REACTOME_CASPASE_ACTIVATION_VIA_DEATH_RECEPTORS_IN_THE_PRESENCE_OF_LIGAND Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CD14 Monocyte differentiation antigen CD14 [1] -7.18[2] -7.33[3] -4.42[4] -3.43[5] -4.75[6] -0.28[7]
2 TNFSF10 Tumor necrosis factor ligand superfamily member 10 [8] -3.32[9] -1.79[10] 0.93[11] -1.10[12] -4.48[13] -1.16[14]
3 CFLAR CASP8 and FADD-like apoptosis regulator [15] 0.77[16] 1.44[17] 1.08[18] 0.83[19] 0.86[20] 1.79[21]
4 TNFRSF10B Tumor necrosis factor receptor superfamily member 10B [22] 3.14[23] 2.94[24] 2.84[25] 1.04[26] 2.52[27] 0.26[28]
5 FAS Tumor necrosis factor receptor superfamily member 6 [29] -0.45[30] 0.26[31] -7.66[32] -0.37[33] 0.02[34] -1.50[35]
6 FADD FAS-associated death domain protein [36] 1.19[37] 0.41[38] 1.23[39] 3.30[40] 0.99[41] -1.55[42]
7 CASP8 Caspase-8 [43] 1.17[44] 1.67[45] 0.93[46] 1.29[47] 0.41[48] -1.19[49]
8 TNFRSF10A Tumor necrosis factor receptor superfamily member 10A [50] -0.29[51] -0.82[52] -0.71[53] -1.65[54] -2.03[55] -1.48[56]
9 TRADD Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.90[57] 0.66[58] -0.42[59] 0.39[60] 0.11[61] -0.36[62]
10 TRAF2 TNF receptor-associated factor 2 [63] 1.38[64] 1.37[65] 1.20[66] 1.49[67] 1.37[68] -0.57[69]
11 TICAM1 TIR domain-containing adapter molecule 1 [70] 0.44[71] -0.73[72] 0.29[73] 0.15[74] 1.06[75] -0.28[76]
12 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [77] 1.44[78] 1.53[79] 1.30[80] 2.45[81] 1.84[82] 1.71[83]
13 LY96 Lymphocyte antigen 96 [84] -1.50[85] -1.96[86] -8.29[87] 0.01[88] -3.74[89] -1.14[90]
14 TLR4 Toll-like receptor 4 [91] 1.42[92] -3.80[93] -4.60[94] -3.73[95] 6.56[96] 4.69[97]
15 TICAM2 TIR domain-containing adapter molecule 2 [98] -6.72[99] [100] -6.13[101] -0.12[102] 0.09[103] -1.75[104]
16 FASLG Tumor necrosis factor ligand superfamily member 6 [105] -2.66[106] -0.86[107] -4.74[108] [109] [110] 0.81[111]
[1]
ref_hepatocyte CD14
Mean 148
Standard deviation 1.9e+02
Values 0.7 1.6 16 3.4e+02 3.8e+02
[2]
HepG2 CD14
Mean 1.01
Standard deviation 0.084
Values 1.1 0.95
[3]
HepG2.C3A CD14
Mean 0.856
Standard deviation 0.32
Values 1.1 0.63
[4]
HuH.7 CD14
Mean 5.78
Standard deviation 1.1
Values 5.8 4.7 6.9
[5]
SNU475 CD14
Mean 9.74
Standard deviation 1.9
Values 8.4 11
[6]
THLE CD14
Mean 4.8
Standard deviation 0.97
Values 5.5 4.1
[7]
liver CD14
Mean 148
Standard deviation 88
Values 2.1e+02 68 2.4e+02 77
[8]
ref_hepatocyte TNFSF10
Mean 20
Standard deviation 23
Values 13 4.3 4.9 18 61
[9]
HepG2 TNFSF10
Mean 1.99
Standard deviation 0.0057
Values 2 2
[10]
HepG2.C3A TNFSF10
Mean 5.38
Standard deviation 0.9
Values 6 4.8
[11]
HuH.7 TNFSF10
Mean 31.9
Standard deviation 15
Values 21 49 26
[12]
SNU475 TNFSF10
Mean 6.62
Standard deviation 4.6
Values 9.9 3.4
[13]
THLE TNFSF10
Mean 0.781
Standard deviation 0.14
Values 0.88 0.68
[14]
liver TNFSF10
Mean 10.8
Standard deviation 3.9
Values 14 7 8 15
[15]
ref_hepatocyte CFLAR
Mean 16.4
Standard deviation 8.4
Values 9.6 29 22 11 11
[16]
HepG2 CFLAR
Mean 27.8
Standard deviation 7.9
Values 22 33
[17]
HepG2.C3A CFLAR
Mean 41.4
Standard deviation 1.1
Values 42 41
[18]
HuH.7 CFLAR
Mean 29.2
Standard deviation 4.7
Values 27 35 26
[19]
SNU475 CFLAR
Mean 20.7
Standard deviation 4
