REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 VNN1 Pantetheinase [1] -4.70[2] -3.27[3] -8.23[4] -9.07[5] -1.72[6] -0.51[7]
2 PPCS Phosphopantothenate--cysteine ligase [8] -2.18[9] -2.58[10] -3.20[11] -1.54[12] -1.55[13] -2.22[14]
3 COASY Bifunctional coenzyme A synthase [15] 0.08[16] 0.41[17] -0.84[18] -0.34[19] -0.14[20] -1.44[21]
4 FASN Fatty acid synthase [22] 2.15[23] 2.11[24] 2.58[25] 1.43[26] 1.46[27] 1.47[28]
5 SLC5A6 Sodium-dependent multivitamin transporter [29] 0.81[30] 0.14[31] -1.13[32] -1.08[33] -0.78[34] 1.04[35]
6 PANK2 Pantothenate kinase 2, mitochondrial [36] -0.11[37] -0.71[38] -1.67[39] 0.41[40] 0.13[41] -2.17[42]
7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase -0.19[43] -0.61[44] -1.11[45] 1.82[46] 1.16[47] -0.71[48]
8 PDZD11 PDZ domain-containing protein 11 [49] -0.43[50] -1.26[51] -1.82[52] 1.07[53] 0.97[54] -1.75[55]
9 ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 0.75[56] 1.13[57] 0.99[58] 0.49[59] -1.78[60] 1.85[61]
10 PANK3 Pantothenate kinase 3 [62] -0.17[63] -0.05[64] 2.25[65] 1.19[66] 0.86[67] 0.98[68]
11 SLC25A16 Graves disease carrier protein [69] -1.68[70] -1.29[71] -2.37[72] -0.49[73] -0.38[74] -0.37[75]
12 PANK1 Pantothenate kinase 1 [76] -1.25[77] 0.19[78] -1.36[79] -1.06[80] -0.79[81] 1.43[82]
13 PANK4 Pantothenate kinase 4 [83] 0.19[84] 0.00[85] -0.63[86] 0.93[87] 1.23[88] -0.76[89]
14 ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 -0.18[90] 1.26[91] -4.21[92] -3.37[93] -5.51[94] -3.02[95]
15 PPCDC Phosphopantothenoylcysteine decarboxylase [96] 0.00[97] -0.10[98] -1.18[99] 0.84[100] 0.64[101] -1.34[102]
16 VNN2 Vascular non-inflammatory molecule 2 [103] -4.41[104] -3.70[105] 0.64[106] -4.90[107] -0.40[108] -0.56[109]
17 ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 -1.17[110] -3.08[111] 2.92[112] 0.02[113] 3.01[114] 1.87[115]
[1]
ref_hepatocyte VNN1
Mean 38.6
Standard deviation 33
Values 0.67 57 86 24 25
[2]
HepG2 VNN1
Mean 3.91
Standard deviation 1.5
Values 2.9 4.9
[3]
HepG2.C3A VNN1
Mean 14.9
Standard deviation 9
Values 8.5 21
[4]
HuH.7 VNN1
Mean 0.492
Standard deviation 0.22
Values 0.36 0.75 0.37
[5]
SNU475 VNN1
Mean 0.0813
Standard deviation 0.043
Values 0.051 0.11
[6]
THLE VNN1
Mean 14.8
Standard deviation 3.6
Values 17 12
[7]
liver VNN1
Mean 79.3
Standard deviation 2.3
Values 82 78 81 77
[8]
ref_hepatocyte PPCS
Mean 31.6
Standard deviation 14
Values 37 26 12 34 50
[9]
HepG2 PPCS
Mean 18.3
Standard deviation 1.1
Values 18 19
[10]
HepG2.C3A PPCS
Mean 19.7
Standard deviation 3.6
Values 17 22
[11]
HuH.7 PPCS
