REACTOME_UCH_PROTEINASES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ACTB | Actin, cytoplasmic 1 | [1] | -0.35[2] | -0.80[3] | -0.26[4] | 0.19[5] | -0.20[6] | 0.14[7] |
2 | UBB | Polyubiquitin-B | [8] | -1.16[9] | -1.12[10] | -1.06[11] | -1.59[12] | -1.14[13] | -0.56[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | -0.72[23] | -0.37[24] | -0.70[25] | -0.74[26] | -0.76[27] | -0.10[28] |
5 | PSME1 | Proteasome activator complex subunit 1 | [29] | -0.49[30] | -1.96[31] | -1.67[32] | -1.46[33] | -1.98[34] | -1.06[35] |
6 | NEDD8 | NEDD8 | [36] | -0.70[37] | -2.04[38] | -1.88[39] | -2.11[40] | -1.96[41] | -2.20[42] |
7 | PSME2 | Proteasome activator complex subunit 2 | [43] | -0.30[44] | -1.58[45] | -1.76[46] | -1.24[47] | -1.52[48] | -0.68[49] |
8 | PSMA7 | Proteasome subunit alpha type-7 | [50] | 0.65[51] | 0.89[52] | -0.51[53] | 0.38[54] | -0.05[55] | 0.34[56] |
9 | PSMB1 | Proteasome subunit beta type-1 | [57] | 0.20[58] | 0.44[59] | -0.71[60] | -0.86[61] | -0.09[62] | 0.18[63] |
10 | PSMB3 | Proteasome subunit beta type-3 | [64] | -0.28[65] | -0.94[66] | 0.02[67] | -0.88[68] | -0.99[69] | -0.12[70] |
11 | PSMB4 | Proteasome subunit beta type-4 | [71] | -0.04[72] | 0.26[73] | 0.31[74] | 0.55[75] | 0.55[76] | -0.44[77] |
12 | PSMB7 | Proteasome subunit beta type-7 | [78] | -0.98[79] | -0.85[80] | -0.78[81] | -1.23[82] | -0.77[83] | -0.88[84] |
13 | PSMB5 | Proteasome subunit beta type-5 | [85] | 1.42[86] | 0.12[87] | -0.03[88] | -0.51[89] | -0.21[90] | -0.41[91] |
14 | PSMA6 | Proteasome subunit alpha type-6 | [92] | 1.54[93] | 0.39[94] | 0.26[95] | 0.02[96] | 0.05[97] | -0.33[98] |
15 | PSMA4 | Proteasome subunit alpha type-4 | [99] | -0.38[100] | 0.41[101] | 0.14[102] | 0.32[103] | 0.17[104] | -0.40[105] |
16 | PSMC3 | 26S proteasome regulatory subunit 6A | [106] | -0.42[107] | -0.35[108] | 0.20[109] | -0.87[110] | -0.66[111] | 0.07[112] |
17 | PSMA3 | Proteasome subunit alpha type-3 | [113] | -1.01[114] | 0.13[115] | -0.62[116] | -0.13[117] | -0.56[118] | -0.16[119] |
18 | PSMB6 | Proteasome subunit beta type-6 | [120] | -0.46[121] | -0.17[122] | -0.10[123] | -0.68[124] | -0.92[125] | 0.00[126] |
19 | PSMA2 | Proteasome subunit alpha type-2 | [127] | -0.54[128] | 0.55[129] | 0.81[130] | -0.18[131] | 0.21[132] | 0.22[133] |
20 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [134] | -0.02[135] | 0.12[136] | 0.26[137] | 0.52[138] | 0.01[139] | -0.10[140] |
21 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [141] | -0.11[142] | 0.40[143] | 0.19[144] | -0.56[145] | -0.07[146] | -0.27[147] |
22 | ADRM1 | Proteasomal ubiquitin receptor ADRM1 | [148] | 0.68[149] | 0.57[150] | -0.38[151] | 0.15[152] | -0.46[153] | -0.20[154] |
23 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [155] | 0.06[156] | 0.44[157] | 0.50[158] | -0.29[159] | 0.49[160] | -0.25[161] |
24 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [162] | 1.59[163] | 0.91[164] | 0.91[165] | 0.82[166] | 2.14[167] | 0.79[168] |
