REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.27[2] | -1.32[3] | -1.21[4] | -1.52[5] | -1.23[6] | -0.62[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.82[16] | -0.57[17] | -0.84[18] | -0.67[19] | -0.85[20] | -0.17[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.59[23] | -2.16[24] | -1.81[25] | -1.39[26] | -2.07[27] | -1.12[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.41[30] | -1.78[31] | -1.90[32] | -1.17[33] | -1.61[34] | -0.74[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.55[37] | 0.69[38] | -0.65[39] | 0.45[40] | -0.13[41] | 0.28[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.09[44] | 0.24[45] | -0.85[46] | -0.79[47] | -0.17[48] | 0.12[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.39[51] | -1.14[52] | -0.13[53] | -0.81[54] | -1.08[55] | -0.18[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.15[58] | 0.06[59] | 0.17[60] | 0.62[61] | 0.46[62] | -0.51[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.09[65] | -1.04[66] | -0.93[67] | -1.16[68] | -0.86[69] | -0.95[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.31[72] | -0.08[73] | -0.17[74] | -0.44[75] | -0.30[76] | -0.47[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.44[79] | 0.19[80] | 0.11[81] | 0.09[82] | -0.03[83] | -0.39[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.49[86] | 0.21[87] | -0.01[88] | 0.39[89] | 0.08[90] | -0.47[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.53[93] | -0.55[94] | 0.05[95] | -0.80[96] | -0.75[97] | 0.00[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -1.11[100] | -0.07[101] | -0.76[102] | -0.06[103] | -0.65[104] | -0.22[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.57[107] | -0.37[108] | -0.24[109] | -0.61[110] | -1.01[111] | -0.06[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -0.65[114] | 0.35[115] | 0.67[116] | -0.11[117] | 0.13[118] | 0.16[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | -0.13[121] | -0.07[122] | 0.11[123] | 0.59[124] | -0.08[125] | -0.16[126] |
19 | HIGD1A | HIG1 domain family member 1A, mitochondrial | [127] | 0.31[128] | 1.00[129] | 0.47[130] | -0.76[131] | 0.21[132] | 1.71[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.22[135] | 0.20[136] | 0.05[137] | -0.49[138] | -0.16[139] | -0.34[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.05[142] | 0.24[143] | 0.36[144] | -0.22[145] | 0.41[146] | -0.31[147] |
22 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [148] | 0.11[149] | 0.57[150] | 0.77[151] | 0.51[152] | 0.83[153] | 1.12[154] |
23 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [155] | 1.48[156] | 0.71[157] | 0.76[158] | 0.89[159] | 2.05[160] | 0.72[161] |
24 | PSMC1 | 26S proteasome regulatory subunit 4 | [162] | -0.19[163] | -0.08[164] | -0.75[165] | 1.08[166] | 0.46[167] | -0.12[168] |
25 | PSMA1 | Proteasome subunit alpha type-1 | [169] | -0.01[170] | 0.43[171] | 0.47[172] | 0.65[173] | 0.02[174] | 0.37[175] |
26 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [176] | 1.61[177] | 1.66[178] | 2.67[179] | 0.73[180] | 1.38[181] | 0.60[182] |
27 | PSMC5 | 26S proteasome regulatory subunit 8 | [183] | 0.31[184] | 0.25[185] | 0.31[186] | 0.06[187] | 0.34[188] | 0.14[189] |
28 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [190] | -1.12[191] | -0.55[192] | -0.70[193] | -1.45[194] | -1.19[195] | -0.84[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.70[198] | 0.24[199] | 0.82[200] | 0.59[201] | 0.68[202] | -0.15[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.69[205] | -2.24[206] | -9.47[207] | 0.56[208] | -0.88[209] | -0.83[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.12[212] | 0.53[213] | 0.77[214] | 0.45[215] | 0.35[216] | -0.29[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 0.31[219] | 0.38[220] | 0.30[221] | 0.08[222] | 0.06[223] | 0.19[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.85[226] | -0.32[227] | -1.42[228] | -0.54[229] | 0.13[230] | -0.40[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.35[233] | 0.51[234] | 0.99[235] | 0.52[236] | -0.11[237] | -0.21[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.47[240] | -0.34[241] | -0.67[242] | 0.14[243] | 0.07[244] | -0.29[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.17[247] | 1.45[248] | 0.25[249] | 0.49[250] | 0.29[251] | 0.36[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.71[254] | 0.37[255] | 0.95[256] | 0.90[257] | 0.92[258] | 1.19[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.47[261] | 0.91[262] | 0.67[263] | 1.30[264] | 0.99[265] | 1.24[266] |
