26 26
[40]
SNU475 SUCLG2
Mean 13.3
Standard deviation 5.2
Values 17 9.7
[41]
THLE SUCLG2
Mean 23.8
Standard deviation 4.1
Values 21 27
[42]
liver SUCLG2
Mean 69.9
Standard deviation 18
Values 77 63 91 48
[43]
ref_hepatocyte SUCLG1
Mean 51.8
Standard deviation 25
Values 36 42 25 85 71
[44]
HepG2 SUCLG1
Mean 35
Standard deviation 6.7
Values 30 40
[45]
HepG2.C3A SUCLG1
Mean 46
Standard deviation 6.9
Values 41 51
[46]
HuH.7 SUCLG1
Mean 82.9
Standard deviation 9.5
Values 77 78 94
[47]
SNU475 SUCLG1
Mean 21.5
Standard deviation 1.6
Values 23 20
[48]
THLE SUCLG1
Mean 29.3
Standard deviation 2.7
Values 27 31
[49]
liver SUCLG1
Mean 48.5
Standard deviation 38
Values 89 18 73 14
[50]
ref_hepatocyte FH
Mean 43.1
Standard deviation 38
Values 17 21 8.7 91 78
[51]
HepG2 FH
Mean 32
Standard deviation 8
Values 26 38
[52]
HepG2.C3A FH
Mean 33.4
Standard deviation 7.2
Values 28 39
[53]
HuH.7 FH
Mean 37.1
Standard deviation 6.3
Values 38 31 43
[54]
SNU475 FH
Mean 44.6
Standard deviation 4.8
Values 48 41
[55]
THLE FH
Mean 35.3
Standard deviation 6.3
Values 31 40
[56]
liver FH
Mean 67.3
Standard deviation 23
Values 82 55 90 42
[57]
ref_hepatocyte DLD
Mean 31.7
Standard deviation 25
Values 39 73 13 16 19
[58]
HepG2 DLD
Mean 31.9
Standard deviation 11
Values 24 39
[59]
HepG2.C3A DLD
Mean 46.4
Standard deviation 13
Values 37 56
[60]
HuH.7 DLD
Mean 39.8
Standard deviation 5.6
Values 44 33 43
[61]
SNU475 DLD
Mean 48.2
Standard deviation 1.7
Values 49 47
[62]
THLE DLD
Mean 37.3
Standard deviation 2.8
Values 35 39
[63]
liver DLD
Mean 47.9
Standard deviation 25
Values 56 37 79 20
[64]
ref_hepatocyte SDHC
Mean 28.6
Standard deviation 18
Values 22 25 5.1 39 52
[65]
HepG2 SDHC
Mean 76.9
Standard deviation 9.9
Values 70 84
[66]
HepG2.C3A SDHC
Mean 70
Standard deviation 21
Values 55 85
[67]
HuH.7 SDHC
Mean 50.2
Standard deviation 12
Values 54 37 60
[68]
SNU475 SDHC
Mean 71.2
Standard deviation 19
Values 85 58
[69]
THLE SDHC
Mean 60.4
Standard deviation 12
Values 52 69
[70]
liver SDHC
Mean 24
Standard deviation 9.1
Values 27 17 35 16
[71]
ref_hepatocyte IDH3B
Mean 28.3
Standard deviation 6.5
Values 31 25 37 30 20
[72]
HepG2 IDH3B
Mean 54.6
Standard deviation 1.5
Values 56 54
[73]
HepG2.C3A IDH3B
Mean 56.9
Standard deviation 3.4
Values 55 59
[74]
HuH.7 IDH3B
Mean 30.9
Standard deviation 9.2
Values 33 21 39
[75]
SNU475 IDH3B
Mean 26.7
Standard deviation 4.1
Values 24 30
[76]
THLE IDH3B
Mean 31.5
Standard deviation 3.2
Values 29 34
[77]
liver IDH3B
Mean 22.9
Standard deviation 10
Values 31 15 32 14
[78]
ref_hepatocyte FAHD1
Mean 23.2
Standard deviation 9
Values 18 19 16 25 38
