REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CALR | Calreticulin | [1] | -0.56[2] | -1.45[3] | -1.35[4] | -1.43[5] | -1.10[6] | -0.94[7] |
2 | HSP90B1 | Endoplasmin | [8] | -0.88[9] | 0.34[10] | -0.35[11] | -0.16[12] | -0.20[13] | 0.03[14] |
3 | HSPA5 | 78 kDa glucose-regulated protein | [15] | -0.05[16] | -0.39[17] | -0.78[18] | -0.60[19] | -0.47[20] | -0.28[21] |
4 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | [22] | -0.76[23] | -0.08[24] | 0.18[25] | -2.32[26] | -0.85[27] | -2.16[28] |
5 | PDIA6 | Protein disulfide-isomerase A6 | [29] | -0.15[30] | -0.64[31] | -1.10[32] | -0.46[33] | -1.18[34] | -0.59[35] |
6 | XBP1 | X-box-binding protein 1 | [36] | -1.14[37] | -1.28[38] | 0.76[39] | -2.19[40] | -2.43[41] | 0.43[42] |
7 | ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | [43] | -0.87[44] | -0.56[45] | -1.08[46] | -0.91[47] | -0.29[48] | 1.08[49] |
8 | HDGF | Hepatoma-derived growth factor | [50] | -0.28[51] | -0.58[52] | 0.25[53] | 0.32[54] | 0.33[55] | -2.41[56] |
9 | CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 | [57] | -4.77[58] | -3.28[59] | -1.42[60] | -9.17[61] | -7.85[62] | -0.07[63] |
10 | LMNA | Prelamin-A/C | [64] | 0.27[65] | -0.70[66] | -1.72[67] | 1.23[68] | 0.49[69] | -0.91[70] |
11 | HERPUD1 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain | -1.51[71] | -1.57[72] | -1.10[73] | -2.42[74] | -1.37[75] | -0.74[76] | |
12 | DNAJB11 | DnaJ homolog subfamily B member 11 | [77] | -1.11[78] | -1.42[79] | -1.23[80] | -1.69[81] | -0.85[82] | -1.26[83] |
13 | IGFBP1 | Insulin-like growth factor-binding protein 1 | [84] | 0.25[85] | 2.90[86] | -4.54[87] | -9.08[88] | -8.54[89] | -0.49[90] |
14 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | [91] | 0.33[92] | 0.86[93] | 0.42[94] | 0.69[95] | 0.53[96] | -1.31[97] |
15 | HYOU1 | Hypoxia up-regulated protein 1 | [98] | 0.95[99] | -0.22[100] | 0.01[101] | 0.67[102] | 0.28[103] | 1.20[104] |
16 | SERP1 | Stress-associated endoplasmic reticulum protein 1 | [105] | -0.28[106] | 0.36[107] | 0.31[108] | -0.23[109] | -0.08[110] | 0.92[111] |
17 | YIF1A | Protein YIF1A | [112] | -0.35[113] | -0.82[114] | 0.80[115] | -0.71[116] | -1.44[117] | -0.59[118] |
18 | CEBPB | CCAAT/enhancer-binding protein beta | [119] | -0.77[120] | -1.82[121] | -1.43[122] | -0.71[123] | 0.26[124] | -1.62[125] |
19 | SRPRB | Signal recognition particle receptor subunit beta | [126] | -0.50[127] | -0.88[128] | -0.99[129] | -1.06[130] | -0.35[131] | 0.38[132] |
20 | EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 | [133] | 0.99[134] | 0.84[135] | 1.64[136] | 1.49[137] | 1.41[138] | -0.23[139] |
21 | DNAJB9 | DnaJ homolog subfamily B member 9 | [140] | -2.04[141] | -1.08[142] | -0.75[143] | -1.73[144] | -1.76[145] | 0.57[146] |
22 | PREB | Prolactin regulatory element-binding protein | [147] | 0.57[148] | 0.78[149] | -0.10[150] | -0.24[151] | -0.25[152] | 0.24[153] |
23 | PDIA5 | Protein disulfide-isomerase A5 | [154] | -0.18[155] | -0.67[156] | -0.85[157] | -1.74[158] | -1.63[159] | -0.05[160] |
