REACTOME_UPTAKE_AND_FUNCTION_OF_ANTHRAX_TOXINS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FURIN Furin [1] 1.20[2] -1.77[3] -0.34[4] -1.47[5] -1.25[6] 0.91[7]
2 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 [8] -1.65[9] -0.57[10] -2.40[11] -2.03[12] -2.40[13] -2.18[14]
3 CALM1 Calmodulin-1 [15] -0.36[16] 0.47[17] 0.20[18] 1.38[19] 0.42[20] 0.88[21]
4 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [22] -1.36[23] -0.90[24] -1.06[25] -0.74[26] -0.48[27] -1.93[28]
5 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [29] -0.38[30] 0.09[31] 0.22[32] -1.04[33] -0.80[34] -2.44[35]
6 PDCD6IP Programmed cell death 6-interacting protein [36] 0.08[37] 0.86[38] 1.40[39] 0.68[40] 0.86[41] 0.34[42]
7 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 [43] 0.27[44] 1.69[45] 0.16[46] 1.01[47] 0.16[48] 0.32[49]
8 ANTXR2 Anthrax toxin receptor 2 [50] -0.35[51] 0.98[52] 1.72[53] -0.42[54] 1.98[55] 1.86[56]
9 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 [57] 0.53[58] 1.47[59] 1.30[60] 0.08[61] 0.40[62] -1.50[63]
10 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 [64] -0.14[65] -2.57[66] 1.55[67] 0.81[68] -3.47[69] -2.36[70]
11 ANTXR1 Anthrax toxin receptor 1 [71] 4.19[72] 5.07[73] -2.34[74] 6.39[75] 7.81[76] 2.64[77]
[1]
ref_hepatocyte FURIN
Mean 36.4
Standard deviation 35
Values 1.6 11 25 83 62
[2]
HepG2 FURIN
Mean 249
Standard deviation 93
Values 3.1e+02 1.8e+02
[3]
HepG2.C3A FURIN
Mean 16.4
Standard deviation 4.8
Values 13 20
[4]
HuH.7 FURIN
Mean 70.6
Standard deviation 9.9
Values 82 63 67
[5]
SNU475 FURIN
Mean 27.8
Standard deviation 0.065
Values 28 28
[6]
THLE FURIN
Mean 42.8
Standard deviation 10
Values 35 50
[7]
liver FURIN
Mean 163
Standard deviation 30
Values 2e+02 1.5e+02 1.3e+02 1.7e+02
[8]
ref_hepatocyte MAP2K3
Mean 32.7
Standard deviation 39
Values 11 17 1e+02 16 17
[9]
HepG2 MAP2K3
Mean 31
Standard deviation 5.7
Values 27 35
[10]
HepG2.C3A MAP2K3
Mean 34
Standard deviation 1.9
Values 35 33
[11]
HuH.7 MAP2K3
Mean 15.2
Standard deviation 4.8
Values 18 9.6 18
[12]
SNU475 MAP2K3
Mean 16.9
Standard deviation 1.1
Values 16 18
[13]
THLE MAP2K3
Mean 17.3
Standard deviation 3
Values 15 19
[14]
liver MAP2K3
Mean 17.2
Standard deviation 13
Values 30 4.9 26 7.1
[15]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[16]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[17]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[18]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[19]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[20]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[21]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[22]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[23]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[24]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[25]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[26]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[27]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[28]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[29]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[30]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[31]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[32]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[33]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[34]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[35]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[36]
