REACTOME_CHK1_CHK2_CDS1_MEDIATED_INACTIVATION_OF_CYCLIN_B_CDK1_COMPLEX Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAE 14-3-3 protein epsilon [1] -0.87[2] -0.77[3] -0.39[4] -1.24[5] -0.66[6] -0.11[7]
2 YWHAZ 14-3-3 protein zeta/delta [8] -0.20[9] -0.36[10] -0.01[11] 0.52[12] -0.35[13] -0.20[14]
3 YWHAH 14-3-3 protein eta [15] -1.00[16] -1.42[17] -1.42[18] -1.58[19] -1.44[20] -0.51[21]
4 YWHAQ 14-3-3 protein theta [22] 0.63[23] 0.44[24] 0.18[25] 0.97[26] 0.84[27] 0.85[28]
5 SFN 14-3-3 protein sigma [29] -1.99[30] -2.36[31] -1.93[32] -8.22[33] -8.60[34] -8.65[35]
6 YWHAG 14-3-3 protein gamma [36] 0.57[37] 0.03[38] 0.12[39] 0.34[40] 0.19[41] 0.10[42]
7 YWHAB 14-3-3 protein beta/alpha [43] 1.41[44] 1.11[45] 0.42[46] 0.92[47] 0.90[48] 1.35[49]
8 CCNB1 G2/mitotic-specific cyclin-B1 [50] 2.21[51] 2.44[52] 2.65[53] 1.22[54] 2.75[55] -0.90[56]
9 CDK1 Cyclin-dependent kinase 1 [57] 1.62[58] 3.68[59] 2.44[60] 1.88[61] 3.25[62] -1.02[63]
10 CHEK2 Serine/threonine-protein kinase Chk2 [64] 0.47[65] 0.90[66] 1.34[67] -0.63[68] -0.46[69] -1.83[70]
11 WEE1 Wee1-like protein kinase [71] 0.67[72] 1.08[73] 1.85[74] 0.34[75] 0.41[76] 0.91[77]
12 CHEK1 Serine/threonine-protein kinase Chk1 [78] 1.90[79] 2.26[80] 1.86[81] 1.77[82] 2.54[83] -0.58[84]
13 CDC25C M-phase inducer phosphatase 3 [85] 2.30[86] 3.45[87] 3.51[88] 1.54[89] 2.94[90] 0.03[91]
[1]
ref_hepatocyte YWHAE
Mean 195
Standard deviation 97
Values 2.2e+02 3.6e+02 1.6e+02 1.3e+02 1.2e+02
[2]
HepG2 YWHAE
Mean 183
Standard deviation 1.8
Values 1.8e+02 1.8e+02
[3]
HepG2.C3A YWHAE
Mean 175
Standard deviation 29
Values 1.5e+02 2e+02
[4]
HuH.7 YWHAE
Mean 215
Standard deviation 62
Values 2.1e+02 1.5e+02 2.8e+02
[5]
SNU475 YWHAE
Mean 197
Standard deviation 19
Values 2.1e+02 1.8e+02
[6]
THLE YWHAE
Mean 227
Standard deviation 21
Values 2.1e+02 2.4e+02
[7]
liver YWHAE
Mean 94.2
Standard deviation 60
Values 1.3e+02 52 1.6e+02 36
[8]
ref_hepatocyte YWHAZ
Mean 161
Standard deviation 1.6e+02
Values 1.3e+02 4.3e+02 1.6e+02 40 41
[9]
HepG2 YWHAZ
Mean 239
Standard deviation 21
Values 2.2e+02 2.5e+02
[10]
HepG2.C3A YWHAZ
Mean 191
Standard deviation 28
Values 1.7e+02 2.1e+02
[11]
HuH.7 YWHAZ
Mean 229
Standard deviation 23
Values 2.5e+02 2.1e+02 2.3e+02
[12]
SNU475 YWHAZ
Mean 552
Standard deviation 94
Values 6.2e+02 4.9e+02
[13]
THLE YWHAZ
Mean 232
Standard deviation 39
Values 2e+02 2.6e+02
[14]
liver YWHAZ
Mean 73.1
Standard deviation 31
Values 81 60 1.1e+02 39
[15]
ref_hepatocyte YWHAH
Mean 64.6
Standard deviation 51
Values 41 1.3e+02 1e+02 26 19
[16]
HepG2 YWHAH
Mean 55.3
Standard deviation 3.4
Values 58 53
[17]
HepG2.C3A YWHAH
Mean 37
Standard deviation 4.4
Values 34 40
[18]
HuH.7 YWHAH
Mean 34.8
Standard deviation 9.2
Values 36 25 43
[19]
SNU475 YWHAH
Mean 51.9
Standard deviation 3.7
Values 55 49
[20]
THLE YWHAH
Mean 44
Standard deviation 12
Values 36 52
[21]
liver YWHAH
Mean 23.6
Standard deviation 16
Values 39 11 36 8.3
[22]
ref_hepatocyte YWHAQ
Mean 63.6
Standard deviation 28
Values 49 1e+02 86 44 39
[23]
HepG2 YWHAQ
Mean 169
Standard deviation 33
Values 1.5e+02 1.9e+02
[24]
HepG2.C3A YWHAQ
Mean 132
Standard deviation 50
Values 96 1.7e+02
[25]
HuH.7 YWHAQ
Mean 103
Standard deviation 30
Values 1.2e+02 69 1.2e+02
[26]
SNU475 YWHAQ
Mean 299
Standard deviation 36
Values 3.2e+02 2.7e+02
[27]
THLE YWHAQ
Mean 210
Standard deviation 34
Values 1.9e+02 2.3e+02
[28]
liver YWHAQ
Mean 59.7
Standard deviation 29
Values 70 42 95 31
[29]
ref_hepatocyte SFN
Mean 59.2
Standard deviation 90
Values 6.3 2.1e+02 78 1.8 0.87
[30]
HepG2 SFN
Mean 25.4
Standard deviation 7.7
Values 31 20
[31]
HepG2.C3A SFN
Mean 17.7
Standard deviation 2.5
Values 16 19
[32]
HuH.7 SFN
Mean 22.3
Standard deviation 9.2
Values 25 12 30
[33]
SNU475 SFN
Mean 0.477
Standard deviation 0.46
Values 0.15 0.81
[34]
THLE SFN
Mean 0.281
Standard deviation 0.029
