REACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NFKBIA NF-kappa-B inhibitor alpha [1] -0.87[2] -2.50[3] -2.89[4] -3.14[5] -1.34[6] -0.90[7]
2 IKBKG NF-kappa-B essential modulator [8] -0.70[9] -0.40[10] -2.65[11] -0.47[12] -1.76[13] -0.36[14]
3 DHX9 ATP-dependent RNA helicase A [15] 1.53[16] 1.63[17] 1.45[18] 2.15[19] 1.78[20] 0.84[21]
4 NFKB2 Nuclear factor NF-kappa-B p100 subunit [22] -0.58[23] -0.12[24] 0.32[25] -1.00[26] -0.23[27] -2.78[28]
5 RELA Transcription factor p65 [29] 0.32[30] -0.03[31] 0.11[32] 0.33[33] 0.15[34] -0.64[35]
6 NFKBIB NF-kappa-B inhibitor beta [36] -0.97[37] -0.99[38] -0.67[39] -1.43[40] -1.17[41] -1.49[42]
7 MYD88 Myeloid differentiation primary response protein MyD88 [43] 0.00[44] 0.22[45] -0.36[46] -0.65[47] -0.44[48] 1.03[49]
8 IRF3 Interferon regulatory factor 3 [50] 0.49[51] 0.81[52] 1.54[53] 0.74[54] 0.25[55] -0.94[56]
9 NKIRAS2 NF-kappa-B inhibitor-interacting Ras-like protein 2 [57] 0.94[58] -0.15[59] 0.91[60] 0.96[61] 0.68[62] 0.44[63]
10 TBK1 Serine/threonine-protein kinase TBK1 [64] -0.45[65] 1.39[66] 0.53[67] 0.87[68] 0.88[69] 0.71[70]
11 NFKB1 Nuclear factor NF-kappa-B p105 subunit [71] 0.86[72] 0.69[73] 0.48[74] 0.14[75] 0.96[76] 0.69[77]
12 NKIRAS1 NF-kappa-B inhibitor-interacting Ras-like protein 1 [78] -1.18[79] -1.23[80] -0.02[81] -0.16[82] 0.04[83] 0.02[84]
13 TICAM1 TIR domain-containing adapter molecule 1 [85] -0.52[86] -1.47[87] -0.54[88] -0.84[89] 0.12[90] -0.26[91]
14 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [92] 0.48[93] 0.79[94] 0.47[95] 1.46[96] 0.90[97] 1.72[98]
15 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [99] 1.09[100] 2.47[101] 2.42[102] 1.03[103] 1.76[104] 1.75[105]
16 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [106] 0.71[107] 0.92[108] 1.03[109] 0.64[110] 0.65[111] 1.42[112]
17 DTX4 E3 ubiquitin-protein ligase DTX4 [113] 1.08[114] 1.25[115] 2.47[116] 1.16[117] -2.39[118] 2.63[119]
18 TLR3 Toll-like receptor 3 [120] -3.65[121] -3.96[122] -4.29[123] 0.02[124] 1.02[125] 1.29[126]
19 RIPK3 Receptor-interacting serine/threonine-protein kinase 3 [127] -6.46[128] [129] -4.98[130] [131] -5.08[132] 0.79[133]
20 ZBP1 Z-DNA-binding protein 1 [134] -4.11[135] -3.15[136] -4.07[137] -2.32[138] -2.67[139] -0.26[140]
21 NLRP4 NACHT, LRR and PYD domains-containing protein 4 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte NFKBIA
Mean 84.3
Standard deviation 48
Values 83 48 1.6e+02 90 40
[2]
HepG2 NFKBIA
Mean 89.6
Standard deviation 1.2
Values 89 90
[3]
HepG2.C3A NFKBIA
Mean 23
Standard deviation 1.2
Values 24 22
[4]
HuH.7 NFKBIA
Mean 17
Standard deviation 7.2
Values 11 25 15
[5]
SNU475 NFKBIA
Mean 13.5
Standard deviation 0.67
Values 13 14
[6]
THLE NFKBIA
Mean 55.8
Standard deviation 6.4
Values 51 60
[7]
liver NFKBIA
Mean 54.5
Standard deviation 46
Values 1.2e+02 19 55 24
[8]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[9]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[10]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[11]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[12]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[13]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[14]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[15]
ref_hepatocyte DHX9
Mean 18.8
Standard deviation 11
Values 31 30 12 12 9.4
[16]
HepG2 DHX9
Mean 105
Standard deviation 32
Values 82 1.3e+02
[17]
HepG2.C3A DHX9
Mean 89.7
Standard deviation 25
Values 72 1.1e+02
[18]
HuH.7 DHX9
Mean 76.1
Standard deviation 20
Values 90 53 86
[19]
SNU475 DHX9
Mean 117
Standard deviation 35
Values 93 1.4e+02
[20]
THLE DHX9
Mean 108
Standard deviation 20
Values 93 1.2e+02
[21]
liver DHX9
Mean 40.4
Standard deviation 18
Values 23 62 29 48
[22]
ref_hepatocyte NFKB2
Mean 16.8
Standard deviation 20
Values 3.6 24 49 4.1 3
[23]
HepG2 NFKB2
Mean 21.8
Standard deviation 8.1
Values 28 16
[24]
HepG2.C3A NFKB2
Mean 23.9
Standard deviation 12
Values 32 16
[25]
HuH.7 NFKB2
Mean 31.3
Standard deviation 3.8
Values 29 36 29
[26]
SNU475 NFKB2
Mean 11.9
Standard deviation 3
Values 9.7 14
[27]
