REACTOME_CIRCADIAN_CLOCK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.27[2] | -1.62[3] | -1.46[4] | -1.76[5] | -2.13[6] | -1.21[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.82[16] | -0.87[17] | -1.09[18] | -0.90[19] | -1.76[20] | -0.76[21] |
4 | SERPINE1 | Plasminogen activator inhibitor 1 | [22] | 2.07[23] | 2.13[24] | -4.59[25] | -2.78[26] | 3.05[27] | -3.21[28] |
5 | SKP1 | S-phase kinase-associated protein 1 | [29] | -0.05[30] | 0.19[31] | -0.67[32] | 0.52[33] | -0.10[34] | -0.03[35] |
6 | NAMPT | Nicotinamide phosphoribosyltransferase | [36] | -1.78[37] | -1.33[38] | -0.75[39] | 0.14[40] | 1.67[41] | 1.64[42] |
7 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [43] | 1.61[44] | 1.37[45] | 2.42[46] | 0.49[47] | 0.47[48] | 0.01[49] |
8 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [50] | 0.91[51] | 0.48[52] | 1.70[53] | 2.56[54] | -0.68[55] | -0.29[56] |
9 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [57] | 0.69[58] | 1.11[59] | 1.21[60] | 1.79[61] | 0.77[62] | 1.16[63] |
10 | RBM4 | RNA-binding protein 4 | [64] | -1.11[65] | -1.36[66] | -0.40[67] | -0.63[68] | -2.41[69] | -1.20[70] |
11 | SREBF1 | Sterol regulatory element-binding protein 1 | [71] | 0.16[72] | 0.29[73] | 0.85[74] | -0.51[75] | -1.17[76] | 1.16[77] |
12 | BHLHE40 | Class E basic helix-loop-helix protein 40 | [78] | 1.06[79] | 1.12[80] | 0.32[81] | -0.37[82] | -0.71[83] | -0.41[84] |
13 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 1.61[85] | 2.24[86] | 2.47[87] | 1.26[88] | 0.53[89] | -0.41[90] | |
14 | HIF1A | Hypoxia-inducible factor 1-alpha | [91] | 0.78[92] | 0.30[93] | 1.10[94] | 3.31[95] | 2.86[96] | -0.14[97] |
15 | NFIL3 | Nuclear factor interleukin-3-regulated protein | [98] | 0.42[99] | 1.12[100] | 0.84[101] | -1.23[102] | -1.24[103] | -1.47[104] |
16 | F7 | Coagulation factor VII | [105] | -1.85[106] | 0.30[107] | -0.91[108] | -9.99[109] | -10.70[110] | 1.21[111] |
17 | CSNK1D | Casein kinase I isoform delta | [112] | 2.11[113] | 1.72[114] | 1.64[115] | 2.05[116] | 0.75[117] | 0.07[118] |
18 | RXRA | Retinoic acid receptor RXR-alpha | [119] | 0.88[120] | 0.53[121] | 1.38[122] | 1.04[123] | -0.13[124] | 2.81[125] |
19 | CUL1 | Cullin-1 | [126] | 0.55[127] | 1.08[128] | 0.64[129] | 1.61[130] | 0.42[131] | 1.41[132] |
20 | KLF15 | Krueppel-like factor 15 | [133] | -2.87[134] | -4.91[135] | 0.00[136] | -9.55[137] | -3.86[138] | 0.79[139] |
21 | HDAC3 | Histone deacetylase 3 | [140] | 1.41[141] | 1.32[142] | 1.13[143] | 0.97[144] | 0.30[145] | 0.26[146] |
22 | CPT1A | Carnitine O-palmitoyltransferase 1, liver isoform | [147] | 2.39[148] | 0.67[149] | 1.46[150] | 3.26[151] | 1.12[152] | 3.60[153] |
23 | CARM1 | Histone-arginine methyltransferase CARM1 | [154] | 2.39[155] | 1.68[156] | 2.02[157] | 0.78[158] | 0.73[159] | -0.35[160] |
24 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [161] | 1.57[162] | 2.47[163] | 2.71[164] | 1.81[165] | 0.74[166] | 1.69[167] |
