REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.59[2] -1.18[3] -1.95[4] -0.63[5] -0.60[6] -1.14[7]
2 TRIB3 Tribbles homolog 3 [8] 0.24[9] 0.17[10] -0.63[11] -2.60[12] -2.08[13] -1.32[14]
3 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 [15] -0.68[16] -1.29[17] -0.76[18] -0.50[19] -0.31[20] -1.08[21]
4 AKT2 RAC-beta serine/threonine-protein kinase [22] 0.29[23] 0.20[24] 0.64[25] 0.28[26] 0.07[27] 0.24[28]
5 MLST8 Target of rapamycin complex subunit LST8 [29] -0.84[30] -0.87[31] -0.19[32] -1.56[33] -1.20[34] -1.46[35]
6 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [36] -1.14[37] -1.38[38] 0.02[39] 1.49[40] 0.99[41] 2.11[42]
7 PRR5 Proline-rich protein 5 [43] -1.26[44] -1.56[45] -2.17[46] -2.87[47] -5.66[48] -1.67[49]
8 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [50] 1.20[51] 1.07[52] 1.99[53] 0.13[54] 0.69[55] -1.19[56]
9 PDPK1 3-phosphoinositide-dependent protein kinase 1 [57] 1.66[58] 2.49[59] 1.51[60] 0.86[61] 1.26[62] 1.61[63]
10 MTOR Serine/threonine-protein kinase mTOR [64] 1.86[65] 2.52[66] 2.39[67] 2.10[68] 2.19[69] 2.55[70]
11 FYN Tyrosine-protein kinase Fyn [71] 0.27[72] -8.69[73] 0.19[74] 0.89[75] 2.42[76] 0.07[77]
12 MAP3K14 Mitogen-activated protein kinase kinase kinase 14 [78] -1.07[79] -0.97[80] -1.83[81] 1.49[82] 0.48[83] -0.02[84]
13 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.05[85] 0.23[86] 0.73[87] 0.55[88] 0.76[89] 1.02[90]
14 THEM4 Acyl-coenzyme A thioesterase THEM4 [91] -0.02[92] 0.06[93] 0.92[94] 1.42[95] 0.85[96] 0.19[97]
15 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 [98] 1.08[99] 0.72[100] 0.22[101] -0.48[102] 0.85[103] -0.41[104]
16 RICTOR Rapamycin-insensitive companion of mTOR [105] 0.06[106] 1.78[107] 2.76[108] 1.77[109] 1.98[110] 2.62[111]
17 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma [112] 1.05[113] 0.70[114] 1.86[115] 2.59[116] 1.61[117] 1.78[118]
18 CD86 T-lymphocyte activation antigen CD86 [119] [120] [121] -5.43[122] -4.68[123] -6.69[124] 0.45[125]
19 AKT3 RAC-gamma serine/threonine-protein kinase [126] -2.51[127] -5.43[128] -4.43[129] 5.26[130] 4.22[131] 2.71[132]
20 LCK Tyrosine-protein kinase Lck [133] 2.11[134] 1.83[135] -7.86[136] -5.66[137] -5.86[138] 0.34[139]
21 CD28 T-cell-specific surface glycoprotein CD28 [140] -4.67[141] -4.16[142] -3.82[143] -2.93[144] -2.98[145] 0.22[146]
22 CD80 T-lymphocyte activation antigen CD80 [147] [148] [149] -5.98[150] -1.74[151] -2.79[152] 1.73[153]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[8]
ref_hepatocyte TRIB3
Mean 31.8
Standard deviation 22
Values 21 25 60 47 5.9
[9]
HepG2 TRIB3
Mean 132
Standard deviation 85
Values 1.9e+02 72
[10]
HepG2.C3A TRIB3
Mean 144
Standard deviation 1.1e+02
Values 2.2e+02 66
[11]
HuH.7 TRIB3
Mean 63.7
Standard deviation 8.9
Values 57 74 61
[12]
SNU475 TRIB3
Mean 14.5
Standard deviation 3.3
Values 12 17
[13]
THLE TRIB3
Mean 23
Standard deviation 5.7
Values 27 19
[14]
liver TRIB3
Mean 33.8
Standard deviation 26
Values 72 16 30 17
[15]
ref_hepatocyte MAPKAP1
Mean 18.9
Standard deviation 8.4
Values 14 33 18 16 13
[16]
HepG2 MAPKAP1
Mean 41.3
Standard deviation 6.5
Values 37 46
[17]
HepG2.C3A MAPKAP1
Mean 31
Standard deviation 5.4
Values 27 35
[18]
HuH.7 MAPKAP1
Mean 34.6
Standard deviation 7.1
Values 38 26 40
[19]
SNU475 MAPKAP1
Mean 36.6
Standard deviation 8.3
Values 43 31
[20]
THLE MAPKAP1
Mean 46.7
Standard deviation 15
Values 36 57
[21]
liver MAPKAP1
Mean 23.6
Standard deviation 2.7
Values 23 26 20 25
[22]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[23]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[24]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[25]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[26]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[27]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[28]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[29]
ref_hepatocyte MLST8
Mean 10
Standard deviation 3.8
Values 7 5.5 14 14 10
[30]
HepG2 MLST8
Mean 19.6
Standard deviation 1.4
Values 21 19
[31]
HepG2.C3A MLST8
Mean 22
Standard deviation 3.6
Values 24 19
[32]
HuH.7 MLST8