25 | PSMC1 | 26S proteasome regulatory subunit 4 | [169] | -0.08[170] | 0.11[171] | -0.60[172] | 1.01[173] | 0.55[174] | -0.05[175] |
26 | PSMA1 | Proteasome subunit alpha type-1 | [176] | 0.10[177] | 0.62[178] | 0.62[179] | 0.58[180] | 0.10[181] | 0.44[182] |
27 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [183] | 1.72[184] | 1.86[185] | 2.81[186] | 0.66[187] | 1.47[188] | 0.67[189] |
28 | PSMC5 | 26S proteasome regulatory subunit 8 | [190] | 0.42[191] | 0.45[192] | 0.45[193] | -0.01[194] | 0.42[195] | 0.20[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.81[198] | 0.44[199] | 0.96[200] | 0.52[201] | 0.76[202] | -0.08[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.58[205] | -2.04[206] | -9.32[207] | 0.49[208] | -0.79[209] | -0.77[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.01[212] | 0.73[213] | 0.92[214] | 0.38[215] | 0.44[216] | -0.23[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 0.42[219] | 0.58[220] | 0.45[221] | 0.01[222] | 0.15[223] | 0.25[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.74[226] | -0.12[227] | -1.28[228] | -0.61[229] | 0.22[230] | -0.34[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.46[233] | 0.71[234] | 1.14[235] | 0.45[236] | -0.02[237] | -0.15[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.36[240] | -0.15[241] | -0.52[242] | 0.07[243] | 0.15[244] | -0.23[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.06[247] | 1.65[248] | 0.40[249] | 0.42[250] | 0.38[251] | 0.42[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.82[254] | 0.57[255] | 1.09[256] | 0.83[257] | 1.01[258] | 1.25[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.57[261] | 1.11[262] | 0.82[263] | 1.23[264] | 1.08[265] | 1.30[266] |
39 | PSME3 | Proteasome activator complex subunit 3 | [267] | 1.80[268] | 1.65[269] | 1.27[270] | 1.25[271] | 1.54[272] | 0.87[273] |
40 | UCHL3 | Ubiquitin carboxyl-terminal hydrolase isozyme L3 | [274] | -0.35[275] | -0.14[276] | -0.32[277] | -1.01[278] | -1.28[279] | -0.31[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.56[282] | 2.02[283] | 1.82[284] | 2.06[285] | 2.09[286] | 2.06[287] |
42 | PSMB10 | Proteasome subunit beta type-10 | [288] | -1.16[289] | -0.43[290] | -2.39[291] | -0.15[292] | -1.30[293] | -0.09[294] |
43 | PSMA5 | Proteasome subunit alpha type-5 | [295] | 1.89[296] | 2.45[297] | 1.94[298] | 2.11[299] | 1.69[300] | 1.89[301] |
44 | PSMF1 | Proteasome inhibitor PI31 subunit | [302] | 2.27[303] | 2.45[304] | 1.18[305] | 1.12[306] | 0.90[307] | 1.84[308] |
45 | PSMB2 | Proteasome subunit beta type-2 | [309] | 2.05[310] | 1.92[311] | 2.23[312] | 2.41[313] | 2.42[314] | 2.38[315] |
46 | PSMB9 | Proteasome subunit beta type-9 | [316] | -1.96[317] | -4.44[318] | -6.82[319] | 1.67[320] | -0.58[321] | -0.51[322] |
47 | RUVBL1 | RuvB-like 1 | [323] | 1.46[324] | 1.32[325] | 1.34[326] | 0.54[327] | 1.22[328] | -0.15[329] |
