REACTOME_CHOLESTEROL_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [1] -2.33[2] -2.16[3] -1.52[4] -2.16[5] -1.36[6] -1.55[7]
2 FDPS Farnesyl pyrophosphate synthase [8] -0.99[9] -1.19[10] -1.08[11] -0.36[12] -0.39[13] -1.75[14]
3 DHCR24 Delta(24)-sterol reductase [15] 1.42[16] 0.49[17] 0.65[18] -0.01[19] 0.86[20] 1.38[21]
4 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [22] -1.83[23] -0.41[24] 0.80[25] -1.69[26] -1.85[27] -0.40[28]
5 MSMO1 Methylsterol monooxygenase 1 [29] -1.59[30] -0.41[31] -0.23[32] -1.63[33] -0.74[34] 0.36[35]
6 FDFT1 Squalene synthase [36] 0.22[37] 0.35[38] -0.28[39] -1.18[40] -0.04[41] -1.11[42]
7 ACAT2 Acetyl-CoA acetyltransferase, cytosolic [43] -0.17[44] 0.03[45] -0.64[46] -1.02[47] -0.40[48] -0.89[49]
8 CYP51A1 Lanosterol 14-alpha demethylase [50] -0.73[51] -0.15[52] -0.40[53] 0.16[54] -0.09[55] 0.65[56]
9 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 [57] -0.87[58] 0.79[59] -0.80[60] 1.03[61] -0.10[62] 0.16[63]
10 SQLE Squalene monooxygenase [64] 0.11[65] 0.87[66] 0.42[67] 0.44[68] -0.05[69] -0.47[70]
11 DHCR7 7-dehydrocholesterol reductase [71] 0.97[72] 0.87[73] 0.95[74] -0.04[75] 0.28[76] 0.96[77]
12 TM7SF2 Delta(14)-sterol reductase [78] 0.57[79] -0.34[80] -0.86[81] 0.04[82] -1.67[83] -0.12[84]
13 PMVK Phosphomevalonate kinase [85] -0.56[86] -2.31[87] -1.26[88] 0.54[89] 0.38[90] -2.33[91]
14 MVD Diphosphomevalonate decarboxylase [92] 0.73[93] 1.39[94] 0.40[95] 0.19[96] 0.30[97] -0.59[98]
15 NSDHL Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating [99] 0.16[100] -0.70[101] -1.48[102] 0.81[103] 0.34[104] -0.82[105]
16 LSS Lanosterol synthase [106] 1.34[107] 1.62[108] 0.38[109] 1.70[110] 1.38[111] 0.90[112]
17 HSD17B7 3-keto-steroid reductase [113] -1.24[114] -1.21[115] -1.36[116] -0.79[117] -1.07[118] -0.94[119]
18 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase [120] 1.42[121] 2.35[122] 2.44[123] 2.28[124] 2.06[125] 1.22[126]
19 MVK Mevalonate kinase [127] -0.33[128] 0.21[129] -0.52[130] -0.63[131] -0.76[132] 0.09[133]
20 LBR Lamin-B receptor [134] 2.72[135] 1.61[136] 2.28[137] 3.93[138] 3.06[139] 0.63[140]
21 ARV1 Protein ARV1 [141] 0.16[142] -1.08[143] -1.55[144] 1.63[145] 1.60[146] -0.73[147]
22 GGPS1 Geranylgeranyl pyrophosphate synthase [148] 2.19[149] 1.62[150] 1.41[151] 4.20[152] 2.65[153] 0.19[154]
23 IDI2 Isopentenyl-diphosphate delta-isomerase 2 [155] 2.74[156] 1.79[157] 1.58[158] 5.36[159] 3.98[160] 0.35[161]
24 SC5D Lathosterol oxidase [162] [163] [164] [165] [166] [167] [168]
25 PLPP6 Phospholipid phosphatase 6 [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte EBP
Mean 181
Standard deviation 65
Values 1.8e+02 2.8e+02 1e+02 1.5e+02 1.9e+02
[2]
HepG2 EBP
Mean 20.1
Standard deviation 4.7
Values 17 23
[3]
HepG2.C3A EBP
Mean 71.4
Standard deviation 13
Values 80 63
[4]
HuH.7 EBP
Mean 120
Standard deviation 17
