REACTOME_CGMP_EFFECTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [1] 0.17[2] 0.62[3] -0.33[4] -5.76[5] -5.94[6] -3.75[7]
2 KCNMB3 Calcium-activated potassium channel subunit beta-3 [8] -1.63[9] -0.08[10] -0.34[11] -1.93[12] -1.89[13] -3.15[14]
3 KCNMA1 Calcium-activated potassium channel subunit alpha-1 [15] -9.05[16] -10.01[17] -4.59[18] -0.10[19] -1.90[20] -1.47[21]
4 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 [22] 1.95[23] 1.53[24] 2.04[25] 1.08[26] 2.50[27] 1.70[28]
5 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase [29] 0.33[30] -6.16[31] -5.75[32] -5.36[33] -0.49[34] 1.91[35]
6 KCNMB4 Calcium-activated potassium channel subunit beta-4 [36] 0.96[37] 0.67[38] 1.00[39] -0.68[40] -1.02[41] -2.01[42]
7 PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [43] 0.94[44] -0.12[45] -0.10[46] 1.28[47] -3.90[48] 1.46[49]
8 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase [50] -1.30[51] -0.30[52] 0.85[53] 2.16[54] 0.99[55] 0.03[56]
9 PDE1B Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B -4.87[57] -6.14[58] [59] -2.59[60] -3.12[61] 0.91[62]
10 KCNMB1 Calcium-activated potassium channel subunit beta-1 [63] [64] [65] [66] -2.26[67] [68] -2.38[69]
11 PRKG1 cGMP-dependent protein kinase 1 [70] -1.35[71] [72] -0.92[73] 1.41[74] 3.87[75] 3.56[76]
12 PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [77] -2.21[78] 1.84[79] 4.35[80] 1.36[81] 3.65[82]
13 KCNMB2 Calcium-activated potassium channel subunit beta-2 [83] [84] -1.04[85] -0.50[86] -3.04[87] -3.47[88] -1.94[89]
14 PRKG2 cGMP-dependent protein kinase 2 [90] 1.71[91] [92] [93] 5.02[94] -0.14[95] -0.91[96]
15 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [97] -1.89[98] [99] [100] 0.61[101] 7.49[102] 4.58[103]
16 IRAG1 [104] [105] [106] [107] [108] [109] [110]
[1]
ref_hepatocyte PDE9A
Mean 1.11
Standard deviation 0.46
Values 0.89 0.75 1.7 1.6 0.7
[2]
HepG2 PDE9A
Mean 6.33
Standard deviation 2
Values 7.7 4.9
[3]
HepG2.C3A PDE9A
Mean 9.42
Standard deviation 4.6
Values 13 6.2
[4]
HuH.7 PDE9A
Mean 7.34
Standard deviation 1.1
Values 7.2 6.3 8.5
[5]
SNU475 PDE9A
Mean 0.129
Standard deviation 0.097
Values 0.06 0.2
[6]
THLE PDE9A
Mean 0.087
Standard deviation 0.078
Values 0.14 0.032
[7]
liver PDE9A
Mean 0.908
Standard deviation 0.36
Values 1.3 0.59 0.62 1.1
[8]
ref_hepatocyte KCNMB3
Mean 1.01
Standard deviation 0.91
Values 0.67 0.13 2.5 0.63 1.1
[9]
HepG2 KCNMB3
Mean 1.66
Standard deviation 0.024
Values 1.6 1.7
[10]
HepG2.C3A KCNMB3
Mean 5.29
Standard deviation 3.1
Values 7.5 3.1
[11]
HuH.7 KCNMB3
Mean 6.65
Standard deviation 4.6
Values 3.5 12 4.6
[12]
SNU475 KCNMB3
Mean 1.67
Standard deviation 0.078
Values 1.6 1.7
[13]
THLE KCNMB3
Mean 1.32
Standard deviation 0.44
Values 1.6 1
[14]
liver KCNMB3
Mean 1.26
Standard deviation 0.46
Values 1.1 1.5 0.72 1.7
[15]
ref_hepatocyte KCNMA1
Mean 0.906
Standard deviation 0.66
Values 0 0.7 0.85 1.2 1.8
[16]
HepG2 KCNMA1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[17]
HepG2.C3A KCNMA1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[18]
HuH.7 KCNMA1
Mean 0.313
Standard deviation 0.19
Values 0.42 0.09 0.43
[19]
SNU475 KCNMA1
Mean 5.29
Standard deviation 2.9
Values 7.3 3.3
[20]
THLE KCNMA1