24 | DDIT3 | DNA damage-inducible transcript 3 protein | [161] | -1.57[162] | -1.22[163] | -1.04[164] | -1.40[165] | -0.49[166] | -2.13[167] |
25 | ATF3 | Cyclic AMP-dependent transcription factor ATF-3 | [168] | -2.22[169] | -2.54[170] | -2.61[171] | -2.73[172] | -2.52[173] | -3.36[174] |
26 | ATP6V0D1 | V-type proton ATPase subunit d 1 | [175] | 0.13[176] | -0.76[177] | -0.02[178] | 0.65[179] | 0.50[180] | 0.07[181] |
27 | SYVN1 | E3 ubiquitin-protein ligase synoviolin | [182] | -0.56[183] | -0.65[184] | -0.69[185] | -0.69[186] | -0.53[187] | 0.47[188] |
28 | EXOSC4 | Exosome complex component RRP41 | [189] | -1.11[190] | -1.17[191] | -1.45[192] | -1.13[193] | -1.78[194] | -1.62[195] |
29 | EXOSC7 | Exosome complex component RRP42 | [196] | -0.95[197] | -1.38[198] | -0.45[199] | -2.01[200] | -1.02[201] | -1.79[202] |
30 | KLHDC3 | Kelch domain-containing protein 3 | [203] | 0.61[204] | 0.88[205] | 0.81[206] | 1.26[207] | 0.77[208] | -0.09[209] |
31 | ADD1 | Alpha-adducin | [210] | 1.49[211] | 0.19[212] | 1.25[213] | 2.70[214] | 1.34[215] | 0.65[216] |
32 | SEC31A | Protein transport protein Sec31A | [217] | 2.19[218] | 1.76[219] | 2.20[220] | 1.74[221] | 1.71[222] | 1.72[223] |
33 | CREB3 | Cyclic AMP-responsive element-binding protein 3 | [224] | -0.22[225] | -0.75[226] | -0.89[227] | -0.46[228] | 0.06[229] | -1.06[230] |
34 | TPP1 | Tripeptidyl-peptidase 1 | [231] | 1.55[232] | 0.08[233] | 1.20[234] | 1.10[235] | 1.19[236] | 1.25[237] |
35 | SHC1 | SHC-transforming protein 1 | [238] | 1.57[239] | 1.37[240] | 1.80[241] | 3.36[242] | 2.88[243] | 0.83[244] |
36 | KHSRP | Far upstream element-binding protein 2 | [245] | 1.82[246] | 0.63[247] | 2.39[248] | 1.41[249] | 1.63[250] | -1.37[251] |
37 | ARFGAP1 | ADP-ribosylation factor GTPase-activating protein 1 | [252] | 1.53[253] | 1.38[254] | 0.97[255] | 1.06[256] | 0.49[257] | -1.05[258] |
38 | CEBPG | CCAAT/enhancer-binding protein gamma | [259] | 0.47[260] | 0.40[261] | 1.90[262] | -0.83[263] | 0.11[264] | 0.81[265] |
39 | EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 | [266] | 0.68[267] | 0.19[268] | 0.29[269] | 1.31[270] | 1.81[271] | 0.46[272] |
40 | EXOSC3 | Exosome complex component RRP40 | [273] | -0.70[274] | -1.22[275] | -0.15[276] | -1.23[277] | -0.53[278] | -1.76[279] |
41 | DCTN1 | Dynactin subunit 1 | [280] | 2.27[281] | 1.01[282] | 0.72[283] | 2.13[284] | 2.18[285] | 0.61[286] |
42 | GOSR2 | Golgi SNAP receptor complex member 2 | [287] | 0.87[288] | 0.48[289] | -0.24[290] | 0.97[291] | 0.46[292] | 0.61[293] |
43 | DNAJC3 | DnaJ homolog subfamily C member 3 | [294] | -0.30[295] | 0.23[296] | -0.68[297] | 0.78[298] | 0.47[299] | 2.79[300] |
44 | MBTPS1 | Membrane-bound transcription factor site-1 protease | [301] | 1.99[302] | 1.39[303] | 1.74[304] | 2.10[305] | 2.18[306] | 1.37[307] |
45 | SSR1 | Translocon-associated protein subunit alpha | [308] | 2.53[309] | 2.76[310] | 2.37[311] | 3.00[312] | 2.45[313] | 3.19[314] |
