REACTOME_CARDIAC_CONDUCTION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FXYD1 | Phospholemman | [1] | -6.99[2] | -5.39[3] | -13.22[4] | -15.97[5] | -13.63[6] | -4.06[7] |
2 | ASPH | Aspartyl/asparaginyl beta-hydroxylase | [8] | -0.20[9] | -1.46[10] | -0.81[11] | 0.78[12] | -0.74[13] | -1.48[14] |
3 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | [15] | 1.55[16] | 0.85[17] | 1.01[18] | -0.72[19] | 0.13[20] | -0.92[21] |
4 | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | [22] | -1.13[23] | -0.49[24] | -0.52[25] | -1.64[26] | -2.50[27] | -1.74[28] |
5 | CALM1 | Calmodulin-1 | [29] | -0.73[30] | -0.49[31] | -0.08[32] | 0.62[33] | 0.32[34] | 0.65[35] |
6 | AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 | [36] | -0.57[37] | -0.27[38] | 0.25[39] | 0.05[40] | 0.34[41] | -0.67[42] |
7 | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | [43] | 0.77[44] | 0.84[45] | 1.09[46] | 1.85[47] | 1.21[48] | 0.77[49] |
8 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [50] | -0.97[51] | -0.94[52] | -0.99[53] | -1.43[54] | -0.42[55] | -1.75[56] |
9 | SRI | Sorcin | [57] | -7.71[58] | -8.96[59] | -1.91[60] | -1.44[61] | -1.03[62] | -1.84[63] |
10 | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 | [64] | 0.15[65] | -0.37[66] | -0.26[67] | -0.16[68] | 0.95[69] | -2.98[70] |
11 | STIM1 | Stromal interaction molecule 1 | [71] | 0.03[72] | 0.22[73] | -0.24[74] | -0.08[75] | -0.75[76] | 0.24[77] |
12 | ORAI1 | Calcium release-activated calcium channel protein 1 | [78] | -1.13[79] | -1.45[80] | -1.97[81] | -2.18[82] | -1.56[83] | -2.55[84] |
13 | RANGRF | Ran guanine nucleotide release factor | [85] | -2.77[86] | -1.80[87] | -3.10[88] | -3.49[89] | -2.95[90] | -3.65[91] |
14 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [92] | -0.68[93] | -0.16[94] | 1.31[95] | -0.29[96] | -0.67[97] | 0.44[98] |
15 | KCNK1 | Potassium channel subfamily K member 1 | [99] | -11.40[100] | [101] | [102] | -7.12[103] | -3.16[104] | -2.25[105] |
16 | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 | [106] | 0.10[107] | 1.76[108] | 0.18[109] | -0.96[110] | -0.40[111] | 2.90[112] |
17 | NPR2 | Atrial natriuretic peptide receptor 2 | [113] | -3.86[114] | -1.71[115] | -2.34[116] | -1.86[117] | -0.25[118] | -1.35[119] |
18 | WWTR1 | WW domain-containing transcription regulator protein 1 | [120] | 1.08[121] | 0.87[122] | -0.16[123] | 1.35[124] | 1.08[125] | -0.23[126] |
19 | HIPK2 | Homeodomain-interacting protein kinase 2 | [127] | 1.18[128] | 1.71[129] | 1.01[130] | 1.76[131] | 2.29[132] | 3.47[133] |
20 | ABCC9 | ATP-binding cassette sub-family C member 9 | [134] | -3.69[135] | -2.28[136] | -1.19[137] | -1.29[138] | -2.65[139] | 2.98[140] |
21 | GATA4 | Transcription factor GATA-4 | [141] | -0.03[142] | 0.12[143] | 1.50[144] | -2.19[145] | 1.18[146] | -0.38[147] |
22 | HIPK1 | Homeodomain-interacting protein kinase 1 | [148] | 0.76[149] | 0.99[150] | 1.88[151] | 1.24[152] | 1.52[153] | 1.28[154] |
23 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | [155] | -0.64[156] | -2.19[157] | 0.83[158] | 2.46[159] | 3.26[160] | 2.69[161] |
24 | FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B | [162] | -0.07[163] | 0.67[164] | -1.39[165] | -4.41[166] | -1.93[167] | -1.73[168] |
25 | KAT2B | Histone acetyltransferase KAT2B | [169] | -2.86[170] | -3.77[171] | -1.45[172] | -1.03[173] | -0.18[174] | 0.82[175] |
