REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDC42 Cell division control protein 42 homolog [1] -0.71[2] -0.14[3] -1.01[4] -0.40[5] -1.06[6] -1.26[7]
2 RAC1 Ras-related C3 botulinum toxin substrate 1 [8] -0.27[9] -0.75[10] 0.09[11] 0.15[12] 0.19[13] -0.14[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 1.32[16] 1.00[17] 1.26[18] 0.69[19] 0.66[20] 1.12[21]
4 PAK2 Serine/threonine-protein kinase PAK 2 [22] 1.57[23] 1.16[24] 1.60[25] 0.89[26] 1.49[27] 2.19[28]
5 PAK1 Serine/threonine-protein kinase PAK 1 [29] 0.11[30] -0.80[31] 1.75[32] -1.72[33] 2.12[34] 1.09[35]
6 FYN Tyrosine-protein kinase Fyn [36] 1.06[37] -7.69[38] 1.02[39] 1.61[40] 3.19[41] 1.79[42]
7 VAV1 Proto-oncogene vav [43] -8.38[44] -3.70[45] -5.27[46] -5.95[47] -7.16[48] 2.00[49]
8 CD86 T-lymphocyte activation antigen CD86 [50] [51] [52] -4.60[53] -3.96[54] -5.92[55] 2.17[56]
9 LCK Tyrosine-protein kinase Lck [57] 2.90[58] 2.83[59] -7.03[60] -4.95[61] -5.09[62] 2.06[63]
10 CD28 T-cell-specific surface glycoprotein CD28 [64] -3.88[65] -3.16[66] -2.99[67] -2.21[68] -2.21[69] 1.94[70]
11 PAK3 Serine/threonine-protein kinase PAK 3 [71] -6.29[72] [73] [74] -1.46[75] 0.31[76] 1.61[77]
12 CD80 T-lymphocyte activation antigen CD80 [78] [79] [80] -5.15[81] -1.02[82] -2.02[83] 3.45[84]
[1]
ref_hepatocyte CDC42
Mean 121
Standard deviation 1e+02
Values 1.6e+02 2.8e+02 75 45 46
[2]
HepG2 CDC42
Mean 150
Standard deviation 13
Values 1.4e+02 1.6e+02
[3]
HepG2.C3A CDC42
Mean 220
Standard deviation 55
Values 1.8e+02 2.6e+02
[4]
HuH.7 CDC42
Mean 105
Standard deviation 19
Values 1.2e+02 83 1.1e+02
[5]
SNU475 CDC42
Mean 153
Standard deviation 20
Values 1.7e+02 1.4e+02
[6]
THLE CDC42
Mean 104
Standard deviation 15
Values 93 1.1e+02
[7]
liver CDC42
Mean 40.5
Standard deviation 9.1
Values 42 43 49 28
[8]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[9]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[10]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[11]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[12]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[13]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[14]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte PAK2
Mean 10.9
Standard deviation 2.8
Values 11 15 11 7.6 9.9
[23]
HepG2 PAK2
Mean 65.6
Standard deviation 14
Values 56 75
[24]
HepG2.C3A PAK2
Mean 49.1
Standard deviation 0.79
Values 49 50
[25]
HuH.7 PAK2
Mean 57.7
Standard deviation 11
Values 66 61 46
[26]
SNU475 PAK2
Mean 33.8
Standard deviation 4.3
Values 37 31
[27]
THLE PAK2
Mean 55.3
Standard deviation 9.9
Values 48 62
[28]
liver PAK2
Mean 39.9
Standard deviation 5.7
Values 44 41 43 32
[29]
ref_hepatocyte PAK1
Mean 2.3
Standard deviation 0.59
Values 1.7 3 2.9 2.1 1.9
[30]
HepG2 PAK1
Mean 5.05
Standard deviation 1.5
Values 6.1 4
[31]
HepG2.C3A PAK1
Mean 2.65
Standard deviation 0.51
Values 3 2.3
[32]
HuH.7 PAK1
Mean 13.5
Standard deviation 2.2
Values 12 16 12
[33]
SNU475 PAK1
Mean 1.17
Standard deviation 0.24
Values 1 1.3
[34]
THLE PAK1
Mean 18
Standard deviation 0.72
Values 18 17
[35]
liver PAK1
Mean 3.94
Standard deviation 1.1
Values 5.3 4 3.9 2.6
[36]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[37]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[38]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[39]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[40]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[41]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[42]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[43]
ref_hepatocyte VAV1
Mean 0.469
Standard deviation 0.4
Values 0 0.2 0.63 0.48 1
[44]
HepG2 VAV1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[45]
HepG2.C3A VAV1
Mean 0.0726
Standard deviation 0.034
Values 0.049 0.097
[46]
HuH.7 VAV1
Mean 0.0213
Standard deviation 0.0061
Values 0.016 0.019 0.028
[47]
SNU475 VAV1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[48]
THLE VAV1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[49]
liver VAV1
Mean 1.51
Standard deviation 0.9
Values 0.75 1.8 0.82 2.6
[50]
ref_hepatocyte CD86
Mean 0.389
Standard deviation 0.38
Values 0 0 0.61 0.48 0.85
[51]
HepG2 CD86
Mean 0
Standard deviation 0
Values 0 0
[52]
HepG2.C3A CD86
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 CD86
Mean 0.0281
Standard deviation 0.02
Values 0.049 0.026 0.0094
[54]
SNU475 CD86
Mean 0.0418
Standard deviation 0.02
Values 0.028 0.056
[55]
THLE CD86
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[56]
liver CD86
Mean 1.41
Standard deviation 0.3
Values 1.2 1.9 1.2 1.3
[57]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.11 0 0.49 0 0.99
[58]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 8 1.7
[59]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.4 4.7
[60]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[61]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[62]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[63]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 1.2 0.49 1.7 0.91
[64]
ref_hepatocyte CD28
Mean 0.0933
Standard deviation 0.1
Values 0.14 0 0 0.086 0.24
[65]
HepG2 CD28
Mean 0.0129
Standard deviation 0.018
Values 0 0.026
[66]
HepG2.C3A CD28
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[67]
HuH.7 CD28
Mean 0.0205
Standard deviation 0.023
Values 0.0082 0.0064 0.047
[68]
SNU475 CD28
Mean 0.0338
Standard deviation 0.0047
Values 0.037 0.03
[69]
THLE CD28
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[70]
liver CD28
Mean 0.288
Standard deviation 0.19
Values 0.094 0.27 0.23 0.56
[71]
ref_hepatocyte PAK3
Mean 0.0826
Standard deviation 0.14
Values 0 0 0.33 0 0.081
[72]
HepG2 PAK3
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[73]
HepG2.C3A PAK3
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 PAK3
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 PAK3
Mean 0.05
Standard deviation 0.051
Values 0.014 0.086
[76]
THLE PAK3
Mean 0.185
Standard deviation 0.065
Values 0.23 0.14
[77]
liver PAK3
Mean 0.202
Standard deviation 0.041
Values 0.24 0.14 0.21 0.23
[78]
ref_hepatocyte CD80
Mean 0.0435
Standard deviation 0.06
Values 0 0 0 0.1 0.11
[79]
HepG2 CD80
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A CD80
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 CD80
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[82]
SNU475 CD80
Mean 0.0359
Standard deviation 0.015
Values 0.046 0.025
[83]
THLE CD80
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[84]
liver CD80
Mean 0.381
Standard deviation 0.28
Values 0.12 0.64 0.15 0.61