Values 0.3 0.26
[35]
liver SFN
Mean 0.0769
Standard deviation 0.053
Values 0 0.086 0.1 0.12
[36]
ref_hepatocyte YWHAG
Mean 50.4
Standard deviation 40
Values 70 1.1e+02 35 18 18
[37]
HepG2 YWHAG
Mean 128
Standard deviation 6.2
Values 1.3e+02 1.2e+02
[38]
HepG2.C3A YWHAG
Mean 78.7
Standard deviation 6.4
Values 74 83
[39]
HuH.7 YWHAG
Mean 78.6
Standard deviation 11
Values 91 70 74
[40]
SNU475 YWHAG
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[41]
THLE YWHAG
Mean 106
Standard deviation 7.5
Values 1e+02 1.1e+02
[42]
liver YWHAG
Mean 28.2
Standard deviation 12
Values 21 40 15 37
[43]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[44]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[45]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[46]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[47]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[48]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[49]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[50]
ref_hepatocyte CCNB1
Mean 8.2
Standard deviation 8.6
Values 15 20 1.8 3.1 1.3
[51]
HepG2 CCNB1
Mean 65.1
Standard deviation 21
Values 50 80
[52]
HepG2.C3A CCNB1
Mean 68.3
Standard deviation 39
Values 41 96
[53]
HuH.7 CCNB1
Mean 74.2
Standard deviation 37
Values 87 33 1e+02
[54]
SNU475 CCNB1
Mean 45.8
Standard deviation 3.3
Values 48 44
[55]
THLE CCNB1
Mean 101
Standard deviation 30
Values 80 1.2e+02
[56]
liver CCNB1
Mean 2.29
Standard deviation 1.6
Values 2.3 2.4 4.2 0.28
[57]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[58]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[59]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[60]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[61]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[62]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[63]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[64]
ref_hepatocyte CHEK2
Mean 5.74
Standard deviation 6.1
Values 16 5.5 4.2 1.7 1.1
[65]
HepG2 CHEK2
Mean 13.6
Standard deviation 0.16
Values 13 14
[66]
HepG2.C3A CHEK2
Mean 16.4
Standard deviation 6.4
Values 12 21
[67]
HuH.7 CHEK2
Mean 20.8
Standard deviation 7.6
Values 22 13 28
[68]
SNU475 CHEK2
Mean 8.87
Standard deviation 0.55
Values 8.5 9.3
[69]
THLE CHEK2
Mean 7.68
Standard deviation 1.3
Values 6.8 8.6
[70]
liver CHEK2
Mean 0.84
Standard deviation 0.33
Values 0.87 0.88 1.2 0.4
[71]
ref_hepatocyte WEE1
Mean 4.87
Standard deviation 1.2
Values 5.1 4.1 6.8 3.9 4.5
[72]
HepG2 WEE1
Mean 13.3
Standard deviation 1.3
Values 14 12
[73]
HepG2.C3A WEE1
Mean 15.8
Standard deviation 0.28
Values 16 16
[74]
HuH.7 WEE1
Mean 25.2
Standard deviation 0.7
Values 24 26 26
[75]
SNU475 WEE1
Mean 14.8
Standard deviation 0.86
Values 15 14
[76]
THLE WEE1
Mean 11.9
Standard deviation 1.6
Values 11 13
[77]
liver WEE1
Mean 4.76
Standard deviation 1.4
Values 6.8 4.4 3.8 4
[78]
ref_hepatocyte CHEK1
Mean 2.44
Standard deviation 1.9
Values 3.2 5.4 1.9 0.69 0.99
[79]
HepG2 CHEK1
Mean 15.6
Standard deviation 7.2
Values 11 21
[80]
HepG2.C3A CHEK1
Mean 17.9
Standard deviation 12
Values 9.6 26
[81]
HuH.7 CHEK1
Mean 12.7
Standard deviation 5.1
Values 15 6.8 16
[82]
SNU475 CHEK1
Mean 19.9
Standard deviation 4.6
Values 17 23
[83]
THLE CHEK1
Mean 26.2
Standard deviation 4.4
Values 23 29
[84]
liver CHEK1
Mean 0.851
Standard deviation 0.2
Values 0.73 1 1 0.64
[85]
ref_hepatocyte CDC25C
Mean 0.731
Standard deviation 0.89
Values 2 1.3 0.11 0.078 0.13
[86]
HepG2 CDC25C
Mean 6.16
Standard deviation 0.58
Values 5.7 6.6
[87]
HepG2.C3A CDC25C
Mean 12.2
Standard deviation 6.2
Values 7.8 17
[88]
HuH.7 CDC25C
Mean 12
Standard deviation 5.4
Values 14 5.9 16
[89]
SNU475 CDC25C
Mean 5.11
Standard deviation 0.28
Values 5.3 4.9
[90]
THLE CDC25C
Mean 10.3
Standard deviation 1.8
Values 9 12
[91]
liver CDC25C
Mean 0.389
Standard deviation 0.27
Values 0.45 0.43 0.67 0.013