REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ECHS1 Enoyl-CoA hydratase, mitochondrial [1] -0.97[2] -0.85[3] -1.21[4] -2.03[5] -1.93[6] -0.62[7]
2 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial [8] -0.80[9] -1.36[10] -2.67[11] -0.92[12] -2.13[13] 0.15[14]
3 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 [15] -1.04[16] -1.74[17] -1.64[18] -0.58[19] 0.09[20] -1.41[21]
4 HIBADH 3-hydroxyisobutyrate dehydrogenase, mitochondrial [22] 0.61[23] -0.14[24] 0.22[25] 0.61[26] -0.64[27] -0.85[28]
5 ACADSB Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial -0.02[29] 2.06[30] 1.47[31] -1.54[32] -1.85[33] 1.62[34]
6 ALDH6A1 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial -2.25[35] -1.01[36] -1.33[37] -2.86[38] -2.70[39] 0.61[40]
7 DLD Dihydrolipoyl dehydrogenase, mitochondrial [41] 0.54[42] 0.81[43] 0.51[44] 1.71[45] 1.07[46] -0.35[47]
8 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [48] 1.82[49] 1.33[50] 1.42[51] 0.89[52] 0.91[53] 0.38[54]
9 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [55] -0.13[56] -0.24[57] 0.95[58] 0.08[59] 0.12[60] -0.03[61]
10 IVD Isovaleryl-CoA dehydrogenase, mitochondrial [62] 2.01[63] 1.71[64] -0.10[65] 1.42[66] 1.20[67] 1.36[68]
11 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [69] -0.54[70] 0.18[71] -0.91[72] -0.50[73] -0.80[74] -0.27[75]
12 MCCC1 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [76] 0.09[77] -0.32[78] 0.49[79] -0.44[80] -0.20[81] 0.08[82]
13 BCKDHB 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [83] -0.76[84] -0.62[85] 0.42[86] 0.26[87] -0.55[88] 0.49[89]
14 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.32[90] 1.31[91] 1.34[92] 1.11[93] 1.47[94] -0.08[95]
15 AUH Methylglutaconyl-CoA hydratase, mitochondrial [96] 0.11[97] 1.44[98] 0.41[99] -0.73[100] 0.34[101] -0.78[102]
16 SLC25A44 Solute carrier family 25 member 44 [103] 1.36[104] 0.51[105] 1.44[106] 2.46[107] 2.15[108] 0.30[109]
17 ACAD8 Isobutyryl-CoA dehydrogenase, mitochondrial [110] 0.96[111] 0.14[112] -0.33[113] 0.84[114] 0.93[115] 0.31[116]
18 BCAT2 Branched-chain-amino-acid aminotransferase, mitochondrial [117] -1.02[118] -0.49[119] 2.46[120] 2.90[121] 2.21[122] -0.20[123]
19 DBT Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial 2.20[124] 2.48[125] 3.83[126] 3.66[127] 3.25[128] 2.61[129]
20 PPM1K Protein phosphatase 1K, mitochondrial [130] 1.00[131] 2.45[132] 2.86[133] 2.86[134] 2.33[135] 0.91[136]
21 BCAT1 Branched-chain-amino-acid aminotransferase, cytosolic [137] 5.13[138] 4.45[139] 6.69[140] 6.20[141] 7.52[142] -0.39[143]
[1]
