REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.90[2] | -1.07[3] | -1.00[4] | -1.65[5] | -1.10[6] | -0.77[7] |
2 | SQSTM1 | Sequestosome-1 | [8] | -0.46[9] | -1.48[10] | -1.01[11] | -0.04[12] | -0.04[13] | -0.68[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | -0.46[23] | -0.32[24] | -0.64[25] | -0.80[26] | -0.72[27] | -0.31[28] |
5 | YWHAE | 14-3-3 protein epsilon | [29] | 0.06[30] | 0.20[31] | 0.47[32] | 0.27[33] | 0.40[34] | -0.45[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 1.98[37] | 1.92[38] | 2.87[39] | 0.60[40] | 1.51[41] | 0.46[42] |
7 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [43] | 0.90[44] | 0.61[45] | 1.23[46] | 1.14[47] | 1.22[48] | 0.15[49] |
8 | APH1A | Gamma-secretase subunit APH-1A | [50] | 1.23[51] | 1.54[52] | 1.67[53] | 0.86[54] | 0.85[55] | 0.10[56] |
9 | PSENEN | Gamma-secretase subunit PEN-2 | [57] | -0.77[58] | -0.72[59] | -0.34[60] | -0.76[61] | -1.08[62] | -0.95[63] |
10 | MAGED1 | Melanoma-associated antigen D1 | [64] | 2.70[65] | 2.50[66] | -6.58[67] | 3.00[68] | 1.59[69] | 1.31[70] |
11 | AATF | Protein AATF | [71] | 0.95[72] | 0.04[73] | 0.68[74] | 0.76[75] | 0.22[76] | -0.66[77] |
12 | BAD | Bcl2-associated agonist of cell death | [78] | -0.37[79] | -0.21[80] | -1.24[81] | 0.06[82] | 0.56[83] | -0.31[84] |
13 | NCSTN | Nicastrin | [85] | 2.65[86] | 1.84[87] | 1.91[88] | 2.22[89] | 2.19[90] | 1.50[91] |
14 | NET1 | Neuroepithelial cell-transforming gene 1 protein | [92] | 1.60[93] | 2.24[94] | 2.18[95] | 1.31[96] | 0.73[97] | 1.52[98] |
15 | CASP3 | Caspase-3 | [99] | 1.43[100] | 2.14[101] | -0.49[102] | 0.23[103] | 1.32[104] | 0.31[105] |
16 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [106] | 1.41[107] | 1.62[108] | 2.00[109] | 2.32[110] | 1.25[111] | 1.65[112] |
17 | ARHGEF35 | Rho guanine nucleotide exchange factor 35 | [113] | -6.34[114] | -5.98[115] | -5.75[116] | -2.50[117] | -1.82[118] | -1.99[119] |
18 | ITSN1 | Intersectin-1 | [120] | 1.18[121] | 1.33[122] | 2.01[123] | 2.14[124] | 2.49[125] | 2.84[126] |
19 | VAV2 | Guanine nucleotide exchange factor VAV2 | [127] | 2.60[128] | 2.88[129] | 2.29[130] | 0.59[131] | 1.11[132] | 1.62[133] |
20 | ARHGEF10 | Rho guanine nucleotide exchange factor 10-like protein | [134] | 1.81[135] | 4.14[136] | 2.86[137] | 1.04[138] | -0.45[139] | 4.11[140] |
21 | MAPK8 | Mitogen-activated protein kinase 8 | [141] | -0.15[142] | 1.30[143] | 0.08[144] | 0.23[145] | 0.18[146] | 0.60[147] |
22 | SOS1 | Son of sevenless homolog 1 | [148] | 1.20[149] | 2.76[150] | 2.18[151] | 1.97[152] | 1.30[153] | 1.65[154] |
23 | PSEN1 | Presenilin-1 | [155] | 2.35[156] | 2.61[157] | 2.09[158] | 2.38[159] | 2.35[160] | 2.11[161] |
24 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [162] | 3.31[163] | 3.11[164] | 2.66[165] | 4.12[166] | 3.38[167] | 5.28[168] |
25 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [169] | 2.22[170] | 2.57[171] | 2.80[172] | 2.05[173] | 2.42[174] | 1.50[175] |
26 | ARHGEF2 | Rho guanine nucleotide exchange factor 2 | [176] | 1.93[177] | 1.88[178] | 1.89[179] | 2.98[180] | 3.45[181] | 0.03[182] |
27 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [183] | -2.71[184] | -1.44[185] | -1.29[186] | -1.17[187] | -1.00[188] | -1.29[189] |
