REACTOME_XENOBIOTICS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -8.09[2] -9.02[3] -5.71[4] -9.77[5] -8.41[6] -0.62[7]
2 CYP2C8 Cytochrome P450 2C8 [8] -10.08[9] -6.13[10] -3.88[11] -6.85[12] [13] 0.30[14]
3 CYP2C9 Cytochrome P450 2C9 [15] [16] -11.05[17] -4.09[18] -9.54[19] -8.93[20] 0.81[21]
4 CYP3A4 Cytochrome P450 3A4 [22] -5.34[23] -6.25[24] -7.90[25] -9.86[26] -8.51[27] 0.52[28]
5 CYP2A6 Cytochrome P450 2A6 [29] -11.45[30] [31] -4.34[32] -6.61[33] -9.24[34] -1.83[35]
6 CYP3A5 Cytochrome P450 3A5 [36] -0.40[37] 1.04[38] -1.66[39] -2.43[40] -4.84[41] 0.88[42]
7 CYP1A2 Cytochrome P450 1A2 [43] -4.51[44] -4.00[45] -4.60[46] -3.42[47] -4.04[48] -1.86[49]
8 CYP2B6 Cytochrome P450 2B6 [50] -3.23[51] -0.59[52] 0.84[53] -4.41[54] -5.61[55] 2.19[56]
9 CYP1A1 Cytochrome P450 1A1 [57] 1.94[58] -0.43[59] 3.29[60] 1.17[61] 0.43[62] -6.01[63]
10 CYP2C18 Cytochrome P450 2C18 [64] -5.06[65] -7.32[66] -1.42[67] -6.69[68] -4.95[69] -0.67[70]
11 CYP2D6 Cytochrome P450 2D6 [71] -1.49[72] 0.20[73] -2.27[74] -2.92[75] -3.64[76] 1.01[77]
12 CYP3A7 Cytochrome P450 3A7 [78] -0.52[79] 0.96[80] -3.71[81] [82] -6.31[83] -1.88[84]
13 CYP2J2 Cytochrome P450 2J2 [85] 1.00[86] 0.22[87] 3.39[88] -1.52[89] -0.25[90] 0.06[91]
14 CYP2C19 Cytochrome P450 2C19 [92] [93] [94] -1.24[95] -7.23[96] -7.24[97] 1.36[98]
15 CYP2A7 Cytochrome P450 2A7 [99] [100] [101] 0.25[102] -5.22[103] [104] -1.98[105]
16 ARNT Aryl hydrocarbon receptor nuclear translocator [106] 6.82[107] 5.83[108] 6.76[109] 8.03[110] 7.60[111] 1.32[112]
17 AHR Aryl hydrocarbon receptor [113] 7.53[114] 7.04[115] 8.12[116] 7.20[117] 7.92[118] 2.38[119]
18 CYP3A43 Cytochrome P450 3A43 [120] 1.55[121] 3.66[122] 3.53[123] [124] -3.68[125] 1.17[126]
19 CYP2W1 Cytochrome P450 2W1 [127] 10.10[128] 11.23[129] 5.20[130] 3.23[131] 2.62[132] -4.23[133]
20 CYP2S1 Cytochrome P450 2S1 [134] 9.32[135] 7.40[136] 6.64[137] 7.84[138] 7.73[139] -0.86[140]
21 AHRR Aryl hydrocarbon receptor repressor [141] 7.79[142] 6.13[143] 6.49[144] 11.45[145] 9.64[146] 0.52[147]
22 CYP2A13 Cytochrome P450 2A13 [148] [149] [150] [151] [152] [153] -0.73[154]
23 CYP2F1 Cytochrome P450 2F1 [155] 5.63[156] 3.23[157] 7.59[158] 8.09[159] 6.80[160] 0.76[161]
24 ARNT2 Aryl hydrocarbon receptor nuclear translocator 2 [162] 11.79[163] 3.00[164] 4.39[165] 13.08[166] 14.65[167] 4.73[168]
25 PDCD6-AHRR [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 0 4.6 90 2.7e+03 4.1e+03
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.21 0.06
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0.21 0
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.67 1.3 0.99
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.032 0.025
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 2.6e+03 1e+03 1.7e+03 6.9e+02
[8]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 0 1.2 19 7.1e+02 9.1e+02
[9]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[10]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.14 0.24
[11]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.16 2 0.3
[12]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.037 0.066
[13]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[14]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 6.8e+02 6.2e+02 1.2e+03 2e+02
[15]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 0.064 20 21 4.7e+02 9.2e+02