25 | NR3C1 | Glucocorticoid receptor | [168] | 0.97[169] | 0.39[170] | 0.70[171] | 2.50[172] | 1.78[173] | 2.44[174] |
26 | CRTC2 | CREB-regulated transcription coactivator 2 | [175] | 0.30[176] | 0.29[177] | 1.36[178] | 1.50[179] | 0.66[180] | -0.40[181] |
27 | NCOR1 | Nuclear receptor corepressor 1 | [182] | 2.01[183] | 2.36[184] | 3.02[185] | 2.59[186] | 1.80[187] | 3.46[188] |
28 | SIK1 | Serine/threonine-protein kinase SIK1 | [189] | 2.43[190] | 1.78[191] | 2.52[192] | 1.14[193] | 0.41[194] | 0.90[195] |
29 | NR1D1 | Nuclear receptor subfamily 1 group D member 1 | [196] | -0.34[197] | -0.82[198] | -0.30[199] | -0.09[200] | -1.53[201] | -0.29[202] |
30 | CREM | cAMP-responsive element modulator | [203] | -0.03[204] | 1.31[205] | 0.36[206] | 0.94[207] | -0.03[208] | 0.40[209] |
31 | CSNK1E | Casein kinase I isoform epsilon | [210] | 2.30[211] | 1.78[212] | 2.45[213] | 1.49[214] | 1.72[215] | -0.16[216] |
32 | FBXL3 | F-box/LRR-repeat protein 3 | [217] | 0.14[218] | 0.58[219] | 1.54[220] | 1.17[221] | 0.64[222] | 1.91[223] |
33 | ARNTL | Aryl hydrocarbon receptor nuclear translocator-like protein 1 | [224] | -1.14[225] | -0.79[226] | -1.74[227] | -0.02[228] | -0.67[229] | 1.45[230] |
34 | CRY1 | Cryptochrome-1 | [231] | 0.64[232] | 1.19[233] | 1.10[234] | 1.37[235] | 0.15[236] | 0.73[237] |
35 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | [238] | 2.01[239] | 2.40[240] | 3.05[241] | 3.43[242] | 2.16[243] | 3.54[244] |
36 | CRY2 | Cryptochrome-2 | [245] | 1.01[246] | 0.90[247] | 2.49[248] | -0.95[249] | -1.00[250] | 3.08[251] |
37 | TBL1X | F-box-like/WD repeat-containing protein TBL1X | [252] | 2.27[253] | 2.52[254] | 4.09[255] | -3.38[256] | 1.28[257] | 2.41[258] |
38 | PER1 | Period circadian protein homolog 1 | [259] | -0.70[260] | -0.05[261] | 1.51[262] | -0.50[263] | 1.91[264] | 2.54[265] |
39 | PPARA | Peroxisome proliferator-activated receptor alpha | [266] | 1.61[267] | 2.43[268] | 3.30[269] | 1.06[270] | -0.61[271] | 4.82[272] |
40 | MED1 | Mediator of RNA polymerase II transcription subunit 1 | [273] | 3.48[274] | 2.65[275] | 3.56[276] | 3.22[277] | 2.54[278] | 1.94[279] |
41 | NPAS2 | Neuronal PAS domain-containing protein 2 | [280] | 2.51[281] | 3.04[282] | 2.63[283] | -1.35[284] | 0.03[285] | 0.48[286] |
42 | NRIP1 | Nuclear receptor-interacting protein 1 | [287] | 2.54[288] | 3.68[289] | 2.44[290] | 3.95[291] | 2.31[292] | 3.28[293] |
43 | NCOA6 | Nuclear receptor coactivator 6 | [294] | 3.14[295] | 2.84[296] | 3.05[297] | 3.59[298] | 2.00[299] | 2.07[300] |
44 | ARNTL2 | Aryl hydrocarbon receptor nuclear translocator-like protein 2 | [301] | 1.69[302] | 2.17[303] | 0.85[304] | 1.66[305] | 1.27[306] | 0.86[307] |
45 | EP300 | Histone acetyltransferase p300 | [308] | 3.66[309] | 3.10[310] | 4.00[311] | 3.60[312] | 2.81[313] | 3.42[314] |
46 | MEF2D | Myocyte-specific enhancer factor 2D | [315] | 1.68[316] | 1.39[317] | 2.11[318] | 3.60[319] | 2.35[320] | 1.52[321] |
47 | TGS1 | Trimethylguanosine synthase | [322] | 1.53[323] | 1.82[324] | 2.36[325] | 2.74[326] | 1.73[327] | 1.64[328] |