26 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | -0.04[176] | 1.38[177] | 0.95[178] | 0.72[179] | 0.71[180] | -0.02[181] | |
27 | KCNK5 | Potassium channel subfamily K member 5 | [182] | -7.94[183] | -8.66[184] | -0.81[185] | -3.99[186] | -7.26[187] | 0.33[188] |
28 | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | [189] | 0.39[190] | 2.25[191] | 3.17[192] | 2.18[193] | 2.54[194] | 1.95[195] |
29 | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 | [196] | 4.48[197] | 3.54[198] | 1.98[199] | 1.39[200] | 3.98[201] | -0.74[202] |
30 | AKAP9 | A-kinase anchor protein 9 | [203] | -0.79[204] | 2.13[205] | 2.26[206] | 0.83[207] | 1.37[208] | 4.10[209] |
31 | ATP2B2 | Plasma membrane calcium-transporting ATPase 2 | [210] | -0.89[211] | 0.15[212] | 3.43[213] | -6.08[214] | -5.36[215] | 3.00[216] |
32 | DMPK | Myotonin-protein kinase | [217] | 0.69[218] | 0.68[219] | 0.59[220] | 2.72[221] | 1.92[222] | -0.41[223] |
33 | KCND3 | Potassium voltage-gated channel subfamily D member 3 | [224] | -7.13[225] | [226] | [227] | [228] | -7.97[229] | 1.37[230] |
34 | FXYD2 | Sodium/potassium-transporting ATPase subunit gamma | [231] | -1.38[232] | -3.09[233] | [234] | [235] | [236] | -1.14[237] |
35 | FGF13 | Fibroblast growth factor 13 | [238] | -4.43[239] | -5.52[240] | [241] | -9.27[242] | -8.73[243] | -2.22[244] |
36 | SCN9A | Sodium channel protein type 9 subunit alpha | [245] | 0.33[246] | 4.43[247] | 3.34[248] | 1.08[249] | -1.57[250] | 2.63[251] |
37 | FXYD6 | FXYD domain-containing ion transport regulator 6 | [252] | -8.83[253] | [254] | [255] | -4.02[256] | -8.57[257] | 1.75[258] |
38 | ORAI2 | Protein orai-2 | [259] | 2.63[260] | 1.75[261] | 0.90[262] | 3.49[263] | 3.19[264] | 0.85[265] |
39 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [266] | -3.35[267] | -4.46[268] | -7.47[269] | -3.83[270] | -2.77[271] | 0.18[272] |
40 | SCN1B | Sodium channel subunit beta-1 | [273] | 0.52[274] | 0.18[275] | -2.24[276] | -0.41[277] | 2.29[278] | -0.51[279] |
41 | KCNK6 | Potassium channel subfamily K member 6 | [280] | -1.26[281] | -6.91[282] | -2.38[283] | -0.84[284] | -0.05[285] | 0.99[286] |
42 | KCNE3 | Potassium voltage-gated channel subfamily E member 3 | [287] | 0.40[288] | -1.77[289] | -0.88[290] | 1.76[291] | -0.05[292] | -0.06[293] |
43 | KCNJ11 | ATP-sensitive inward rectifier potassium channel 11 | [294] | -0.51[295] | -0.80[296] | -1.42[297] | -2.17[298] | -2.48[299] | -1.42[300] |
44 | TRPC1 | Short transient receptor potential channel 1 | [301] | 1.26[302] | 2.79[303] | 2.92[304] | 2.08[305] | 2.52[306] | -1.03[307] |
45 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | [308] | 2.33[309] | 2.42[310] | 3.52[311] | 1.89[312] | 3.18[313] | 3.68[314] |
46 | CLIC2 | Chloride intracellular channel protein 2 | [315] | -4.92[316] | -4.03[317] | -2.18[318] | 1.56[319] | -4.55[320] | 1.09[321] |
47 | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2 | [322] | -3.15[323] | -2.21[324] | -1.04[325] | -1.65[326] | -2.07[327] | 0.84[328] |
48 | ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | [329] | 1.32[330] | -2.98[331] | 0.81[332] | 0.15[333] | 0.18[334] | 1.70[335] |
49 | KCNK13 | Potassium channel subfamily K member 13 | [336] | 0.10[337] | 2.33[338] | -7.67[339] | -4.54[340] | -7.92[341] | -2.44[342] |