THLE NFKB2
Mean 24
Standard deviation 2.2
Values 22 26
[28]
liver NFKB2
Mean 2.95
Standard deviation 1.2
Values 2.1 3.3 1.8 4.5
[29]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 9.8 12 35 15 8.1
[30]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 42 35
[31]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 29 20
[32]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 29 25 23
[33]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[34]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[35]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 19 4.1 20 5.7
[36]
ref_hepatocyte NFKBIB
Mean 13.2
Standard deviation 9.2
Values 3.7 6.2 27 17 12
[37]
HepG2 NFKBIB
Mean 13
Standard deviation 3.4
Values 15 11
[38]
HepG2.C3A NFKBIB
Mean 10.3
Standard deviation 1.5
Values 11 9.2
[39]
HuH.7 NFKBIB
Mean 12.4
Standard deviation 1.7
Values 11 12 14
[40]
SNU475 NFKBIB
Mean 6.88
Standard deviation 1.6
Values 5.7 8
[41]
THLE NFKBIB
Mean 9.79
Standard deviation 0.9
Values 9.1 10
[42]
liver NFKBIB
Mean 5.65
Standard deviation 1
Values 6.1 4.3 5.5 6.8
[43]
ref_hepatocyte MYD88
Mean 12.3
Standard deviation 6.2
Values 5.4 6 14 19 17
[44]
HepG2 MYD88
Mean 23.8
Standard deviation 12
Values 16 32
[45]
HepG2.C3A MYD88
Mean 22.1
Standard deviation 5.1
Values 18 26
[46]
HuH.7 MYD88
Mean 14.3
Standard deviation 1.1
Values 15 13 15
[47]
SNU475 MYD88
Mean 11
Standard deviation 1.1
Values 12 10
[48]
THLE MYD88
Mean 15.1
Standard deviation 1.7
Values 14 16
[49]
liver MYD88
Mean 30.3
Standard deviation 21
Values 47 9.8 51 14
[50]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[51]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[52]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[53]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[54]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[55]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[56]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[57]
ref_hepatocyte NKIRAS2
Mean 7.22
Standard deviation 5.2
Values 4.7 3.4 16 7.2 4.6
[58]
HepG2 NKIRAS2
Mean 26.9
Standard deviation 4.4
Values 30 24
[59]
HepG2.C3A NKIRAS2
Mean 10
Standard deviation 1.8
Values 11 8.8
[60]
HuH.7 NKIRAS2
Mean 20.2
Standard deviation 2.6
Values 22 17 21
[61]
SNU475 NKIRAS2
Mean 19.8
Standard deviation 1.9
Values 21 18
[62]
THLE NKIRAS2
Mean 19.3
Standard deviation 1.3
Values 18 20
[63]
liver NKIRAS2
Mean 11.8
Standard deviation 7.8
Values 19 4.9 18 5.2
[64]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[65]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[66]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[67]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[68]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[69]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[70]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[71]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 3 6.7 12 5.3 4.7
[72]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 18 26
[73]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 15 17
[74]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 14 12 13
[75]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 9.6 10
[76]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[77]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 9.7 15 7.2 17
[78]
ref_hepatocyte NKIRAS1
Mean 5.36
Standard deviation 2.8
Values 3.2 10 4.7 5.4 3.4
[79]
HepG2 NKIRAS1
Mean 4.58
Standard deviation 0.0091
Values 4.6 4.6
[80]
HepG2.C3A NKIRAS1
Mean 3.54
Standard deviation 0.22
Values 3.4 3.7
[81]
HuH.7 NKIRAS1
Mean 7.9
Standard deviation 2.6
Values 6.2 11 6.6
[82]
SNU475 NKIRAS1
Mean 6.75
Standard deviation 0.8
Values 6.2 7.3
[83]
THLE NKIRAS1
Mean 9.2
Standard deviation 0.3
Values 9 9.4
[84]
liver NKIRAS1
Mean 6.52
Standard deviation 2.2
Values 9.3 4.4 7.1 5.3
[85]
ref_hepatocyte TICAM1
Mean 4.75
Standard deviation 6.4
Values 0 1.4 16 3.4 3
[86]
HepG2 TICAM1
Mean 6.41
Standard deviation 2.9
Values 8.5 4.3
[87]
HepG2.C3A TICAM1
Mean 2.66
Standard deviation 0.59
Values 3.1 2.2
[88]
HuH.7 TICAM1