48 | BTRC | F-box/WD repeat-containing protein 1A | [329] | 2.35[330] | 2.99[331] | 2.61[332] | 1.78[333] | 1.48[334] | 2.01[335] |
49 | NCOA1 | Nuclear receptor coactivator 1 | [336] | 1.40[337] | 1.81[338] | 2.02[339] | 2.82[340] | 1.43[341] | 3.32[342] |
50 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | -0.16[343] | 2.58[344] | -8.19[345] | 1.79[346] | -2.35[347] | 4.10[348] | |
51 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | [349] | 1.43[350] | 2.38[351] | 1.94[352] | 2.59[353] | 2.00[354] | 2.00[355] |
52 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [356] | 2.66[357] | 3.66[358] | 4.16[359] | 3.57[360] | 2.67[361] | 3.01[362] |
53 | CREBBP | CREB-binding protein | [363] | 3.83[364] | 2.90[365] | 3.51[366] | 3.78[367] | 2.95[368] | 3.90[369] |
54 | CLOCK | Circadian locomoter output cycles protein kaput | [370] | 1.72[371] | 2.77[372] | 2.53[373] | 3.36[374] | 3.15[375] | 4.09[376] |
55 | CRTC3 | CREB-regulated transcription coactivator 3 | [377] | 2.32[378] | 1.80[379] | 2.20[380] | 3.12[381] | 2.19[382] | 1.96[383] |
56 | RORA | Nuclear receptor ROR-alpha | [384] | 1.22[385] | 3.25[386] | 1.47[387] | -2.17[388] | -1.62[389] | 5.01[390] |
57 | DBP | D site-binding protein | [391] | 0.36[392] | 0.14[393] | 3.00[394] | 2.28[395] | -1.65[396] | -1.07[397] |
58 | CHD9 | Chromodomain-helicase-DNA-binding protein 9 | [398] | 2.26[399] | 4.20[400] | 3.45[401] | 3.40[402] | 3.58[403] | 5.59[404] |
59 | NCOA2 | Nuclear receptor coactivator 2 | [405] | 2.51[406] | 3.17[407] | 5.01[408] | 4.23[409] | 1.68[410] | 5.27[411] |
60 | USP46 | Ubiquitin carboxyl-terminal hydrolase 46 | [412] | 3.15[413] | 2.83[414] | 4.35[415] | 3.21[416] | 2.88[417] | 2.79[418] |
61 | PER2 | Period circadian protein homolog 2 | [419] | 2.64[420] | 2.64[421] | 4.03[422] | 1.41[423] | 0.20[424] | 3.13[425] |
62 | RAI1 | Retinoic acid-induced protein 1 | [426] | 4.91[427] | 4.11[428] | 4.32[429] | 5.55[430] | 4.21[431] | 2.84[432] |
63 | CRTC1 | CREB-regulated transcription coactivator 1 | [433] | 3.63[434] | 3.99[435] | 5.06[436] | 3.42[437] | 2.35[438] | 2.62[439] |
64 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 2.41[440] | 0.58[441] | 2.64[442] | 4.29[443] | 3.64[444] | 2.03[445] | |
65 | AVP | Vasopressin-neurophysin 2-copeptin | [446] | -3.13[447] | -0.83[448] | -1.25[449] | [450] | -7.37[451] | -0.40[452] |
66 | BHLHE41 | Class E basic helix-loop-helix protein 41 | [453] | 2.18[454] | -3.30[455] | 0.52[456] | 6.69[457] | 3.93[458] | 0.39[459] |
67 | MEF2C | Myocyte-specific enhancer factor 2C | [460] | -2.18[461] | -1.20[462] | 3.77[463] | 6.64[464] | 1.78[465] | 5.95[466] |
68 | ELOVL3 | Elongation of very long chain fatty acids protein 3 | [467] | 4.07[468] | 3.32[469] | 3.54[470] | 1.10[471] | 4.23[472] | [473] |
69 | NOCT | Nocturnin | [474] | [475] | [476] | [477] | [478] | [479] | [480] |
70 | HELZ2 | Helicase with zinc finger domain 2 | [481] | [482] | [483] | [484] | [485] | [486] | [487] |