Mean 1.17
Standard deviation 0.89
Values 0.53 1.8
[21]
liver KCNMA1
Mean 3.61
Standard deviation 1.8
Values 3.2 4.5 1.3 5.3
[22]
ref_hepatocyte ITPR1
Mean 0.398
Standard deviation 0.44
Values 1.2 0.25 0.1 0.2 0.25
[23]
HepG2 ITPR1
Mean 7.73
Standard deviation 1.3
Values 8.7 6.8
[24]
HepG2.C3A ITPR1
Mean 6.36
Standard deviation 0.83
Values 7 5.8
[25]
HuH.7 ITPR1
Mean 13.6
Standard deviation 3.5
Values 15 16 9.6
[26]
SNU475 ITPR1
Mean 5.27
Standard deviation 3.4
Values 2.8 7.7
[27]
THLE ITPR1
Mean 10.8
Standard deviation 2.1
Values 12 9.3
[28]
liver ITPR1
Mean 14.2
Standard deviation 12
Values 4.3 20 3.8 29
[29]
ref_hepatocyte PDE2A
Mean 0.315
Standard deviation 0.3
Values 0 0 0.54 0.41 0.63
[30]
HepG2 PDE2A
Mean 2
Standard deviation 2
Values 3.4 0.6
[31]
HepG2.C3A PDE2A
Mean 0.0243
Standard deviation 0.034
Values 0.049 0
[32]
HuH.7 PDE2A
Mean 0.0485
Standard deviation 0.0085
Values 0.041 0.058 0.047
[33]
SNU475 PDE2A
Mean 0.0483
Standard deviation 0.0038
Values 0.051 0.046
[34]
THLE PDE2A
Mean 1.08
Standard deviation 0.29
Values 1.3 0.87
[35]
liver PDE2A
Mean 13.1
Standard deviation 4.8
Values 6.4 17 13 16
[36]
ref_hepatocyte KCNMB4
Mean 0.29
Standard deviation 0.15
Values 0.51 0.25 0.23 0.12 0.34
[37]
HepG2 KCNMB4
Mean 2.85
Standard deviation 0.22
Values 2.7 3
[38]
HepG2.C3A KCNMB4
Mean 2.54
Standard deviation 0.13
Values 2.4 2.6
[39]
HuH.7 KCNMB4
Mean 4.83
Standard deviation 1.4
Values 5.6 3.2 5.7
[40]
SNU475 KCNMB4
Mean 1.14
Standard deviation 0.076
Values 1.2 1.1
[41]
THLE KCNMB4
Mean 0.685
Standard deviation 0.27
Values 0.88 0.49
[42]
liver KCNMB4
Mean 0.791
Standard deviation 0.31
Values 1 1 0.36 0.77
[43]
ref_hepatocyte PDE11A
Mean 0.283
Standard deviation 0.2
Values 0.12 0.25 0.14 0.61 0.29
[44]
HepG2 PDE11A
Mean 2.75
Standard deviation 1.3
Values 1.8 3.7
[45]
HepG2.C3A PDE11A
Mean 1.44
Standard deviation 0.66
Values 0.97 1.9
[46]
HuH.7 PDE11A
Mean 2.2
Standard deviation 0.53
Values 2.6 2.4 1.6
[47]
SNU475 PDE11A
Mean 4.31
Standard deviation 2.3
Values 5.9 2.7
[48]
THLE PDE11A
Mean 0.0908
Standard deviation 0.031
Values 0.11 0.069
[49]
liver PDE11A
Mean 8.57
Standard deviation 3.9
Values 6.4 13 4.6 9.8
[50]
ref_hepatocyte PDE5A
Mean 0.272
Standard deviation 0.28
Values 0.087 0.77 0.15 0.15 0.2
[51]
HepG2 PDE5A
Mean 0.557
Standard deviation 0.27
Values 0.37 0.75
[52]
HepG2.C3A PDE5A
Mean 1.22
Standard deviation 0.49
Values 0.87 1.6
[53]
HuH.7 PDE5A
Mean 4.06
Standard deviation 1.4
Values 3.4 5.7 3.1
[54]
SNU475 PDE5A
Mean 7.63
Standard deviation 6
Values 12 3.4
[55]
THLE PDE5A
Mean 2.59
Standard deviation 0.16
Values 2.5 2.7
[56]
liver PDE5A
Mean 3.05
Standard deviation 1.4
Values 2.2 4.1 1.6 4.3
[57]
ref_hepatocyte PDE1B
Mean 0.0622
Standard deviation 0.087
Values 0 0 0 0.18 0.13
[58]
HepG2 PDE1B
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[59]
HepG2.C3A PDE1B
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 PDE1B
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 PDE1B
Mean 0.0648
Standard deviation 0.059
Values 0.023 0.11
[62]
THLE PDE1B
Mean 0.0343
Standard deviation 0.018
Values 0.047 0.021
[63]
liver PDE1B
Mean 1.29
Standard deviation 0.48
Values 0.92 1.7 0.82 1.7
[64]
ref_hepatocyte KCNMB1
