REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | EEF1A1 | Elongation factor 1-alpha 1 | [1] | 1.01[2] | 1.26[3] | 1.42[4] | 0.03[5] | 0.56[6] | 0.42[7] |
2 | UBB | Polyubiquitin-B | [8] | -2.22[9] | -2.87[10] | -2.83[11] | -2.21[12] | -1.80[13] | -1.00[14] |
3 | HSP90AB1 | Heat shock protein HSP 90-beta | [15] | 0.21[16] | -0.15[17] | -1.06[18] | 0.02[19] | -0.65[20] | -1.23[21] |
4 | HSPA8 | Heat shock cognate 71 kDa protein | [22] | -0.34[23] | -0.79[24] | -1.59[25] | 0.53[26] | 0.18[27] | -0.20[28] |
5 | HSP90AA1 | Heat shock protein HSP 90-alpha | [29] | -0.67[30] | -0.15[31] | -1.02[32] | 0.66[33] | 0.29[34] | -0.38[35] |
6 | HSPB1 | Heat shock protein beta-1 | [36] | -3.51[37] | -4.79[38] | -4.14[39] | -0.82[40] | -3.05[41] | -2.93[42] |
7 | HSPA5 | 78 kDa glucose-regulated protein | [43] | -0.47[44] | -0.86[45] | -1.71[46] | -0.74[47] | -0.69[48] | 0.54[49] |
8 | HSPA1A | Heat shock 70 kDa protein 1A | [50] | -5.60[51] | -5.72[52] | -6.93[53] | -4.36[54] | -5.85[55] | -4.87[56] |
9 | YWHAE | 14-3-3 protein epsilon | [57] | -1.26[58] | -1.61[59] | -1.36[60] | -0.29[61] | -0.31[62] | -0.68[63] |
10 | PTGES3 | Prostaglandin E synthase 3 | [64] | -0.79[65] | -0.91[66] | -0.67[67] | -0.11[68] | -0.21[69] | -1.20[70] |
11 | HSPA9 | Stress-70 protein, mitochondrial | [71] | -0.15[72] | -0.70[73] | -0.81[74] | -0.42[75] | 0.01[76] | 1.29[77] |
12 | HSPA1B | Heat shock 70 kDa protein 1B | [78] | -3.77[79] | -4.41[80] | -5.41[81] | -3.51[82] | -4.01[83] | -4.30[84] |
13 | VCP | Transitional endoplasmic reticulum ATPase | [85] | 0.22[86] | -0.50[87] | -0.68[88] | 0.07[89] | 0.58[90] | 1.11[91] |
14 | ST13 | Hsc70-interacting protein | [92] | -0.33[93] | -0.75[94] | 0.23[95] | -0.42[96] | -0.39[97] | 0.58[98] |
15 | SEC13 | Protein SEC13 homolog | [99] | -0.97[100] | -1.05[101] | -0.97[102] | -1.16[103] | -1.06[104] | -0.69[105] |
16 | MRPL18 | 39S ribosomal protein L18, mitochondrial | [106] | [107] | [108] | [109] | [110] | [111] | [112] |
17 | RPS19BP1 | Active regulator of SIRT1 | [113] | [114] | [115] | [116] | [117] | [118] | [119] |
18 | DNAJB1 | DnaJ homolog subfamily B member 1 | [120] | 0.23[121] | -0.76[122] | -0.91[123] | -0.81[124] | -0.54[125] | -0.65[126] |
19 | HSPA6 | Heat shock 70 kDa protein 6 | [127] | -10.55[128] | -11.57[129] | -8.71[130] | -8.05[131] | -7.54[132] | -5.85[133] |
20 | FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 | [134] | -0.16[135] | -1.04[136] | -0.04[137] | -0.74[138] | 0.59[139] | 0.13[140] |
21 | DNAJB6 | DnaJ homolog subfamily B member 6 | [141] | -0.62[142] | -1.10[143] | -1.34[144] | 0.51[145] | -0.31[146] | -0.40[147] |
22 | HSPA4 | Heat shock 70 kDa protein 4 | [148] | 0.13[149] | -0.14[150] | -0.33[151] | 1.32[152] | 0.86[153] | 0.38[154] |
23 | DNAJC7 | DnaJ homolog subfamily C member 7 | [155] | -0.58[156] | -1.80[157] | -1.04[158] | -0.64[159] | -0.32[160] | -1.13[161] |
24 | HSBP1 | Heat shock factor-binding protein 1 | [162] | -0.07[163] | 0.03[164] | -0.62[165] | -0.27[166] | 0.20[167] | 0.18[168] |
25 | RPA2 | Replication protein A 32 kDa subunit | [169] | -1.48[170] | -1.86[171] | -1.40[172] | -0.18[173] | -0.15[174] | -1.52[175] |
