REACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CD14 Monocyte differentiation antigen CD14 [1] -7.75[2] -7.90[3] -4.52[4] -4.21[5] -5.31[6] -0.40[7]
2 MAGED1 Melanoma-associated antigen D1 [8] 1.99[9] 1.68[10] -6.75[11] 2.47[12] 1.05[13] 0.31[14]
3 TNFSF10 Tumor necrosis factor ligand superfamily member 10 [15] -3.88[16] -2.36[17] 0.83[18] -1.88[19] -5.04[20] -1.28[21]
4 DAPK3 Death-associated protein kinase 3 [22] -0.02[23] -0.31[24] 0.08[25] -0.18[26] 0.18[27] -2.45[28]
5 CFLAR CASP8 and FADD-like apoptosis regulator [29] 0.20[30] 0.87[31] 0.99[32] 0.05[33] 0.29[34] 1.67[35]
6 TNFRSF10B Tumor necrosis factor receptor superfamily member 10B [36] 2.58[37] 2.37[38] 2.74[39] 0.26[40] 1.96[41] 0.14[42]
7 CASP3 Caspase-3 [43] 0.72[44] 1.32[45] -0.66[46] -0.30[47] 0.78[48] -0.70[49]
8 FAS Tumor necrosis factor receptor superfamily member 6 [50] -1.01[51] -0.31[52] -7.76[53] -1.15[54] -0.55[55] -1.61[56]
9 FADD FAS-associated death domain protein [57] 0.63[58] -0.16[59] 1.13[60] 2.53[61] 0.42[62] -1.66[63]
10 CASP8 Caspase-8 [64] 0.61[65] 1.10[66] 0.84[67] 0.51[68] -0.15[69] -1.31[70]
11 TNFRSF10A Tumor necrosis factor receptor superfamily member 10A [71] -0.85[72] -1.39[73] -0.81[74] -2.43[75] -2.60[76] -1.60[77]
12 TRADD Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.33[78] 0.09[79] -0.51[80] -0.39[81] -0.46[82] -0.48[83]
13 TRAF2 TNF receptor-associated factor 2 [84] 0.82[85] 0.80[86] 1.10[87] 0.71[88] 0.81[89] -0.69[90]
14 TICAM1 TIR domain-containing adapter molecule 1 [91] -0.12[92] -1.30[93] 0.19[94] -0.63[95] 0.50[96] -0.39[97]
15 APPL1 DCC-interacting protein 13-alpha [98] 0.64[99] 1.75[100] 1.54[101] 1.36[102] 1.94[103] 1.91[104]
16 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [105] 0.88[106] 0.96[107] 1.21[108] 1.67[109] 1.28[110] 1.59[111]
17 DAPK1 Death-associated protein kinase 1 [112] 1.67[113] 1.58[114] 3.11[115] 1.30[116] 1.53[117] 2.81[118]
18 LY96 Lymphocyte antigen 96 [119] -2.06[120] -2.53[121] -8.38[122] -0.77[123] -4.30[124] -1.25[125]
19 CASP9 Caspase-9 [126] 0.75[127] 1.63[128] 1.31[129] 0.84[130] 0.24[131] -0.43[132]
20 TLR4 Toll-like receptor 4 [133] 0.86[134] -4.37[135] -4.70[136] -4.51[137] 6.00[138] 4.58[139]
21 TICAM2 TIR domain-containing adapter molecule 2 [140] -7.28[141] [142] -6.22[143] -0.90[144] -0.48[145] -1.87[146]
22 DAPK2 Death-associated protein kinase 2 [147] -0.30[148] -1.73[149] 3.50[150] 1.85[151] 0.63[152] 1.14[153]
23 UNC5B Netrin receptor UNC5B [154] 2.97[155] -0.47[156] 2.62[157] 3.40[158] 7.79[159] 3.20[160]
24 FASLG Tumor necrosis factor ligand superfamily member 6 [161] -3.22[162] -1.43[163] -4.84[164] [165] [166] 0.69[167]
25 UNC5A Netrin receptor UNC5A [168] 1.92[169] [170] 2.49[171] [172] 1.52[173] 4.46[174]
26 DCC Netrin receptor DCC [175] [176] [177] [178] [179] [180] [181]
[1]
ref_hepatocyte CD14
Mean 148
Standard deviation 1.9e+02
Values 0.7 1.6 16 3.4e+02 3.8e+02
[2]
HepG2 CD14
Mean 1.01
Standard deviation 0.084
Values 1.1 0.95
[3]
HepG2.C3A CD14
Mean 0.856
Standard deviation 0.32
Values 1.1 0.63
[4]
HuH.7 CD14
Mean 5.78
Standard deviation 1.1