46 | TLN1 | Talin-1 | [315] | 3.40[316] | 1.61[317] | 2.75[318] | 3.82[319] | 3.87[320] | 3.41[321] |
47 | EXOSC9 | Exosome complex component RRP45 | [322] | -0.93[323] | -0.90[324] | -1.07[325] | -0.73[326] | 0.98[327] | -2.08[328] |
48 | EXOSC5 | Exosome complex component RRP46 | [329] | -0.53[330] | -0.92[331] | 0.51[332] | -1.21[333] | -0.74[334] | -1.01[335] |
49 | CCL2 | C-C motif chemokine 2 | [336] | -12.99[337] | [338] | -12.47[339] | -3.41[340] | -1.21[341] | -3.64[342] |
50 | NFYC | Nuclear transcription factor Y subunit gamma | [343] | 0.11[344] | -0.45[345] | -0.01[346] | 0.45[347] | -0.22[348] | -0.37[349] |
51 | SULT1A3 | Sulfotransferase 1A3 | [350] | [351] | [352] | [353] | [354] | [355] | [356] |
52 | GSK3A | Glycogen synthase kinase-3 alpha | [357] | 1.03[358] | 0.35[359] | 0.80[360] | 0.79[361] | 1.58[362] | -1.78[363] |
53 | WIPI1 | WD repeat domain phosphoinositide-interacting protein 1 | [364] | 0.50[365] | 0.96[366] | 0.39[367] | -0.53[368] | 0.23[369] | 0.11[370] |
54 | GFPT1 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | [371] | 1.82[372] | 2.42[373] | 2.57[374] | 1.97[375] | 1.83[376] | 2.66[377] |
55 | PARN | Poly(A)-specific ribonuclease PARN | [378] | 1.34[379] | 0.27[380] | 0.28[381] | 0.66[382] | 0.66[383] | -0.01[384] |
56 | CTDSP2 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 | 2.00[385] | 1.84[386] | 2.48[387] | 3.12[388] | 2.55[389] | 1.80[390] | |
57 | EDEM1 | ER degradation-enhancing alpha-mannosidase-like protein 1 | [391] | 1.39[392] | 1.19[393] | 1.68[394] | 0.82[395] | 2.22[396] | 3.22[397] |
58 | CXXC1 | CXXC-type zinc finger protein 1 | [398] | 0.60[399] | 0.19[400] | 0.42[401] | -0.04[402] | 0.86[403] | 0.26[404] |
59 | EXOSC2 | Exosome complex component RRP4 | [405] | 0.63[406] | 0.05[407] | 0.72[408] | 0.38[409] | 1.36[410] | -0.64[411] |
60 | EXOSC1 | Exosome complex component CSL4 | [412] | 0.31[413] | 0.58[414] | 1.23[415] | -0.20[416] | 0.76[417] | -0.90[418] |
61 | EXOSC6 | Exosome complex component MTR3 | [419] | 0.19[420] | -0.20[421] | -1.08[422] | -0.34[423] | 0.28[424] | -0.58[425] |
62 | TSPYL2 | Testis-specific Y-encoded-like protein 2 | [426] | -0.64[427] | -0.24[428] | -0.80[429] | -0.42[430] | 1.17[431] | -1.17[432] |
63 | EXOSC8 | Exosome complex component RRP43 | [433] | 0.55[434] | 0.96[435] | 1.51[436] | -0.03[437] | 1.06[438] | -0.61[439] |
64 | ASNS | Asparagine synthetase [glutamine-hydrolyzing] | [440] | 3.24[441] | 2.82[442] | 2.86[443] | 0.65[444] | 2.50[445] | -1.34[446] |
65 | WFS1 | Wolframin | [447] | 2.54[448] | 1.38[449] | 1.46[450] | 3.23[451] | 0.89[452] | 0.78[453] |
66 | NFYB | Nuclear transcription factor Y subunit beta | [454] | -0.23[455] | 0.96[456] | 0.68[457] | 1.10[458] | 1.47[459] | 0.05[460] |
67 | ATF6 | Cyclic AMP-dependent transcription factor ATF-6 alpha | [461] | 2.15[462] | 1.77[463] | 1.72[464] | 3.16[465] | 3.29[466] | 2.75[467] |
68 | CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 | [468] | 2.80[469] | 2.74[470] | 3.15[471] | 2.61[472] | 2.28[473] | 1.76[474] |