Mean 0.059
Standard deviation 0.084
Values 0 0 0 0.18 0.11
[65]
HepG2 KCNMB1
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A KCNMB1
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 KCNMB1
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 KCNMB1
Mean 0.0772
Standard deviation 0.0089
Values 0.083 0.071
[69]
THLE KCNMB1
Mean 0
Standard deviation 0
Values 0 0
[70]
liver KCNMB1
Mean 0.125
Standard deviation 0.065
Values 0.047 0.11 0.21 0.13
[71]
ref_hepatocyte PRKG1
Mean 0.0174
Standard deviation 0.027
Values 0 0 0.062 0 0.024
[72]
HepG2 PRKG1
Mean 0.0343
Standard deviation 0.024
Values 0.017 0.051
[73]
HepG2.C3A PRKG1
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 PRKG1
Mean 0.0764
Standard deviation 0.034
Values 0.057 0.12 0.056
[75]
SNU475 PRKG1
Mean 0.289
Standard deviation 0.11
Values 0.21 0.36
[76]
THLE PRKG1
Mean 1.22
Standard deviation 0.23
Values 1.4 1.1
[77]
liver PRKG1
Mean 2.25
Standard deviation 1
Values 1.3 3.1 1.4 3.2
[78]
ref_hepatocyte PDE1A
Mean 0.0163
Standard deviation 0.036
Values 0 0 0 0 0.081
[79]
HepG2 PDE1A
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A PDE1A
Mean 0.0194
Standard deviation 0.027
Values 0.039 0
[81]
HuH.7 PDE1A
Mean 0.483
Standard deviation 0.49
Values 0.13 1 0.27
[82]
SNU475 PDE1A
Mean 2.08
Standard deviation 0.94
Values 2.7 1.4
[83]
THLE PDE1A
Mean 0.2
Standard deviation 0.048
Values 0.17 0.23
[84]
liver PDE1A
Mean 2.24
Standard deviation 1
Values 0.92 2.9 2.1 3.1
[85]
ref_hepatocyte KCNMB2
Mean 0.013
Standard deviation 0.029
Values 0 0 0 0 0.065
[86]
HepG2 KCNMB2
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A KCNMB2
Mean 0.035
Standard deviation 0.019
Values 0.049 0.021
[88]
HuH.7 KCNMB2
Mean 0.0763
Standard deviation 0.027
Values 0.09 0.045 0.094
[89]
SNU475 KCNMB2
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[90]
THLE KCNMB2
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[91]
liver KCNMB2
Mean 0.0373
Standard deviation 0.031
Values 0 0.071 0.051 0.026
[92]
ref_hepatocyte PRKG2
Mean 0.00924
Standard deviation 0.021
Values 0 0 0.046 0 0
[93]
HepG2 PRKG2
Mean 0.153
Standard deviation 0.12
Values 0.24 0.064
[94]
HepG2.C3A PRKG2
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 PRKG2
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 PRKG2
Mean 1.87
Standard deviation 0.4
Values 2.2 1.6
[97]
THLE PRKG2
Mean 0.0402
Standard deviation 0.048
Values 0.0059 0.074
[98]
liver PRKG2
Mean 0.054
Standard deviation 0.05
Values 0.024 0.1 0 0.093
[99]
ref_hepatocyte PDE10A
Mean 0.00422
Standard deviation 0.006
Values 0 0.013 0 0 0.0081
[100]
HepG2 PDE10A
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[101]
HepG2.C3A PDE10A
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 PDE10A
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 PDE10A
Mean 0.0403
Standard deviation 0.028
Values 0.06 0.02
[104]
THLE PDE10A
Mean 3.63
Standard deviation 0.96
Values 2.9 4.3
[105]
liver PDE10A
Mean 1.11
Standard deviation 0.82
Values 0.63 1.6 0.23 2
[106]
ref_hepatocyte IRAG1
Missing
[107]
HepG2 IRAG1
Missing
[108]
HepG2.C3A IRAG1
Missing
[109]
HuH.7 IRAG1
Missing
[110]
SNU475 IRAG1
Missing
[111]
THLE IRAG1
Missing
[112]
liver IRAG1
Missing