26 | DNAJC2 | DnaJ homolog subfamily C member 2 | [176] | -2.46[177] | -0.75[178] | -1.33[179] | -0.64[180] | -0.96[181] | -0.90[182] |
27 | HSPH1 | Heat shock protein 105 kDa | [183] | 0.29[184] | 0.49[185] | -0.02[186] | 2.23[187] | 1.35[188] | 0.56[189] |
28 | AKT1S1 | Proline-rich AKT1 substrate 1 | [190] | -0.48[191] | -1.09[192] | -0.84[193] | -0.18[194] | 0.39[195] | -0.32[196] |
29 | BAG3 | BAG family molecular chaperone regulator 3 | [197] | -0.74[198] | -1.18[199] | -2.20[200] | 0.40[201] | 0.70[202] | -0.86[203] |
30 | MAPKAPK | MAP kinase-activated protein kinase 2 | [204] | 0.44[205] | -0.98[206] | -0.67[207] | 1.97[208] | 1.12[209] | -0.07[210] |
31 | TNFRSF21 | Tumor necrosis factor receptor superfamily member 21 | [211] | 1.91[212] | -0.96[213] | -0.83[214] | 1.72[215] | 1.59[216] | -1.81[217] |
32 | HSF1 | Heat shock factor protein 1 | [218] | 0.34[219] | -0.54[220] | -0.39[221] | 1.08[222] | 0.62[223] | 0.04[224] |
33 | RAE1 | mRNA export factor | [225] | 0.55[226] | -0.18[227] | -1.42[228] | 1.15[229] | 0.40[230] | -0.14[231] |
34 | SERPINH1 | Serpin H1 | [232] | 2.09[233] | 1.23[234] | 0.33[235] | 4.20[236] | 3.41[237] | 0.50[238] |
35 | MAPK1 | Mitogen-activated protein kinase 1 | [239] | 1.69[240] | 1.37[241] | 1.10[242] | 2.42[243] | 2.01[244] | 2.65[245] |
36 | NUP88 | Nuclear pore complex protein Nup88 | [246] | -0.08[247] | -0.01[248] | 0.00[249] | 0.24[250] | 0.69[251] | 1.99[252] |
37 | SEH1L | Nucleoporin SEH1 | [253] | 0.21[254] | 0.24[255] | 0.59[256] | 1.14[257] | 0.31[258] | 1.05[259] |
38 | MLST8 | Target of rapamycin complex subunit LST8 | [260] | -0.19[261] | -0.32[262] | -0.05[263] | -0.41[264] | -0.11[265] | 0.31[266] |
39 | BAG1 | BAG family molecular chaperone regulator 1 | [267] | -0.04[268] | -0.17[269] | -1.15[270] | -0.53[271] | -0.03[272] | 0.94[273] |
40 | HSPA14 | Heat shock 70 kDa protein 14 | [274] | -1.68[275] | -0.78[276] | -1.10[277] | 0.35[278] | 0.19[279] | -0.62[280] |
41 | NUP35 | Nucleoporin NUP53 | [281] | -1.10[282] | -0.98[283] | -1.10[284] | -0.52[285] | -0.79[286] | -0.35[287] |
42 | BAG2 | BAG family molecular chaperone regulator 2 | [288] | 0.46[289] | 0.51[290] | -0.77[291] | 1.04[292] | 0.64[293] | -0.22[294] |
43 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [295] | 1.29[296] | 0.57[297] | 0.74[298] | 2.42[299] | 2.39[300] | 0.88[301] |
44 | RPA3 | Replication protein A 14 kDa subunit | [302] | -0.39[303] | -0.04[304] | 0.58[305] | -0.34[306] | -0.10[307] | 0.18[308] |
45 | NUP62 | Nuclear pore glycoprotein p62 | [309] | 1.15[310] | 0.31[311] | 1.26[312] | 1.78[313] | 1.81[314] | 1.29[315] |
46 | DEDD2 | DNA-binding death effector domain-containing protein 2 | [316] | -0.88[317] | -0.64[318] | -0.57[319] | -0.63[320] | -0.33[321] | -0.18[322] |
47 | NUP85 | Nuclear pore complex protein Nup85 | [323] | 0.72[324] | 0.62[325] | 0.76[326] | 1.14[327] | 1.30[328] | 1.09[329] |
48 | AAAS | Aladin | [330] | 0.24[331] | 0.11[332] | -0.40[333] | 0.78[334] | 0.77[335] | 0.69[336] |
49 | HDAC6 | Histone deacetylase 6 | [337] | 0.63[338] | 1.13[339] | 1.11[340] | 0.85[341] | 0.27[342] | 3.03[343] |
50 | NUP50 | Nuclear pore complex protein Nup50 | [344] | 0.75[345] | 0.98[346] | 1.28[347] | 1.55[348] | 1.99[349] | 2.43[350] |