50 | KCNIP3 | Calsenilin | [343] | -7.05[344] | -6.92[345] | -6.09[346] | -0.57[347] | 2.10[348] | -0.88[349] |
51 | KCNE1 | Potassium voltage-gated channel subfamily E member 1 | [350] | -8.01[351] | [352] | -5.77[353] | -0.96[354] | -1.23[355] | 0.59[356] |
52 | KCNIP2 | Kv channel-interacting protein 2 | [357] | -2.16[358] | 0.80[359] | 0.00[360] | -1.32[361] | -0.60[362] | -0.43[363] |
53 | FGF11 | Fibroblast growth factor 11 | [364] | 3.14[365] | 3.17[366] | 4.08[367] | 1.55[368] | 0.52[369] | -1.50[370] |
54 | FGF14 | Fibroblast growth factor 14 | [371] | [372] | [373] | [374] | -4.28[375] | -2.14[376] | 0.98[377] |
55 | TNNI3 | Troponin I, cardiac muscle | [378] | 1.93[379] | -0.21[380] | -6.10[381] | -1.98[382] | 0.55[383] | -6.21[384] |
56 | SCN8A | Sodium channel protein type 8 subunit alpha | [385] | 0.50[386] | -3.24[387] | 3.16[388] | 3.98[389] | 3.00[390] | 4.13[391] |
57 | CACNG8 | Voltage-dependent calcium channel gamma-8 subunit | [392] | 0.21[393] | 1.54[394] | 0.16[395] | 0.48[396] | 3.91[397] | -1.41[398] |
58 | NPR1 | Atrial natriuretic peptide receptor 1 | [399] | -3.58[400] | -4.31[401] | -1.35[402] | -2.19[403] | 3.77[404] | 4.32[405] |
59 | CACNG7 | Voltage-dependent calcium channel gamma-7 subunit | [406] | -7.69[407] | -5.55[408] | [409] | -3.60[410] | 2.70[411] | [412] |
60 | NKX2-5 | Homeobox protein Nkx-2.5 | [413] | 1.24[414] | -1.07[415] | -7.20[416] | -4.81[417] | 4.70[418] | [419] |
61 | KCNK15 | Potassium channel subfamily K member 15 | [420] | -7.51[421] | [422] | [423] | -4.46[424] | -3.23[425] | -1.87[426] |
62 | KCNE2 | Potassium voltage-gated channel subfamily E member 2 | [427] | -3.62[428] | -1.18[429] | -1.35[430] | -2.02[431] | -1.99[432] | -1.16[433] |
63 | KCNJ4 | Inward rectifier potassium channel 4 | [434] | -0.56[435] | -0.28[436] | 1.15[437] | -5.96[438] | -2.36[439] | -2.12[440] |
64 | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1 | [441] | -2.03[442] | -1.69[443] | -3.93[444] | -4.93[445] | -3.74[446] | 0.49[447] |
65 | CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 | [448] | -0.80[449] | 1.36[450] | 1.33[451] | 2.61[452] | 1.45[453] | 4.07[454] |
66 | CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 | [455] | 2.23[456] | 0.97[457] | 2.51[458] | 1.77[459] | 3.49[460] | -0.07[461] |
67 | ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | [462] | 0.03[463] | [464] | -4.86[465] | -1.72[466] | -1.46[467] | -2.18[468] |
68 | CASQ1 | Calsequestrin-1 | [469] | -1.93[470] | [471] | -4.94[472] | 0.36[473] | -3.69[474] | -3.16[475] |
69 | KCNE4 | Potassium voltage-gated channel subfamily E member 4 | [476] | -2.34[477] | -1.54[478] | -1.42[479] | 6.18[480] | -1.06[481] | 0.71[482] |
70 | KCNH2 | Potassium voltage-gated channel subfamily H member 2 | [483] | 1.43[484] | -3.22[485] | 0.17[486] | 5.90[487] | -0.57[488] | -1.10[489] |
71 | KCNK3 | Potassium channel subfamily K member 3 | [490] | 1.80[491] | -3.53[492] | -6.42[493] | 1.34[494] | -0.32[495] | 3.70[496] |
72 | TRDN | Triadin | [497] | -5.73[498] | -5.46[499] | 1.36[500] | 3.31[501] | -5.32[502] | -3.44[503] |
73 | SCN11A | Sodium channel protein type 11 subunit alpha | [504] | -0.92[505] | 0.95[506] | -0.36[507] | -0.11[508] | -0.45[509] | 0.82[510] |
