REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GC Vitamin D-binding protein [1] -8.90[2] -7.97[3] -0.45[4] -8.20[5] -7.88[6] 0.02[7]
2 SUMO2 Small ubiquitin-related modifier 2 [8] 2.77[9] 3.83[10] 1.95[11] 3.39[12] 3.43[13] -1.14[14]
3 LGMN Legumain [15] 2.43[16] 2.48[17] 1.17[18] 3.96[19] 3.50[20] 0.66[21]
4 UBE2I SUMO-conjugating enzyme UBC9 [22] 4.03[23] 4.55[24] 3.02[25] 4.36[26] 4.98[27] -0.11[28]
5 PIAS4 E3 SUMO-protein ligase PIAS4 [29] 2.98[30] 3.35[31] 2.18[32] 3.50[33] 3.67[34] 0.02[35]
6 CYP2R1 Vitamin D 25-hydroxylase [36] -1.24[37] 1.40[38] 1.70[39] 2.71[40] 2.25[41] -0.44[42]
7 CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [43] 10.88[44] 6.87[45] -0.70[46] 8.14[47] 1.39[48] -6.66[49]
8 VDR Vitamin D3 receptor [50] 2.58[51] 3.85[52] 2.57[53] 6.37[54] 7.76[55] 0.91[56]
9 LRP2 Low-density lipoprotein receptor-related protein 2 [57] 5.05[58] 2.56[59] 9.33[60] 1.75[61] 1.54[62] 6.66[63]
10 CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [64] 5.42[65] 7.70[66] 5.17[67] 5.22[68] 6.01[69] 2.11[70]
11 CUBN Cubilin [71] 3.96[72] 6.32[73] 2.65[74] 9.33[75] 7.85[76] 5.15[77]
[1]
ref_hepatocyte GC
Mean 1.32e+03
Standard deviation 1.8e+03
Values 0.066 6.6 97 2.9e+03 3.6e+03
[2]
HepG2 GC
Mean 0.917
Standard deviation 0.12
Values 0.83 1
[3]
HepG2.C3A GC
Mean 0.862
Standard deviation 0.14
Values 0.96 0.76
[4]
HuH.7 GC
Mean 573
Standard deviation 3.1e+02
Values 3.6e+02 9.2e+02 4.4e+02
[5]
SNU475 GC
Mean 0.507
Standard deviation 0.13
Values 0.6 0.42
[6]
THLE GC
Mean 0.681
Standard deviation 0.23
Values 0.84 0.52
[7]
liver GC
Mean 1.41e+03
Standard deviation 6.2e+02
Values 2.2e+03 1.1e+03 1.5e+03 8.1e+02
[8]
ref_hepatocyte SUMO2
Mean 67.7
Standard deviation 34
Values 1.2e+02 53 37 48 76
[9]
HepG2 SUMO2
Mean 153
Standard deviation 10
Values 1.5e+02 1.6e+02
[10]
HepG2.C3A SUMO2
Mean 157
Standard deviation 23
Values 1.4e+02 1.7e+02
[11]
HuH.7 SUMO2
Mean 155
Standard deviation 18
Values 1.5e+02 1.4e+02 1.8e+02
[12]
SNU475 SUMO2
Mean 80
Standard deviation 11
Values 88 72
[13]
THLE SUMO2
Mean 88.4
Standard deviation 8.1
Values 83 94
[14]
liver SUMO2
Mean 32.2
Standard deviation 23
Values 57 15 46 11
[15]
ref_hepatocyte LGMN
Mean 19.2
Standard deviation 8
Values 11 12 20 28 26
[16]
HepG2 LGMN
Mean 34.2
Standard deviation 9.1
Values 41 28
[17]
HepG2.C3A LGMN
Mean 17.5
Standard deviation 4.3
Values 20 14
[18]
HuH.7 LGMN
Mean 25.6
Standard deviation 4
Values 23 24 30
[19]
SNU475 LGMN
Mean 33.5
Standard deviation 8.8
Values 27 40
[20]
THLE LGMN
Mean 26.2
Standard deviation 0.5
Values 27 26
[21]
liver LGMN
Mean 31.9
Standard deviation 13
Values 41 24 45 18
[22]
ref_hepatocyte UBE2I
Mean 10.7
Standard deviation 3.4
Values 12 8.6 16 9 7.8
[23]
HepG2 UBE2I
Mean 58
Standard deviation 6.1
Values 62 54
[24]
HepG2.C3A UBE2I
Mean 41.3
Standard deviation 6.2
Values 37 46
[25]
HuH.7 UBE2I
Mean 51.7
Standard deviation 14
Values 57 36 63
[26]
SNU475 UBE2I
Mean 24.7
Standard deviation 1.6
Values 26 24
[27]
THLE UBE2I
Mean 41
Standard deviation 5.6
Values 37 45
[28]
liver UBE2I
Mean 10.4
Standard deviation 6.3
Values 16 5.3 15 4.7
[29]
ref_hepatocyte PIAS4
Mean 3.53
Standard deviation 1
Values 4.5 2.7 3.6 4.6 2.3
[30]
HepG2 PIAS4
Mean 9.22
Standard deviation 1.8
Values 10 8
[31]
HepG2.C3A PIAS4
Mean 5.88
Standard deviation 0.98
Values 6.6 5.2
[32]
HuH.7 PIAS4
Mean 9.46