Values 24 18
[20]
THLE CFLAR
Mean 25.9
Standard deviation 3.2
Values 28 24
[21]
liver CFLAR
Mean 68.9
Standard deviation 22
Values 63 73 44 97
[22]
ref_hepatocyte TNFRSF10B
Mean 14.6
Standard deviation 7.1
Values 17 19 23 9.2 5.4
[23]
HepG2 TNFRSF10B
Mean 128
Standard deviation 33
Values 1.5e+02 1e+02
[24]
HepG2.C3A TNFRSF10B
Mean 105
Standard deviation 32
Values 1.3e+02 82
[25]
HuH.7 TNFRSF10B
Mean 87.5
Standard deviation 7.5
Values 81 95 86
[26]
SNU475 TNFRSF10B
Mean 21.3
Standard deviation 2.9
Values 19 23
[27]
THLE TNFRSF10B
Mean 73
Standard deviation 11
Values 81 66
[28]
liver TNFRSF10B
Mean 21.3
Standard deviation 4.6
Values 21 22 16 27
[29]
ref_hepatocyte FAS
Mean 10.9
Standard deviation 10
Values 5.6 28 13 5 3.1
[30]
HepG2 FAS
Mean 7.93
Standard deviation 5
Values 4.4 11
[31]
HepG2.C3A FAS
Mean 12.1
Standard deviation 8.5
Values 6.1 18
[32]
HuH.7 FAS
Mean 0.0451
Standard deviation 0.028
Values 0.041 0.019 0.075
[33]
SNU475 FAS
Mean 5.96
Standard deviation 1.8
Values 4.7 7.2
[34]
THLE FAS
Mean 9.58
Standard deviation 1.5
Values 11 8.5
[35]
liver FAS
Mean 4.68
Standard deviation 1.2
Values 6.4 4.1 4.5 3.7
[36]
ref_hepatocyte FADD
Mean 9.28
Standard deviation 6.6
Values 3.8 12 20 6.3 5.1
[37]
HepG2 FADD
Mean 21.1
Standard deviation 4.6
Values 24 18
[38]
HepG2.C3A FADD
Mean 11.5
Standard deviation 1.6
Values 10 13
[39]
HuH.7 FADD
Mean 18.2
Standard deviation 3.2
Values 16 16 22
[40]
SNU475 FADD
Mean 65.1
Standard deviation 11
Values 73 58
[41]
THLE FADD
Mean 16
Standard deviation 3.5
Values 14 19
[42]
liver FADD
Mean 3.86
Standard deviation 1.3
Values 2.5 4.9 3 5.1
[43]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 18 13 8.9 1.9 2.8
[44]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 22 18
[45]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 17 35
[46]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 14 11 18
[47]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 16 15
[48]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[49]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 3.4 5.2 5.3 5
[50]
ref_hepatocyte TNFRSF10A
Mean 8.1
Standard deviation 8.4
Values 4.2 21 12 2.1 0.98
[51]
HepG2 TNFRSF10A
Mean 6.59
Standard deviation 2.7
Values 8.5 4.7
[52]
HepG2.C3A TNFRSF10A
Mean 4.25
Standard deviation 0.05
Values 4.2 4.3
[53]
HuH.7 TNFRSF10A
Mean 4.14
Standard deviation 0.46
Values 4.4 4.5 3.6
[54]
SNU475 TNFRSF10A
Mean 1.83
Standard deviation 0.29
Values 1.6 2
[55]
THLE TNFRSF10A
Mean 1.72
Standard deviation 0.37
Values 2 1.5
[56]
liver TNFRSF10A
Mean 3.52
Standard deviation 1.4
Values 1.8 5.2 3.1 4
[57]
ref_hepatocyte TRADD
Mean 5.53
Standard deviation 1.5
Values 3.6 4.8 5.3 7.4 6.5
[58]
HepG2 TRADD
Mean 10.2
Standard deviation 3.2
Values 12 8
[59]
HepG2.C3A TRADD
Mean 8.12
Standard deviation 2.3
Values 9.8 6.5
[60]
HuH.7 TRADD
Mean 3.47
Standard deviation 1.2
Values 2.9 2.7 4.9
[61]
SNU475 TRADD
Mean 5.13
Standard deviation 1
Values 5.8 4.4
[62]
THLE TRADD
Mean 5.18
Standard deviation 0.33
Values 4.9 5.4
[63]
liver TRADD
Mean 5.22
Standard deviation 3
Values 9.2 2.7 6 3
[64]
ref_hepatocyte TRAF2
Mean 5.07
Standard deviation 4.4
Values 1.1 5.1 12 4.2 2.5
[65]
HepG2 TRAF2
Mean 13.1
Standard deviation 2.2
Values 15 12
