REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CLTA Clathrin light chain A [1] -1.79[2] -2.09[3] -2.64[4] -2.59[5] -2.41[6] -3.36[7]
2 AP2M1 AP-2 complex subunit mu [8] 0.30[9] -0.01[10] -1.18[11] 0.85[12] 1.17[13] -0.26[14]
3 AP2S1 AP-2 complex subunit sigma [15] -1.53[16] -1.67[17] -1.64[18] -0.87[19] -0.62[20] -1.12[21]
4 CLTC Clathrin heavy chain 1 [22] 1.70[23] 1.68[24] 1.19[25] 1.55[26] 1.51[27] 2.36[28]
5 NR1H3 Oxysterols receptor LXR-alpha [29] -1.58[30] -0.68[31] -0.42[32] -2.86[33] -4.39[34] -0.40[35]
6 NR1H2 Oxysterols receptor LXR-beta [36] -0.60[37] -0.83[38] -1.13[39] -0.38[40] -0.21[41] -0.07[42]
7 AP2A1 AP-2 complex subunit alpha-1 [43] 1.29[44] 0.84[45] 1.01[46] 1.27[47] 1.16[48] 0.86[49]
8 PCSK9 Proprotein convertase subtilisin/kexin type 9 [50] -2.87[51] 2.10[52] 2.78[53] -6.11[54] -6.72[55] 1.17[56]
9 AP2B1 AP-2 complex subunit beta [57] 2.33[58] 1.93[59] 3.00[60] 2.42[61] 2.10[62] 0.84[63]
10 AP2A2 AP-2 complex subunit alpha-2 [64] 1.35[65] 1.07[66] 0.53[67] 0.72[68] 0.18[69] 0.58[70]
11 VLDLR Very low-density lipoprotein receptor [71] 1.68[72] 0.92[73] 0.66[74] 2.28[75] 0.09[76] -0.46[77]
12 MYLIP E3 ubiquitin-protein ligase MYLIP [78] 2.08[79] 1.70[80] 1.97[81] 1.92[82] 1.29[83] 1.93[84]
[1]
ref_hepatocyte CLTA
Mean 139
Standard deviation 77
Values 2e+02 2.3e+02 1.4e+02 74 53
[2]
HepG2 CLTA
Mean 83.5
Standard deviation 9.9
Values 91 77
[3]
HepG2.C3A CLTA
Mean 65.7
Standard deviation 0.97
Values 66 65
[4]
HuH.7 CLTA
Mean 68.1
Standard deviation 8
Values 60 68 76
[5]
SNU475 CLTA
Mean 46.3
Standard deviation 2.6
Values 48 45
[6]
THLE CLTA
Mean 67.1
Standard deviation 17
Values 55 79
[7]
liver CLTA
Mean 20.5
Standard deviation 13
Values 32 10 31 8.4
[8]
ref_hepatocyte AP2M1
Mean 41.6
Standard deviation 13
Values 28 39 35 63 44
[9]
HepG2 AP2M1
Mean 107
Standard deviation 14
Values 97 1.2e+02
[10]
HepG2.C3A AP2M1
Mean 83
Standard deviation 17
Values 71 95
[11]
HuH.7 AP2M1
Mean 56.4
Standard deviation 14
Values 67 40 62
[12]
SNU475 AP2M1
Mean 150
Standard deviation 32
Values 1.7e+02 1.3e+02
[13]
THLE AP2M1
Mean 241
Standard deviation 26
Values 2.2e+02 2.6e+02
[14]
liver AP2M1
Mean 52.8
Standard deviation 26
Values 55 35 89 32
[15]
ref_hepatocyte AP2S1
Mean 38.3
Standard deviation 23
Values 13 36 20 57 66
[16]
HepG2 AP2S1
Mean 27.5
Standard deviation 0.19
Values 28 27
[17]
HepG2.C3A AP2S1