69 | NFYA | Nuclear transcription factor Y subunit alpha | [475] | 1.96[476] | 1.76[477] | 1.99[478] | 2.14[479] | 1.63[480] | 0.52[481] |
70 | TATDN2 | Putative deoxyribonuclease TATDN2 | [482] | 2.04[483] | 1.50[484] | 2.11[485] | 1.64[486] | 2.62[487] | 0.85[488] |
71 | KDELR3 | ER lumen protein-retaining receptor 3 | [489] | 2.46[490] | 1.47[491] | 2.66[492] | 1.42[493] | 1.02[494] | 0.10[495] |
72 | DIS3 | Exosome complex exonuclease RRP44 | [496] | 1.31[497] | 1.91[498] | 2.95[499] | 2.50[500] | 2.58[501] | 2.01[502] |
73 | ZBTB17 | Zinc finger and BTB domain-containing protein 17 | [503] | 1.05[504] | 1.26[505] | 0.85[506] | 1.38[507] | 1.23[508] | 0.19[509] |
74 | EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | [510] | 0.95[511] | 1.35[512] | 1.88[513] | 0.90[514] | 1.46[515] | 1.81[516] |
75 | MBTPS2 | Membrane-bound transcription factor site-2 protease | [517] | 1.35[518] | 1.29[519] | 2.44[520] | 2.80[521] | 2.74[522] | 1.61[523] |
76 | DDX11 | ATP-dependent DNA helicase DDX11 | [524] | 0.64[525] | 0.74[526] | 1.53[527] | 2.61[528] | 1.72[529] | 0.09[530] |
77 | CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 | [531] | -0.18[532] | 0.37[533] | 1.93[534] | 1.08[535] | 0.28[536] | -0.62[537] |
78 | EXTL3 | Exostosin-like 3 | [538] | 3.12[539] | 1.80[540] | 3.15[541] | 2.88[542] | 2.98[543] | 2.18[544] |
79 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | 1.18[545] | 0.53[546] | 0.24[547] | 1.00[548] | 2.19[549] | 0.15[550] | |
80 | FKBP14 | Peptidyl-prolyl cis-trans isomerase FKBP14 | [551] | 1.94[552] | 2.41[553] | 2.46[554] | 2.95[555] | 2.71[556] | 0.59[557] |
81 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | [558] | 0.23[559] | 0.40[560] | 0.75[561] | -0.27[562] | 1.10[563] | 2.22[564] |
82 | CUL7 | Cullin-7 | [565] | 4.12[566] | 3.94[567] | 2.68[568] | 4.06[569] | 2.32[570] | 1.82[571] |
83 | EXTL2 | Exostosin-like 2 | [572] | 1.61[573] | 2.44[574] | 3.04[575] | 2.63[576] | 3.61[577] | 0.91[578] |
84 | DCP2 | m7GpppN-mRNA hydrolase | [579] | 2.20[580] | 3.50[581] | 3.01[582] | 3.14[583] | 3.06[584] | 3.26[585] |
85 | CREBRF | CREB3 regulatory factor | [586] | 0.40[587] | 1.97[588] | 4.02[589] | 1.86[590] | 2.02[591] | 2.98[592] |
86 | PLA2G4B | Cytosolic phospholipase A2 beta | [593] | -6.16[594] | -7.59[595] | -4.65[596] | -3.94[597] | -4.24[598] | [599] |
87 | CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1 | [600] | 0.40[601] | -2.95[602] | 7.09[603] | 6.02[604] | 6.33[605] | -0.18[606] |
88 | EXTL1 | Exostosin-like 1 | [607] | 0.43[608] | 2.30[609] | -0.54[610] | 0.09[611] | 0.73[612] | -2.00[613] |
89 | DCSTAMP | Dendritic cell-specific transmembrane protein | [614] | [615] | [616] | [617] | [618] | [619] | [620] |
90 | MYDGF | Myeloid-derived growth factor | [621] | [622] | [623] | [624] | [625] | [626] | [627] |
91 | SRPRA | Signal recognition particle receptor subunit alpha | [628] | [629] | [630] | [631] | [632] | [633] | [634] |
92 | CXCL8 | Interleukin-8 | [635] | [636] | [637] | [638] | [639] | [640] | [641] |