REACTOME_UREA_CYCLE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ASS1 Argininosuccinate synthase [1] 0.00[2] 0.12[3] -0.06[4] -0.12[5] -0.06[6] -1.97[7]
2 ARG1 Arginase-1 [8] -6.59[9] -6.89[10] -0.97[11] -7.68[12] -8.31[13] 0.12[14]
3 CPS1 Carbamoyl-phosphate synthase [ammonia], mitochondrial [15] -0.71[16] -0.77[17] -1.46[18] -7.00[19] -0.42[20] 1.61[21]
4 ASL Argininosuccinate lyase [22] 1.05[23] 0.93[24] 1.30[25] 1.87[26] 0.32[27] -0.80[28]
5 OTC Ornithine carbamoyltransferase, mitochondrial [29] -6.93[30] -6.22[31] -1.41[32] -8.15[33] -6.96[34] -1.63[35]
6 NAGS N-acetylglutamate synthase, mitochondrial [36] 0.43[37] 1.63[38] 1.22[39] -1.81[40] -0.32[41] -0.71[42]
7 NMRAL1 NmrA-like family domain-containing protein 1 [43] 1.95[44] -1.87[45] -3.53[46] 3.01[47] 3.31[48] -1.53[49]
8 SLC25A15 Mitochondrial ornithine transporter 1 [50] 3.66[51] 3.69[52] 3.43[53] 3.30[54] 3.91[55] 2.03[56]
9 ARG2 Arginase-2, mitochondrial [57] 4.45[58] 4.61[59] 2.79[60] 3.57[61] 3.89[62] -2.14[63]
10 SLC25A2 Mitochondrial ornithine transporter 2 [64] [65] -0.20[66] -3.89[67] 2.67[68] -0.59[69] -2.53[70]
[1]
ref_hepatocyte ASS1
Mean 312
Standard deviation 3.6e+02
Values 57 90 56 5.1e+02 8.5e+02
[2]
HepG2 ASS1
Mean 73
Standard deviation 14
Values 83 63
[3]
HepG2.C3A ASS1
Mean 81.4
Standard deviation 45
Values 1.1e+02 50
[4]
HuH.7 ASS1
Mean 94.9
Standard deviation 22
Values 79 1.2e+02 86
[5]
SNU475 ASS1
Mean 19.2
Standard deviation 7
Values 24 14
[6]
THLE ASS1
Mean 23.8
Standard deviation 0.31
Values 24 24
[7]
liver ASS1
Mean 218
Standard deviation 27
Values 2.3e+02 2.5e+02 2e+02 1.9e+02
[8]
ref_hepatocyte ARG1
Mean 190
Standard deviation 2.6e+02
Values 0.48 1.9 15 3.9e+02 5.4e+02
[9]
HepG2 ARG1
Mean 0.462
Standard deviation 0.059
Values 0.5 0.42
[10]
HepG2.C3A ARG1
Mean 0.387
Standard deviation 0.27
Values 0.19 0.58
[11]
HuH.7 ARG1
Mean 30.5
Standard deviation 25
Values 14 60 18
[12]
SNU475 ARG1
Mean 0.062
Standard deviation 0.03
Values 0.083 0.041
[13]
THLE ARG1
Mean 0.0476
Standard deviation 0.00039
Values 0.047 0.048
[14]
liver ARG1
Mean 562
Standard deviation 3.3e+02
Values 7.7e+02 4.1e+02 8.9e+02 1.8e+02
[15]
ref_hepatocyte CPS1
Mean 128
Standard deviation 1.9e+02
Values 7.7 8.2 1.6 2e+02 4.2e+02
[16]
HepG2 CPS1
Mean 18.3
Standard deviation 4.2
Values 15 21
[17]
HepG2.C3A CPS1
Mean 18
Standard deviation 4.7
Values 15 21
[18]
HuH.7 CPS1
Mean 14.7
Standard deviation 2.6
Values 15 17 12
[19]
SNU475 CPS1
Mean 0.0667
Standard deviation 0.042
Values 0.037 0.096
[20]
THLE CPS1
Mean 7.64
Standard deviation 0.35
Values 7.4 7.9
[21]
liver CPS1
Mean 1.06e+03
Standard deviation 4.4e+02
Values 7.5e+02 1.7e+03 7.9e+02 1e+03
[22]
ref_hepatocyte ASL
Mean 75.2
Standard deviation 60
Values 8.2 57 35 1.3e+02 1.4e+02
[23]
HepG2 ASL
Mean 36.6
Standard deviation 1.9
Values 35 38
[24]
HepG2.C3A ASL
Mean 34.4
Standard deviation 3
Values 37 32
[25]
HuH.7 ASL
Mean 58.5
Standard deviation 21
Values 63 36 77
[26]
SNU475 ASL
Mean 18.3
Standard deviation 1.6
Values 19 17
[27]
THLE ASL
Mean 7.49
Standard deviation 0.63
Values 7 7.9