Mean 24.1
Standard deviation 3.4
Values 22 27
[18]
HuH.7 AP2S1
Mean 37.6
Standard deviation 15
Values 43 21 49
[19]
SNU475 AP2S1
Mean 42
Standard deviation 3.1
Values 44 40
[20]
THLE AP2S1
Mean 63.5
Standard deviation 6.7
Values 59 68
[21]
liver AP2S1
Mean 26.7
Standard deviation 27
Values 53 3.8 46 3.4
[22]
ref_hepatocyte CLTC
Mean 30
Standard deviation 17
Values 53 42 13 19 24
[23]
HepG2 CLTC
Mean 203
Standard deviation 93
Values 1.4e+02 2.7e+02
[24]
HepG2.C3A CLTC
Mean 193
Standard deviation 28
Values 1.7e+02 2.1e+02
[25]
HuH.7 CLTC
Mean 209
Standard deviation 37
Values 2.5e+02 2.1e+02 1.7e+02
[26]
SNU475 CLTC
Mean 176
Standard deviation 18
Values 1.9e+02 1.6e+02
[27]
THLE CLTC
Mean 218
Standard deviation 18
Values 2.1e+02 2.3e+02
[28]
liver CLTC
Mean 234
Standard deviation 1.1e+02
Values 1.2e+02 3.7e+02 1.8e+02 2.7e+02
[29]
ref_hepatocyte NR1H3
Mean 14.8
Standard deviation 10
Values 6.4 9.6 6.4 22 29
[30]
HepG2 NR1H3
Mean 10.3
Standard deviation 0.1
Values 10 10
[31]
HepG2.C3A NR1H3
Mean 18.6
Standard deviation 4.7
Values 22 15
[32]
HuH.7 NR1H3
Mean 33.8
Standard deviation 2.7
Values 31 36 35
[33]
SNU475 NR1H3
Mean 4.08
Standard deviation 1.1
Values 3.3 4.8
[34]
THLE NR1H3
Mean 1.8
Standard deviation 0.21
Values 1.7 1.9
[35]
liver NR1H3
Mean 16.9
Standard deviation 7.5
Values 25 12 21 9.7
[36]
ref_hepatocyte NR1H2
Mean 12.9
Standard deviation 7.5
Values 2.8 8 19 20 14
[37]
HepG2 NR1H2
Mean 17.7
Standard deviation 3.5
Values 20 15
[38]
HepG2.C3A NR1H2
Mean 14.5
Standard deviation 1.7
Values 16 13
[39]
HuH.7 NR1H2
Mean 17.9
Standard deviation 2.7
Values 19 15 20
[40]
SNU475 NR1H2
Mean 19.9
Standard deviation 0.35
Values 20 20
[41]
THLE NR1H2
Mean 28.5
Standard deviation 1.7
Values 27 30
[42]
liver NR1H2
Mean 18.5
Standard deviation 8.5
Values 27 11 25 11
[43]
ref_hepatocyte AP2A1
Mean 10.6
Standard deviation 3.7
Values 6.9 8.6 9.7 17 11
[44]
HepG2 AP2A1
Mean 54
Standard deviation 4.5
Values 57 51
[45]
HepG2.C3A AP2A1
Mean 38.1
Standard deviation 9.3
Values 45 32
[46]
HuH.7 AP2A1
Mean 65.1
Standard deviation 18
Values 85 50 60
[47]
SNU475 AP2A1
Mean 51.3
Standard deviation 9.3
Values 58 45
[48]
THLE AP2A1
Mean 60.6
Standard deviation 7.6
Values 55 66
[49]
liver AP2A1
Mean 29.1
Standard deviation 3.1
Values 28 27 27 34
[50]
ref_hepatocyte PCSK9
Mean 9.97
Standard deviation 5.7
Values 5.6 3.3 9.8 16 15
[51]