ref_hepatocyte ECHS1
Mean 234
Standard deviation 2.7e+02
Values 50 41 36 4.2e+02 6.2e+02
[2]
HepG2 ECHS1
Mean 82.5
Standard deviation 19
Values 69 96
[3]
HepG2.C3A ECHS1
Mean 108
Standard deviation 1.4
Values 1.1e+02 1.1e+02
[4]
HuH.7 ECHS1
Mean 88.7
Standard deviation 28
Values 93 59 1.1e+02
[5]
SNU475 ECHS1
Mean 26.6
Standard deviation 2.9
Values 29 25
[6]
THLE ECHS1
Mean 34.4
Standard deviation 3
Values 32 37
[7]
liver ECHS1
Mean 293
Standard deviation 2.8e+02
Values 6.2e+02 64 4.2e+02 63
[8]
ref_hepatocyte ACAT1
Mean 166
Standard deviation 1.7e+02
Values 49 47 23 3.2e+02 3.9e+02
[9]
HepG2 ACAT1
Mean 65.7
Standard deviation 6.9
Values 61 71
[10]
HepG2.C3A ACAT1
Mean 53.7
Standard deviation 16
Values 43 65
[11]
HuH.7 ACAT1
Mean 22.9
Standard deviation 6
Values 22 17 29
[12]
SNU475 ACAT1
Mean 40.9
Standard deviation 14
Values 51 31
[13]
THLE ACAT1
Mean 21.3
Standard deviation 4.8
Values 18 25
[14]
liver ACAT1
Mean 353
Standard deviation 1.8e+02
Values 4.7e+02 2.4e+02 5.4e+02 1.6e+02
[15]
ref_hepatocyte HSD17B10
Mean 85.5
Standard deviation 74
Values 14 52 31 1.7e+02 1.7e+02
[16]
HepG2 HSD17B10
Mean 28.7
Standard deviation 2
Values 27 30
[17]
HepG2.C3A HSD17B10
Mean 21.3
Standard deviation 2.8
Values 19 23
[18]
HuH.7 HSD17B10
Mean 24.2
Standard deviation 9.3
Values 26 14 32
[19]
SNU475 HSD17B10
Mean 26.6
Standard deviation 1.5
Values 26 28
[20]
THLE HSD17B10
Mean 51.1
Standard deviation 6
Values 47 55
[21]
liver HSD17B10
Mean 61.9
Standard deviation 43
Values 95 25 1e+02 24
[22]
ref_hepatocyte HIBADH
Mean 46.3
Standard deviation 38
Values 26 38 6.7 52 1.1e+02
[23]
HepG2 HIBADH
Mean 48.7
Standard deviation 3.3
Values 51 46
[24]
HepG2.C3A HIBADH
Mean 35.1
Standard deviation 7.6
Values 30 40
[25]
HuH.7 HIBADH
Mean 47.5
Standard deviation 11
Values 48 36 59
[26]
SNU475 HIBADH
Mean 32.8
Standard deviation 18
Values 46 20
[27]
THLE HIBADH
Mean 16.6
Standard deviation 2.1
Values 15 18
[28]
liver HIBADH
Mean 49.4
Standard deviation 25
Values 70 36 71 21
[29]
ref_hepatocyte ACADSB
Mean 36.4
Standard deviation 43
Values 31 4.8 2.3 34 1.1e+02
[30]
HepG2 ACADSB
Mean 24.8
Standard deviation 16
Values 14 36
[31]
HepG2.C3A ACADSB
Mean 127
Standard deviation 7.3
Values 1.3e+02 1.2e+02
[32]
HuH.7 ACADSB
Mean 89
Standard deviation 9.8
Values 87 99 80
[33]
SNU475 ACADSB
Mean 5.81
Standard deviation 1.1
Values 6.6 5
[34]
THLE ACADSB
Mean 5.65
Standard deviation 0.82
Values 5.1 6.2
[35]
liver ACADSB
Mean 215
Standard deviation 71
Values 2.6e+02 2.3e+02 2.6e+02 1.1e+02
[36]
ref_hepatocyte ALDH6A1
Mean 35.8
Standard deviation 40