Values 5.8 4.7 6.9
[5]
SNU475 CD14
Mean 9.74
Standard deviation 1.9
Values 8.4 11
[6]
THLE CD14
Mean 4.8
Standard deviation 0.97
Values 5.5 4.1
[7]
liver CD14
Mean 148
Standard deviation 88
Values 2.1e+02 68 2.4e+02 77
[8]
ref_hepatocyte MAGED1
Mean 21.3
Standard deviation 12
Values 32 10 6.7 27 31
[9]
HepG2 MAGED1
Mean 125
Standard deviation 43
Values 94 1.6e+02
[10]
HepG2.C3A MAGED1
Mean 94.2
Standard deviation 35
Values 1.2e+02 69
[11]
HuH.7 MAGED1
Mean 0.177
Standard deviation 0.12
Values 0.24 0.26 0.037
[12]
SNU475 MAGED1
Mean 144
Standard deviation 64
Values 1.9e+02 98
[13]
THLE MAGED1
Mean 56.7
Standard deviation 14
Values 47 67
[14]
liver MAGED1
Mean 34.8
Standard deviation 20
Values 48 16 56 20
[15]
ref_hepatocyte TNFSF10
Mean 20
Standard deviation 23
Values 13 4.3 4.9 18 61
[16]
HepG2 TNFSF10
Mean 1.99
Standard deviation 0.0057
Values 2 2
[17]
HepG2.C3A TNFSF10
Mean 5.38
Standard deviation 0.9
Values 6 4.8
[18]
HuH.7 TNFSF10
Mean 31.9
Standard deviation 15
Values 21 49 26
[19]
SNU475 TNFSF10
Mean 6.62
Standard deviation 4.6
Values 9.9 3.4
[20]
THLE TNFSF10
Mean 0.781
Standard deviation 0.14
Values 0.88 0.68
[21]
liver TNFSF10
Mean 10.8
Standard deviation 3.9
Values 14 7 8 15
[22]
ref_hepatocyte DAPK3
Mean 16.8
Standard deviation 15
Values 6.2 30 36 6.4 5.3
[23]
HepG2 DAPK3
Mean 24.2
Standard deviation 4.9
Values 28 21
[24]
HepG2.C3A DAPK3
Mean 18.7
Standard deviation 8.3
Values 25 13
[25]
HuH.7 DAPK3
Mean 15.9
Standard deviation 1.3
Values 15 15 17
[26]
SNU475 DAPK3
Mean 18.1
Standard deviation 0.98
Values 19 17
[27]
THLE DAPK3
Mean 24.5
Standard deviation 3.4
Values 22 27
[28]
liver DAPK3
Mean 4.04
Standard deviation 1.6
Values 2.5 4.6 3 6
[29]
ref_hepatocyte CFLAR
Mean 16.4
Standard deviation 8.4
Values 9.6 29 22 11 11
[30]
HepG2 CFLAR
Mean 27.8
Standard deviation 7.9
Values 22 33
[31]
HepG2.C3A CFLAR
Mean 41.4
Standard deviation 1.1
Values 42 41
[32]
HuH.7 CFLAR
Mean 29.2
Standard deviation 4.7
Values 27 35 26
[33]
SNU475 CFLAR
Mean 20.7
Standard deviation 4
Values 24 18
[34]
THLE CFLAR
Mean 25.9
Standard deviation 3.2
Values 28 24
[35]
liver CFLAR
Mean 68.9
Standard deviation 22
Values 63 73 44 97
[36]
ref_hepatocyte TNFRSF10B
Mean 14.6
Standard deviation 7.1
Values 17 19 23 9.2 5.4
[37]
HepG2 TNFRSF10B
Mean 128
Standard deviation 33
Values 1.5e+02 1e+02
[38]
HepG2.C3A TNFRSF10B
Mean 105
Standard deviation 32
Values 1.3e+02 82
[39]
HuH.7 TNFRSF10B
Mean 87.5
Standard deviation 7.5
Values 81 95 86
[40]
SNU475 TNFRSF10B
Mean 21.3
Standard deviation 2.9
Values 19 23
[41]
THLE TNFRSF10B
Mean 73
Standard deviation 11
Values 81 66
[42]
liver TNFRSF10B
Mean 21.3
Standard deviation 4.6
Values 21 22 16 27
[43]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 33 13 6.8 4.9 5.1
[44]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 25 36
[45]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 27 59
[46]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 5.9 7.5 7.8
[47]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 13 12
[48]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[49]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 9.5 9 16 6.1
