REACTOME_CA2_PATHWAY |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
GNG5 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-5 |
-1.98[1] |
-1.60[2] |
-2.59[3] |
-2.51[4] |
-2.87[5] |
-2.24[6] |
2 |
GNB1 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
[7] |
0.24[8] |
0.46[9] |
-0.15[10] |
0.58[11] |
0.28[12] |
-1.88[13] |
3 |
GNB2 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
[14] |
-1.37[15] |
-1.43[16] |
-1.22[17] |
-1.07[18] |
-1.11[19] |
-2.25[20] |
4 |
CTNNB1 |
Catenin beta-1 |
[21] |
0.85[22] |
0.54[23] |
1.30[24] |
0.05[25] |
0.18[26] |
0.46[27] |
5 |
GNG10 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-10 |
-5.47[28] |
-4.99[29] |
-5.42[30] |
-4.51[31] |
-3.80[32] |
-4.99[33] |
6 |
MYC |
Myc proto-oncogene protein |
[34] |
-0.34[35] |
-0.48[36] |
-2.64[37] |
-3.49[38] |
-1.22[39] |
-2.65[40] |
7 |
CALM1 |
Calmodulin-1 |
[41] |
-0.69[42] |
-0.46[43] |
-0.13[44] |
0.88[45] |
0.05[46] |
0.97[47] |
8 |
GNG12 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-12 |
-5.52[48] |
-8.25[49] |
-0.43[50] |
1.18[51] |
1.17[52] |
-0.17[53] |
9 |
PPP3R1 |
Calcineurin subunit B type 1 |
[54] |
-0.58[55] |
-0.20[56] |
-0.42[57] |
0.00[58] |
-0.34[59] |
-1.80[60] |
10 |
KRAS |
GTPase KRas |
[61] |
-1.29[62] |
-1.11[63] |
0.36[64] |
0.10[65] |
-0.34[66] |
0.03[67] |
11 |
MAP3K7 |
Mitogen-activated protein kinase kinase kinase 7 |
[68] |
-0.87[69] |
0.40[70] |
0.14[71] |
-0.21[72] |
-0.13[73] |
-0.40[74] |
12 |
WNT11 |
Protein Wnt-11 |
[75] |
-2.19[76] |
-7.70[77] |
-6.81[78] |
-7.23[79] |
-7.76[80] |
-3.73[81] |
13 |
MOV10 |
Putative helicase MOV-10 |
[82] |
0.21[83] |
0.63[84] |
0.49[85] |
0.37[86] |
0.12[87] |
0.43[88] |
14 |
FZD5 |
Frizzled-5 |
[89] |
0.20[90] |
1.27[91] |
2.13[92] |
-1.84[93] |
-3.25[94] |
1.94[95] |
15 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[96] |
0.14[97] |
1.80[98] |
0.13[99] |
-0.69[100] |
-0.66[101] |
3.22[102] |
16 |
GNB5 |
Guanine nucleotide-binding protein subunit beta-5 |
[103] |
-0.67[104] |
-0.43[105] |
0.46[106] |
0.09[107] |
0.11[108] |
0.24[109] |
17 |
PPP3CB |
Serine/threonine-protein phosphatase
2B catalytic subunit beta isoform |
-0.28[110] |
0.71[111] |
0.09[112] |
0.05[113] |
-0.30[114] |
-0.80[115] |
18 |
AXIN2 |
Axin-2 |
[116] |
2.70[117] |
0.50[118] |
-3.68[119] |
-1.79[120] |
-2.26[121] |
-2.99[122] |
19 |
PPP3CA |
Serine/threonine-protein phosphatase
2B catalytic subunit alpha isoform |
-0.05[123] |
-0.09[124] |
-0.41[125] |
1.24[126] |
0.89[127] |
1.16[128] |
20 |
TNRC6A |
Trinucleotide repeat-containing gene 6A protein |
[129] |
1.48[130] |
2.32[131] |
1.38[132] |
1.59[133] |
1.52[134] |
2.35[135] |
21 |
FZD4 |
Frizzled-4 |
[136] |
3.31[137] |
2.45[138] |
1.36[139] |
-0.01[140] |