74 | SCN2A | Sodium channel protein type 2 subunit alpha | [511] | -1.19[512] | 1.66[513] | 1.83[514] | 1.33[515] | 3.96[516] | 1.03[517] |
75 | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | [518] | 1.68[519] | 0.37[520] | -0.51[521] | 1.46[522] | -0.30[523] | 1.51[524] |
76 | NOS1 | Nitric oxide synthase, brain | [525] | -2.37[526] | -0.19[527] | -1.81[528] | -1.64[529] | -1.32[530] | -0.28[531] |
77 | KCND2 | Potassium voltage-gated channel subfamily D member 2 | [532] | [533] | [534] | -4.17[535] | -2.04[536] | 2.36[537] | -1.03[538] |
78 | SCN1A | Sodium channel protein type 1 subunit alpha | [539] | 2.01[540] | 9.83[541] | -1.64[542] | 0.60[543] | -0.23[544] | -0.38[545] |
79 | FXYD3 | FXYD domain-containing ion transport regulator 3 | [546] | 2.59[547] | 6.83[548] | 2.96[549] | -3.74[550] | -5.20[551] | -0.76[552] |
80 | KCNJ14 | ATP-sensitive inward rectifier potassium channel 14 | [553] | 1.03[554] | 1.18[555] | 3.36[556] | 2.66[557] | 2.96[558] | 1.86[559] |
81 | ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | [560] | 3.74[561] | 5.89[562] | 2.27[563] | 1.31[564] | 2.17[565] | 0.63[566] |
82 | SCN2B | Sodium channel subunit beta-2 | [567] | 1.11[568] | 1.12[569] | -0.91[570] | -3.05[571] | 0.12[572] | 0.31[573] |
83 | CACNG4 | Voltage-dependent calcium channel gamma-4 subunit | [574] | 3.99[575] | 5.57[576] | -2.77[577] | 2.77[578] | -3.58[579] | -2.19[580] |
84 | FGF12 | Fibroblast growth factor 12 | [581] | [582] | [583] | 2.04[584] | -2.66[585] | 2.92[586] | 1.63[587] |
85 | NPPA | Natriuretic peptides A | [588] | -1.36[589] | 3.86[590] | -0.21[591] | -0.68[592] | -1.40[593] | -1.58[594] |
86 | SLC8A1 | Sodium/calcium exchanger 1 | [595] | 0.73[596] | [597] | [598] | 3.79[599] | 2.18[600] | 6.63[601] |
87 | CACNA2D | Voltage-dependent calcium channel subunit alpha-2/delta-2 | [602] | -2.12[603] | 0.28[604] | 0.81[605] | -0.73[606] | 1.46[607] | 0.86[608] |
88 | SCN3B | Sodium channel subunit beta-3 | [609] | -0.42[610] | -0.14[611] | -2.51[612] | 0.40[613] | 0.34[614] | 0.70[615] |
89 | KCNJ2 | Inward rectifier potassium channel 2 | [616] | -3.15[617] | [618] | [619] | 2.32[620] | 2.89[621] | 4.90[622] |
90 | SLC8A3 | Sodium/calcium exchanger 3 | [623] | -1.36[624] | -3.10[625] | -3.99[626] | [627] | -3.05[628] | -0.34[629] |
91 | KCND1 | Potassium voltage-gated channel subfamily D member 1 | [630] | 0.24[631] | 3.46[632] | 2.83[633] | 5.50[634] | 4.47[635] | 2.18[636] |
92 | SCN4B | Sodium channel subunit beta-4 | [637] | 1.09[638] | 1.12[639] | 1.00[640] | -0.88[641] | 2.05[642] | 1.63[643] |
93 | KCNK2 | Potassium channel subfamily K member 2 | [644] | -3.84[645] | [646] | -4.49[647] | -1.64[648] | 3.69[649] | [650] |
94 | TBX5 | T-box transcription factor TBX5 | [651] | [652] | [653] | [654] | -4.14[655] | [656] | [657] |
95 | KCNIP4 | Kv channel-interacting protein 4 | [658] | 1.57[659] | 1.60[660] | 3.31[661] | 2.06[662] | 2.90[663] | 2.91[664] |
96 | PLN | Cardiac phospholamban | [665] | [666] | [667] | [668] | 1.19[669] | -2.24[670] | 2.99[671] |
97 | KCNK17 | Potassium channel subfamily K member 17 | [672] | [673] | [674] | [675] | [676] | [677] | 2.82[678] |
98 | SCN4A | Sodium channel protein type 4 subunit alpha | [679] | 2.41[680] | 0.23[681] | 0.93[682] | -1.75[683] | -0.81[684] | 2.86[685] |
99 | RYR1 | Ryanodine receptor 1 | [686] | 0.67[687] | -3.18[688] | -1.03[689] | 2.44[690] | 1.48[691] | 3.93[692] |
