REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | TF | Serotransferrin | [1] | -0.66[2] | 0.12[3] | -0.64[4] | -8.81[5] | -9.05[6] | -0.83[7] |
2 | UBB | Polyubiquitin-B | [8] | -1.57[9] | -2.29[10] | -1.61[11] | -1.04[12] | -0.87[13] | -2.57[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | -1.13[23] | -1.54[24] | -1.25[25] | -0.19[26] | -0.49[27] | -2.12[28] |
5 | APOB | Apolipoprotein B-100 | [29] | 2.57[30] | 2.82[31] | 2.53[32] | -5.71[33] | -5.93[34] | 4.17[35] |
6 | CLTA | Clathrin light chain A | [36] | -1.25[37] | -1.95[38] | -1.31[39] | -0.73[40] | -0.64[41] | -3.96[42] |
7 | NEDD8 | NEDD8 | [43] | -1.11[44] | -3.20[45] | -2.43[46] | -1.56[47] | -1.69[48] | -4.22[49] |
8 | VAMP8 | Vesicle-associated membrane protein 8 | [50] | -1.94[51] | -1.33[52] | -2.23[53] | -3.09[54] | -2.06[55] | -3.06[56] |
9 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [57] | 1.31[58] | 0.70[59] | 2.26[60] | 1.21[61] | 1.73[62] | -1.35[63] |
10 | CLTB | Clathrin light chain B | [64] | 0.06[65] | -2.46[66] | -2.13[67] | -0.91[68] | -0.84[69] | -2.99[70] |
11 | AP2M1 | AP-2 complex subunit mu | [71] | 0.85[72] | 0.13[73] | 0.16[74] | 2.71[75] | 2.94[76] | -0.86[77] |
12 | M6PR | Cation-dependent mannose-6-phosphate receptor | [78] | 0.12[79] | -1.35[80] | -0.08[81] | -0.07[82] | 0.80[83] | -2.12[84] |
13 | COPS6 | COP9 signalosome complex subunit 6 | [85] | -0.59[86] | -1.28[87] | -0.77[88] | 0.63[89] | 0.62[90] | -2.14[91] |
14 | AP2S1 | AP-2 complex subunit sigma | [92] | -0.99[93] | -1.53[94] | -0.31[95] | 0.99[96] | 1.14[97] | -1.72[98] |
15 | CLTC | Clathrin heavy chain 1 | [99] | 2.25[100] | 1.82[101] | 2.52[102] | 3.41[103] | 3.27[104] | 1.76[105] |
16 | PICALM | Phosphatidylinositol-binding clathrin assembly protein | [106] | 0.62[107] | -0.03[108] | 0.88[109] | 2.63[110] | 1.96[111] | -0.84[112] |
17 | SCARB2 | Lysosome membrane protein 2 | [113] | 0.67[114] | 0.04[115] | 1.24[116] | 2.04[117] | 2.53[118] | 0.73[119] |
18 | EPN1 | Epsin-1 | [120] | 0.65[121] | -0.24[122] | 0.39[123] | 1.16[124] | 1.29[125] | -1.45[126] |
19 | UBQLN1 | Ubiquilin-1 | [127] | 1.04[128] | 0.60[129] | 1.39[130] | 2.72[131] | 2.89[132] | 0.13[133] |
20 | NECAP2 | Adaptin ear-binding coat-associated protein 2 | [134] | -0.01[135] | 0.32[136] | -0.80[137] | 1.23[138] | 0.55[139] | -1.74[140] |
21 | VAMP3 | Vesicle-associated membrane protein 3 | [141] | 0.86[142] | 0.89[143] | 0.60[144] | 2.45[145] | 1.72[146] | -1.72[147] |
22 | GPS1 | COP9 signalosome complex subunit 1 | [148] | 1.21[149] | 0.70[150] | 0.46[151] | 1.55[152] | 1.18[153] | -0.88[154] |
23 | GRB2 | Growth factor receptor-bound protein 2 | [155] | 1.83[156] | 1.14[157] | 1.79[158] | 2.29[159] | 1.92[160] | -0.40[161] |
24 | TGOLN2 | Trans-Golgi network integral membrane protein 2 | [162] | 3.09[163] | 2.05[164] | 2.05[165] | 2.86[166] | 3.04[167] | 1.48[168] |
25 | COPS5 | COP9 signalosome complex subunit 5 | [169] | -0.65[170] | -0.33[171] | 0.41[172] | 1.57[173] | 0.85[174] | -1.18[175] |
26 | COPS3 | COP9 signalosome complex subunit 3 | [176] | 0.31[177] | -0.10[178] | 0.85[179] | 1.88[180] | 1.64[181] | -1.83[182] |
27 | COPS7A | COP9 signalosome complex subunit 7a | [183] | 0.16[184] | 0.07[185] | 0.43[186] | 1.01[187] | 1.07[188] | -1.12[189] |