51 | RANBP2 | E3 SUMO-protein ligase RanBP2 | [351] | 0.46[352] | 1.69[353] | 1.32[354] | 2.10[355] | 2.21[356] | 3.82[357] |
52 | NUP93 | Nuclear pore complex protein Nup93 | [358] | 1.66[359] | 0.72[360] | 0.60[361] | 1.51[362] | 1.76[363] | 0.37[364] |
53 | NUP98 | Nuclear pore complex protein Nup98-Nup96 | [365] | 2.15[366] | 1.38[367] | 1.54[368] | 2.80[369] | 2.30[370] | 2.73[371] |
54 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [372] | 0.11[373] | -0.04[374] | 1.38[375] | 1.24[376] | 0.38[377] | 2.28[378] |
55 | NUP54 | Nucleoporin p54 | [379] | 0.08[380] | 0.27[381] | 0.17[382] | 0.90[383] | 1.32[384] | 0.89[385] |
56 | NUP107 | Nuclear pore complex protein Nup107 | [386] | 0.48[387] | 1.14[388] | 1.02[389] | 1.86[390] | 1.73[391] | 0.87[392] |
57 | NUP37 | Nucleoporin Nup37 | [393] | 0.64[394] | 0.47[395] | 0.46[396] | 1.02[397] | 0.96[398] | -0.55[399] |
58 | TPR | Nucleoprotein TPR | [400] | 0.61[401] | 2.02[402] | 2.23[403] | 3.11[404] | 3.29[405] | 3.47[406] |
59 | HSPA13 | Heat shock 70 kDa protein 13 | [407] | 0.90[408] | 2.22[409] | 0.80[410] | 2.21[411] | 2.91[412] | 1.91[413] |
60 | HSPB8 | Heat shock protein beta-8 | [414] | -1.16[415] | -5.14[416] | -5.72[417] | 1.54[418] | 1.17[419] | -2.78[420] |
61 | NUP160 | Nuclear pore complex protein Nup160 | [421] | 1.84[422] | 1.53[423] | 2.03[424] | 1.74[425] | 1.99[426] | 2.34[427] |
62 | MAPK3 | Mitogen-activated protein kinase 3 | [428] | 1.83[429] | 1.42[430] | 1.36[431] | 0.99[432] | 0.96[433] | -0.17[434] |
63 | GSK3B | Glycogen synthase kinase-3 beta | [435] | 1.25[436] | 0.43[437] | 0.89[438] | 2.38[439] | 2.16[440] | 2.04[441] |
64 | POM121 | Nuclear envelope pore membrane protein POM 121 | [442] | 1.42[443] | 1.32[444] | 1.06[445] | 2.12[446] | 1.51[447] | 2.17[448] |
65 | NUP133 | Nuclear pore complex protein Nup133 | [449] | 1.17[450] | 1.06[451] | 1.91[452] | 2.78[453] | 2.07[454] | 1.92[455] |
66 | BAG5 | BAG family molecular chaperone regulator 5 | [456] | 0.75[457] | 0.43[458] | 0.17[459] | 1.98[460] | 2.26[461] | 2.16[462] |
67 | CRYAB | Alpha-crystallin B chain | [463] | -1.29[464] | -5.57[465] | -7.42[466] | 3.02[467] | -2.63[468] | -1.53[469] |
68 | NUP153 | Nuclear pore complex protein Nup153 | [470] | 2.38[471] | 2.12[472] | 1.65[473] | 3.83[474] | 2.93[475] | 2.81[476] |
69 | NUP43 | Nucleoporin Nup43 | [477] | 1.89[478] | 1.61[479] | 1.26[480] | 2.65[481] | 2.33[482] | 1.18[483] |
70 | NUP205 | Nuclear pore complex protein Nup205 | [484] | 2.16[485] | 1.62[486] | 2.69[487] | 3.35[488] | 3.47[489] | 2.38[490] |
71 | POM121C | Nuclear envelope pore membrane protein POM 121C | [491] | 1.26[492] | 0.07[493] | -0.36[494] | 1.97[495] | 1.34[496] | 1.31[497] |
72 | MTOR | Serine/threonine-protein kinase mTOR | [498] | 2.51[499] | 3.07[500] | 2.53[501] | 3.25[502] | 3.28[503] | 4.32[504] |
73 | BAG4 | BAG family molecular chaperone regulator 4 | [505] | 0.33[506] | 0.83[507] | 2.03[508] | 0.51[509] | 0.68[510] | 2.69[511] |
74 | HSPA4L | Heat shock 70 kDa protein 4L | [512] | 0.11[513] | 0.38[514] | -1.50[515] | 0.27[516] | -0.28[517] | 1.34[518] |
