REACTOME_CALNEXIN_CALRETICULIN_CYCLE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -1.04[2] -1.16[3] -1.26[4] -1.24[5] -0.94[6] -1.10[7]
2 CALR Calreticulin [8] 0.20[9] -0.20[10] -0.71[11] -0.59[12] -0.46[13] -0.22[14]
3 RPS27A Ubiquitin-40S ribosomal protein S27a [15] [16] [17] [18] [19] [20] [21]
4 UBC Polyubiquitin-C [22] -0.59[23] -0.41[24] -0.90[25] -0.38[26] -0.56[27] -0.65[28]
5 PDIA3 Protein disulfide-isomerase A3 [29] 0.83[30] 0.61[31] -0.27[32] 1.06[33] 0.58[34] 0.02[35]
6 CANX Calnexin [36] 1.41[37] 1.95[38] 2.02[39] 2.17[40] 1.90[41] 2.17[42]
7 OS9 Protein OS-9 [43] 0.41[44] 0.89[45] 0.39[46] -0.07[47] 0.00[48] 0.74[49]
8 UBA52 Ubiquitin-60S ribosomal protein L40 [50] 1.84[51] 1.83[52] 2.61[53] 1.02[54] 1.66[55] 0.12[56]
9 PRKCSH Glucosidase 2 subunit beta [57] 1.23[58] 0.80[59] 2.29[60] 0.96[61] 1.31[62] -0.61[63]
10 RNF5 E3 ubiquitin-protein ligase RNF5 [64] -9.19[65] -8.45[66] -7.82[67] -9.28[68] -10.74[69] -9.41[70]
11 GANAB Neutral alpha-glucosidase AB [71] 2.10[72] 1.87[73] 3.28[74] 2.73[75] 3.12[76] 1.83[77]
12 DERL2 Derlin-2 [78] -1.06[79] -0.34[80] -1.11[81] -0.16[82] -0.59[83] -0.40[84]
13 AMFR E3 ubiquitin-protein ligase AMFR [85] 1.60[86] 1.10[87] 0.04[88] 1.04[89] 1.32[90] 2.38[91]
14 SYVN1 E3 ubiquitin-protein ligase synoviolin [92] 0.20[93] 0.60[94] -0.06[95] 0.15[96] 0.11[97] 1.19[98]
15 SEL1L Protein sel-1 homolog 1 [99] 1.48[100] 2.00[101] 1.66[102] 2.51[103] 2.03[104] 3.60[105]
16 EDEM2 ER degradation-enhancing alpha-mannosidase-like protein 2 [106] 1.81[107] 1.63[108] 0.15[109] 1.06[110] -0.10[111] 0.46[112]
17 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1.95[113] 1.69[114] 1.76[115] 1.71[116] 1.29[117] 0.68[118]
18 RNF103 E3 ubiquitin-protein ligase RNF103 [119] 0.07[120] 1.17[121] 0.94[122] 0.87[123] 0.35[124] 1.11[125]
19 RNF185 E3 ubiquitin-protein ligase RNF185 [126] 1.14[127] 1.05[128] 1.25[129] 1.13[130] 0.83[131] 1.62[132]
20 EDEM1 ER degradation-enhancing alpha-mannosidase-like protein 1 [133] 2.15[134] 2.44[135] 2.32[136] 1.66[137] 2.86[138] 3.94[139]
21 RNF139 E3 ubiquitin-protein ligase RNF139 [140] 1.28[141] 1.69[142] 1.16[143] 1.87[144] 1.17[145] 1.02[146]
22 EDEM3 ER degradation-enhancing alpha-mannosidase-like protein 3 [147] 0.82[148] 2.62[149] 3.36[150] 3.43[151] 3.17[152] 3.88[153]
23 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 [154] 4.42[155] 4.31[156] 4.26[157] 4.54[158] 4.42[159] 4.35[160]
24 UGGT2 UDP-glucose:glycoprotein glucosyltransferase 2 [161] 2.41[162] 3.48[163] 1.84[164] 2.65[165] 3.50[166] 2.78[167]
25 TRIM13 E3 ubiquitin-protein ligase TRIM13 [168] 3.21[169] 3.82[170] 3.41[171] 3.29[172] 3.30[173] 3.72[174]
26 MARCHF6 [175] [176] [177] [178] [179] [180] [181]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte CALR
Mean 617
Standard deviation 2.8e+02
Values 7.7e+02 4.7e+02 3.5e+02 1e+03 4.6e+02
[9]
HepG2 CALR
Mean 698
Standard deviation 0.66