28 | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate | [190] | 1.53[191] | 0.51[192] | 0.51[193] | 2.23[194] | 1.87[195] | -1.47[196] |
29 | TFRC | Transferrin receptor protein 1 | [197] | 4.07[198] | 3.04[199] | 3.69[200] | 3.18[201] | 4.38[202] | 0.88[203] |
30 | CD4 | T-cell surface glycoprotein CD4 | [204] | -5.13[205] | -3.46[206] | -5.57[207] | -5.72[208] | -8.06[209] | -0.78[210] |
31 | COPS2 | COP9 signalosome complex subunit 2 | [211] | -0.20[212] | 1.26[213] | 2.02[214] | 2.05[215] | 1.98[216] | -1.10[217] |
32 | LDLR | Low-density lipoprotein receptor | [218] | 0.82[219] | 1.14[220] | 2.67[221] | 0.84[222] | 1.75[223] | 0.53[224] |
33 | IGF2R | Cation-independent mannose-6-phosphate receptor | [225] | 3.94[226] | 1.98[227] | 2.04[228] | 3.53[229] | 4.05[230] | 1.52[231] |
34 | TOR1A | Torsin-1A | [232] | 0.42[233] | -0.43[234] | -0.02[235] | 1.60[236] | 1.54[237] | -0.51[238] |
35 | SH3GL1 | Endophilin-A2 | [239] | 1.70[240] | 1.57[241] | 1.26[242] | 2.27[243] | 2.32[244] | -1.13[245] |
36 | VAMP7 | Vesicle-associated membrane protein 7 | [246] | [247] | [248] | [249] | [250] | [251] | [252] |
37 | AP2A1 | AP-2 complex subunit alpha-1 | [253] | 1.84[254] | 0.98[255] | 2.34[256] | 3.14[257] | 2.92[258] | 0.26[259] |
38 | COPS4 | COP9 signalosome complex subunit 4 | [260] | 0.10[261] | 0.57[262] | 0.98[263] | 1.56[264] | 1.51[265] | -1.14[266] |
39 | SLC2A8 | Solute carrier family 2, facilitated glucose transporter member 8 | [267] | 1.89[268] | 0.31[269] | 0.80[270] | 0.50[271] | -0.57[272] | -1.10[273] |
40 | AP2B1 | AP-2 complex subunit beta | [274] | 2.87[275] | 2.08[276] | 4.33[277] | 4.29[278] | 3.86[279] | 0.24[280] |
41 | ITSN1 | Intersectin-1 | [281] | 0.52[282] | 0.11[283] | 1.40[284] | 2.74[285] | 2.72[286] | 1.03[287] |
42 | COPS8 | COP9 signalosome complex subunit 8 | [288] | 1.32[289] | 0.74[290] | 0.62[291] | 2.73[292] | 3.42[293] | -0.78[294] |
43 | AP2A2 | AP-2 complex subunit alpha-2 | [295] | 1.89[296] | 1.21[297] | 1.87[298] | 2.58[299] | 1.94[300] | -0.02[301] |
44 | ARRB2 | Beta-arrestin-2 | [302] | 0.80[303] | 0.66[304] | 1.14[305] | 0.42[306] | 0.94[307] | -1.57[308] |
45 | VAMP2 | Vesicle-associated membrane protein 2 | [309] | -0.72[310] | -0.88[311] | 0.00[312] | 1.27[313] | 0.79[314] | -0.89[315] |
46 | AGTR1 | Type-1 angiotensin II receptor | [316] | -6.72[317] | -5.41[318] | 0.63[319] | 0.47[320] | -4.22[321] | 0.74[322] |
47 | NECAP1 | Adaptin ear-binding coat-associated protein 1 | [323] | 0.79[324] | 0.06[325] | 1.15[326] | 0.99[327] | 1.97[328] | -0.08[329] |
48 | EGFR | Epidermal growth factor receptor | [330] | -0.07[331] | -0.96[332] | 2.44[333] | 2.17[334] | 2.50[335] | 1.96[336] |
49 | AREG | Amphiregulin | [337] | -2.23[338] | -5.99[339] | -7.23[340] | -7.96[341] | 2.05[342] | -11.00[343] |
50 | UBQLN2 | Ubiquilin-2 | [344] | 0.79[345] | -0.43[346] | 0.41[347] | 2.91[348] | 2.13[349] | 0.03[350] |
51 | COPS7B | COP9 signalosome complex subunit 7b | [351] | 1.58[352] | 1.46[353] | 1.90[354] | 2.35[355] | 2.11[356] | -1.33[357] |
52 | EPS15 | Epidermal growth factor receptor substrate 15 | [358] | 0.77[359] | 1.13[360] | 1.94[361] | 3.33[362] | 2.57[363] | 1.55[364] |