Mean 27.2
Standard deviation 3.6
Values 28 23 30
[33]
SNU475 MLST8
Mean 9.36
Standard deviation 0.84
Values 9.9 8.8
[34]
THLE MLST8
Mean 13.3
Standard deviation 1.9
Values 12 15
[35]
liver MLST8
Mean 9.64
Standard deviation 7.6
Values 17 2.5 15 3.8
[36]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[37]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[38]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[39]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[40]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[41]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[42]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[43]
ref_hepatocyte PRR5
Mean 7.43
Standard deviation 4.5
Values 11 2 3.1 10 11
[44]
HepG2 PRR5
Mean 10.9
Standard deviation 2.6
Values 13 9.1
[45]
HepG2.C3A PRR5
Mean 10.1
Standard deviation 0.29
Values 10 9.9
[46]
HuH.7 PRR5
Mean 5.13
Standard deviation 0.59
Values 4.7 4.9 5.8
[47]
SNU475 PRR5
Mean 2.8
Standard deviation 0.093
Values 2.7 2.9
[48]
THLE PRR5
Mean 0.452
Standard deviation 0.2
Values 0.31 0.59
[49]
liver PRR5
Mean 6.15
Standard deviation 3.4
Values 7.7 2.9 10 3.9
[50]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[51]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[52]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[53]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[54]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[55]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[56]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[57]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 6.9 3.4 3.6 1.8 2
[58]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 35 43
[59]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 89 71
[60]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 35 33 26
[61]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 17 18
[62]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[63]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 34 27 22 31
[64]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 2.6 3.1 4.3 3.5 3.2
[65]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 38 47
[66]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 89 65
[67]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 73 50 41
[68]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 39 40
[69]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[70]
liver MTOR
Mean 51.8
Standard deviation 18
Values 34 72 39 62
[71]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[72]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[73]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[74]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[75]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[76]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[77]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[78]
ref_hepatocyte MAP3K14
Mean 1.9
Standard deviation 1.1
Values 0.92 2.2 3.6 1.7 1.1
[79]
HepG2 MAP3K14
Mean 3.19
Standard deviation 0.37
Values 3.4 2.9
[80]
HepG2.C3A MAP3K14
Mean 3.89
Standard deviation 0.18
Values 4 3.8
[81]
HuH.7 MAP3K14
Mean 1.66
Standard deviation 0.35
Values 1.3 1.9 1.8
[82]
SNU475 MAP3K14
Mean 14.7
Standard deviation 3
Values 13 17
[83]
THLE MAP3K14
Mean 8.14
Standard deviation 0.86
Values 8.8 7.5
[84]
liver MAP3K14
Mean 4.97
Standard deviation 1.7
Values 2.9 4.3 6.3 6.4
[85]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[86]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[87]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[88]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[89]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[90]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[91]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[92]
ref_hepatocyte THEM4
Mean 1.85
Standard deviation 0.19
Values 1.8 1.7 2.1 2 1.7
[93]
HepG2 THEM4
Mean 6.4
Standard deviation 0.64
Values 5.9 6.9
[94]
HepG2.C3A THEM4
Mean 7.77
Standard deviation 1.9
Values 6.5 9.1
[95]
HuH.7 THEM4
Mean 10.9
Standard deviation 3.9
Values 12 6.4 14
[96]
SNU475 THEM4
Mean 13.7