[50]
ref_hepatocyte FAS
Mean 10.9
Standard deviation 10
Values 5.6 28 13 5 3.1
[51]
HepG2 FAS
Mean 7.93
Standard deviation 5
Values 4.4 11
[52]
HepG2.C3A FAS
Mean 12.1
Standard deviation 8.5
Values 6.1 18
[53]
HuH.7 FAS
Mean 0.0451
Standard deviation 0.028
Values 0.041 0.019 0.075
[54]
SNU475 FAS
Mean 5.96
Standard deviation 1.8
Values 4.7 7.2
[55]
THLE FAS
Mean 9.58
Standard deviation 1.5
Values 11 8.5
[56]
liver FAS
Mean 4.68
Standard deviation 1.2
Values 6.4 4.1 4.5 3.7
[57]
ref_hepatocyte FADD
Mean 9.28
Standard deviation 6.6
Values 3.8 12 20 6.3 5.1
[58]
HepG2 FADD
Mean 21.1
Standard deviation 4.6
Values 24 18
[59]
HepG2.C3A FADD
Mean 11.5
Standard deviation 1.6
Values 10 13
[60]
HuH.7 FADD
Mean 18.2
Standard deviation 3.2
Values 16 16 22
[61]
SNU475 FADD
Mean 65.1
Standard deviation 11
Values 73 58
[62]
THLE FADD
Mean 16
Standard deviation 3.5
Values 14 19
[63]
liver FADD
Mean 3.86
Standard deviation 1.3
Values 2.5 4.9 3 5.1
[64]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 18 13 8.9 1.9 2.8
[65]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 22 18
[66]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 17 35
[67]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 14 11 18
[68]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 16 15
[69]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[70]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 3.4 5.2 5.3 5
[71]
ref_hepatocyte TNFRSF10A
Mean 8.1
Standard deviation 8.4
Values 4.2 21 12 2.1 0.98
[72]
HepG2 TNFRSF10A
Mean 6.59
Standard deviation 2.7
Values 8.5 4.7
[73]
HepG2.C3A TNFRSF10A
Mean 4.25
Standard deviation 0.05
Values 4.2 4.3
[74]
HuH.7 TNFRSF10A
Mean 4.14
Standard deviation 0.46
Values 4.4 4.5 3.6
[75]
SNU475 TNFRSF10A
Mean 1.83
Standard deviation 0.29
Values 1.6 2
[76]
THLE TNFRSF10A
Mean 1.72
Standard deviation 0.37
Values 2 1.5
[77]
liver TNFRSF10A
Mean 3.52
Standard deviation 1.4
Values 1.8 5.2 3.1 4
[78]
ref_hepatocyte TRADD
Mean 5.53
Standard deviation 1.5
Values 3.6 4.8 5.3 7.4 6.5
[79]
HepG2 TRADD
Mean 10.2
Standard deviation 3.2
Values 12 8
[80]
HepG2.C3A TRADD
Mean 8.12
Standard deviation 2.3
Values 9.8 6.5
[81]
HuH.7 TRADD
Mean 3.47
Standard deviation 1.2
Values 2.9 2.7 4.9
[82]
SNU475 TRADD
Mean 5.13
Standard deviation 1
Values 5.8 4.4
[83]
THLE TRADD
Mean 5.18
Standard deviation 0.33
Values 4.9 5.4
[84]
liver TRADD
Mean 5.22
Standard deviation 3
Values 9.2 2.7 6 3
[85]
ref_hepatocyte TRAF2
Mean 5.07
Standard deviation 4.4
Values 1.1 5.1 12 4.2 2.5
[86]
HepG2 TRAF2
Mean 13.1
Standard deviation 2.2
Values 15 12
[87]
HepG2.C3A TRAF2
Mean 12.2
Standard deviation 1.2
Values 13 11
[88]
HuH.7 TRAF2
Mean 9.75
Standard deviation 2.3
Values 9.4 7.6 12
[89]
SNU475 TRAF2
Mean 10.1
Standard deviation 0.75
Values 9.6 11
[90]
THLE TRAF2
Mean 11.4
Standard deviation 2.7
Values 9.5 13
[91]
liver TRAF2
Mean 4.15
Standard deviation 1.4
Values 4 2.6 6 4.1
[92]
ref_hepatocyte TICAM1
Mean 4.75
Standard deviation 6.4
Values 0 1.4 16 3.4 3
[93]
HepG2 TICAM1
Mean 6.41
Standard deviation 2.9