39 | PSME3 | Proteasome activator complex subunit 3 | [267] | 1.69[268] | 1.46[269] | 1.12[270] | 1.32[271] | 1.45[272] | 0.80[273] |
40 | HIF1A | Hypoxia-inducible factor 1-alpha | [274] | 0.78[275] | 0.59[276] | 1.35[277] | 3.54[278] | 3.76[279] | 0.45[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.45[282] | 1.82[283] | 1.68[284] | 2.13[285] | 2.00[286] | 1.99[287] |
42 | CITED2 | Cbp/p300-interacting transactivator 2 | [288] | -0.09[289] | -0.13[290] | 1.21[291] | 1.16[292] | 0.22[293] | -0.22[294] |
43 | PSMB10 | Proteasome subunit beta type-10 | [295] | -1.27[296] | -0.63[297] | -2.53[298] | -0.08[299] | -1.38[300] | -0.16[301] |
44 | PSMA5 | Proteasome subunit alpha type-5 | [302] | 1.78[303] | 2.25[304] | 1.80[305] | 2.18[306] | 1.61[307] | 1.83[308] |
45 | PSMF1 | Proteasome inhibitor PI31 subunit | [309] | 2.16[310] | 2.25[311] | 1.04[312] | 1.19[313] | 0.81[314] | 1.77[315] |
46 | PSMB2 | Proteasome subunit beta type-2 | [316] | 1.94[317] | 1.72[318] | 2.09[319] | 2.48[320] | 2.33[321] | 2.32[322] |
47 | VEGFA | Vascular endothelial growth factor A | [323] | 2.15[324] | 3.63[325] | 2.20[326] | 1.69[327] | 2.24[328] | 2.04[329] |
48 | PSMB9 | Proteasome subunit beta type-9 | [330] | -2.07[331] | -4.64[332] | -6.97[333] | 1.74[334] | -0.67[335] | -0.58[336] |
49 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [337] | 0.32[338] | 0.85[339] | -0.15[340] | 0.36[341] | 0.66[342] | 0.65[343] |
50 | EGLN2 | Egl nine homolog 2 | [344] | -4.46[345] | -4.62[346] | -3.85[347] | -3.99[348] | -3.79[349] | -5.20[350] |
51 | EPAS1 | Endothelial PAS domain-containing protein 1 | [351] | 3.64[352] | 3.00[353] | 2.62[354] | 0.69[355] | 3.54[356] | 3.19[357] |
52 | UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 | [358] | 1.93[359] | 2.12[360] | 1.37[361] | 2.05[362] | 2.09[363] | 1.22[364] |
53 | AJUBA | LIM domain-containing protein ajuba | [365] | 3.46[366] | 2.10[367] | 4.01[368] | 2.49[369] | 1.39[370] | 1.82[371] |
54 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [372] | 0.87[373] | 1.24[374] | 1.25[375] | 2.03[376] | 1.21[377] | 0.63[378] |
55 | EGLN1 | Egl nine homolog 1 | [379] | 2.26[380] | 2.06[381] | 1.50[382] | 2.73[383] | 2.53[384] | 2.76[385] |
56 | PSME4 | Proteasome activator complex subunit 4 | [386] | 2.40[387] | 3.36[388] | 3.34[389] | 2.59[390] | 2.41[391] | 2.90[392] |
57 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [393] | 1.29[394] | 0.89[395] | 2.43[396] | 2.42[397] | 2.36[398] | 2.08[399] |
58 | ARNT | Aryl hydrocarbon receptor nuclear translocator | [400] | 1.35[401] | 1.28[402] | 2.12[403] | 2.62[404] | 2.23[405] | 2.79[406] |
59 | VHL | von Hippel-Lindau disease tumor suppressor | [407] | 2.88[408] | 3.14[409] | 3.88[410] | 2.10[411] | 2.62[412] | 2.23[413] |
60 | CUL2 | Cullin-2 | [414] | 1.03[415] | 2.60[416] | 2.71[417] | 3.71[418] | 2.91[419] | 2.26[420] |
61 | EPO | Erythropoietin | [421] | -0.20[422] | 2.11[423] | -1.78[424] | -8.41[425] | -10.45[426] | 1.24[427] |
62 | LIMD1 | LIM domain-containing protein 1 | [428] | 1.56[429] | 1.50[430] | 3.60[431] | 1.03[432] | 1.06[433] | 2.90[434] |
63 | HIF1AN | Hypoxia-inducible factor 1-alpha inhibitor | [435] | 3.36[436] | 3.50[437] | 4.01[438] | 2.89[439] | 2.82[440] | 2.48[441] |
64 | EP300 | Histone acetyltransferase p300 | [442] | 3.66[443] | 3.39[444] | 4.25[445] | 3.83[446] | 3.72[447] | 4.01[448] |
65 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [449] | 1.73[450] | 2.74[451] | 3.05[452] | 2.78[453] | 2.38[454] | 1.76[455] |
66 | CREBBP | CREB-binding protein | [456] | 3.83[457] | 3.19[458] | 3.77[459] | 4.01[460] | 3.86[461] | 4.49[462] |
67 | EGLN3 | Egl nine homolog 3 | [463] | 4.07[464] | 3.08[465] | 2.28[466] | 4.20[467] | 0.44[468] | 0.67[469] |
68 | WTIP | Wilms tumor protein 1-interacting protein | [470] | 3.79[471] | 3.08[472] | 1.93[473] | 3.98[474] | 2.95[475] | 0.57[476] |
69 | HIF3A | Hypoxia-inducible factor 3-alpha | [477] | 0.00[478] | 0.68[479] | -2.02[480] | -0.67[481] | -0.93[482] | 4.85[483] |
70 | CA9 | Carbonic anhydrase 9 | [484] | 9.83[485] | 7.92[486] | 0.25[487] | 7.18[488] | 6.58[489] | 3.75[490] |
71 | PSMB11 | Proteasome subunit beta type-11 | [491] | [492] | [493] | [494] | [495] | [496] | [497] |
72 | ELOC | Elongin-C | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | ELOB | Elongin-B | [505] | [506] | [507] | [508] | [509] | [510] | [511] |
74 | SEM1 | Putative protein SEM1, isoform 2 | [512] | [513] | [514] | [515] | [516] | [517] | [518] |
75 | PSMA8 | Proteasome subunit alpha type-7-like | [519] | [520] | [521] | [522] | [523] | [524] | [525] |