75 | NUP214 | Nuclear pore complex protein Nup214 | [519] | 2.00[520] | 0.86[521] | 1.88[522] | 2.75[523] | 2.63[524] | 2.63[525] |
76 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | 0.75[526] | 1.51[527] | 1.02[528] | 2.25[529] | 1.76[530] | 1.83[531] | |
77 | NUP188 | Nucleoporin NUP188 homolog | [532] | 3.24[533] | 2.17[534] | 2.70[535] | 3.09[536] | 4.20[537] | 2.70[538] |
78 | NUP210 | Nuclear pore membrane glycoprotein 210 | [539] | 3.68[540] | 3.04[541] | 4.04[542] | 2.68[543] | 1.01[544] | 3.87[545] |
79 | EP300 | Histone acetyltransferase p300 | [546] | 2.70[547] | 1.84[548] | 2.63[549] | 3.14[550] | 3.14[551] | 3.63[552] |
80 | NUP155 | Nuclear pore complex protein Nup155 | [553] | 2.10[554] | 1.25[555] | 2.13[556] | 3.05[557] | 3.86[558] | 2.61[559] |
81 | RPTOR | Regulatory-associated protein of mTOR | [560] | 3.07[561] | 1.85[562] | 1.84[563] | 2.42[564] | 2.60[565] | 3.21[566] |
82 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | [567] | 0.48[568] | 1.12[569] | 0.57[570] | 2.13[571] | 2.32[572] | 2.21[573] |
83 | CREBBP | CREB-binding protein | [574] | 2.88[575] | 1.64[576] | 2.14[577] | 3.32[578] | 3.28[579] | 4.11[580] |
84 | ATR | Serine/threonine-protein kinase ATR | [581] | 1.07[582] | 1.62[583] | 1.59[584] | 3.10[585] | 3.01[586] | 4.42[587] |
85 | ATM | Serine-protein kinase ATM | [588] | 3.01[589] | 4.16[590] | 3.78[591] | 4.72[592] | 4.16[593] | 5.86[594] |
86 | HSPA12A | Heat shock 70 kDa protein 12A | [595] | 2.03[596] | 2.03[597] | -5.19[598] | 2.73[599] | 1.34[600] | 0.67[601] |
87 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [602] | -2.56[603] | -4.33[604] | -7.40[605] | -2.29[606] | -1.71[607] | 2.02[608] |
88 | HSPA2 | Heat shock-related 70 kDa protein 2 | [609] | -2.46[610] | -3.25[611] | 1.58[612] | 3.80[613] | 3.35[614] | 2.94[615] |
89 | HSPA1L | Heat shock 70 kDa protein 1-like | [616] | -0.56[617] | -0.31[618] | 0.15[619] | 0.81[620] | -0.01[621] | 0.03[622] |
90 | COL4A6 | Collagen alpha-6(IV) chain | [623] | 4.47[624] | -5.28[625] | -4.82[626] | 1.98[627] | 5.70[628] | -0.75[629] |
91 | HSPA12B | Heat shock 70 kDa protein 12B | [630] | 4.72[631] | 4.28[632] | 0.67[633] | -0.03[634] | 0.24[635] | 4.74[636] |
92 | HSPB2 | Heat shock protein beta-2 | [637] | 1.08[638] | 1.37[639] | -3.68[640] | 3.52[641] | 2.75[642] | 4.35[643] |
93 | CRYBA4 | Beta-crystallin A4 | [644] | -3.93[645] | [646] | -3.14[647] | -1.71[648] | -3.40[649] | -1.24[650] |
94 | RLN1 | Prorelaxin H1 | [651] | [652] | [653] | [654] | [655] | [656] | [657] |
95 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [658] | [659] | [660] | [661] | [662] | [663] | [664] |
96 | NUP58 | Nucleoporin p58/p45 | [665] | [666] | [667] | [668] | [669] | [670] | [671] |
97 | NUP42 | [672] | [673] | [674] | [675] | [676] | [677] | [678] | |
98 | GML | Glycosyl-phosphatidylinositol-anchored molecule-like protein | [679] | [680] | [681] | [682] | [683] | [684] | [685] |
99 | NDC1 | Nucleoporin NDC1 | [686] | [687] | [688] | [689] | [690] | [691] | [692] |
100 | CCAR2 | Cell cycle and apoptosis regulator protein 2 | [693] | [694] | [695] | [696] | [697] | [698] | [699] |
101 | HIKESHI | Protein Hikeshi | [700] | [701] | [702] | [703] | [704] | [705] | [706] |