Values 8.5 4.3
[94]
HepG2.C3A TICAM1
Mean 2.66
Standard deviation 0.59
Values 3.1 2.2
[95]
HuH.7 TICAM1
Mean 4.87
Standard deviation 0.33
Values 5.2 4.5 4.9
[96]
SNU475 TICAM1
Mean 3.73
Standard deviation 0.28
Values 3.5 3.9
[97]
THLE TICAM1
Mean 8.64
Standard deviation 1.3
Values 7.7 9.5
[98]
liver TICAM1
Mean 4.77
Standard deviation 3.4
Values 7.9 1.4 7.4 2.3
[99]
ref_hepatocyte APPL1
Mean 4.53
Standard deviation 2.5
Values 5 8.5 4.2 1.9 3
[100]
HepG2 APPL1
Mean 10.4
Standard deviation 4.1
Values 7.5 13
[101]
HepG2.C3A APPL1
Mean 21
Standard deviation 2.9
Values 19 23
[102]
HuH.7 APPL1
Mean 11.8
Standard deviation 2
Values 13 13 9.5
[103]
SNU475 APPL1
Mean 14.2
Standard deviation 0.14
Values 14 14
[104]
THLE APPL1
Mean 22.4
Standard deviation 0.84
Values 23 22
[105]
liver APPL1
Mean 22.4
Standard deviation 5.5
Values 18 30 21 20
[106]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[107]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[108]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[109]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[110]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[111]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[112]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[113]
ref_hepatocyte DAPK1
Mean 3.31
Standard deviation 0.59
Values 3.2 3.3 4 2.4 3.7
[114]
HepG2 DAPK1
Mean 15.4
Standard deviation 5.3
Values 12 19
[115]
HepG2.C3A DAPK1
Mean 13.6
Standard deviation 0.21
Values 14 13
[116]
HuH.7 DAPK1
Mean 25.6
Standard deviation 6.1
Values 25 32 20
[117]
SNU475 DAPK1
Mean 9.91
Standard deviation 4.8
Values 13 6.5
[118]
THLE DAPK1
Mean 12.3
Standard deviation 2.9
Values 10 14
[119]
liver DAPK1
Mean 30.7
Standard deviation 5.3
Values 32 37 24 29
[120]
ref_hepatocyte LY96
Mean 2.98
Standard deviation 1.7
Values 3 4.2 0 4 3.7
[121]
HepG2 LY96
Mean 1.05
Standard deviation 0.03
Values 1 1.1
[122]
HepG2.C3A LY96
Mean 0.711
Standard deviation 0.08
Values 0.77 0.65
[123]
HuH.7 LY96
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[124]
SNU475 LY96
Mean 2.13
Standard deviation 0.56
Values 2.5 1.7
[125]
THLE LY96
Mean 0.194
Standard deviation 0.13
Values 0.1 0.29
[126]
liver LY96
Mean 1.65
Standard deviation 1.4
Values 2.6 0.6 3 0.34
[127]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 1.9 1.9 2 2.7 4.4
[128]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 5.8 7
[129]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[130]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.7 4.1 6.6
[131]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 6.3 5
[132]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[133]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 2.4 1.9 4.2 1.6
[134]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0 1.1 0.33 0.64 0.66
[135]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 0.82 2.1
[136]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[137]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0 0.019 0.037
[138]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[139]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[140]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 13 19 11 25