HepG2 PCSK9
Mean 2.85
Standard deviation 1.6
Values 1.7 4
[52]
HepG2.C3A PCSK9
Mean 86.2
Standard deviation 65
Values 1.3e+02 40
[53]
HuH.7 PCSK9
Mean 210
Standard deviation 31
Values 1.8e+02 2.4e+02 2e+02
[54]
SNU475 PCSK9
Mean 0.289
Standard deviation 0.022
Values 0.27 0.3
[55]
THLE PCSK9
Mean 0.242
Standard deviation 0.1
Values 0.31 0.17
[56]
liver PCSK9
Mean 34
Standard deviation 15
Values 18 39 27 52
[57]
ref_hepatocyte AP2B1
Mean 9
Standard deviation 4.1
Values 11 15 5.6 5.9 7.2
[58]
HepG2 AP2B1
Mean 93.9
Standard deviation 10
Values 87 1e+02
[59]
HepG2.C3A AP2B1
Mean 69.3
Standard deviation 14
Values 79 59
[60]
HuH.7 AP2B1
Mean 220
Standard deviation 43
Values 2.7e+02 2e+02 1.9e+02
[61]
SNU475 AP2B1
Mean 96.9
Standard deviation 32
Values 1.2e+02 74
[62]
THLE AP2B1
Mean 98.4
Standard deviation 18
Values 86 1.1e+02
[63]
liver AP2B1
Mean 24.4
Standard deviation 6.6
Values 18 34 23 23
[64]
ref_hepatocyte AP2A2
Mean 8.24
Standard deviation 1.1
Values 7.8 6.8 8.3 9.9 8.3
[65]
HepG2 AP2A2
Mean 43.6
Standard deviation 9.6
Values 50 37
[66]
HepG2.C3A AP2A2
Mean 34.8
Standard deviation 12
Values 43 26
[67]
HuH.7 AP2A2
Mean 36.5
Standard deviation 2.7
Values 39 36 34
[68]
SNU475 AP2A2
Mean 27.1
Standard deviation 8.1
Values 33 21
[69]
THLE AP2A2
Mean 23.9
Standard deviation 4.3
Values 21 27
[70]
liver AP2A2
Mean 18.6
Standard deviation 3.8
Values 21 19 13 22
[71]
ref_hepatocyte VLDLR
Mean 1.72
Standard deviation 1.4
Values 0.67 3.4 3 1 0.46
[72]
HepG2 VLDLR
Mean 11.5
Standard deviation 2.9
Values 14 9.4
[73]
HepG2.C3A VLDLR
Mean 6.53
Standard deviation 2.8
Values 8.5 4.6
[74]
HuH.7 VLDLR
Mean 8.31
Standard deviation 0.89
Values 8.6 9 7.3
[75]
SNU475 VLDLR
Mean 16.7
Standard deviation 9.1
Values 23 10
[76]
THLE VLDLR
Mean 4.7
Standard deviation 1.2
Values 5.6 3.8
[77]
liver VLDLR
Mean 1.9
Standard deviation 0.9
Values 0.78 3 1.9 1.9
[78]
ref_hepatocyte MYLIP
Mean 0.452
Standard deviation 0.49
Values 1.2 0.078 0 0.59 0.37
[79]
HepG2 MYLIP
Mean 3.97
Standard deviation 0.79
Values 4.5 3.4
[80]
HepG2.C3A MYLIP
Mean 2.96
Standard deviation 0.36
Values 3.2 2.7
[81]
HuH.7 MYLIP
Mean 5.4
Standard deviation 0.39
Values 5.3 5.8 5.1
[82]
SNU475 MYLIP
Mean 3.43
Standard deviation 0.94
Values 2.8 4.1
[83]
THLE MYLIP
Mean 2.83
Standard deviation 0.44
Values 3.1 2.5
[84]
liver MYLIP
Mean 2.62
Standard deviation 0.45
Values 2.8 2.8 2 2.9