Mean 13.2
Standard deviation 2.4
Values 12 12 16
[12]
SNU475 PPCS
Mean 12.3
Standard deviation 2.6
Values 14 11
[13]
THLE PPCS
Mean 13.7
Standard deviation 2.2
Values 12 15
[14]
liver PPCS
Mean 19.7
Standard deviation 17
Values 35 5.3 35 4.3
[15]
ref_hepatocyte COASY
Mean 27.4
Standard deviation 9.2
Values 27 14 28 40 27
[16]
HepG2 COASY
Mean 76.2
Standard deviation 9.1
Values 83 70
[17]
HepG2.C3A COASY
Mean 136
Standard deviation 28
Values 1.6e+02 1.2e+02
[18]
HuH.7 COASY
Mean 58.8
Standard deviation 12
Values 67 45 64
[19]
SNU475 COASY
Mean 24.4
Standard deviation 2.3
Values 26 23
[20]
THLE COASY
Mean 31.5
Standard deviation 0.16
Values 31 32
[21]
liver COASY
Mean 29.4
Standard deviation 24
Values 53 7.7 46 10
[22]
ref_hepatocyte FASN
Mean 16.9
Standard deviation 11
Values 31 3.5 11 17 22
[23]
HepG2 FASN
Mean 197
Standard deviation 11
Values 1.9e+02 2e+02
[24]
HepG2.C3A FASN
Mean 273
Standard deviation 1.4e+02
Values 3.7e+02 1.7e+02
[25]
HuH.7 FASN
Mean 387
Standard deviation 1.1e+02
Values 5e+02 3.8e+02 2.9e+02
[26]
SNU475 FASN
Mean 51.5
Standard deviation 12
Values 60 43
[27]
THLE FASN
Mean 59
Standard deviation 19
Values 46 72
[28]
liver FASN
Mean 136
Standard deviation 1e+02
Values 92 1.2e+02 54 2.8e+02
[29]
ref_hepatocyte SLC5A6
Mean 14.9
Standard deviation 15
Values 16 4.1 4.7 40 10
[30]
HepG2 SLC5A6
Mean 68.6
Standard deviation 9.5
Values 75 62
[31]
HepG2.C3A SLC5A6
Mean 61.4
Standard deviation 6.8
Values 66 57
[32]
HuH.7 SLC5A6
Mean 26.1
Standard deviation 9.9
Values 34 15 30
[33]
SNU475 SLC5A6
Mean 8.03
Standard deviation 1.1
Values 7.3 8.8
[34]
THLE SLC5A6
Mean 11
Standard deviation 0.48
Values 11 11
[35]
liver SLC5A6
Mean 89.8
Standard deviation 70
Values 48 1e+02 1.8e+02 26
[36]
ref_hepatocyte PANK2
Mean 11.5
Standard deviation 9
Values 27 7.9 8.8 7.2 6.3
[37]
HepG2 PANK2
Mean 28.1
Standard deviation 4.2
Values 25 31
[38]
HepG2.C3A PANK2
Mean 26.3
Standard deviation 0.44
Values 26 27
[39]
HuH.7 PANK2
Mean 13.9
Standard deviation 3.5
Values 15 9.9 17
[40]
SNU475 PANK2
Mean 17.3
Standard deviation 0.65
Values 17 18
[41]
THLE PANK2
Mean 16
Standard deviation 2.4
Values 14 18
[42]
liver PANK2
Mean 7.46
Standard deviation 1.5
Values 6.6 8.9 5.8 8.4
[43]
ref_hepatocyte AASDHPPT
Mean 10.1
Standard deviation 6.6
Values 21 9.5 3.1 6.5 11
[44]
HepG2 AASDHPPT
Mean 23.3
Standard deviation 6.1
Values 19 28
[45]
HepG2.C3A AASDHPPT
Mean 24.8
Standard deviation 4.9
Values 21 28
[46]
HuH.7 AASDHPPT
Mean 17.9
Standard deviation 0.72
Values 19 17 18
[47]
SNU475 AASDHPPT
Mean 40.2
Standard deviation 1.8