[79]
HepG2 FAHD1
Mean 20.3
Standard deviation 1.7
Values 19 22
[80]
HepG2.C3A FAHD1
Mean 20.1
Standard deviation 1.9
Values 19 21
[81]
HuH.7 FAHD1
Mean 15.4
Standard deviation 3.3
Values 17 12 18
[82]
SNU475 FAHD1
Mean 5.21
Standard deviation 0.31
Values 5.4 5
[83]
THLE FAHD1
Mean 14.4
Standard deviation 2.5
Values 13 16
[84]
liver FAHD1
Mean 22.7
Standard deviation 12
Values 34 12 31 13
[85]
ref_hepatocyte NNT
Mean 22.4
Standard deviation 15
Values 24 22 3.2 18 45
[86]
HepG2 NNT
Mean 22.4
Standard deviation 9.3
Values 16 29
[87]
HepG2.C3A NNT
Mean 31.4
Standard deviation 5.1
Values 28 35
[88]
HuH.7 NNT
Mean 20.1
Standard deviation 2.4
Values 21 22 17
[89]
SNU475 NNT
Mean 20.3
Standard deviation 12
Values 29 12
[90]
THLE NNT
Mean 27.6
Standard deviation 0.58
Values 28 27
[91]
liver NNT
Mean 114
Standard deviation 15
Values 1.3e+02 1.3e+02 1.1e+02 98
[92]
ref_hepatocyte DLST
Mean 19.4
Standard deviation 4.5
Values 12 20 24 22 19
[93]
HepG2 DLST
Mean 58.7
Standard deviation 1.6
Values 60 58
[94]
HepG2.C3A DLST
Mean 74.5
Standard deviation 3.3
Values 77 72
[95]
HuH.7 DLST
Mean 34.1
Standard deviation 5.6
Values 36 28 39
[96]
SNU475 DLST
Mean 43.8
Standard deviation 3.5
Values 46 41
[97]
THLE DLST
Mean 53.2
Standard deviation 2.1
Values 52 55
[98]
liver DLST
Mean 18.7
Standard deviation 14
Values 6.4 33 6.7 28
[99]
ref_hepatocyte ACO2
Mean 19
Standard deviation 5.5
Values 20 14 13 26 22
[100]
HepG2 ACO2
Mean 36.1
Standard deviation 0.091
Values 36 36
[101]
HepG2.C3A ACO2
Mean 33.5
Standard deviation 6
Values 38 29
[102]
HuH.7 ACO2
Mean 35.4
Standard deviation 5.1
Values 41 33 32
[103]
SNU475 ACO2
Mean 17.1
Standard deviation 6.3
Values 22 13
[104]
THLE ACO2
Mean 21.5
Standard deviation 7.4
Values 16 27
[105]
liver ACO2
Mean 31.8
Standard deviation 8.4
Values 25 29 44 29
[106]
ref_hepatocyte CS
Mean 15.3
Standard deviation 5.2
Values 23 9.8 19 13 12
[107]
HepG2 CS
Mean 170
Standard deviation 16
Values 1.6e+02 1.8e+02
[108]
HepG2.C3A CS
Mean 129
Standard deviation 6.5
Values 1.3e+02 1.2e+02
[109]
HuH.7 CS
Mean 85.2
Standard deviation 12
Values 96 73 86
[110]
SNU475 CS
Mean 65.5
Standard deviation 9.6
Values 72 59
[111]
THLE CS
Mean 76.6
Standard deviation 19
Values 63 90
[112]
liver CS
Mean 26.9
Standard deviation 9.6
Values 31 18 38 20
[113]
ref_hepatocyte IDH3G
Mean 13.3
Standard deviation 5.7
Values 6.6 11 14 22 14
[114]
HepG2 IDH3G
Mean 12.7
Standard deviation 1.8
Values 11 14
[115]
HepG2.C3A IDH3G
Mean 12.8
Standard deviation 3.2
Values 15 11
[116]
HuH.7 IDH3G
Mean 14
Standard deviation 3.5
Values 17 10 15
[117]
SNU475 IDH3G