Values 7e+02 7e+02
[10]
HepG2.C3A CALR
Mean 448
Standard deviation 1.7e+02
Values 3.3e+02 5.7e+02
[11]
HuH.7 CALR
Mean 360
Standard deviation 34
Values 3.3e+02 3.5e+02 4e+02
[12]
SNU475 CALR
Mean 258
Standard deviation 1.5e+02
Values 3.6e+02 1.6e+02
[13]
THLE CALR
Mean 356
Standard deviation 52
Values 3.2e+02 3.9e+02
[14]
liver CALR
Mean 440
Standard deviation 89
Values 4e+02 3.7e+02 5.7e+02 4.2e+02
[15]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[16]
HepG2 RPS27A
Missing
[17]
HepG2.C3A RPS27A
Missing
[18]
HuH.7 RPS27A
Missing
[19]
SNU475 RPS27A
Missing
[20]
THLE RPS27A
Missing
[21]
liver RPS27A
Missing
[22]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[23]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[24]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[25]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[26]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[27]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[28]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[29]
ref_hepatocyte PDIA3
Mean 173
Standard deviation 1.1e+02
Values 1.6e+02 78 1e+02 3.6e+02 1.7e+02
[30]
HepG2 PDIA3
Mean 304
Standard deviation 33
Values 3.3e+02 2.8e+02
[31]
HepG2.C3A PDIA3
Mean 221
Standard deviation 2.9
Values 2.2e+02 2.2e+02
[32]
HuH.7 PDIA3
Mean 137
Standard deviation 4.5
Values 1.3e+02 1.4e+02 1.4e+02
[33]
SNU475 PDIA3
Mean 227
Standard deviation 79
Values 2.8e+02 1.7e+02
[34]
THLE PDIA3
Mean 205
Standard deviation 43
Values 1.7e+02 2.4e+02
[35]
liver PDIA3
Mean 146
Standard deviation 45
Values 92 1.6e+02 2e+02 1.4e+02
[36]
ref_hepatocyte CANX
Mean 128
Standard deviation 89
Values 2.7e+02 1.4e+02 43 1.1e+02 75
[37]
HepG2 CANX
Mean 335
Standard deviation 37
Values 3.1e+02 3.6e+02
[38]
HepG2.C3A CANX
Mean 411
Standard deviation 40
Values 4.4e+02 3.8e+02
[39]
HuH.7 CANX
Mean 494
Standard deviation 1.9e+02
Values 4.4e+02 7.1e+02 3.4e+02
[40]
SNU475 CANX
Mean 362
Standard deviation 31
Values 3.8e+02 3.4e+02
[41]
THLE CANX
Mean 379
Standard deviation 58
Values 3.4e+02 4.2e+02
[42]
liver CANX
Mean 477
Standard deviation 1.8e+02
Values 2.6e+02 6.9e+02 4.4e+02 5.2e+02
[43]
ref_hepatocyte OS9
Mean 87.3
Standard deviation 51
Values 86 52 24 1.3e+02 1.4e+02
[44]
HepG2 OS9
Mean 114
Standard deviation 14
Values 1.2e+02 1e+02
[45]
HepG2.C3A OS9
Mean 135
Standard deviation 40
Values 1.6e+02 1.1e+02
[46]
HuH.7 OS9
Mean 109
Standard deviation 15
Values 94 1.2e+02 1.1e+02
[47]
SNU475 OS9
Mean 52.4
Standard deviation 4.7
Values 56 49
[48]
THLE OS9
Mean 69.2
Standard deviation 8.7
Values 63 75
[49]
liver OS9
Mean 121
Standard deviation 20
Values 1.3e+02 1.1e+02 1.4e+02 1e+02
[50]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[51]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[52]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[53]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[54]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[55]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[56]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[57]