48 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [330] | 0.43[331] | 1.05[332] | 0.00[333] | 0.29[334] | 0.75[335] | 0.71[336] |
49 | INO80C | INO80 complex subunit C | [337] | -1.22[338] | -0.58[339] | -0.98[340] | -0.73[341] | -1.44[342] | -1.78[343] |
50 | YY1 | Transcriptional repressor protein YY1 | [344] | 1.06[345] | 1.30[346] | 1.11[347] | 1.88[348] | 1.42[349] | 1.34[350] |
51 | ACTL6A | Actin-like protein 6A | [351] | 1.34[352] | 1.69[353] | 1.65[354] | 1.39[355] | 1.62[356] | 0.17[357] |
52 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | [358] | 0.02[359] | 1.11[360] | 0.65[361] | 1.69[362] | 1.25[363] | 1.11[364] |
53 | INO80E | INO80 complex subunit E | [365] | 0.33[366] | 0.45[367] | 0.22[368] | -0.76[369] | -0.27[370] | -1.61[371] |
54 | UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | [372] | -4.66[373] | -4.37[374] | 3.38[375] | 4.14[376] | 4.49[377] | -4.30[378] |
55 | TGFBR2 | TGF-beta receptor type-2 | [379] | 3.86[380] | 3.56[381] | 3.13[382] | 2.25[383] | 3.96[384] | 2.83[385] |
56 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [386] | 0.98[387] | 1.44[388] | 1.39[389] | 1.96[390] | 1.30[391] | 0.70[392] |
57 | MCRS1 | Microspherule protein 1 | [393] | 1.37[394] | 2.46[395] | 1.79[396] | 1.29[397] | 1.26[398] | 1.11[399] |
58 | BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 | [400] | 2.12[401] | 2.54[402] | 1.59[403] | 1.64[404] | 2.45[405] | 1.71[406] |
59 | TFPT | TCF3 fusion partner | [407] | -1.09[408] | -1.23[409] | -0.51[410] | -0.87[411] | 0.25[412] | -2.01[413] |
60 | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subu | 2.26[414] | 3.35[415] | 3.30[416] | 2.71[417] | 2.67[418] | 3.68[419] | |
61 | PSME4 | Proteasome activator complex subunit 4 | [420] | 2.51[421] | 3.56[422] | 3.49[423] | 2.52[424] | 2.50[425] | 2.96[426] |
62 | INO80B | INO80 complex subunit B | [427] | -4.41[428] | -3.73[429] | -4.19[430] | -4.55[431] | -4.64[432] | -4.47[433] |
63 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [434] | 1.40[435] | 1.09[436] | 2.58[437] | 2.35[438] | 2.45[439] | 2.14[440] |
64 | FOXK2 | Forkhead box protein K2 | [441] | 3.21[442] | 3.72[443] | 3.00[444] | 2.35[445] | 2.08[446] | 1.12[447] |
65 | TGFBR1 | TGF-beta receptor type-1 | [448] | 1.37[449] | 1.83[450] | 1.24[451] | 1.53[452] | 2.63[453] | 2.65[454] |
66 | SMAD7 | Mothers against decapentaplegic homolog 7 | [455] | 2.90[456] | 1.25[457] | 0.14[458] | 1.77[459] | 1.47[460] | 1.32[461] |
67 | KDM1B | Lysine-specific histone demethylase 1B | [462] | 1.48[463] | 1.56[464] | 1.56[465] | 1.90[466] | 0.51[467] | 0.83[468] |
68 | ASXL1 | Putative Polycomb group protein ASXL1 | [469] | 4.21[470] | 4.73[471] | 4.38[472] | 4.50[473] | 3.72[474] | 3.64[475] |
69 | USP15 | Ubiquitin carboxyl-terminal hydrolase 15 | [476] | 1.16[477] | 3.27[478] | 2.58[479] | 3.17[480] | 3.09[481] | 3.97[482] |
70 | MBD6 | Methyl-CpG-binding domain protein 6 | [483] | 2.12[484] | 2.41[485] | 2.66[486] | 2.37[487] | 2.45[488] | 1.51[489] |