Values 1.1e+02 1.1e+02 1.4e+02
[5]
SNU475 EBP
Mean 12.4
Standard deviation 1.5
Values 11 13
[6]
THLE EBP
Mean 22.6
Standard deviation 3.6
Values 20 25
[7]
liver EBP
Mean 97.6
Standard deviation 78
Values 1.8e+02 24 1.5e+02 37
[8]
ref_hepatocyte FDPS
Mean 168
Standard deviation 1.2e+02
Values 1.8e+02 3.6e+02 65 1e+02 1.3e+02
[9]
HepG2 FDPS
Mean 47.3
Standard deviation 9.8
Values 40 54
[10]
HepG2.C3A FDPS
Mean 130
Standard deviation 36
Values 1.5e+02 1e+02
[11]
HuH.7 FDPS
Mean 153
Standard deviation 26
Values 1.4e+02 1.3e+02 1.8e+02
[12]
SNU475 FDPS
Mean 40
Standard deviation 13
Values 49 31
[13]
THLE FDPS
Mean 41.3
Standard deviation 7.5
Values 36 47
[14]
liver FDPS
Mean 78.7
Standard deviation 39
Values 76 54 1.3e+02 50
[15]
ref_hepatocyte DHCR24
Mean 160
Standard deviation 83
Values 1.8e+02 1.1e+02 44 2e+02 2.6e+02
[16]
HepG2 DHCR24
Mean 239
Standard deviation 90
Values 1.8e+02 3e+02
[17]
HepG2.C3A DHCR24
Mean 395
Standard deviation 1.3e+02
Values 4.9e+02 3e+02
[18]
HuH.7 DHCR24
Mean 482
Standard deviation 1.1e+02
Values 4.9e+02 5.9e+02 3.7e+02
[19]
SNU475 DHCR24
Mean 48.6
Standard deviation 27
Values 68 29
[20]
THLE DHCR24
Mean 93.2
Standard deviation 28
Values 73 1.1e+02
[21]
liver DHCR24
Mean 661
Standard deviation 1.8e+02
Values 5.4e+02 6.7e+02 9.1e+02 5.3e+02
[22]
ref_hepatocyte HMGCS1
Mean 128
Standard deviation 1e+02
Values 2.5e+02 2.3e+02 58 32 72
[23]
HepG2 HMGCS1
Mean 20.3
Standard deviation 12
Values 12 28
[24]
HepG2.C3A HMGCS1
Mean 170
Standard deviation 81
Values 2.3e+02 1.1e+02
[25]
HuH.7 HMGCS1
Mean 427
Standard deviation 1.7e+02
Values 3.3e+02 6.2e+02 3.3e+02
[26]
SNU475 HMGCS1
Mean 12.1
Standard deviation 4.1
Values 15 9.2
[27]
THLE HMGCS1
Mean 11.4
Standard deviation 0.78
Values 11 12
[28]
liver HMGCS1
Mean 154
Standard deviation 63
Values 79 1.9e+02 1.3e+02 2.2e+02
[29]
ref_hepatocyte MSMO1
Mean 108
Standard deviation 90
Values 88 72 21 1e+02 2.6e+02
[30]
HepG2 MSMO1
Mean 20.1
Standard deviation 11
Values 12 28
[31]
HepG2.C3A MSMO1
Mean 144
Standard deviation 56
Values 1.8e+02 1e+02
[32]
HuH.7 MSMO1
Mean 177
Standard deviation 63
Values 1.3e+02 2.5e+02 1.6e+02
[33]
SNU475 MSMO1
Mean 10.6
Standard deviation 4
Values 13 7.8
[34]
THLE MSMO1
Mean 20.7
Standard deviation 3.4
Values 18 23
[35]
liver MSMO1
Mean 219
Standard deviation 94
Values 1.6e+02 1.9e+02 3.6e+02 1.7e+02
[36]
ref_hepatocyte FDFT1
Mean 87.4
Standard deviation 77
Values 2.2e+02 91 41 48 38
[37]
HepG2 FDFT1
Mean 56.9
Standard deviation 24
Values 40 74
[38]
HepG2.C3A FDFT1
Mean 196
Standard deviation 63
Values 2.4e+02 1.5e+02
[39]
HuH.7 FDFT1
Mean 138
Standard deviation 16
Values 1.3e+02 1.3e+02 1.6e+02
[40]
SNU475 FDFT1
Mean 11.8
Standard deviation 4
Values 15 9
[41]
THLE FDFT1
Mean 27.4
Standard deviation 0.93
Values 27 28
[42]
liver FDFT1
Mean 64.1
Standard deviation 23
Values 62 45 98 52
[43]
ref_hepatocyte ACAT2
Mean 68.2