Values 41 39
[48]
THLE AASDHPPT
Mean 28.6
Standard deviation 2.3
Values 27 30
[49]
liver AASDHPPT
Mean 17.9
Standard deviation 5.5
Values 22 17 22 10
[50]
ref_hepatocyte PDZD11
Mean 7.69
Standard deviation 3.4
Values 3 8.2 5.6 11 11
[51]
HepG2 PDZD11
Mean 15
Standard deviation 2.5
Values 13 17
[52]
HepG2.C3A PDZD11
Mean 12
Standard deviation 3.4
Values 9.5 14
[53]
HuH.7 PDZD11
Mean 8.35
Standard deviation 1.3
Values 8.5 7 9.6
[54]
SNU475 PDZD11
Mean 18.3
Standard deviation 4.5
Values 21 15
[55]
THLE PDZD11
Mean 19.1
Standard deviation 2.2
Values 18 21
[56]
liver PDZD11
Mean 6.65
Standard deviation 5.4
Values 11 2.4 11 1.6
[57]
ref_hepatocyte ENPP1
Mean 6.12
Standard deviation 3.9
Values 9.8 2.9 1.4 6.7 9.9
[58]
HepG2 ENPP1
Mean 27.1
Standard deviation 7.8
Values 22 33
[59]
HepG2.C3A ENPP1
Mean 50
Standard deviation 14
Values 60 40
[60]
HuH.7 ENPP1
Mean 46.7
Standard deviation 8.1
Values 46 55 39
[61]
SNU475 ENPP1
Mean 9.73
Standard deviation 5.5
Values 14 5.8
[62]
THLE ENPP1
Mean 2.26
Standard deviation 0.11
Values 2.2 2.3
[63]
liver ENPP1
Mean 64.2
Standard deviation 27
Values 1e+02 56 38 61
[64]
ref_hepatocyte PANK3
Mean 6.05
Standard deviation 2.6
Values 7.1 10 4.3 4.6 4
[65]
HepG2 PANK3
Mean 14.1
Standard deviation 7.5
Values 8.8 19
[66]
HepG2.C3A PANK3
Mean 21.9
Standard deviation 6.1
Values 18 26
[67]
HuH.7 PANK3
Mean 111
Standard deviation 53
Values 1e+02 1.7e+02 61
[68]
SNU475 PANK3
Mean 15.6
Standard deviation 2.6
Values 17 14
[69]
THLE PANK3
Mean 14
Standard deviation 2.7
Values 12 16
[70]
liver PANK3
Mean 34.8
Standard deviation 22
Values 19 47 14 59
[71]
ref_hepatocyte SLC25A16
Mean 5.74
Standard deviation 4.6
Values 6.6 13 0.3 3.4 5.7
[72]
HepG2 SLC25A16
Mean 4.72
Standard deviation 1.5
Values 3.6 5.8
[73]
HepG2.C3A SLC25A16
Mean 8.78
Standard deviation 2.5
Values 7 11
[74]
HuH.7 SLC25A16
Mean 4.26
Standard deviation 0.17
Values 4.1 4.4 4.3
[75]
SNU475 SLC25A16
Mean 4.64
Standard deviation 1.5
Values 5.7 3.5
[76]
THLE SLC25A16
Mean 5.61
Standard deviation 1.2
Values 4.8 6.4
[77]
liver SLC25A16
Mean 12.9
Standard deviation 3.4
Values 9.9 17 10 15
[78]
ref_hepatocyte PANK1
Mean 5.48
Standard deviation 3.9
Values 7.9 1.8 0.88 7.2 9.7
[79]
HepG2 PANK1
Mean 6.06
Standard deviation 0.93
Values 5.4 6.7
[80]
HepG2.C3A PANK1
Mean 23.4
Standard deviation 1.4
Values 24 22
[81]
HuH.7 PANK1
Mean 8.2
Standard deviation 1.2
Values 7.3 9.5 7.7
[82]
SNU475 PANK1
Mean 2.98
Standard deviation 0.56
Values 3.4 2.6
[83]
THLE PANK1
Mean 4.02
Standard deviation 0.35
Values 3.8 4.3
[84]
liver PANK1