71 | HCFC1 | Host cell factor 1 | [490] | 3.79[491] | 3.56[492] | 3.73[493] | 3.75[494] | 3.64[495] | 3.39[496] |
72 | ACTR8 | Actin-related protein 8 | [497] | 1.99[498] | 2.40[499] | 1.22[500] | 1.54[501] | 2.38[502] | 2.31[503] |
73 | INO80 | DNA helicase INO80 | [504] | 2.36[505] | 2.90[506] | 2.78[507] | 2.95[508] | 2.70[509] | 3.17[510] |
74 | TGFB1 | Transforming growth factor beta-1 | [511] | 4.51[512] | 3.71[513] | 0.87[514] | 5.02[515] | 4.25[516] | 0.09[517] |
75 | ACTR5 | Actin-related protein 5 | [518] | 2.24[519] | 2.09[520] | 1.48[521] | 1.53[522] | 0.72[523] | 1.55[524] |
76 | NFRKB | Nuclear factor related to kappa-B-binding protein | [525] | 3.92[526] | 4.01[527] | 3.87[528] | 3.66[529] | 3.25[530] | 3.62[531] |
77 | ASXL2 | Putative Polycomb group protein ASXL2 | [532] | 3.53[533] | 3.93[534] | 3.62[535] | 3.73[536] | 3.64[537] | 3.72[538] |
78 | FOXK1 | Forkhead box protein K1 | [539] | 4.32[540] | 3.83[541] | 4.35[542] | 3.84[543] | 4.56[544] | 4.54[545] |
79 | SENP8 | Sentrin-specific protease 8 | [546] | 0.41[547] | 1.37[548] | 1.01[549] | 1.03[550] | 1.15[551] | 0.93[552] |
80 | INO80D | INO80 complex subunit D | [553] | 3.19[554] | 5.27[555] | 5.64[556] | 3.75[557] | 3.99[558] | 6.08[559] |
81 | BARD1 | BRCA1-associated RING domain protein 1 | [560] | 2.35[561] | 3.58[562] | 3.51[563] | 3.88[564] | 3.96[565] | 3.19[566] |
82 | MBD5 | Methyl-CpG-binding domain protein 5 | [567] | 2.59[568] | 3.76[569] | 4.09[570] | 3.90[571] | 3.76[572] | 3.51[573] |
83 | H2AC8 | [574] | [575] | [576] | [577] | [578] | [579] | [580] | |
84 | H2AC13 | [581] | [582] | [583] | [584] | [585] | [586] | [587] | |
85 | H2AC4 | [588] | [589] | [590] | [591] | [592] | [593] | [594] | |
86 | H2AC6 | [595] | [596] | [597] | [598] | [599] | [600] | [601] | |
87 | H2AC7 | [602] | [603] | [604] | [605] | [606] | [607] | [608] | |
88 | H2AW | [609] | [610] | [611] | [612] | [613] | [614] | [615] | |
89 | H2AC14 | [616] | [617] | [618] | [619] | [620] | [621] | [622] | |
90 | H2AC12 | [623] | [624] | [625] | [626] | [627] | [628] | [629] | |
91 | H2AC11 | [630] | [631] | [632] | [633] | [634] | [635] | [636] | |
92 | PSMB11 | Proteasome subunit beta type-11 | [637] | [638] | [639] | [640] | [641] | [642] | [643] |
93 | H2AC16 | [644] | [645] | [646] | [647] | [648] | [649] | [650] | |
94 | H2AC17 | [651] | [652] | [653] | [654] | [655] | [656] | [657] | |
95 | H2AC21 | [658] | [659] | [660] | [661] | [662] | [663] | [664] | |
96 | H2AC15 | [665] | [666] | [667] | [668] | [669] | [670] | [671] | |
97 | SEM1 | Putative protein SEM1, isoform 2 | [672] | [673] | [674] | [675] | [676] | [677] | [678] |
98 | H2AC1 | [679] | [680] | [681] | [682] | [683] | [684] | [685] | |
99 | H2AC20 | [686] | [687] | [688] | [689] | [690] | [691] | [692] | |
100 | PSMA8 | Proteasome subunit alpha type-7-like | [693] | [694] | [695] | [696] | [697] | [698] | [699] |