Standard deviation 50
Values 1.5e+02 51 17 49 76
[44]
HepG2 ACAT2
Mean 33.9
Standard deviation 23
Values 18 50
[45]
HepG2.C3A ACAT2
Mean 123
Standard deviation 6.4
Values 1.3e+02 1.2e+02
[46]
HuH.7 ACAT2
Mean 84.1
Standard deviation 10
Values 82 76 95
[47]
SNU475 ACAT2
Mean 10.3
Standard deviation 0.34
Values 11 10
[48]
THLE ACAT2
Mean 16.6
Standard deviation 3.1
Values 14 19
[49]
liver ACAT2
Mean 58.5
Standard deviation 28
Values 48 47 1e+02 39
[50]
ref_hepatocyte CYP51A1
Mean 63
Standard deviation 38
Values 1.2e+02 88 38 27 46
[51]
HepG2 CYP51A1
Mean 21.2
Standard deviation 5.5
Values 17 25
[52]
HepG2.C3A CYP51A1
Mean 99.9
Standard deviation 49
Values 1.3e+02 66
[53]
HuH.7 CYP51A1
Mean 91.5
Standard deviation 23
Values 79 1.2e+02 78
[54]
SNU475 CYP51A1
Mean 21.5
Standard deviation 2.5
Values 23 20
[55]
THLE CYP51A1
Mean 19
Standard deviation 1.2
Values 18 20
[56]
liver CYP51A1
Mean 156
Standard deviation 52
Values 89 1.8e+02 2.1e+02 1.5e+02
[57]
ref_hepatocyte IDI1
Mean 49.3
Standard deviation 26
Values 79 59 14 33 62
[58]
HepG2 IDI1
Mean 15.1
Standard deviation 12
Values 6.9 23
[59]
HepG2.C3A IDI1
Mean 151
Standard deviation 3.5
Values 1.5e+02 1.5e+02
[60]
HuH.7 IDI1
Mean 54.3
Standard deviation 7.2
Values 46 58 59
[61]
SNU475 IDI1
Mean 30.7
Standard deviation 8.7
Values 37 24
[62]
THLE IDI1
Mean 14.8
Standard deviation 3.6
Values 12 17
[63]
liver IDI1
Mean 87.2
Standard deviation 46
Values 84 57 1.5e+02 55
[64]
ref_hepatocyte SQLE
Mean 34.4
Standard deviation 33
Values 86 47 17 12 9.9
[65]
HepG2 SQLE
Mean 20.7
Standard deviation 9.1
Values 14 27
[66]
HepG2.C3A SQLE
Mean 111
Standard deviation 44
Values 1.4e+02 80
[67]
HuH.7 SQLE
Mean 88.5
Standard deviation 14
Values 88 1e+02 75
[68]
SNU475 SQLE
Mean 14.3
Standard deviation 3.6
Values 17 12
[69]
THLE SQLE
Mean 10.7
Standard deviation 4.6
Values 7.4 14
[70]
liver SQLE
Mean 39.4
Standard deviation 14
Values 27 28 54 49
[71]
ref_hepatocyte DHCR7
Mean 31.8
Standard deviation 19
Values 21 13 23 43 59
[72]
HepG2 DHCR7
Mean 34.7
Standard deviation 11
Values 27 43
[73]
HepG2.C3A DHCR7
Mean 103
Standard deviation 68
Values 1.5e+02 54
[74]
HuH.7 DHCR7
Mean 117
Standard deviation 29
Values 1.1e+02 1.5e+02 90
[75]
SNU475 DHCR7
Mean 9.4
Standard deviation 1.9
Values 11 8
[76]
THLE DHCR7
Mean 12.4
Standard deviation 3.1
Values 10 15
[77]
liver DHCR7
Mean 98.2
Standard deviation 72
Values 69 50 2.1e+02 68
[78]
ref_hepatocyte TM7SF2
Mean 22.9
Standard deviation 25
Values 24 1.4 0.92 26 62
[79]
HepG2 TM7SF2
Mean 19
Standard deviation 5.7
Values 15 23
[80]
HepG2.C3A TM7SF2
Mean 32
Standard deviation 9.1
Values 38 26
[81]
HuH.7 TM7SF2
Mean 24.2
Standard deviation 0.33
Values 25 24 24
[82]
SNU475 TM7SF2
Mean 7.18
Standard deviation 2.2
Values 8.8 5.6
[83]
THLE TM7SF2
Mean 2.32
Standard deviation 0.45
Values 2.6 2
[84]
liver TM7SF2
Mean 33.4
Standard deviation 23