[66]
HepG2.C3A TRAF2
Mean 12.2
Standard deviation 1.2
Values 13 11
[67]
HuH.7 TRAF2
Mean 9.75
Standard deviation 2.3
Values 9.4 7.6 12
[68]
SNU475 TRAF2
Mean 10.1
Standard deviation 0.75
Values 9.6 11
[69]
THLE TRAF2
Mean 11.4
Standard deviation 2.7
Values 9.5 13
[70]
liver TRAF2
Mean 4.15
Standard deviation 1.4
Values 4 2.6 6 4.1
[71]
ref_hepatocyte TICAM1
Mean 4.75
Standard deviation 6.4
Values 0 1.4 16 3.4 3
[72]
HepG2 TICAM1
Mean 6.41
Standard deviation 2.9
Values 8.5 4.3
[73]
HepG2.C3A TICAM1
Mean 2.66
Standard deviation 0.59
Values 3.1 2.2
[74]
HuH.7 TICAM1
Mean 4.87
Standard deviation 0.33
Values 5.2 4.5 4.9
[75]
SNU475 TICAM1
Mean 3.73
Standard deviation 0.28
Values 3.5 3.9
[76]
THLE TICAM1
Mean 8.64
Standard deviation 1.3
Values 7.7 9.5
[77]
liver TICAM1
Mean 4.77
Standard deviation 3.4
Values 7.9 1.4 7.4 2.3
[78]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[79]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[80]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[81]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[82]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[83]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[84]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[85]
ref_hepatocyte LY96
Mean 2.98
Standard deviation 1.7
Values 3 4.2 0 4 3.7
[86]
HepG2 LY96
Mean 1.05
Standard deviation 0.03
Values 1 1.1
[87]
HepG2.C3A LY96
Mean 0.711
Standard deviation 0.08
Values 0.77 0.65
[88]
HuH.7 LY96
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[89]
SNU475 LY96
Mean 2.13
Standard deviation 0.56
Values 2.5 1.7
[90]
THLE LY96
Mean 0.194
Standard deviation 0.13
Values 0.1 0.29
[91]
liver LY96
Mean 1.65
Standard deviation 1.4
Values 2.6 0.6 3 0.34
[92]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0 1.1 0.33 0.64 0.66
[93]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 0.82 2.1
[94]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[95]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0 0.019 0.037
[96]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[97]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[98]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 13 19 11 25
[99]
ref_hepatocyte TICAM2
Mean 0.456
Standard deviation 0.51
Values 0 0.53 0 0.51 1.2
[100]
HepG2 TICAM2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[101]
HepG2.C3A TICAM2
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 TICAM2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[103]
SNU475 TICAM2
Mean 0.297
Standard deviation 0.053
Values 0.26 0.33
[104]
THLE TICAM2
Mean 0.422
Standard deviation 0.036
Values 0.4 0.45
[105]
liver TICAM2
Mean 0.164
Standard deviation 0.11
Values 0.21 0.14 0.026 0.28
[106]
ref_hepatocyte FASLG
Mean 0.0683
Standard deviation 0.15
Values 0 0 0 0 0.34
[107]
HepG2 FASLG
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[108]
HepG2.C3A FASLG
Mean 0.035
Standard deviation 0.019
Values 0.049 0.021
[109]
HuH.7 FASLG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[110]
SNU475 FASLG
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE FASLG
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FASLG
Mean 0.145
Standard deviation 0.073
Values 0.19 0.043 0.21 0.15