Standard deviation 1.8
Values 12 15
[97]
THLE THEM4
Mean 10.2
Standard deviation 1.5
Values 9.2 11
[98]
liver THEM4
Mean 5.58
Standard deviation 2.4
Values 8.6 3.8 6.5 3.5
[99]
ref_hepatocyte MAP3K8
Mean 1.71
Standard deviation 2
Values 1.4 0.66 5.2 0.8 0.54
[100]
HepG2 MAP3K8
Mean 12.6
Standard deviation 0.62
Values 13 12
[101]
HepG2.C3A MAP3K8
Mean 11.3
Standard deviation 2.4
Values 9.6 13
[102]
HuH.7 MAP3K8
Mean 6.17
Standard deviation 0.35
Values 5.9 6.1 6.6
[103]
SNU475 MAP3K8
Mean 3.37
Standard deviation 0.26
Values 3.2 3.6
[104]
THLE MAP3K8
Mean 9.43
Standard deviation 0.46
Values 9.8 9.1
[105]
liver MAP3K8
Mean 3.4
Standard deviation 1
Values 3.1 3.3 2.4 4.8
[106]
ref_hepatocyte RICTOR
Mean 1.67
Standard deviation 0.88
Values 2.2 2.1 2.6 0.49 1
[107]
HepG2 RICTOR
Mean 6.11
Standard deviation 1
Values 5.4 6.8
[108]
HepG2.C3A RICTOR
Mean 23
Standard deviation 1
Values 22 24
[109]
HuH.7 RICTOR
Mean 35.2
Standard deviation 17
Values 31 54 21
[110]
SNU475 RICTOR
Mean 15.7
Standard deviation 0.97
Values 16 15
[111]
THLE RICTOR
Mean 20.3
Standard deviation 7.9
Values 26 15
[112]
liver RICTOR
Mean 27.1
Standard deviation 8.5
Values 24 35 17 33
[113]
ref_hepatocyte PIK3R3
Mean 0.405
Standard deviation 0.3
Values 0.52 0.81 0.47 0.078 0.15
[114]
HepG2 PIK3R3
Mean 2.95
Standard deviation 2.5
Values 1.2 4.7
[115]
HepG2.C3A PIK3R3
Mean 2.65
Standard deviation 1.6
Values 1.5 3.8
[116]
HuH.7 PIK3R3
Mean 4.56
Standard deviation 1.3
Values 5.7 3.1 5
[117]
SNU475 PIK3R3
Mean 6.68
Standard deviation 0.22
Values 6.5 6.8
[118]
THLE PIK3R3
Mean 3.8
Standard deviation 0.9
Values 3.2 4.4
[119]
liver PIK3R3
Mean 3.68
Standard deviation 0.27
Values 3.7 3.8 3.3 4
[120]
ref_hepatocyte CD86
Mean 0.389
Standard deviation 0.38
Values 0 0 0.61 0.48 0.85
[121]
HepG2 CD86
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A CD86
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 CD86
Mean 0.0281
Standard deviation 0.02
Values 0.049 0.026 0.0094
[124]
SNU475 CD86
Mean 0.0418
Standard deviation 0.02
Values 0.028 0.056
[125]
THLE CD86
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[126]
liver CD86
Mean 1.41
Standard deviation 0.3
Values 1.2 1.9 1.2 1.3
[127]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[128]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[129]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[130]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[131]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[132]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[133]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[134]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.11 0 0.49 0 0.99
[135]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 8 1.7
[136]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.4 4.7
[137]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[138]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[139]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[140]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 1.2 0.49 1.7 0.91
[141]
ref_hepatocyte CD28
Mean 0.0933
Standard deviation 0.1
Values 0.14 0 0 0.086 0.24
[142]
HepG2 CD28
Mean 0.0129
Standard deviation 0.018
Values 0 0.026
[143]
HepG2.C3A CD28
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[144]
HuH.7 CD28
Mean 0.0205
Standard deviation 0.023
Values 0.0082 0.0064 0.047
[145]
SNU475 CD28
Mean 0.0338
Standard deviation 0.0047
Values 0.037 0.03
[146]
THLE CD28
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[147]
liver CD28
Mean 0.288
Standard deviation 0.19
Values 0.094 0.27 0.23 0.56
[148]
ref_hepatocyte CD80
Mean 0.0435
Standard deviation 0.06
Values 0 0 0 0.1 0.11
[149]
HepG2 CD80
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A CD80
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 CD80
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[152]
SNU475 CD80
Mean 0.0359
Standard deviation 0.015
Values 0.046 0.025
[153]
THLE CD80
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[154]
liver CD80
Mean 0.381
Standard deviation 0.28
Values 0.12 0.64 0.15 0.61