ref_hepatocyte PDCD6IP
Mean 13.1
Standard deviation 3.9
Values 15 18 15 8.4 9.8
[37]
HepG2 PDCD6IP
Mean 41.4
Standard deviation 9.9
Values 34 48
[38]
HepG2.C3A PDCD6IP
Mean 36.6
Standard deviation 0.5
Values 36 37
[39]
HuH.7 PDCD6IP
Mean 84.6
Standard deviation 5.9
Values 90 86 78
[40]
SNU475 PDCD6IP
Mean 44.3
Standard deviation 3.2
Values 47 42
[41]
THLE PDCD6IP
Mean 66.5
Standard deviation 4.9
Values 63 70
[42]
liver PDCD6IP
Mean 39.3
Standard deviation 4.8
Values 39 42 44 33
[43]
ref_hepatocyte MAP2K4
Mean 5.23
Standard deviation 0.4
Values 5.1 5.9 5.1 4.9 5.2
[44]
HepG2 MAP2K4
Mean 18.8
Standard deviation 5.8
Values 15 23
[45]
HepG2.C3A MAP2K4
Mean 26
Standard deviation 3.4
Values 24 28
[46]
HuH.7 MAP2K4
Mean 14.3
Standard deviation 2.4
Values 14 17 12
[47]
SNU475 MAP2K4
Mean 22.2
Standard deviation 0.79
Values 23 22
[48]
THLE MAP2K4
Mean 16.4
Standard deviation 1.6
Values 15 17
[49]
liver MAP2K4
Mean 15.6
Standard deviation 2
Values 16 17 17 13
[50]
ref_hepatocyte ANTXR2
Mean 4.02
Standard deviation 1.5
Values 2.8 4.7 2 5.2 5.4
[51]
HepG2 ANTXR2
Mean 9.38
Standard deviation 0.92
Values 10 8.7
[52]
HepG2.C3A ANTXR2
Mean 12.2
Standard deviation 0.46
Values 13 12
[53]
HuH.7 ANTXR2
Mean 32.5
Standard deviation 4.4
Values 34 36 28
[54]
SNU475 ANTXR2
Mean 6.35
Standard deviation 0.45
Values 6 6.7
[55]
THLE ANTXR2
Mean 44.4
Standard deviation 6.8
Values 40 49
[56]
liver ANTXR2
Mean 34.8
Standard deviation 12
Values 24 51 36 28
[57]
ref_hepatocyte MAP2K7
Mean 3.82
Standard deviation 2
Values 2.7 1.5 6.2 5.7 3
[58]
HepG2 MAP2K7
Mean 16.4
Standard deviation 3.3
Values 19 14
[59]
HepG2.C3A MAP2K7
Mean 16.2
Standard deviation 4
Values 19 13
[60]
HuH.7 MAP2K7
Mean 23.1
Standard deviation 1.5
Values 24 22 23
[61]
SNU475 MAP2K7
Mean 8.53
Standard deviation 0.26
Values 8.3 8.7
[62]
THLE MAP2K7
Mean 14
Standard deviation 0.17
Values 14 14
[63]
liver MAP2K7
Mean 3.21
Standard deviation 0.87
Values 3.1 3 2.3 4.4
[64]
ref_hepatocyte MAP2K6
Mean 1.65
Standard deviation 2.1
Values 5.3 0.69 0.17 0.98 1.1
[65]
HepG2 MAP2K6
Mean 4.46
Standard deviation 1.8
Values 3.2 5.7
[66]
HepG2.C3A MAP2K6
Mean 0.428
Standard deviation 0.00091
Values 0.43 0.43
[67]
HuH.7 MAP2K6
Mean 11.9
Standard deviation 2.1
Values 13 9.5 13
[68]
SNU475 MAP2K6
Mean 6.1
Standard deviation 1.1
Values 6.8 5.4
[69]
THLE MAP2K6
Mean 0.418
Standard deviation 0.064
Values 0.37 0.46
[70]
liver MAP2K6
Mean 0.764
Standard deviation 0.64
Values 1.6 0.61 0.051 0.79
[71]
ref_hepatocyte ANTXR1
Mean 0.155
Standard deviation 0.12
Values 0.36 0.14 0.13 0.017 0.13
[72]
HepG2 ANTXR1
Mean 8.43
Standard deviation 2.3
Values 6.8 10
[73]
HepG2.C3A ANTXR1
Mean 7.97
Standard deviation 1.6
Values 6.8 9.1
[74]
HuH.7 ANTXR1
Mean 0.0747
Standard deviation 0.066
Values 0.15 0.058 0.019
[75]
SNU475 ANTXR1
Mean 27.4
Standard deviation 3.6
Values 30 25
[76]
THLE ANTXR1
Mean 97.2
Standard deviation 8.6
Values 91 1e+02
[77]
liver ANTXR1
Mean 2.29
Standard deviation 0.49
Values 1.6 2.3 2.5 2.8