Values 27 24 67 16
[85]
ref_hepatocyte PMVK
Mean 22.4
Standard deviation 12
Values 3.4 22 20 33 34
[86]
HepG2 PMVK
Mean 8.49
Standard deviation 1
Values 9.2 7.8
[87]
HepG2.C3A PMVK
Mean 7.97
Standard deviation 0.74
Values 8.5 7.4
[88]
HuH.7 PMVK
Mean 17.9
Standard deviation 3.9
Values 18 14 22
[89]
SNU475 PMVK
Mean 9.92
Standard deviation 2.1
Values 11 8.5
[90]
THLE PMVK
Mean 9.34
Standard deviation 1.8
Values 8 11
[91]
liver PMVK
Mean 7.06
Standard deviation 5.2
Values 13 2.4 9 3.4
[92]
ref_hepatocyte MVD
Mean 20.1
Standard deviation 9.1
Values 34 10 15 17 24
[93]
HepG2 MVD
Mean 18.7
Standard deviation 5.5
Values 15 23
[94]
HepG2.C3A MVD
Mean 92.8
Standard deviation 59
Values 1.3e+02 51
[95]
HuH.7 MVD
Mean 50.8
Standard deviation 5.1
Values 51 45 56
[96]
SNU475 MVD
Mean 7
Standard deviation 2.5
Values 8.8 5.2
[97]
THLE MVD
Mean 7.96
Standard deviation 0.012
Values 8 8
[98]
liver MVD
Mean 21.1
Standard deviation 12
Values 12 14 39 19
[99]
ref_hepatocyte NSDHL
Mean 19.7
Standard deviation 8
Values 14 17 12 31 24
[100]
HepG2 NSDHL
Mean 12.3
Standard deviation 4.3
Values 9.2 15
[101]
HepG2.C3A NSDHL
Mean 21.5
Standard deviation 0.63
Values 22 21
[102]
HuH.7 NSDHL
Mean 13.6
Standard deviation 1.6
Values 14 12 15
[103]
SNU475 NSDHL
Mean 10.5
Standard deviation 1
Values 11 9.8
[104]
THLE NSDHL
Mean 8.01
Standard deviation 1.5
Values 6.9 9.1
[105]
liver NSDHL
Mean 17.7
Standard deviation 6.5
Values 18 11 26 15
[106]
ref_hepatocyte LSS
Mean 16.9
Standard deviation 8
Values 31 16 11 12 14
[107]
HepG2 LSS
Mean 23.9
Standard deviation 12
Values 15 32
[108]
HepG2.C3A LSS
Mean 91.2
Standard deviation 46
Values 1.2e+02 59
[109]
HuH.7 LSS
Mean 42.1
Standard deviation 4.8
Values 40 48 39
[110]
SNU475 LSS
Mean 16.7
Standard deviation 8.9
Values 23 10
[111]
THLE LSS
Mean 14.1
Standard deviation 4.1
Values 11 17
[112]
liver LSS
Mean 49.9
Standard deviation 22
Values 39 44 34 83
[113]
ref_hepatocyte HSD17B7
Mean 14.9
Standard deviation 12
Values 14 8.9 4 35 12
[114]
HepG2 HSD17B7
Mean 3.52
Standard deviation 0.97
Values 2.8 4.2
[115]
HepG2.C3A HSD17B7
Mean 11.3
Standard deviation 3.5
Values 14 8.9
[116]
HuH.7 HSD17B7
Mean 11.1
Standard deviation 1.6
Values 9.5 13 11
[117]
SNU475 HSD17B7
Mean 2.62
Standard deviation 1.2
Values 3.5 1.7
[118]
THLE HSD17B7
Mean 2.28
Standard deviation 0.47
Values 1.9 2.6
[119]
liver HSD17B7
Mean 12.3
Standard deviation 4.1
Values 15 6.2 13 15
[120]
ref_hepatocyte HMGCR
Mean 14.8
Standard deviation 13
Values 37 12 9.1 5.9 9.8
[121]
HepG2 HMGCR
Mean 22.2
Standard deviation 14
Values 12 32
[122]
HepG2.C3A HMGCR
Mean 133
Standard deviation 31
Values 1.5e+02 1.1e+02
[123]
HuH.7 HMGCR
Mean 154
Standard deviation 61
Values 1.3e+02 2.2e+02 1.1e+02
[124]
SNU475 HMGCR
Mean 22
Standard deviation 2.5
Values 24 20
[125]
THLE HMGCR
Mean 19.8
Standard deviation 3.5
Values 17 22
[126]
liver HMGCR
Mean 54.5