Standard deviation 0.82
Values 10 8.9 9.1
[33]
SNU475 PIAS4
Mean 4.49
Standard deviation 0.4
Values 4.2 4.8
[34]
THLE PIAS4
Mean 5.43
Standard deviation 0.61
Values 5 5.9
[35]
liver PIAS4
Mean 3.76
Standard deviation 0.52
Values 4.1 3.9 3 4.1
[36]
ref_hepatocyte CYP2R1
Mean 2.89
Standard deviation 1.8
Values 0 4.7 3.6 3.9 2.3
[37]
HepG2 CYP2R1
Mean 0.405
Standard deviation 0.2
Values 0.54 0.27
[38]
HepG2.C3A CYP2R1
Mean 1.25
Standard deviation 0.41
Values 1.5 0.95
[39]
HuH.7 CYP2R1
Mean 5.56
Standard deviation 0.93
Values 4.6 5.8 6.4
[40]
SNU475 CYP2R1
Mean 2.12
Standard deviation 0.069
Values 2.2 2.1
[41]
THLE CYP2R1
Mean 1.67
Standard deviation 0.39
Values 1.9 1.4
[42]
liver CYP2R1
Mean 2.24
Standard deviation 0.78
Values 3.4 1.6 2 2
[43]
ref_hepatocyte CYP24A1
Mean 0.344
Standard deviation 0.69
Values 1.6 0.15 0 0 0
[44]
HepG2 CYP24A1
Mean 215
Standard deviation 90
Values 2.8e+02 1.5e+02
[45]
HepG2.C3A CYP24A1
Mean 6.56
Standard deviation 2.9
Values 4.5 8.6
[46]
HuH.7 CYP24A1
Mean 0.126
Standard deviation 0.11
Values 0.11 0.24 0.019
[47]
SNU475 CYP24A1
Mean 10.9
Standard deviation 10
Values 3.8 18
[48]
THLE CYP24A1
Mean 0.109
Standard deviation 0.079
Values 0.053 0.16
[49]
liver CYP24A1
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[50]
ref_hepatocyte VDR
Mean 0.333
Standard deviation 0.23
Values 0.038 0.63 0.19 0.41 0.39
[51]
HepG2 VDR
Mean 0.657
Standard deviation 0.019
Values 0.67 0.64
[52]
HepG2.C3A VDR
Mean 0.783
Standard deviation 0.23
Values 0.62 0.94
[53]
HuH.7 VDR
Mean 1.17
Standard deviation 0.57
Values 1.7 0.56 1.3
[54]
SNU475 VDR
Mean 3.08
Standard deviation 3
Values 0.97 5.2
[55]
THLE VDR
Mean 8.71
Standard deviation 1.4
Values 7.8 9.7
[56]
liver VDR
Mean 0.658
Standard deviation 0.17
Values 0.63 0.56 0.9 0.54
[57]
ref_hepatocyte LRP2
Mean 0.0646
Standard deviation 0.098
Values 0 0 0 0.1 0.22
[58]
HepG2 LRP2
Mean 0.706
Standard deviation 0.72
Values 1.2 0.2
[59]
HepG2.C3A LRP2
Mean 0.0623
Standard deviation 0.033
Values 0.039 0.086
[60]
HuH.7 LRP2
Mean 24.6
Standard deviation 11
Values 37 21 16
[61]
SNU475 LRP2
Mean 0.0245
Standard deviation 0.0084
Values 0.019 0.03
[62]
THLE LRP2
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[63]
liver LRP2
Mean 6.84
Standard deviation 6.2
Values 1.3 12 1.6 13
[64]
ref_hepatocyte CYP27B1
Mean 0.0505
Standard deviation 0.082
Values 0 0 0.19 0 0.065
[65]
HepG2 CYP27B1
Mean 0.715
Standard deviation 0.14
Values 0.62 0.81
[66]
HepG2.C3A CYP27B1
Mean 1.72
Standard deviation 0.25
Values 1.9 1.5
[67]
HuH.7 CYP27B1
Mean 1.08
Standard deviation 0.18
Values 1.1 0.89 1.3
[68]
SNU475 CYP27B1
Mean 0.211
Standard deviation 0.1
Values 0.14 0.28
[69]
THLE CYP27B1
Mean 0.395
Standard deviation 0.14
Values 0.5 0.29
[70]
liver CYP27B1
Mean 0.228
Standard deviation 0.17
Values 0.071 0.14 0.46 0.24
[71]
ref_hepatocyte CUBN
Mean 0.0112
Standard deviation 0.0085
Values 0.021 0.018 0 0.0086 0.0081
[72]
HepG2 CUBN
Mean 0.058
Standard deviation 0.009
Values 0.052 0.064
[73]
HepG2.C3A CUBN
Mean 0.146
Standard deviation 0.055
Values 0.18 0.11
[74]
HuH.7 CUBN
Mean 0.0417
Standard deviation 0.0065
Values 0.049 0.039 0.037
[75]
SNU475 CUBN
Mean 0.813
Standard deviation 0.66
Values 0.34 1.3
[76]
THLE CUBN
Mean 0.313
Standard deviation 0.059
Values 0.35 0.27
[77]
liver CUBN
Mean 0.416
Standard deviation 0.32
Values 0.12 0.61 0.18 0.75