ref_hepatocyte PRKCSH
Mean 52.1
Standard deviation 17
Values 45 36 46 80 54
[58]
HepG2 PRKCSH
Mean 120
Standard deviation 35
Values 1.5e+02 95
[59]
HepG2.C3A PRKCSH
Mean 75.2
Standard deviation 29
Values 95 55
[60]
HuH.7 PRKCSH
Mean 243
Standard deviation 15
Values 2.6e+02 2.3e+02 2.4e+02
[61]
SNU475 PRKCSH
Mean 63.5
Standard deviation 1.6
Values 65 62
[62]
THLE PRKCSH
Mean 102
Standard deviation 17
Values 91 1.1e+02
[63]
liver PRKCSH
Mean 28.4
Standard deviation 4.5
Values 25 30 24 34
[64]
ref_hepatocyte RNF5
Mean 46.7
Standard deviation 24
Values 42 19 30 66 77
[65]
HepG2 RNF5
Mean 0.0788
Standard deviation 0.075
Values 0.13 0.026
[66]
HepG2.C3A RNF5
Mean 0.111
Standard deviation 0.021
Values 0.13 0.097
[67]
HuH.7 RNF5
Mean 0.197
Standard deviation 0.031
Values 0.23 0.19 0.17
[68]
SNU475 RNF5
Mean 0.0475
Standard deviation 0.031
Values 0.07 0.025
[69]
THLE RNF5
Mean 0.0216
Standard deviation 0.022
Values 0.0059 0.037
[70]
liver RNF5
Mean 0.0572
Standard deviation 0.099
Values 0.024 0 0.21 0
[71]
ref_hepatocyte GANAB
Mean 36.9
Standard deviation 24
Values 20 18 23 72 51
[72]
HepG2 GANAB
Mean 156
Standard deviation 19
Values 1.7e+02 1.4e+02
[73]
HepG2.C3A GANAB
Mean 112
Standard deviation 20
Values 1.3e+02 98
[74]
HuH.7 GANAB
Mean 341
Standard deviation 22
Values 3.6e+02 3.4e+02 3.2e+02
[75]
SNU475 GANAB
Mean 154
Standard deviation 18
Values 1.7e+02 1.4e+02
[76]
THLE GANAB
Mean 254
Standard deviation 49
Values 2.2e+02 2.9e+02
[77]
liver GANAB
Mean 109
Standard deviation 34
Values 72 1.4e+02 87 1.4e+02
[78]
ref_hepatocyte DERL2
Mean 27.8
Standard deviation 9.8
Values 20 27 20 44 28
[79]
HepG2 DERL2
Mean 13.1
Standard deviation 3.2
Values 11 15
[80]
HepG2.C3A DERL2
Mean 18.3
Standard deviation 2.5
Values 17 20
[81]
HuH.7 DERL2
Mean 12.2
Standard deviation 0.88
Values 11 12 13
[82]
SNU475 DERL2
Mean 15.6
Standard deviation 3.9
Values 18 13
[83]
THLE DERL2
Mean 14.6
Standard deviation 2.6
Values 13 16
[84]
liver DERL2
Mean 17.5
Standard deviation 12
Values 23 8.3 31 7.3
[85]
ref_hepatocyte AMFR
Mean 23.1
Standard deviation 6
Values 19 23 16 32 25
[86]
HepG2 AMFR
Mean 69.4
Standard deviation 13
Values 79 60
[87]
HepG2.C3A AMFR
Mean 41.4
Standard deviation 7.9
Values 47 36
[88]
HuH.7 AMFR
Mean 22.7
Standard deviation 2.5
Values 21 26 21
[89]
SNU475 AMFR
Mean 30
Standard deviation 3.7
Values 33 27
[90]
THLE AMFR
Mean 45.8
Standard deviation 1.6
Values 47 45
[91]
liver AMFR
Mean 100
Standard deviation 51
Values 81 82 63 1.8e+02
[92]
ref_hepatocyte SYVN1
Mean 20.3
Standard deviation 18
Values 2.3 2.6 24 44 29
[93]
HepG2 SYVN1
Mean 22.9
Standard deviation 2.1
Values 24 21
[94]
HepG2.C3A SYVN1
Mean 25.6
Standard deviation 13
Values 35 16
[95]
HuH.7 SYVN1
Mean 18.6
Standard deviation 3.1
Values 16 22 17