Values 26 7.4 2.1 42 1e+02
[37]
HepG2 ALDH6A1
Mean 5.2
Standard deviation 2.2
Values 3.7 6.7
[38]
HepG2.C3A ALDH6A1
Mean 14.8
Standard deviation 3.5
Values 12 17
[39]
HuH.7 ALDH6A1
Mean 12.5
Standard deviation 3.1
Values 15 14 9
[40]
SNU475 ALDH6A1
Mean 2.29
Standard deviation 1.4
Values 3.3 1.3
[41]
THLE ALDH6A1
Mean 3.08
Standard deviation 1.2
Values 2.3 3.9
[42]
liver ALDH6A1
Mean 105
Standard deviation 24
Values 1.3e+02 84 1.2e+02 85
[43]
ref_hepatocyte DLD
Mean 31.7
Standard deviation 25
Values 39 73 13 16 19
[44]
HepG2 DLD
Mean 31.9
Standard deviation 11
Values 24 39
[45]
HepG2.C3A DLD
Mean 46.4
Standard deviation 13
Values 37 56
[46]
HuH.7 DLD
Mean 39.8
Standard deviation 5.6
Values 44 33 43
[47]
SNU475 DLD
Mean 48.2
Standard deviation 1.7
Values 49 47
[48]
THLE DLD
Mean 37.3
Standard deviation 2.8
Values 35 39
[49]
liver DLD
Mean 47.9
Standard deviation 25
Values 56 37 79 20
[50]
ref_hepatocyte MCCC2
Mean 24.7
Standard deviation 9.8
Values 22 26 11 27 38
[51]
HepG2 MCCC2
Mean 60.1
Standard deviation 16
Values 49 71
[52]
HepG2.C3A MCCC2
Mean 51.8
Standard deviation 17
Values 40 64
[53]
HuH.7 MCCC2
Mean 58.3
Standard deviation 19
Values 74 37 63
[54]
SNU475 MCCC2
Mean 21.4
Standard deviation 2.4
Values 23 20
[55]
THLE MCCC2
Mean 26.1
Standard deviation 3.3
Values 24 28
[56]
liver MCCC2
Mean 62.1
Standard deviation 26
Values 72 46 94 36
[57]
ref_hepatocyte BCKDHA
Mean 21.2
Standard deviation 23
Values 2.1 5.2 7 48 43
[58]
HepG2 BCKDHA
Mean 13.3
Standard deviation 4.2
Values 16 10
[59]
HepG2.C3A BCKDHA
Mean 15
Standard deviation 6.3
Values 19 10
[60]
HuH.7 BCKDHA
Mean 35.9
Standard deviation 11
Values 42 24 42
[61]
SNU475 BCKDHA
Mean 10.4
Standard deviation 2.4
Values 12 8.7
[62]
THLE BCKDHA
Mean 12.9
Standard deviation 0.022
Values 13 13
[63]
liver BCKDHA
Mean 39.9
Standard deviation 28
Values 56 18 71 14
[64]
ref_hepatocyte IVD
Mean 18
Standard deviation 19
Values 4.4 5.2 3.9 30 46
[65]
HepG2 IVD
Mean 49.8
Standard deviation 10
Values 42 57
[66]
HepG2.C3A IVD
Mean 49
Standard deviation 0.63
Values 49 49
[67]
HuH.7 IVD
Mean 14.8
Standard deviation 4.7
Values 16 9.4 18
[68]
SNU475 IVD
Mean 22.4
Standard deviation 4.6
Values 26 19
[69]
THLE IVD
Mean 23.1
Standard deviation 2.9
Values 21 25
[70]
liver IVD
Mean 88.7
Standard deviation 47
Values 99 69 1.5e+02 38
[71]
ref_hepatocyte HIBCH
Mean 17.4
Standard deviation 12
Values 9.9 13 4.1 32 29
[72]
HepG2 HIBCH
Mean 8.24
Standard deviation 3.1
Values 6 10
[73]
HepG2.C3A HIBCH
Mean 16.4
Standard deviation 5.1
Values 13 20
[74]
HuH.7 HIBCH
Mean 8.14