[16]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[17]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[18]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[19]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[20]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[21]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 8.6e+02 6.1e+02 1.5e+03 2.9e+02
[22]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 11 3.2e+02 9.6e+02
[23]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[24]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[25]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[26]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[27]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[28]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 4.3e+02 6.4e+02 1.3e+03 49
[29]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 0 4.6 38 5.6e+02 5.5e+02
[30]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[31]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[32]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.11 1 0.12
[33]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.06 0.025
[34]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[35]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 29 1.8e+02 2.1e+02 13
[36]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 22 55 35 2e+02 3.9e+02
[37]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 1.3 4.2
[38]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 14 8.7
[39]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.58 3.5 0.83
[40]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.56 0.39
[41]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[42]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 9e+02 2.7e+02 2.5e+02 2.8e+02
[43]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 0.97 71 3e+02
[44]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[45]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[46]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[47]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[48]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[49]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 55 12 58 19
[50]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 0 4.1 12 1.3e+02 1e+02
[51]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.24 0.034
[52]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 1.7 0.92
[53]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 2.1 5.9 1.9
[54]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.014 0.071
[55]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[56]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 23 3.2e+02 1.1e+03 7.4
[57]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 77 43 0.06 17 82
[58]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 6.2 2.6
[59]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.4 1.2
[60]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 14 17 17
[61]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 0.49 3.1
[62]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[63]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 1.2 0.47 0.92 1.8
[64]
ref_hepatocyte CYP2C18
Mean 43
Standard deviation 35
Values 0 90 18 51 56
[65]
HepG2 CYP2C18
Mean 0.0336
Standard deviation 0.017
Values 0.046 0.021
[66]
HepG2.C3A CYP2C18
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[67]
HuH.7 CYP2C18
Mean 0.593
Standard deviation 0.1
Values 0.53 0.71 0.53
[68]
SNU475 CYP2C18
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[69]
THLE CYP2C18
Mean 0.0325
Standard deviation 0.029
Values 0.012 0.053
[70]
liver CYP2C18
Mean 44.5