-0.78[141] |
2.30[142] |
22 |
GNAO1 |
Guanine nucleotide-binding protein G(o) subunit alpha |
[143] |
-7.20[144] |
-8.58[145] |
-7.87[146] |
-3.28[147] |
-7.25[148] |
-0.16[149] |
23 |
PRKCA |
Protein kinase C alpha type |
[150] |
2.07[151] |
2.30[152] |
2.54[153] |
1.45[154] |
1.71[155] |
1.27[156] |
24 |
TCF7L2 |
Transcription factor 7-like 2 |
[157] |
0.10[158] |
1.06[159] |
1.13[160] |
-0.01[161] |
-0.13[162] |
1.07[163] |
25 |
NLK |
Serine/threonine-protein kinase NLK |
[164] |
-0.50[165] |
0.26[166] |
0.63[167] |
0.02[168] |
-0.33[169] |
0.16[170] |
26 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[171] |
4.52[172] |
3.57[173] |
1.93[174] |
1.65[175] |
3.72[176] |
-0.42[177] |
27 |
TCF7L1 |
Transcription factor 7-like 1 |
[178] |
-3.82[179] |
-1.82[180] |
0.25[181] |
-2.52[182] |
-2.50[183] |
-0.36[184] |
28 |
TCF7 |
Transcription factor 7 |
[185] |
1.67[186] |
0.52[187] |
-0.55[188] |
-0.54[189] |
-0.95[190] |
-1.02[191] |
29 |
PLCB3 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
[192] |
1.23[193] |
0.92[194] |
1.25[195] |
2.01[196] |
1.55[197] |
0.08[198] |
30 |
GNG11 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-11 |
-8.95[199] |
-8.75[200] |
-8.19[201] |
1.56[202] |
2.78[203] |
1.59[204] |
31 |
FZD6 |
Frizzled-6 |
[205] |
1.01[206] |
2.04[207] |
-0.60[208] |
4.03[209] |
2.69[210] |
0.47[211] |
32 |
PLCB1 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
[212] |
2.02[213] |
3.84[214] |
3.14[215] |
0.08[216] |
0.47[217] |
1.84[218] |
33 |
GNG7 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-7 |
0.78[219] |
0.63[220] |
1.31[221] |
-2.94[222] |
-2.42[223] |
-0.63[224] |
34 |
TNRC6B |
Trinucleotide repeat-containing gene 6B protein |
[225] |
1.46[226] |
1.87[227] |
3.41[228] |
2.02[229] |
1.89[230] |
4.69[231] |
35 |
GNG4 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-4 |
2.70[232] |
0.66[233] |
4.33[234] |
0.56[235] |
-1.66[236] |
-3.20[237] |
36 |
TNRC6C |
Trinucleotide repeat-containing gene 6C protein |
[238] |
1.31[239] |
1.46[240] |
1.62[241] |
0.07[242] |
-0.06[243] |
2.65[244] |
37 |
PLCB2 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
[245] |
-2.39[246] |
-6.98[247] |
-8.95[248] |
-2.64[249] |
-3.45[250] |
1.59[251] |
38 |
NFATC1 |
Nuclear factor of activated T-cells, cytoplasmic 1 |
[252] |
-2.72[253] |
-5.04[254] |
1.43[255] |
-6.68[256] |
1.63[257] |
0.08[258] |
39 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[259] |
2.37[260] |
2.45[261] |
3.48[262] |
2.15[263] |
2.92[264] |
4.00[265] |
40 |
GNB4 |
Guanine nucleotide-binding protein subunit beta-4 |
[266] |
-1.14[267] |
-0.45[268] |
0.42[269] |
1.98[270] |
4.62[271] |
3.44[272] |
41 |
GNG2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-2 |