53 | REPS1 | RalBP1-associated Eps domain-containing protein 1 | [365] | 1.32[366] | 0.63[367] | 2.03[368] | 2.94[369] | 1.96[370] | 0.59[371] |
54 | STAM | Signal transducing adapter molecule 1 | [372] | 1.68[373] | 1.61[374] | 1.18[375] | 3.42[376] | 2.44[377] | -0.94[378] |
55 | LDLRAP1 | Low density lipoprotein receptor adapter protein 1 | [379] | 0.43[380] | 0.35[381] | -0.06[382] | 2.26[383] | 1.99[384] | 0.09[385] |
56 | ITSN2 | Intersectin-2 | [386] | 0.32[387] | 0.69[388] | 0.66[389] | 1.94[390] | 1.37[391] | 1.12[392] |
57 | TOR1B | Torsin-1B | [393] | 1.31[394] | 0.29[395] | 1.46[396] | 2.06[397] | 2.52[398] | 0.51[399] |
58 | AGFG1 | Arf-GAP domain and FG repeat-containing protein 1 | [400] | 3.01[401] | 2.72[402] | 3.68[403] | 4.37[404] | 4.05[405] | 0.83[406] |
59 | STAM2 | Signal transducing adapter molecule 2 | [407] | 0.89[408] | 1.15[409] | 0.80[410] | 3.30[411] | 2.29[412] | 0.50[413] |
60 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | [414] | 2.22[415] | 1.57[416] | 2.83[417] | 3.53[418] | 3.72[419] | -0.22[420] |
61 | EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 | [421] | 1.56[422] | 0.89[423] | 2.20[424] | 2.16[425] | 2.60[426] | -0.39[427] |
62 | FZD4 | Frizzled-4 | [428] | 4.72[429] | 3.14[430] | 2.70[431] | 2.43[432] | 1.47[433] | 2.25[434] |
63 | DVL2 | Segment polarity protein dishevelled homolog DVL-2 | [435] | 2.75[436] | 1.98[437] | 3.49[438] | 3.96[439] | 3.32[440] | -0.68[441] |
64 | ADRB2 | Beta-2 adrenergic receptor | [442] | -6.89[443] | [444] | [445] | -1.66[446] | -2.57[447] | -0.49[448] |
65 | DAB2 | Disabled homolog 2 | [449] | 1.91[450] | -0.49[451] | 2.94[452] | 6.03[453] | 3.60[454] | 1.55[455] |
66 | FCHO2 | F-BAR domain only protein 2 | [456] | 0.49[457] | 2.00[458] | 1.83[459] | 3.39[460] | 2.10[461] | 1.44[462] |
67 | TGFA | Protransforming growth factor alpha | [463] | 2.42[464] | 2.96[465] | -7.56[466] | 0.77[467] | -0.74[468] | -1.09[469] |
68 | HBEGF | Proheparin-binding EGF-like growth factor | [470] | -0.36[471] | -1.69[472] | -2.23[473] | 2.04[474] | 1.44[475] | -3.13[476] |
69 | EPN2 | Epsin-2 | [477] | 2.73[478] | 1.95[479] | 3.37[480] | 4.46[481] | 3.34[482] | 0.71[483] |
70 | VAMP4 | Vesicle-associated membrane protein 4 | [484] | -0.21[485] | 0.05[486] | 2.67[487] | 3.23[488] | 3.17[489] | 1.11[490] |
71 | REPS2 | RalBP1-associated Eps domain-containing protein 2 | [491] | -1.29[492] | -2.45[493] | -3.24[494] | 0.56[495] | 3.91[496] | 2.52[497] |
72 | BTC | Probetacellulin | [498] | -7.51[499] | -8.42[500] | -3.68[501] | -1.14[502] | -1.45[503] | -3.61[504] |
73 | SYT9 | Synaptotagmin-9 | [505] | -7.80[506] | -7.20[507] | [508] | -2.43[509] | -5.79[510] | 1.41[511] |
74 | CLTCL1 | Clathrin heavy chain 2 | [512] | 2.71[513] | 1.74[514] | 2.12[515] | 3.64[516] | 2.79[517] | 1.05[518] |
75 | ARRB1 | Beta-arrestin-1 | [519] | 4.21[520] | 3.50[521] | 3.32[522] | 3.89[523] | 3.41[524] | 2.58[525] |
76 | AAK1 | AP2-associated protein kinase 1 | [526] | 4.44[527] | 3.42[528] | 3.85[529] | 6.01[530] | 5.56[531] | 3.42[532] |
77 | CBL | E3 ubiquitin-protein ligase CBL | [533] | 5.08[534] | 3.50[535] | 4.25[536] | 6.87[537] | 6.07[538] | 3.06[539] |
78 | STON2 | Stonin-2 | [540] | 1.87[541] | 1.61[542] | 2.48[543] | 5.36[544] | 1.23[545] | 3.52[546] |