Mean 43.2
Standard deviation 8.1
Values 50 41 33 49
[85]
ref_hepatocyte PANK4
Mean 3.62
Standard deviation 0.96
Values 3.2 2.5 5.1 4 3.3
[86]
HepG2 PANK4
Mean 10.8
Standard deviation 2.4
Values 13 9.1
[87]
HepG2.C3A PANK4
Mean 13.5
Standard deviation 3.3
Values 16 11
[88]
HuH.7 PANK4
Mean 9.01
Standard deviation 1.4
Values 8.8 7.7 11
[89]
SNU475 PANK4
Mean 7.81
Standard deviation 0.89
Values 8.4 7.2
[90]
THLE PANK4
Mean 10.8
Standard deviation 0.68
Values 10 11
[91]
liver PANK4
Mean 6.26
Standard deviation 1.5
Values 5 5 7.8 7.3
[92]
ref_hepatocyte ENPP3
Mean 3.1
Standard deviation 5.7
Values 13 0.18 0 0.48 1.7
[93]
HepG2 ENPP3
Mean 7.2
Standard deviation 2.6
Values 5.4 9
[94]
HepG2.C3A ENPP3
Mean 27.8
Standard deviation 0.8
Values 28 27
[95]
HuH.7 ENPP3
Mean 0.644
Standard deviation 0.37
Values 0.5 1.1 0.37
[96]
SNU475 ENPP3
Mean 0.341
Standard deviation 0.03
Values 0.36 0.32
[97]
THLE ENPP3
Mean 0.0866
Standard deviation 0.0054
Values 0.083 0.09
[98]
liver ENPP3
Mean 1.12
Standard deviation 0.72
Values 2.1 1.2 0.69 0.46
[99]
ref_hepatocyte PPCDC
Mean 2.28
Standard deviation 1
Values 0.48 2.4 3.2 2.5 2.7
[100]
HepG2 PPCDC
Mean 5.99
Standard deviation 0.55
Values 5.6 6.4
[101]
HepG2.C3A PPCDC
Mean 7.96
Standard deviation 1.6
Values 6.8 9.1
[102]
HuH.7 PPCDC
Mean 3.86
Standard deviation 1.5
Values 3.9 2.3 5.4
[103]
SNU475 PPCDC
Mean 4.63
Standard deviation 0.87
Values 4 5.2
[104]
THLE PPCDC
Mean 4.51
Standard deviation 0.76
Values 4 5
[105]
liver PPCDC
Mean 2.62
Standard deviation 0.76
Values 3 2.3 3.5 1.8
[106]
ref_hepatocyte VNN2
Mean 1.2
Standard deviation 0.91
Values 0.44 1.9 0 1.9 1.7
[107]
HepG2 VNN2
Mean 0.147
Standard deviation 0.075
Values 0.2 0.094
[108]
HepG2.C3A VNN2
Mean 0.345
Standard deviation 0.063
Values 0.39 0.3
[109]
HuH.7 VNN2
Mean 7.15
Standard deviation 2.5
Values 5.4 10 6
[110]
SNU475 VNN2
Mean 0.0454
Standard deviation 0.021
Values 0.06 0.03
[111]
THLE VNN2
Mean 1.15
Standard deviation 0.19
Values 1.3 1
[112]
liver VNN2
Mean 2.36
Standard deviation 0.89
Values 1.3 2.9 2 3.3
[113]
ref_hepatocyte ENPP2
Mean 0.862
Standard deviation 0.83
Values 0.98 0 0.3 2.2 0.88
[114]
HepG2 ENPP2
Mean 1.01
Standard deviation 0.65
Values 0.55 1.5
[115]
HepG2.C3A ENPP2
Mean 0.382
Standard deviation 0.13
Values 0.29 0.47
[116]
HuH.7 ENPP2
Mean 25
Standard deviation 3.5
Values 22 29 25
[117]
SNU475 ENPP2
Mean 0.994
Standard deviation 0.82
Values 0.42 1.6
[118]
THLE ENPP2
Mean 8.79
Standard deviation 6
Values 13 4.6
[119]
liver ENPP2
Mean 9.19
Standard deviation 5.5
Values 15 4.6 4.5 12