[96]
SNU475 SYVN1
Mean 14.1
Standard deviation 1.9
Values 15 13
[97]
THLE SYVN1
Mean 17.3
Standard deviation 0.72
Values 17 18
[98]
liver SYVN1
Mean 38.6
Standard deviation 9.3
Values 43 26 48 38
[99]
ref_hepatocyte SEL1L
Mean 15.3
Standard deviation 6
Values 6.6 15 14 23 17
[100]
HepG2 SEL1L
Mean 42.2
Standard deviation 13
Values 33 51
[101]
HepG2.C3A SEL1L
Mean 50.8
Standard deviation 5.2
Values 47 54
[102]
HuH.7 SEL1L
Mean 46.1
Standard deviation 17
Values 45 64 30
[103]
SNU475 SEL1L
Mean 54.8
Standard deviation 20
Values 69 40
[104]
THLE SEL1L
Mean 49.6
Standard deviation 0.3
Values 49 50
[105]
liver SEL1L
Mean 154
Standard deviation 39
Values 1.1e+02 2e+02 1.4e+02 1.7e+02
[106]
ref_hepatocyte EDEM2
Mean 13.9
Standard deviation 4.1
Values 15 14 9.2 20 12
[107]
HepG2 EDEM2
Mean 48.2
Standard deviation 1.9
Values 50 47
[108]
HepG2.C3A EDEM2
Mean 36.1
Standard deviation 6.9
Values 41 31
[109]
HuH.7 EDEM2
Mean 14.7
Standard deviation 1.3
Values 14 14 16
[110]
SNU475 EDEM2
Mean 18.3
Standard deviation 4.2
Values 21 15
[111]
THLE EDEM2
Mean 10.3
Standard deviation 1.2
Values 9.4 11
[112]
liver EDEM2
Mean 15.9
Standard deviation 4.7
Values 20 11 20 13
[113]
ref_hepatocyte MAN1B1
Mean 12.6
Standard deviation 4
Values 10 18 7.3 15 13
[114]
HepG2 MAN1B1
Mean 48
Standard deviation 5.2
Values 52 44
[115]
HepG2.C3A MAN1B1
Mean 33.8
Standard deviation 8.4
Values 40 28
[116]
HuH.7 MAN1B1
Mean 40.7
Standard deviation 9.9
Values 44 30 48
[117]
SNU475 MAN1B1
Mean 25.9
Standard deviation 7
Values 31 21
[118]
THLE MAN1B1
Mean 24.4
Standard deviation 7.8
Values 19 30
[119]
liver MAN1B1
Mean 16.8
Standard deviation 4.7
Values 18 13 23 13
[120]
ref_hepatocyte RNF103
Mean 11.8
Standard deviation 2.6
Values 13 10 8.7 12 16
[121]
HepG2 RNF103
Mean 12.2
Standard deviation 0.93
Values 12 13
[122]
HepG2.C3A RNF103
Mean 22.2
Standard deviation 5.1
Values 26 19
[123]
HuH.7 RNF103
Mean 21.6
Standard deviation 6.5
Values 17 29 19
[124]
SNU475 RNF103
Mean 13.6
Standard deviation 4.2
Values 17 11
[125]
THLE RNF103
Mean 11.9
Standard deviation 1.8
Values 11 13
[126]
liver RNF103
Mean 21.2
Standard deviation 4.1
Values 25 22 16 22
[127]
ref_hepatocyte RNF185
Mean 11.6
Standard deviation 7.6
Values 3.8 5.5 10 22 17
[128]
HepG2 RNF185
Mean 25.1
Standard deviation 0.51
Values 25 25
[129]
HepG2.C3A RNF185
Mean 20
Standard deviation 0.07
Values 20 20
[130]
HuH.7 RNF185
Mean 26.3
Standard deviation 2.2
Values 24 29 26
[131]
SNU475 RNF185
Mean 15.9
Standard deviation 1.4
Values 17 15
[132]
THLE RNF185
Mean 16.4
Standard deviation 3.6
Values 14 19
[133]
liver RNF185
Mean 29.5
Standard deviation 11
Values 34 19 43 22
[134]
ref_hepatocyte EDEM1
Mean 7.75
Standard deviation 3.2
Values 8.7 6.4 3.1 8.7 12
[135]
HepG2 EDEM1
Mean 33.8
Standard deviation 0.56
Values 34 33
[136]
HepG2.C3A EDEM1
Mean 35
Standard deviation 5.1
Values 39 31
[137]
HuH.7 EDEM1
Mean 36.9
Standard deviation 10