79 | IL7R | Interleukin-7 receptor subunit alpha | [547] | -3.60[548] | -4.72[549] | -4.29[550] | 6.98[551] | 6.60[552] | 1.52[553] |
80 | CD3D | T-cell surface glycoprotein CD3 delta chain | [554] | 2.03[555] | -0.50[556] | -2.35[557] | -4.77[558] | -3.06[559] | -1.02[560] |
81 | CD3G | T-cell surface glycoprotein CD3 gamma chain | [561] | -2.96[562] | -2.73[563] | -3.26[564] | -2.88[565] | -2.57[566] | -1.04[567] |
82 | WNT5A | Protein Wnt-5a | [568] | -2.56[569] | -3.07[570] | -1.38[571] | 8.33[572] | 9.61[573] | 0.62[574] |
83 | AVP | Vasopressin-neurophysin 2-copeptin | [575] | -3.43[576] | -1.51[577] | -1.41[578] | [579] | -6.11[580] | -1.76[581] |
84 | EREG | Proepiregulin | [582] | 2.38[583] | 1.79[584] | -2.10[585] | 0.17[586] | 5.13[587] | -2.17[588] |
85 | FCHO1 | F-BAR domain only protein 1 | [589] | 3.95[590] | 3.37[591] | 2.67[592] | 1.42[593] | 2.43[594] | 0.63[595] |
86 | SYT11 | Synaptotagmin-11 | [596] | 4.04[597] | 2.19[598] | 1.25[599] | 6.84[600] | 8.22[601] | 1.90[602] |
87 | LRP2 | Low-density lipoprotein receptor-related protein 2 | [603] | 2.94[604] | -0.92[605] | 8.29[606] | -0.54[607] | -1.10[608] | 5.53[609] |
88 | SYT8 | Synaptotagmin-8 | [610] | 4.67[611] | 5.82[612] | 0.52[613] | 0.69[614] | -3.02[615] | -0.63[616] |
89 | SH3GL2 | Endophilin-A1 | [617] | -1.63[618] | [619] | -4.41[620] | 2.75[621] | 1.23[622] | -0.51[623] |
90 | SYT1 | Synaptotagmin-1 | [624] | -1.47[625] | -2.74[626] | 6.42[627] | 8.92[628] | 4.81[629] | 3.52[630] |
91 | SYT2 | Synaptotagmin-2 | [631] | 0.97[632] | 1.81[633] | 5.20[634] | 6.98[635] | 2.60[636] | 3.94[637] |
92 | KIAA0319 | Dyslexia-associated protein KIAA0319 | [638] | 0.25[639] | 0.02[640] | 2.82[641] | 5.78[642] | 2.81[643] | 0.43[644] |
93 | CFTR | Cystic fibrosis transmembrane conductance regulator | [645] | -1.55[646] | -2.58[647] | 1.50[648] | 5.56[649] | -2.32[650] | 6.46[651] |
94 | STON1 | Stonin-1 | [652] | 1.03[653] | 0.71[654] | 5.09[655] | 8.03[656] | 9.02[657] | 5.15[658] |
95 | AVPR2 | Vasopressin V2 receptor | [659] | 0.65[660] | 0.51[661] | -3.29[662] | 2.11[663] | -1.13[664] | 1.45[665] |
96 | SGIP1 | SH3-containing GRB2-like protein 3-interacting protein 1 | [666] | [667] | [668] | [669] | 2.75[670] | 3.85[671] | 3.15[672] |
97 | SNAP91 | Clathrin coat assembly protein AP180 | [673] | 1.21[674] | [675] | -1.33[676] | 0.64[677] | 4.77[678] | [679] |
98 | EGF | Pro-epidermal growth factor | [680] | 2.60[681] | 3.86[682] | 8.00[683] | 10.76[684] | 7.89[685] | 0.88[686] |
99 | GRK2 | Beta-adrenergic receptor kinase 1 | [687] | [688] | [689] | [690] | [691] | [692] | [693] |
100 | SH3GL3 | Endophilin-A3 | [694] | [695] | [696] | [697] | [698] | [699] | [700] |
101 | EPGN | Epigen | [701] | [702] | [703] | [704] | [705] | [706] | [707] |
102 | GRK3 | Beta-adrenergic receptor kinase 2 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |
103 | SLC18A3 | Vesicular acetylcholine transporter | [715] | [716] | [717] | [718] | [719] | [720] | [721] |
104 | TACR1 | Substance-P receptor | [722] | [723] | [724] | [725] | [726] | [727] | [728] |
105 | CHRM2 | Muscarinic acetylcholine receptor M2 | [729] | [730] | [731] | [732] | [733] | [734] | [735] |