Standard deviation 3
Values 8.9 4.9 11
[75]
SNU475 HIBCH
Mean 5.71
Standard deviation 0.56
Values 6.1 5.3
[76]
THLE HIBCH
Mean 5.58
Standard deviation 0.28
Values 5.8 5.4
[77]
liver HIBCH
Mean 27.8
Standard deviation 18
Values 50 15 35 11
[78]
ref_hepatocyte MCCC1
Mean 13.4
Standard deviation 8.4
Values 5.1 14 4.4 21 22
[79]
HepG2 MCCC1
Mean 9.8
Standard deviation 2
Values 8.4 11
[80]
HepG2.C3A MCCC1
Mean 8.89
Standard deviation 0.017
Values 8.9 8.9
[81]
HuH.7 MCCC1
Mean 16.5
Standard deviation 1.3
Values 16 15 18
[82]
SNU475 MCCC1
Mean 4.59
Standard deviation 1.2
Values 5.4 3.7
[83]
THLE MCCC1
Mean 6.51
Standard deviation 0.64
Values 6.1 7
[84]
liver MCCC1
Mean 27.2
Standard deviation 5.9
Values 27 28 34 20
[85]
ref_hepatocyte BCKDHB
Mean 12.3
Standard deviation 13
Values 6.3 7.9 1 12 34
[86]
HepG2 BCKDHB
Mean 5.01
Standard deviation 1.8
Values 3.8 6.3
[87]
HepG2.C3A BCKDHB
Mean 6.65
Standard deviation 1.7
Values 5.4 7.9
[88]
HuH.7 BCKDHB
Mean 14.4
Standard deviation 4.1
Values 16 9.9 18
[89]
SNU475 BCKDHB
Mean 6.85
Standard deviation 3.3
Values 9.2 4.5
[90]
THLE BCKDHB
Mean 4.69
Standard deviation 0.33
Values 4.5 4.9
[91]
liver BCKDHB
Mean 33.2
Standard deviation 14
Values 46 26 44 18
[92]
ref_hepatocyte BCKDK
Mean 11.9
Standard deviation 7.4
Values 5.4 3.5 13 21 16
[93]
HepG2 BCKDK
Mean 40.9
Standard deviation 5.4
Values 45 37
[94]
HepG2.C3A BCKDK
Mean 24.7
Standard deviation 3.8
Values 27 22
[95]
HuH.7 BCKDK
Mean 26.6
Standard deviation 7.3
Values 32 18 30
[96]
SNU475 BCKDK
Mean 11.9
Standard deviation 0.64
Values 12 11
[97]
THLE BCKDK
Mean 18.5
Standard deviation 3.5
Values 16 21
[98]
liver BCKDK
Mean 21.6
Standard deviation 15
Values 35 6.6 34 11
[99]
ref_hepatocyte AUH
Mean 8.5
Standard deviation 4.1
Values 11 4.7 3.6 10 13
[100]
HepG2 AUH
Mean 6.31
Standard deviation 0.014
Values 6.3 6.3
[101]
HepG2.C3A AUH
Mean 19.2
Standard deviation 5.1
Values 23 16
[102]
HuH.7 AUH
Mean 9.9
Standard deviation 1.2
Values 8.7 9.9 11
[103]
SNU475 AUH
Mean 2.38
Standard deviation 1.1
Values 3.2 1.6
[104]
THLE AUH
Mean 6.02
Standard deviation 0.36
Values 5.8 6.3
[105]
liver AUH
Mean 9.53
Standard deviation 5.6
Values 17 5.9 11 4.6
[106]
ref_hepatocyte SLC25A44
Mean 7.72
Standard deviation 1.6
Values 7.9 9.9 8.1 7.3 5.4
[107]
HepG2 SLC25A44
Mean 13.7
Standard deviation 2.9
Values 12 16
[108]
HepG2.C3A SLC25A44
Mean 9.17
Standard deviation 0.76
Values 8.6 9.7
[109]
HuH.7 SLC25A44
Mean 18.4
Standard deviation 1.7
Values 20 17 18
[110]
SNU475 SLC25A44
Mean 19.7
Standard deviation 2.6
Values 22 18
[111]
THLE SLC25A44
Mean 19.2