28 | ARHGEF40 | Rho guanine nucleotide exchange factor 40 | [190] | 2.00[191] | 2.82[192] | 1.01[193] | 3.00[194] | 2.71[195] | 3.06[196] |
29 | PSEN2 | Presenilin-2 | [197] | 0.61[198] | -0.21[199] | -4.11[200] | 1.21[201] | -0.07[202] | 1.01[203] |
30 | NGEF | Ephexin-1 | [204] | 1.65[205] | 2.58[206] | 2.67[207] | -3.89[208] | -1.19[209] | 1.92[210] |
31 | TRIO | Triple functional domain protein | [211] | 3.30[212] | 3.06[213] | 3.22[214] | 3.73[215] | 4.71[216] | 3.86[217] |
32 | ITGB3BP | Centromere protein R | [218] | 0.38[219] | 2.11[220] | 2.32[221] | 0.76[222] | 1.52[223] | -0.33[224] |
33 | ECT2 | Protein ECT2 | [225] | 1.98[226] | 3.71[227] | 4.62[228] | 3.26[229] | 3.94[230] | 0.23[231] |
34 | AKAP13 | A-kinase anchor protein 13 | [232] | 3.03[233] | 2.19[234] | 3.07[235] | 3.83[236] | 3.54[237] | 5.25[238] |
35 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [239] | 2.92[240] | 2.94[241] | 2.71[242] | 2.94[243] | 2.79[244] | 3.46[245] |
36 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 | [246] | 3.97[247] | 3.10[248] | 3.82[249] | 2.46[250] | 2.89[251] | 2.70[252] |
37 | SOS2 | Son of sevenless homolog 2 | [253] | 1.27[254] | 2.43[255] | 1.57[256] | 2.82[257] | 2.77[258] | 2.95[259] |
38 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | [260] | 0.34[261] | 1.37[262] | 1.87[263] | 1.50[264] | 3.20[265] | 4.34[266] |
39 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | [267] | 3.34[268] | 3.49[269] | 3.09[270] | 4.39[271] | 3.78[272] | 3.70[273] |
40 | FGD4 | FYVE, RhoGEF and PH domain-containing protein 4 | [274] | 0.64[275] | 2.79[276] | 2.18[277] | 1.90[278] | 2.44[279] | 4.41[280] |
41 | BCL2L11 | Bcl-2-like protein 11 | [281] | 2.80[282] | 2.84[283] | 3.08[284] | 2.99[285] | 2.06[286] | 3.10[287] |
42 | CASP2 | Caspase-2 | [288] | 2.99[289] | 2.67[290] | 3.38[291] | 3.00[292] | 3.53[293] | 2.70[294] |
43 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | [295] | 3.87[296] | 2.61[297] | 1.69[298] | 2.58[299] | 2.93[300] | 1.25[301] |
44 | MCF2L | Guanine nucleotide exchange factor DBS | [302] | 3.57[303] | 3.80[304] | 1.51[305] | -3.49[306] | -6.61[307] | 2.62[308] |
45 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | [309] | 4.17[310] | 5.57[311] | 1.66[312] | 3.09[313] | -0.38[314] | 2.01[315] |
46 | TRAF6 | TNF receptor-associated factor 6 | [316] | 2.39[317] | 2.31[318] | 2.79[319] | 2.79[320] | 2.34[321] | 4.02[322] |
47 | RASGRF2 | Ras-specific guanine nucleotide-releasing factor 2 | [323] | 5.14[324] | 4.43[325] | 0.03[326] | -1.81[327] | 0.52[328] | 1.63[329] |
48 | KALRN | Kalirin | [330] | 2.64[331] | 4.22[332] | 3.63[333] | 3.03[334] | -1.54[335] | 4.67[336] |
49 | ABR | Active breakpoint cluster region-related protein | [337] | 5.25[338] | 4.86[339] | 4.30[340] | 4.56[341] | 5.36[342] | 2.95[343] |
50 | APH1B | Gamma-secretase subunit APH-1B | [344] | 1.06[345] | 1.90[346] | 4.94[347] | 4.22[348] | 3.36[349] | 2.34[350] |
51 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [351] | -3.41[352] | -0.70[353] | -5.97[354] | -0.23[355] | 1.91[356] | 4.46[357] |
52 | VAV3 | Guanine nucleotide exchange factor VAV3 | [358] | 3.11[359] | 1.43[360] | 3.52[361] | 4.81[362] | -1.07[363] | 2.46[364] |