Standard deviation 13
Values 36 57 54 31
[71]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 0.24 0.47 3.7 1.1e+02 87
[72]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.36 0.4
[73]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 2.6 1.2
[74]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.23 0.4 0.31
[75]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.1 0.096
[76]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[77]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 3.1e+02 53 1.3e+02 57
[78]
ref_hepatocyte CYP3A7
Mean 29.1
Standard deviation 41
Values 8.7 0.12 5 1e+02 32
[79]
HepG2 CYP3A7
Mean 0.531
Standard deviation 0.38
Values 0.26 0.8
[80]
HepG2.C3A CYP3A7
Mean 2.26
Standard deviation 0.013
Values 2.3 2.3
[81]
HuH.7 CYP3A7
Mean 0.0822
Standard deviation 0.074
Values 0.033 0.17 0.047
[82]
SNU475 CYP3A7
Mean 0
Standard deviation 0
Values 0 0
[83]
THLE CYP3A7
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[84]
liver CYP3A7
Mean 13
Standard deviation 12
Values 30 5.2 11 5.1
[85]
ref_hepatocyte CYP2J2
Mean 23.2
Standard deviation 23
Values 1.9 9.2 9.9 44 51
[86]
HepG2 CYP2J2
Mean 1.21
Standard deviation 0.23
Values 1.4 1
[87]
HepG2.C3A CYP2J2
Mean 1.08
Standard deviation 0.51
Values 1.4 0.72
[88]
HuH.7 CYP2J2
Mean 8.98
Standard deviation 0.32
Values 8.6 9 9.3
[89]
SNU475 CYP2J2
Mean 0.147
Standard deviation 0.13
Values 0.056 0.24
[90]
THLE CYP2J2
Mean 0.454
Standard deviation 0.094
Values 0.52 0.39
[91]
liver CYP2J2
Mean 39.7
Standard deviation 21
Values 66 21 48 24
[92]
ref_hepatocyte CYP2C19
Mean 19.2
Standard deviation 30
Values 0 5.9 0 18 72
[93]
HepG2 CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 CYP2C19
Mean 0.3
Standard deviation 0.27
Values 0.098 0.6 0.2
[96]
SNU475 CYP2C19
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[97]
THLE CYP2C19
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[98]
liver CYP2C19
Mean 81.4
Standard deviation 39
Values 65 92 1.3e+02 38
[99]
ref_hepatocyte CYP2A7
Mean 15.1
Standard deviation 22
Values 0 0.06 11 52 12
[100]
HepG2 CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 CYP2A7
Mean 0.663
Standard deviation 0.76
Values 0.16 1.5 0.3
[103]
SNU475 CYP2A7
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[104]
THLE CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[105]
liver CYP2A7
Mean 6.31
Standard deviation 5.5
Values 2 13 9 1.4
[106]
ref_hepatocyte ARNT
Mean 5.93
Standard deviation 1.4
Values 7.7 6.5 4.1 4.8 6.5
[107]
HepG2 ARNT
Mean 17.5
Standard deviation 1.2
Values 17 18
[108]
HepG2.C3A ARNT
Mean 13.5
Standard deviation 3
Values 16 11
[109]
HuH.7 ARNT
Mean 23.6
Standard deviation 6.3
Values 22 31 19
[110]
SNU475 ARNT
Mean 28.1
Standard deviation 0.55
Values 28 28
[111]
THLE ARNT
Mean 26.8
Standard deviation 1.6
Values 26 28
[112]
liver ARNT
Mean 24.4
Standard deviation 4.2
Values 29 19 26 23
[113]
ref_hepatocyte AHR
Mean 4.68
Standard deviation 3.7
Values 1.7 5.3 2.7 2.8 11
[114]
HepG2 AHR
Mean 22.5
Standard deviation 5.4
Values 19 26
[115]
HepG2.C3A AHR
Mean 24.6
Standard deviation 3.3
Values 27 22
[116]
HuH.7 AHR
Mean 47.9
Standard deviation 14
Values 46 63 34
[117]
SNU475 AHR
Mean 12.5
Standard deviation 1.6
Values 11 14
[118]
THLE AHR
Mean 26.4
Standard deviation 1.2
Values 26 27
[119]
liver AHR
Mean 40.1
Standard deviation 20
Values 28 58 19 55
[120]
ref_hepatocyte CYP3A43
Mean 1.46
Standard deviation 2.7
Values 0.059 0 0 1.1 6.1
[121]
HepG2 CYP3A43
Mean 0.112
Standard deviation 0.061
Values 0.069 0.15