Mean 4.87
Standard deviation 0.33
Values 5.2 4.5 4.9
[89]
SNU475 TICAM1
Mean 3.73
Standard deviation 0.28
Values 3.5 3.9
[90]
THLE TICAM1
Mean 8.64
Standard deviation 1.3
Values 7.7 9.5
[91]
liver TICAM1
Mean 4.77
Standard deviation 3.4
Values 7.9 1.4 7.4 2.3
[92]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[93]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[94]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[95]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[96]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[97]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[98]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[99]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[100]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[101]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[102]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[103]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[104]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[105]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[106]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 2.9 4.3 4.2 3.5 2.5
[107]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[108]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 11 9.5
[109]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 11 8.4 12
[110]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 8.9 6.4
[111]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[112]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 11 11 11 12
[113]
ref_hepatocyte DTX4
Mean 2.52
Standard deviation 1.8
Values 0.67 1.7 1.6 4.9 3.8
[114]
HepG2 DTX4
Mean 10.3
Standard deviation 1.7
Values 9.1 12
[115]
HepG2.C3A DTX4
Mean 9.29
Standard deviation 0.13
Values 9.2 9.4
[116]
HuH.7 DTX4
Mean 20.7
Standard deviation 3.3
Values 23 22 17
[117]
SNU475 DTX4
Mean 7.93
Standard deviation 2.6
Values 9.8 6.1
[118]
THLE DTX4
Mean 0.804
Standard deviation 0.22
Values 0.64 0.96
[119]
liver DTX4
Mean 18.7
Standard deviation 4.9
Values 17 25 14 19
[120]
ref_hepatocyte TLR3
Mean 1.04
Standard deviation 0.74
Values 0 2 0.89 0.97 1.3
[121]
HepG2 TLR3
Mean 0.16
Standard deviation 0.0012
Values 0.16 0.16
[122]
HepG2.C3A TLR3
Mean 0.103
Standard deviation 0.036
Values 0.078 0.13
[123]
HuH.7 TLR3
Mean 0.0792
Standard deviation 0.093
Values 0.033 0.19 0.019
[124]
SNU475 TLR3
Mean 1.48
Standard deviation 0.068
Values 1.5 1.4
[125]
THLE TLR3
Mean 3.51
Standard deviation 0.81
Values 4.1 2.9
[126]
liver TLR3
Mean 3.05
Standard deviation 0.49
Values 2.5 3.4 2.8 3.5
[127]
ref_hepatocyte RIPK3
Mean 0.227
Standard deviation 0.15
Values 0 0.37 0.33 0.15 0.29
[128]
HepG2 RIPK3
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[129]
HepG2.C3A RIPK3
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 RIPK3
Mean 0.0107
Standard deviation 0.019
Values 0 0.032 0
[131]
SNU475 RIPK3
Mean 0
Standard deviation 0
Values 0 0
[132]
THLE RIPK3
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[133]
liver RIPK3
Mean 0.474
Standard deviation 0.21
Values 0.78 0.43 0.36 0.33
[134]
ref_hepatocyte ZBP1
Mean 0.153
Standard deviation 0.17
Values 0.13 0.065 0 0.12 0.45
[135]
HepG2 ZBP1
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[136]
HepG2.C3A ZBP1
Mean 0.0268
Standard deviation 0.038
Values 0 0.054
[137]
HuH.7 ZBP1
Mean 0.0137
Standard deviation 0.014
Values 0 0.013 0.028
[138]
SNU475 ZBP1
Mean 0.0432
Standard deviation 0.011
Values 0.051 0.035
[139]
THLE ZBP1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[140]
liver ZBP1
Mean 0.154
Standard deviation 0.026
Values 0.12 0.17 0.15 0.17
[141]
ref_hepatocyte NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 NLRP4
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A NLRP4
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 NLRP4
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[145]
SNU475 NLRP4
Mean 0.0327
Standard deviation 0.04
Values 0.0046 0.061
[146]
THLE NLRP4
Mean 0
Standard deviation 0
Values 0 0
[147]
liver NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0