53 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | [365] | -0.14[366] | -1.31[367] | -6.68[368] | 3.30[369] | 3.40[370] | 3.47[371] |
54 | FGD2 | FYVE, RhoGEF and PH domain-containing protein 2 | [372] | -4.27[373] | -5.23[374] | -6.97[375] | -2.93[376] | -5.61[377] | 3.98[378] |
55 | VAV1 | Proto-oncogene vav | [379] | -7.20[380] | -2.34[381] | -4.13[382] | -4.96[383] | -6.13[384] | 2.29[385] |
56 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | [386] | -4.72[387] | -2.44[388] | -3.14[389] | 4.36[390] | 2.98[391] | 4.25[392] |
57 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | [393] | 2.79[394] | 4.24[395] | 2.68[396] | 2.87[397] | 3.87[398] | 1.99[399] |
58 | PLEKHG2 | Pleckstrin homology domain-containing family G member 2 | [400] | 5.01[401] | 4.47[402] | 5.24[403] | 5.85[404] | 4.99[405] | 2.62[406] |
59 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | 0.88[407] | -4.91[408] | -2.69[409] | 6.24[410] | 4.68[411] | 5.32[412] | |
60 | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3 | [413] | 1.92[414] | 2.32[415] | 0.97[416] | 0.31[417] | -3.90[418] | 3.38[419] |
61 | ARHGEF10 | Rho guanine nucleotide exchange factor 10 | [420] | -2.71[421] | -2.20[422] | -3.25[423] | 4.24[424] | 5.21[425] | 2.98[426] |
62 | ARHGEF37 | Rho guanine nucleotide exchange factor 37 | [427] | 2.08[428] | -2.83[429] | -0.05[430] | 3.33[431] | 2.40[432] | 3.82[433] |
63 | PLEKHG5 | Pleckstrin homology domain-containing family G member 5 | [434] | 4.80[435] | 4.33[436] | 2.99[437] | 3.49[438] | 4.00[439] | 2.57[440] |
64 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | [441] | 6.49[442] | 7.18[443] | 5.76[444] | 8.88[445] | 6.77[446] | 5.45[447] |
65 | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1 | [448] | 4.04[449] | 4.58[450] | 3.38[451] | 6.37[452] | 5.92[453] | 2.75[454] |
66 | TIAM2 | T-lymphoma invasion and metastasis-inducing protein 2 | [455] | 5.21[456] | 4.65[457] | 5.99[458] | 5.67[459] | 3.64[460] | 1.08[461] |
67 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | [462] | [463] | -3.62[464] | [465] | -2.79[466] | [467] | 5.07[468] |
68 | NGFR | Tumor necrosis factor receptor superfamily member 16 | [469] | 9.76[470] | 2.95[471] | -1.14[472] | 2.88[473] | 3.91[474] | 8.71[475] |
69 | OBSCN | Obscurin | [476] | 5.22[477] | 2.66[478] | 3.23[479] | 8.94[480] | 6.20[481] | 7.73[482] |
70 | ARHGEF4 | Rho guanine nucleotide exchange factor 4 | [483] | 3.62[484] | -1.82[485] | -2.81[486] | 6.07[487] | 6.49[488] | 3.07[489] |
71 | ARHGEF38 | Rho guanine nucleotide exchange factor 38 | [490] | 0.53[491] | 2.81[492] | 7.75[493] | 1.50[494] | 1.21[495] | 5.40[496] |
72 | ARHGEF33 | Rho guanine nucleotide exchange factor 33 | [497] | 2.67[498] | 4.16[499] | 2.61[500] | 3.42[501] | 6.52[502] | 5.97[503] |
73 | BEX3 | Protein BEX3 | [504] | [505] | [506] | [507] | [508] | [509] | [510] |
74 | NGF | Beta-nerve growth factor | [511] | [512] | [513] | [514] | [515] | [516] | [517] |
75 | MCF2 | Proto-oncogene DBL | [518] | [519] | [520] | [521] | [522] | [523] | [524] |
76 | ARHGEF39 | Rho guanine nucleotide exchange factor 39 | [525] | [526] | [527] | [528] | [529] | [530] | [531] |