Mean 19.3
Standard deviation 5
Values 23 16
[118]
THLE IDH3G
Mean 16.4
Standard deviation 1.5
Values 15 17
[119]
liver IDH3G
Mean 14.6
Standard deviation 9.7
Values 19 6.4 26 6.7
[120]
ref_hepatocyte SUCLA2
Mean 11.9
Standard deviation 8.1
Values 24 16 5.1 5 9.7
[121]
HepG2 SUCLA2
Mean 14.5
Standard deviation 6.2
Values 10 19
[122]
HepG2.C3A SUCLA2
Mean 28.3
Standard deviation 6.8
Values 23 33
[123]
HuH.7 SUCLA2
Mean 13.6
Standard deviation 0.97
Values 13 13 15
[124]
SNU475 SUCLA2
Mean 11.5
Standard deviation 1.5
Values 13 10
[125]
THLE SUCLA2
Mean 20.1
Standard deviation 0.15
Values 20 20
[126]
liver SUCLA2
Mean 14.4
Standard deviation 5.4
Values 18 11 20 8.4
[127]
ref_hepatocyte OGDH
Mean 9.59
Standard deviation 2.6
Values 6.1 11 12 11 7.8
[128]
HepG2 OGDH
Mean 35.5
Standard deviation 0.48
Values 35 36
[129]
HepG2.C3A OGDH
Mean 20.6
Standard deviation 2.9
Values 23 19
[130]
HuH.7 OGDH
Mean 37
Standard deviation 11
Values 47 26 38
[131]
SNU475 OGDH
Mean 36.2
Standard deviation 8.1
Values 42 31
[132]
THLE OGDH
Mean 38.9
Standard deviation 6
Values 35 43
[133]
liver OGDH
Mean 33.2
Standard deviation 11
Values 21 41 26 45
[134]
ref_hepatocyte IDH3A
Mean 8.88
Standard deviation 1.1
Values 7.4 9.8 8.8 10 8.3
[135]
HepG2 IDH3A
Mean 14.4
Standard deviation 2.4
Values 13 16
[136]
HepG2.C3A IDH3A
Mean 18.5
Standard deviation 3.9
Values 16 21
[137]
HuH.7 IDH3A
Mean 8.96
Standard deviation 1.7
Values 10 7 9.9
[138]
SNU475 IDH3A
Mean 19.2
Standard deviation 3.3
Values 17 22
[139]
THLE IDH3A
Mean 28
Standard deviation 4
Values 25 31
[140]
liver IDH3A
Mean 21.2
Standard deviation 6.2
Values 25 19 27 13
[141]
ref_hepatocyte ME2
Mean 3.58
Standard deviation 2.1
Values 2.4 6.9 4.5 2.2 1.9
[142]
HepG2 ME2
Mean 14.4
Standard deviation 2.8
Values 12 16
[143]
HepG2.C3A ME2
Mean 11.7
Standard deviation 3.5
Values 9.2 14
[144]
HuH.7 ME2
Mean 16
Standard deviation 2.5
Values 18 13 17
[145]
SNU475 ME2
Mean 24.6
Standard deviation 2.3
Values 26 23
[146]
THLE ME2
Mean 35.5
Standard deviation 2.3
Values 34 37
[147]
liver ME2
Mean 11.7
Standard deviation 2.3
Values 10 14 13 9.1
[148]
ref_hepatocyte ME3
Mean 0.746
Standard deviation 1
Values 0 2.5 0.55 0.47 0.19
[149]
HepG2 ME3
Mean 0.11
Standard deviation 0.04
Values 0.14 0.082
[150]
HepG2.C3A ME3
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[151]
HuH.7 ME3
Mean 0.161
Standard deviation 0.2
Values 0.074 0.39 0.019
[152]
SNU475 ME3
Mean 3.84
Standard deviation 1.2
Values 4.7 3
[153]
THLE ME3
Mean 2.68
Standard deviation 0.2
Values 2.5 2.8
[154]
liver ME3
Mean 2.1
Standard deviation 0.32
Values 1.8 2.4 1.8 2.4