Standard deviation 3
Values 17 21
[112]
liver SLC25A44
Mean 18.3
Standard deviation 8.1
Values 25 9.8 25 13
[113]
ref_hepatocyte ACAD8
Mean 7.53
Standard deviation 5.4
Values 2.9 4.5 3.4 14 13
[114]
HepG2 ACAD8
Mean 10.1
Standard deviation 2.3
Values 8.5 12
[115]
HepG2.C3A ACAD8
Mean 6.91
Standard deviation 0.29
Values 6.7 7.1
[116]
HuH.7 ACAD8
Mean 5.26
Standard deviation 2
Values 5.4 3.2 7.2
[117]
SNU475 ACAD8
Mean 6.25
Standard deviation 0.64
Values 6.7 5.8
[118]
THLE ACAD8
Mean 8.02
Standard deviation 1.2
Values 8.8 7.2
[119]
liver ACAD8
Mean 18
Standard deviation 8.6
Values 21 13 29 9.8
[120]
ref_hepatocyte BCAT2
Mean 3.91
Standard deviation 2.4
Values 0.36 6.6 2.9 4.6 5
[121]
HepG2 BCAT2
Mean 1.33
Standard deviation 0.16
Values 1.4 1.2
[122]
HepG2.C3A BCAT2
Mean 2.32
Standard deviation 0.055
Values 2.4 2.3
[123]
HuH.7 BCAT2
Mean 18.9
Standard deviation 8.7
Values 23 8.8 24
[124]
SNU475 BCAT2
Mean 13.6
Standard deviation 2.8
Values 16 12
[125]
THLE BCAT2
Mean 10.2
Standard deviation 1.4
Values 9.2 11
[126]
liver BCAT2
Mean 6.53
Standard deviation 4.8
Values 13 2.3 7.9 3.2
[127]
ref_hepatocyte DBT
Mean 2.27
Standard deviation 1.7
Values 1.9 1.5 0.89 1.9 5.2
[128]
HepG2 DBT
Mean 7.17
Standard deviation 2.1
Values 5.7 8.6
[129]
HepG2.C3A DBT
Mean 10.5
Standard deviation 1.4
Values 9.5 12
[130]
HuH.7 DBT
Mean 28.3
Standard deviation 6.2
Values 32 32 21
[131]
SNU475 DBT
Mean 13.4
Standard deviation 3.1
Values 16 11
[132]
THLE DBT
Mean 12.1
Standard deviation 0.54
Values 12 13
[133]
liver DBT
Mean 26.7
Standard deviation 4.5
Values 30 29 27 20
[134]
ref_hepatocyte PPM1K
Mean 1.93
Standard deviation 1
Values 2.5 3.3 2 1.1 0.8
[135]
HepG2 PPM1K
Mean 2.67
Standard deviation 0.15
Values 2.6 2.8
[136]
HepG2.C3A PPM1K
Mean 8.78
Standard deviation 2
Values 10 7.4
[137]
HuH.7 PPM1K
Mean 12.3
Standard deviation 0.79
Values 12 13 12
[138]
SNU475 PPM1K
Mean 6.52
Standard deviation 1.7
Values 7.7 5.3
[139]
THLE PPM1K
Mean 5.46
Standard deviation 0.81
Values 6 4.9
[140]
liver PPM1K
Mean 6.97
Standard deviation 1.2
Values 6.9 8.1 5.4 7.5
[141]
ref_hepatocyte BCAT1
Mean 1.1
Standard deviation 1.6
Values 4 0.11 0.91 0.078 0.46
[142]
HepG2 BCAT1
Mean 26.7
Standard deviation 1
Values 27 26
[143]
HepG2.C3A BCAT1
Mean 20
Standard deviation 6.4
Values 25 16
[144]
HuH.7 BCAT1
Mean 100
Standard deviation 19
Values 1.2e+02 87 92
[145]
SNU475 BCAT1
Mean 37.8
Standard deviation 14
Values 48 28
[146]
THLE BCAT1
Mean 114
Standard deviation 20
Values 1.3e+02 99
[147]
liver BCAT1
Mean 1.62
Standard deviation 0.82
Values 0.59 2.5 1.4 2.1