[28]
liver ASL
Mean 118
Standard deviation 52
Values 1.7e+02 67 1.5e+02 81
[29]
ref_hepatocyte OTC
Mean 32.4
Standard deviation 50
Values 1.7 0.78 2.1 41 1.2e+02
[30]
HepG2 OTC
Mean 0.0623
Standard deviation 0.015
Values 0.052 0.073
[31]
HepG2.C3A OTC
Mean 0.104
Standard deviation 0.065
Values 0.058 0.15
[32]
HuH.7 OTC
Mean 3.85
Standard deviation 0.39
Values 4.3 3.6 3.7
[33]
SNU475 OTC
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[34]
THLE OTC
Mean 0.0207
Standard deviation 0.029
Values 0.041 0
[35]
liver OTC
Mean 28.5
Standard deviation 16
Values 52 19 24 19
[36]
ref_hepatocyte NAGS
Mean 11.3
Standard deviation 9.6
Values 0.8 2.6 13 17 23
[37]
HepG2 NAGS
Mean 3.57
Standard deviation 2.1
Values 5 2.1
[38]
HepG2.C3A NAGS
Mean 8.44
Standard deviation 4.2
Values 11 5.5
[39]
HuH.7 NAGS
Mean 8.34
Standard deviation 1.5
Values 6.8 9.8 8.5
[40]
SNU475 NAGS
Mean 0.215
Standard deviation 0.075
Values 0.16 0.27
[41]
THLE NAGS
Mean 0.725
Standard deviation 0.054
Values 0.76 0.69
[42]
liver NAGS
Mean 19
Standard deviation 5.9
Values 26 15 21 13
[43]
ref_hepatocyte NMRAL1
Mean 11.3
Standard deviation 3.4
Values 8.7 11 8.5 12 17
[44]
HepG2 NMRAL1
Mean 10.2
Standard deviation 1.1
Values 11 9.4
[45]
HepG2.C3A NMRAL1
Mean 0.746
Standard deviation 0.39
Values 1 0.47
[46]
HuH.7 NMRAL1
Mean 0.31
Standard deviation 0.13
Values 0.39 0.16 0.38
[47]
SNU475 NMRAL1
Mean 6.11
Standard deviation 0.59
Values 6.5 5.7
[48]
THLE NMRAL1
Mean 8.95
Standard deviation 1
Values 8.2 9.7
[49]
liver NMRAL1
Mean 10.7
Standard deviation 7.3
Values 19 5 14 4.1
[50]
ref_hepatocyte SLC25A15
Mean 7.49
Standard deviation 4.7
Values 5.2 6.2 1.6 12 13
[51]
HepG2 SLC25A15
Mean 22.1
Standard deviation 0.4
Values 22 22
[52]
HepG2.C3A SLC25A15
Mean 23.4
Standard deviation 2.2
Values 22 25
[53]
HuH.7 SLC25A15
Mean 25.5
Standard deviation 6.9
Values 30 18 29
[54]
SNU475 SLC25A15
Mean 4.94
Standard deviation 0.17
Values 5.1 4.8
[55]
THLE SLC25A15
Mean 9
Standard deviation 1.6
Values 7.9 10
[56]
liver SLC25A15
Mean 83.8
Standard deviation 25
Values 69 1.1e+02 1e+02 56
[57]
ref_hepatocyte ARG2
Mean 3.18
Standard deviation 1.9
Values 3.3 1.7 6.5 2 2.5
[58]
HepG2 ARG2
Mean 16.3
Standard deviation 5.8
Values 20 12
[59]
HepG2.C3A ARG2
Mean 18.6
Standard deviation 2.3
Values 20 17
[60]
HuH.7 ARG2
Mean 6.92
Standard deviation 0.27
Values 7.1 7 6.6
[61]
SNU475 ARG2
Mean 2.53
Standard deviation 0.049
Values 2.5 2.6
[62]
THLE ARG2
Mean 3.75
Standard deviation 0.28
Values 4 3.6
[63]
liver ARG2
Mean 1.96
Standard deviation 0.4
Values 1.8 2.5 1.6 1.9
[64]
ref_hepatocyte SLC25A2
Mean 0.1
Standard deviation 0.22
Values 0.5 0 0 0 0
[65]
HepG2 SLC25A2
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A SLC25A2
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[67]
HuH.7 SLC25A2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[68]
SNU475 SLC25A2
Mean 0.0426
Standard deviation 0.032
Values 0.065 0.02
[69]
THLE SLC25A2
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[70]
liver SLC25A2
Mean 0.0474
Standard deviation 0.044
Values 0.024 0.1 0 0.066