[122]
HepG2.C3A CYP3A43
Mean 0.735
Standard deviation 0.42
Values 1 0.44
[123]
HuH.7 CYP3A43
Mean 0.622
Standard deviation 0.91
Values 0.057 1.7 0.14
[124]
SNU475 CYP3A43
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE CYP3A43
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[126]
liver CYP3A43
Mean 5.41
Standard deviation 4.2
Values 12 2.9 3.4 3.6
[127]
ref_hepatocyte CYP2W1
Mean 0.591
Standard deviation 1.2
Values 2.8 0 0 0.16 0
[128]
HepG2 CYP2W1
Mean 16.9
Standard deviation 4.5
Values 14 20
[129]
HepG2.C3A CYP2W1
Mean 56.5
Standard deviation 39
Values 84 29
[130]
HuH.7 CYP2W1
Mean 0.798
Standard deviation 0.23
Values 0.68 1.1 0.65
[131]
SNU475 CYP2W1
Mean 0.101
Standard deviation 0.028
Values 0.12 0.081
[132]
THLE CYP2W1
Mean 0.0849
Standard deviation 0.022
Values 0.1 0.069
[133]
liver CYP2W1
Mean 0.0517
Standard deviation 0.06
Values 0 0.11 0 0.093
[134]
ref_hepatocyte CYP2S1
Mean 0.536
Standard deviation 0.51
Values 0.27 0.31 1.4 0.1 0.61
[135]
HepG2 CYP2S1
Mean 8.91
Standard deviation 2.7
Values 11 7
[136]
HepG2.C3A CYP2S1
Mean 3.61
Standard deviation 0.85
Values 4.2 3
[137]
HuH.7 CYP2S1
Mean 1.97
Standard deviation 1.2
Values 3 0.73 2.2
[138]
SNU475 CYP2S1
Mean 2.23
Standard deviation 1.5
Values 1.2 3.3
[139]
THLE CYP2S1
Mean 2.64
Standard deviation 0.9
Values 2 3.3
[140]
liver CYP2S1
Mean 0.486
Standard deviation 0.16
Values 0.38 0.4 0.72 0.45
[141]
ref_hepatocyte AHRR
Mean 0.118
Standard deviation 0.18
Values 0.44 0.06 0 0.026 0.065
[142]
HepG2 AHRR
Mean 0.681
Standard deviation 0.23
Values 0.84 0.52
[143]
HepG2.C3A AHRR
Mean 0.329
Standard deviation 0.22
Values 0.49 0.17
[144]
HuH.7 AHRR
Mean 0.388
Standard deviation 0.1
Values 0.3 0.37 0.5
[145]
SNU475 AHRR
Mean 5.99
Standard deviation 1.7
Values 7.2 4.8
[146]
THLE AHRR
Mean 2.19
Standard deviation 0.32
Values 2.4 2
[147]
liver AHRR
Mean 0.277
Standard deviation 0.057
Values 0.33 0.26 0.21 0.32
[148]
ref_hepatocyte CYP2A13
Mean 0.0683
Standard deviation 0.12
Values 0 0 0 0.28 0.057
[149]
HepG2 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 CYP2A13
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[154]
liver CYP2A13
Mean 0.0677
Standard deviation 0.059
Values 0 0.13 0.1 0.04
[155]
ref_hepatocyte CYP2F1
Mean 0.026
Standard deviation 0.058
Values 0 0 0 0 0.13
[156]
HepG2 CYP2F1
Mean 0.0336
Standard deviation 0.007
Values 0.029 0.039
[157]
HepG2.C3A CYP2F1
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[158]
HuH.7 CYP2F1
Mean 0.185
Standard deviation 0.058
Values 0.16 0.25 0.14
[159]
SNU475 CYP2F1
Mean 0.129
Standard deviation 0.047
Values 0.16 0.096
[160]
THLE CYP2F1
Mean 0.0674
Standard deviation 0.0051
Values 0.071 0.064
[161]
liver CYP2F1
Mean 0.0726
Standard deviation 0.035
Values 0.024 0.071 0.1 0.093
[162]
ref_hepatocyte ARNT2
Mean 0.0152
Standard deviation 0.021
Values 0.035 0 0 0 0.041
[163]
HepG2 ARNT2
Mean 1.4
Standard deviation 0.00016
Values 1.4 1.4
[164]
HepG2.C3A ARNT2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[165]
HuH.7 ARNT2
Mean 0.0117
Standard deviation 0.01
Values 0.016 0 0.019
[166]
SNU475 ARNT2
Mean 2.4
Standard deviation 1.8
Values 3.7 1.1
[167]
THLE ARNT2
Mean 9.12
Standard deviation 1.9
Values 7.8 10
[168]
liver ARNT2
Mean 0.665
Standard deviation 0.33
Values 0.38 0.67 0.49 1.1
[169]
ref_hepatocyte PDCD6-AHRR
Missing
[170]
HepG2 PDCD6-AHRR
Missing
[171]
HepG2.C3A PDCD6-AHRR
Missing
[172]
HuH.7 PDCD6-AHRR
Missing
[173]
SNU475 PDCD6-AHRR
Missing
[174]
THLE PDCD6-AHRR
Missing
[175]
liver PDCD6-AHRR
Missing