100 | SLC8A2 | Sodium/calcium exchanger 2 | [693] | 0.20[694] | -0.23[695] | -0.64[696] | 0.06[697] | -0.99[698] | -0.96[699] |
101 | CORIN | Atrial natriuretic peptide-converting enzyme | [700] | 0.98[701] | -0.52[702] | 3.97[703] | 1.66[704] | 1.71[705] | 3.34[706] |
102 | RYR3 | Ryanodine receptor 3 | [707] | 3.17[708] | 4.41[709] | 2.22[710] | 5.12[711] | 4.43[712] | 5.79[713] |
103 | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | [714] | 3.91[715] | 1.62[716] | 4.43[717] | 4.76[718] | 7.41[719] | 7.34[720] |
104 | KCNJ12 | ATP-sensitive inward rectifier potassium channel 12 | [721] | [722] | [723] | -0.82[724] | 6.81[725] | 6.58[726] | 4.46[727] |
105 | SCN5A | Sodium channel protein type 5 subunit alpha | [728] | 7.92[729] | 1.63[730] | 1.23[731] | 3.16[732] | 6.92[733] | 1.60[734] |
106 | RYR2 | Ryanodine receptor 2 | [735] | 2.03[736] | 0.00[737] | 2.42[738] | 3.89[739] | 2.00[740] | 7.94[741] |
107 | FXYD7 | FXYD domain-containing ion transport regulator 7 | [742] | [743] | [744] | [745] | [746] | [747] | [748] |
108 | SCN3A | Sodium channel protein type 3 subunit alpha | [749] | [750] | [751] | [752] | [753] | [754] | [755] |
109 | SCN10A | Sodium channel protein type 10 subunit alpha | [756] | [757] | [758] | [759] | [760] | [761] | [762] |
110 | KCNK10 | Potassium channel subfamily K member 10 | [763] | [764] | [765] | [766] | [767] | [768] | [769] |
111 | ATP2B3 | Plasma membrane calcium-transporting ATPase 3 | [770] | [771] | [772] | [773] | [774] | [775] | [776] |
112 | SLN | Sarcolipin | [777] | [778] | [779] | [780] | [781] | [782] | [783] |
113 | KCNK9 | Potassium channel subfamily K member 9 | [784] | [785] | [786] | [787] | [788] | [789] | [790] |
114 | KCNK7 | Potassium channel subfamily K member 7 | [791] | [792] | [793] | [794] | [795] | [796] | [797] |
115 | KCNIP1 | Kv channel-interacting protein 1 | [798] | [799] | [800] | [801] | [802] | [803] | [804] |
116 | CACNG6 | Voltage-dependent calcium channel gamma-6 subunit | [805] | [806] | [807] | [808] | [809] | [810] | [811] |
117 | FXYD4 | FXYD domain-containing ion transport regulator 4 | [812] | [813] | [814] | [815] | [816] | [817] | [818] |
118 | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | [819] | [820] | [821] | [822] | [823] | [824] | [825] |
119 | KCNK12 | Potassium channel subfamily K member 12 | [826] | [827] | [828] | [829] | [830] | [831] | [832] |
120 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [833] | [834] | [835] | [836] | [837] | [838] | [839] |
121 | CASQ2 | Calsequestrin-2 | [840] | [841] | [842] | [843] | [844] | [845] | [846] |
122 | KCNK18 | Potassium channel subfamily K member 18 | [847] | [848] | [849] | [850] | [851] | [852] | [853] |
123 | SCN7A | Sodium channel protein type 7 subunit alpha | [854] | [855] | [856] | [857] | [858] | [859] | [860] |
124 | KCNK4 | Potassium channel subfamily K member 4 | [861] | [862] | [863] | [864] | [865] | [866] | [867] |
125 | KCNK16 | Potassium channel subfamily K member 16 | [868] | [869] | [870] | [871] | [872] | [873] | [874] |
126 | KCNE5 | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 | [875] | [876] | [877] | [878] | [879] | [880] | |
127 | NPPC | C-type natriuretic peptide | [881] | [882] | [883] | [884] | [885] | [886] | [887] |