REACTOME_CD28_CO_STIMULATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CDC42 | Cell division control protein 42 homolog | [1] | -1.10[2] | -0.70[3] | -1.47[4] | -0.81[5] | -1.39[6] | -2.20[7] |
2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [8] | -0.67[9] | -1.31[10] | -0.36[11] | -0.26[12] | -0.14[13] | -1.09[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.20[16] | -0.74[17] | -1.58[18] | -0.33[19] | -0.16[20] | -0.36[21] |
4 | TRIB3 | Tribbles homolog 3 | [22] | 0.63[23] | 0.61[24] | -0.26[25] | -2.29[26] | -1.64[27] | -0.54[28] |
5 | GRB2 | Growth factor receptor-bound protein 2 | [29] | 0.92[30] | 0.44[31] | 0.80[32] | 0.28[33] | 0.33[34] | 0.18[35] |
6 | YES1 | Tyrosine-protein kinase Yes | [36] | -1.14[37] | 0.04[38] | 0.50[39] | 0.18[40] | -0.22[41] | 0.00[42] |
7 | MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | [43] | -0.29[44] | -0.85[45] | -0.39[46] | -0.19[47] | 0.13[48] | -0.30[49] |
8 | PAK2 | Serine/threonine-protein kinase PAK 2 | [50] | 1.17[51] | 0.61[52] | 1.14[53] | 0.48[54] | 1.16[55] | 1.24[56] |
9 | AKT2 | RAC-beta serine/threonine-protein kinase | [57] | 0.68[58] | 0.65[59] | 1.01[60] | 0.58[61] | 0.51[62] | 1.01[63] |
10 | MLST8 | Target of rapamycin complex subunit LST8 | [64] | -0.45[65] | -0.43[66] | 0.18[67] | -1.25[68] | -0.76[69] | -0.68[70] |
11 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [71] | -0.75[72] | -0.94[73] | 0.39[74] | 1.79[75] | 1.43[76] | 2.88[77] |
12 | PRR5 | Proline-rich protein 5 | [78] | -0.87[79] | -1.12[80] | -1.80[81] | -2.56[82] | -5.22[83] | -0.90[84] |
13 | LYN | Tyrosine-protein kinase Lyn | [85] | -1.14[86] | -1.63[87] | -0.86[88] | 0.78[89] | -0.32[90] | -0.10[91] |
14 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [92] | 1.60[93] | 1.51[94] | 2.36[95] | 0.43[96] | 1.13[97] | -0.41[98] |
15 | SRC | Proto-oncogene tyrosine-protein kinase Src | [99] | 2.75[100] | 2.42[101] | 1.66[102] | 2.12[103] | 1.44[104] | -0.97[105] |
16 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [106] | 2.05[107] | 2.93[108] | 1.88[109] | 1.16[110] | 1.70[111] | 2.38[112] |
17 | MTOR | Serine/threonine-protein kinase mTOR | [113] | 2.25[114] | 2.96[115] | 2.76[116] | 2.41[117] | 2.63[118] | 3.33[119] |
18 | PAK1 | Serine/threonine-protein kinase PAK 1 | [120] | -0.29[121] | -1.36[122] | 1.29[123] | -2.13[124] | 1.79[125] | 0.15[126] |
19 | FYN | Tyrosine-protein kinase Fyn | [127] | 0.66[128] | -8.25[129] | 0.56[130] | 1.20[131] | 2.86[132] | 0.85[133] |
20 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [134] | -0.68[135] | -0.53[136] | -1.46[137] | 1.80[138] | 0.92[139] | 0.76[140] |
21 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.66[141] | 0.67[142] | 1.10[143] | 0.85[144] | 1.20[145] | 1.79[146] | |
22 | THEM4 | Acyl-coenzyme A thioesterase THEM4 | [147] | 0.37[148] | 0.50[149] | 1.29[150] | 1.73[151] | 1.29[152] | 0.96[153] |
23 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [154] | 1.47[155] | 1.16[156] | 0.59[157] | -0.17[158] | 1.29[159] | 0.37[160] |
24 | RICTOR | Rapamycin-insensitive companion of mTOR | [161] | 0.45[162] | 2.22[163] | 3.13[164] | 2.08[165] | 2.42[166] | 3.39[167] |
25 | VAV1 | Proto-oncogene vav | [168] | -8.78[169] | -4.26[170] | -5.73[171] | -6.36[172] | -7.48[173] | 1.06[174] |
26 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [175] | 1.44[176] | 1.14[177] | 2.23[178] | 2.89[179] | 2.05[180] | 2.56[181] |
27 | CD86 | T-lymphocyte activation antigen CD86 | [182] | [183] | [184] | -5.06[185] | -4.37[186] | -6.25[187] | 1.23[188] |
28 | AKT3 | RAC-gamma serine/threonine-protein kinase | [189] | -2.12[190] | -4.99[191] | -4.06[192] | 5.57[193] | 4.66[194] | 3.49[195] |
29 | LCK | Tyrosine-protein kinase Lck | [196] | 2.50[197] | 2.27[198] | -7.49[199] | -5.36[200] | -5.42[201] | 1.11[202] |
30 | CD28 | T-cell-specific surface glycoprotein CD28 | [203] | -4.28[204] | -3.72[205] | -3.45[206] | -2.62[207] | -2.54[208] | 1.00[209] |
31 | PAK3 | Serine/threonine-protein kinase PAK 3 | [210] | -6.69[211] | [212] | [213] | -1.87[214] | -0.02[215] | 0.66[216] |
32 | GRAP2 | GRB2-related adapter protein 2 | [217] | -6.13[218] | [219] | -2.58[220] | -2.25[221] | -1.07[222] | 0.72[223] |
33 | CD80 | T-lymphocyte activation antigen CD80 | [224] | [225] | [226] | -5.61[227] | -1.43[228] | -2.35[229] | 2.50[230] |