[141]
ref_hepatocyte TICAM2
Mean 0.456
Standard deviation 0.51
Values 0 0.53 0 0.51 1.2
[142]
HepG2 TICAM2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[143]
HepG2.C3A TICAM2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 TICAM2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[145]
SNU475 TICAM2
Mean 0.297
Standard deviation 0.053
Values 0.26 0.33
[146]
THLE TICAM2
Mean 0.422
Standard deviation 0.036
Values 0.4 0.45
[147]
liver TICAM2
Mean 0.164
Standard deviation 0.11
Values 0.21 0.14 0.026 0.28
[148]
ref_hepatocyte DAPK2
Mean 0.305
Standard deviation 0.2
Values 0.045 0.57 0.38 0.32 0.21
[149]
HepG2 DAPK2
Mean 0.362
Standard deviation 0.18
Values 0.49 0.23
[150]
HepG2.C3A DAPK2
Mean 0.127
Standard deviation 0.027
Values 0.15 0.11
[151]
HuH.7 DAPK2
Mean 3.1
Standard deviation 0.58
Values 2.4 3.5 3.4
[152]
SNU475 DAPK2
Mean 1.34
Standard deviation 0.16
Values 1.5 1.2
[153]
THLE DAPK2
Mean 0.606
Standard deviation 0.1
Values 0.68 0.53
[154]
liver DAPK2
Mean 0.885
Standard deviation 0.18
Values 1.1 0.88 0.69 0.83
[155]
ref_hepatocyte UNC5B
Mean 0.138
Standard deviation 0.21
Values 0 0 0.13 0.49 0.065
[156]
HepG2 UNC5B
Mean 1.58
Standard deviation 1.7
Values 2.8 0.39
[157]
HepG2.C3A UNC5B
Mean 0.137
Standard deviation 0.16
Values 0.25 0.021
[158]
HuH.7 UNC5B
Mean 0.761
Standard deviation 1.1
Values 0.13 2 0.13
[159]
SNU475 UNC5B
Mean 1.77
Standard deviation 0.05
Values 1.8 1.7
[160]
THLE UNC5B
Mean 39.2
Standard deviation 6.6
Values 44 35
[161]
liver UNC5B
Mean 1.67
Standard deviation 0.5
Values 1.8 1.8 0.98 2.2
[162]
ref_hepatocyte FASLG
Mean 0.0683
Standard deviation 0.15
Values 0 0 0 0 0.34
[163]
HepG2 FASLG
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[164]
HepG2.C3A FASLG
Mean 0.035
Standard deviation 0.019
Values 0.049 0.021
[165]
HuH.7 FASLG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[166]
SNU475 FASLG
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE FASLG
Mean 0
Standard deviation 0
Values 0 0
[168]
liver FASLG
Mean 0.145
Standard deviation 0.073
Values 0.19 0.043 0.21 0.15
[169]
ref_hepatocyte UNC5A
Mean 0.00862
Standard deviation 0.019
Values 0 0 0 0.043 0
[170]
HepG2 UNC5A
Mean 0.048
Standard deviation 0.038
Values 0.074 0.021
[171]
HepG2.C3A UNC5A
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 UNC5A
Mean 0.0435
Standard deviation 0.028
Values 0.074 0.019 0.037
[173]
SNU475 UNC5A
Mean 0
Standard deviation 0
Values 0 0
[174]
THLE UNC5A
Mean 0.0319
Standard deviation 0.045
Values 0 0.064
[175]
liver UNC5A
Mean 0.251
Standard deviation 0.22
Values 0.12 0.36 0.026 0.5
[176]
ref_hepatocyte DCC
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 DCC
Mean 0
Standard deviation 0
Values 0 0
[178]
HepG2.C3A DCC
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 DCC
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 DCC
Mean 0.0228
Standard deviation 0.032
Values 0 0.046
[181]
THLE DCC
Mean 0
Standard deviation 0
Values 0 0
[182]
liver DCC
Mean 0.0171
Standard deviation 0.02
Values 0 0.029 0 0.04