-7.05[273] |
-7.73[274] |
[275] |
2.42[276] |
1.79[277] |
2.13[278] |
42 |
WNT5A |
Protein Wnt-5a |
[279] |
-3.96[280] |
-3.75[281] |
-2.71[282] |
5.89[283] |
7.36[284] |
0.66[285] |
43 |
FZD3 |
Frizzled-3 |
[286] |
2.16[287] |
3.29[288] |
4.86[289] |
3.10[290] |
2.22[291] |
3.00[292] |
44 |
GNGT2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2 |
[293] |
[294] |
[295] |
-2.77[296] |
-7.54[297] |
-0.54[298] |
45 |
PDE6B |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
[299] |
-1.73[300] |
-1.94[301] |
-2.98[302] |
0.74[303] |
-2.55[304] |
0.07[305] |
46 |
PDE6A |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
[306] |
-0.71[307] |
0.17[308] |
0.09[309] |
0.76[310] |
0.90[311] |
0.83[312] |
47 |
GNG3 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-3 |
-1.63[313] |
0.41[314] |
-1.95[315] |
-1.40[316] |
-1.82[317] |
-0.73[318] |
48 |
FZD2 |
Frizzled-2 |
[319] |
0.38[320] |
-1.04[321] |
1.55[322] |
6.19[323] |
3.54[324] |
-1.01[325] |
49 |
GNAT2 |
Guanine nucleotide-binding protein G(t) subunit alpha-2 |
[326] |
-3.07[327] |
-1.72[328] |
-1.07[329] |
-1.66[330] |
-1.74[331] |
0.49[332] |
50 |
GNB3 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
[333] |
0.82[334] |
3.27[335] |
2.44[336] |
0.31[337] |
2.92[338] |
-2.33[339] |
51 |
LEF1 |
Lymphoid enhancer-binding factor 1 |
[340] |
1.88[341] |
-4.85[342] |
2.94[343] |
0.38[344] |
-1.43[345] |
0.44[346] |
52 |
PRKG1 |
cGMP-dependent protein kinase 1 |
[347] |
-0.93[348] |
[349] |
0.52[350] |
2.48[351] |
4.28[352] |
5.86[353] |
53 |
PDE6G |
Retinal rod rhodopsin-sensitive cGMP
3',5'-cyclic phosphodiesterase subunit gamma |
4.02[354] |
5.37[355] |
0.17[356] |
2.28[357] |
0.49[358] |
2.43[359] |
54 |
PRKG2 |
cGMP-dependent protein kinase 2 |
[360] |
2.13[361] |
[362] |
[363] |
6.09[364] |
0.28[365] |
1.39[366] |
55 |
AGO3 |
Protein argonaute-3 |
[367] |
[368] |
[369] |
[370] |
[371] |
[372] |
[373] |
56 |
AGO4 |
Protein argonaute-4 |
[374] |
[375] |
[376] |
[377] |
[378] |
[379] |
[380] |
57 |
GNG8 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-8 |
[381] |
[382] |
[383] |
[384] |
[385] |
[386] |
58 |
AGO1 |
Protein argonaute-1 |
[387] |
[388] |
[389] |
[390] |
[391] |
[392] |
[393] |
59 |
GNGT1 |
Guanine nucleotide-binding protein G(T) subunit gamma-T1 |
[394] |
[395] |
[396] |
[397] |
[398] |
[399] |
[400] |
60 |
GNG13 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-13 |
[401] |
[402] |
[403] |
[404] |
[405] |
[406] |
61 |
CAMK2A |
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
[407] |
[408] |
[409] |
[410] |
[411] |
[412] |
[413] |
62 |
AGO2 |
Protein argonaute-2 |
[414] |
[415] |
[416] |
[417] |
[418] |
[419] |
[420] |
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