Standard deviation 28
Values 20 71 46 81
[127]
ref_hepatocyte MVK
Mean 14.5
Standard deviation 7.2
Values 12 8.7 7.9 20 24
[128]
HepG2 MVK
Mean 6.45
Standard deviation 1.7
Values 5.3 7.6
[129]
HepG2.C3A MVK
Mean 29.6
Standard deviation 8.4
Values 36 24
[130]
HuH.7 MVK
Mean 19.4
Standard deviation 2
Values 19 18 22
[131]
SNU475 MVK
Mean 2.86
Standard deviation 0.47
Values 3.2 2.5
[132]
THLE MVK
Mean 2.76
Standard deviation 0.64
Values 2.3 3.2
[133]
liver MVK
Mean 24.4
Standard deviation 13
Values 36 11 35 16
[134]
ref_hepatocyte LBR
Mean 10.7
Standard deviation 5.2
Values 18 14 7.4 5.9 8.2
[135]
HepG2 LBR
Mean 39.5
Standard deviation 2.4
Values 38 41
[136]
HepG2.C3A LBR
Mean 57.7
Standard deviation 9.9
Values 51 65
[137]
HuH.7 LBR
Mean 99.9
Standard deviation 21
Values 1.2e+02 78 1e+02
[138]
SNU475 LBR
Mean 49.8
Standard deviation 4.3
Values 53 47
[139]
THLE LBR
Mean 28.8
Standard deviation 2.8
Values 27 31
[140]
liver LBR
Mean 26.2
Standard deviation 6.9
Values 24 28 35 18
[141]
ref_hepatocyte ARV1
Mean 6.78
Standard deviation 4
Values 2.3 3.8 5.9 11 11
[142]
HepG2 ARV1
Mean 4.25
Standard deviation 1.3
Values 3.3 5.2
[143]
HepG2.C3A ARV1
Mean 5.64
Standard deviation 1.1
Values 4.8 6.5
[144]
HuH.7 ARV1
Mean 4.45
Standard deviation 1.9
Values 4.4 2.5 6.4
[145]
SNU475 ARV1
Mean 6.38
Standard deviation 0.51
Values 6.7 6
[146]
THLE ARV1
Mean 6.6
Standard deviation 0.36
Values 6.9 6.3
[147]
liver ARV1
Mean 6.47
Standard deviation 3.8
Values 11 3.8 8.6 2.8
[148]
ref_hepatocyte GGPS1
Mean 3.62
Standard deviation 1.6
Values 6.4 2.5 2.9 3.1 3.2
[149]
HepG2 GGPS1
Mean 9.28
Standard deviation 2.3
Values 7.6 11
[150]
HepG2.C3A GGPS1
Mean 19.7
Standard deviation 0.38
Values 20 19
[151]
HuH.7 GGPS1
Mean 18.5
Standard deviation 0.7
Values 18 18 19
[152]
SNU475 GGPS1
Mean 20.3
Standard deviation 4.3
Values 23 17
[153]
THLE GGPS1
Mean 7.32
Standard deviation 0.42
Values 7.6 7
[154]
liver GGPS1
Mean 6.56
Standard deviation 3.2
Values 10 4.6 8.2 3.3
[155]
ref_hepatocyte IDI2
Mean 0.262
Standard deviation 0.32
Values 0 0 0.079 0.63 0.6
[156]
HepG2 IDI2
Mean 0.98
Standard deviation 0.15
Values 1.1 0.87
[157]
HepG2.C3A IDI2
Mean 1.6
Standard deviation 0.39
Values 1.9 1.3
[158]
HuH.7 IDI2
Mean 1.5
Standard deviation 0.45
Values 1.5 1 1.9
[159]
SNU475 IDI2
Mean 3.28
Standard deviation 1.1
Values 2.5 4.1
[160]
THLE IDI2
Mean 1.33
Standard deviation 0.055
Values 1.3 1.4
[161]
liver IDI2
Mean 0.531
Standard deviation 0.12
Values 0.71 0.41 0.51 0.49
[162]
ref_hepatocyte SC5D
Missing
[163]
HepG2 SC5D
Missing
[164]
HepG2.C3A SC5D
Missing
[165]
HuH.7 SC5D
Missing
[166]
SNU475 SC5D
Missing
[167]
THLE SC5D
Missing
[168]
liver SC5D
Missing
[169]
ref_hepatocyte PLPP6
Missing
[170]
HepG2 PLPP6
Missing
[171]
HepG2.C3A PLPP6
Missing
[172]
HuH.7 PLPP6
Missing
[173]
SNU475 PLPP6
Missing
[174]
THLE PLPP6
Missing
[175]
liver PLPP6
Missing