Values 32 49 30
[138]
SNU475 EDEM1
Mean 15.4
Standard deviation 2.9
Values 17 13
[139]
THLE EDEM1
Mean 44.5
Standard deviation 7.7
Values 39 50
[140]
liver EDEM1
Mean 98.6
Standard deviation 29
Values 58 1.2e+02 1.1e+02 1e+02
[141]
ref_hepatocyte RNF139
Mean 6.96
Standard deviation 2.2
Values 9.7 7.3 3.8 6 8
[142]
HepG2 RNF139
Mean 16.7
Standard deviation 4.7
Values 13 20
[143]
HepG2.C3A RNF139
Mean 18.7
Standard deviation 1.9
Values 17 20
[144]
HuH.7 RNF139
Mean 14.8
Standard deviation 0.97
Values 14 15 16
[145]
SNU475 RNF139
Mean 16
Standard deviation 1.6
Values 17 15
[146]
THLE RNF139
Mean 12.4
Standard deviation 1.4
Values 11 13
[147]
liver RNF139
Mean 11.7
Standard deviation 0.75
Values 13 12 11 12
[148]
ref_hepatocyte EDEM3
Mean 4.65
Standard deviation 1.5
Values 2.9 5.5 5.2 3.3 6.4
[149]
HepG2 EDEM3
Mean 8.08
Standard deviation 3.4
Values 5.7 10
[150]
HepG2.C3A EDEM3
Mean 23.9
Standard deviation 3.5
Values 26 21
[151]
HuH.7 EDEM3
Mean 45.7
Standard deviation 9
Values 48 54 36
[152]
SNU475 EDEM3
Mean 31.5
Standard deviation 3.9
Values 34 29
[153]
THLE EDEM3
Mean 33.1
Standard deviation 2
Values 32 34
[154]
liver EDEM3
Mean 56.9
Standard deviation 24
Values 29 86 48 64
[155]
ref_hepatocyte UGGT1
Mean 4.26
Standard deviation 2.2
Values 7.7 3.7 1.9 4.7 3.3
[156]
HepG2 UGGT1
Mean 89.9
Standard deviation 3.3
Values 92 88
[157]
HepG2.C3A UGGT1
Mean 70.2
Standard deviation 17
Values 58 82
[158]
HuH.7 UGGT1
Mean 77.7
Standard deviation 27
Values 1.1e+02 68 58
[159]
SNU475 UGGT1
Mean 62.2
Standard deviation 12
Values 71 54
[160]
THLE UGGT1
Mean 72
Standard deviation 17
Values 60 84
[161]
liver UGGT1
Mean 72.1
Standard deviation 48
Values 28 1.1e+02 33 1.1e+02
[162]
ref_hepatocyte UGGT2
Mean 2
Standard deviation 1.8
Values 5.1 1.6 0.58 1.8 0.99
[163]
HepG2 UGGT2
Mean 10.5
Standard deviation 0.67
Values 10 11
[164]
HepG2.C3A UGGT2
Mean 18.6
Standard deviation 1.3
Values 18 20
[165]
HuH.7 UGGT2
Mean 6.83
Standard deviation 0.3
Values 6.8 7.2 6.6
[166]
SNU475 UGGT2
Mean 7.92
Standard deviation 1.4
Values 8.9 6.9
[167]
THLE UGGT2
Mean 17.9
Standard deviation 0.97
Values 19 17
[168]
liver UGGT2
Mean 11.4
Standard deviation 2.4
Values 9.7 15 11 10
[169]
ref_hepatocyte TRIM13
Mean 1.1
Standard deviation 0.34
Values 1.1 1.4 0.52 1.3 1.1
[170]
HepG2 TRIM13
Mean 10
Standard deviation 0.72
Values 9.5 11
[171]
HepG2.C3A TRIM13
Mean 12.9
Standard deviation 0.63
Values 13 12
[172]
HuH.7 TRIM13
Mean 11.2
Standard deviation 3.4
Values 8.5 15 10
[173]
SNU475 TRIM13
Mean 6.76
Standard deviation 0.77
Values 7.3 6.2
[174]
THLE TRIM13
Mean 8.58
Standard deviation 0.025
Values 8.6 8.6
[175]
liver TRIM13
Mean 12
Standard deviation 0.97
Values 13 11 13 11
[176]
ref_hepatocyte MARCHF6
Missing
[177]
HepG2 MARCHF6
Missing
[178]
HepG2.C3A MARCHF6
Missing
[179]
HuH.7 MARCHF6
Missing
[180]
SNU475 MARCHF6
Missing
[181]
THLE MARCHF6
Missing
[182]
liver MARCHF6
Missing