REACTOME_TRYPTOPHAN_CATABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TDO2 Tryptophan 2,3-dioxygenase [1] -13.94[2] -11.38[3] -6.82[4] -5.25[5] -8.23[6] 1.12[7]
2 KYNU Kynureninase [8] -2.09[9] -0.90[10] -2.86[11] -1.70[12] -3.00[13] -2.55[14]
3 SLC3A2 4F2 cell-surface antigen heavy chain [15] 0.72[16] 0.23[17] 1.31[18] 1.79[19] 1.85[20] -2.04[21]
4 HAAO 3-hydroxyanthranilate 3,4-dioxygenase [22] -2.74[23] -1.06[24] -2.11[25] -8.50[26] -10.97[27] -0.67[28]
5 ACMSD 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [29] -13.16[30] -9.77[31] -2.01[32] -9.49[33] -9.55[34] -0.60[35]
6 AFMID Kynurenine formamidase [36] 0.12[37] 1.97[38] 1.23[39] -1.50[40] -1.46[41] 0.48[42]
7 SLC7A5 Large neutral amino acids transporter small subunit 1 [43] 3.65[44] 3.03[45] 2.87[46] 2.51[47] 2.79[48] -1.75[49]
8 AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [50] -1.10[51] -0.27[52] -1.05[53] -0.39[54] -0.48[55] 0.24[56]
9 KMO Kynurenine 3-monooxygenase [57] -8.16[58] -5.92[59] -2.69[60] -0.77[61] -6.24[62] 1.68[63]
10 SLC36A4 Proton-coupled amino acid transporter 4 [64] 0.47[65] -0.44[66] 1.81[67] 2.72[68] 2.21[69] 0.51[70]
11 IDO1 Indoleamine 2,3-dioxygenase 1 [71] -0.60[72] 0.81[73] 0.83[74] 4.37[75] 0.50[76] 0.38[77]
12 IDO2 Indoleamine 2,3-dioxygenase 2 [78] [79] [80] [81] -4.55[82] [83] -0.08[84]
13 KYAT1 Kynurenine--oxoglutarate transaminase 1 [85] [86] [87] [88] [89] [90] [91]
14 KYAT3 Kynurenine--oxoglutarate transaminase 3 [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte TDO2
Mean 130
Standard deviation 1.9e+02
Values 0 18 5.3 2e+02 4.3e+02
[2]
HepG2 TDO2
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[3]
HepG2.C3A TDO2
Mean 0.037
Standard deviation 0.039
Values 0.0097 0.064
[4]
HuH.7 TDO2
Mean 0.435
Standard deviation 0.39
Values 0.16 0.89 0.26
[5]
SNU475 TDO2
Mean 1.01
Standard deviation 0.68
Values 0.53 1.5
[6]
THLE TDO2
Mean 0.203
Standard deviation 0.19
Values 0.34 0.069
[7]
liver TDO2
Mean 397
Standard deviation 2.8e+02
Values 7.8e+02 1.8e+02 4.4e+02 1.8e+02
[8]
ref_hepatocyte KYNU
Mean 90.5
Standard deviation 1.2e+02
Values 22 3.1e+02 70 31 24
[9]
HepG2 KYNU
Mean 27.4
Standard deviation 17
Values 39 16
[10]
HepG2.C3A KYNU
Mean 36.6
Standard deviation 14
Values 26 47
[11]
HuH.7 KYNU
Mean 4.72
Standard deviation 2.1
Values 3.9 7.1 3.2
[12]
SNU475 KYNU
Mean 8.24
Standard deviation 5.2
Values 4.6 12
[13]
THLE KYNU
Mean 5.29
Standard deviation 2.8
Values 7.2 3.3
[14]
liver KYNU
Mean 21.7
Standard deviation 3.4
Values 26 18 22 21
[15]
ref_hepatocyte SLC3A2
Mean 72.1
Standard deviation 43
Values 56 49 1.3e+02 1e+02 22
[16]
HepG2 SLC3A2
Mean 153
Standard deviation 40
Values 1.8e+02 1.2e+02
[17]
HepG2.C3A SLC3A2
Mean 64.2
Standard deviation 13
Values 74 55
[18]
HuH.7 SLC3A2
Mean 67.5
Standard deviation 3
Values 64 68 70
[19]
SNU475 SLC3A2
Mean 73.5
Standard deviation 36
Values 48 99
[20]
THLE SLC3A2
Mean 122
Standard deviation 3.4
Values 1.2e+02 1.2e+02
[21]
liver SLC3A2
Mean 24.7
Standard deviation 11
Values 28 16 39 16
[22]
ref_hepatocyte HAAO
Mean 49.4
Standard deviation 65
Values 8.2 3.8 9.1 72 1.5e+02
[23]
HepG2 HAAO
Mean 9.61
Standard deviation 2.4
Values 7.9 11
[24]
HepG2.C3A HAAO
Mean 18
Standard deviation 2.2
Values 20 16
[25]
HuH.7 HAAO
Mean 4.33
Standard deviation 0.95
Values 4.8 3.2 4.9
[26]
SNU475 HAAO
Mean 0.0405
Standard deviation 0.021
Values 0.056 0.025
[27]
THLE HAAO
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[28]
liver HAAO
Mean 43.7
Standard deviation 25
Values 64 21 67 23
[29]
ref_hepatocyte ACMSD
Mean 35.4
Standard deviation 47
Values 0 1.6 3 91 81
[30]
HepG2 ACMSD
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[31]
HepG2.C3A ACMSD
Mean 0.0307
Standard deviation 0.0021
Values 0.029 0.032
[32]
HuH.7 ACMSD
Mean 3.33
Standard deviation 0.47
Values 3 3.2 3.9
[33]
SNU475 ACMSD
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[34]
THLE ACMSD
Mean 0.0222
Standard deviation 0.0063
Values 0.018 0.027
[35]
liver ACMSD
Mean 32.8
Standard deviation 10
Values 35 32 44 19
[36]
ref_hepatocyte AFMID
Mean 27.8
Standard deviation 20
Values 41 7.6 4.8 51 35
[37]
HepG2 AFMID
Mean 39
Standard deviation 12
Values 31 47
[38]
HepG2.C3A AFMID
Mean 82.2
Standard deviation 14
Values 92 72
[39]
HuH.7 AFMID
Mean 24.5
Standard deviation 7.7
Values 25 17 32
[40]
SNU475 AFMID
Mean 2.9
Standard deviation 0.18
Values 3 2.8
[41]
THLE AFMID
Mean 4.73
Standard deviation 0.045
Values 4.7 4.8
[42]
liver AFMID
Mean 54.5
Standard deviation 41
Values 1.1e+02 23 54 28
[43]
ref_hepatocyte SLC7A5
Mean 20.3
Standard deviation 37
Values 86 1.6 8.1 3.7 1.8
[44]
HepG2 SLC7A5
Mean 330
Standard deviation 84
Values 3.9e+02 2.7e+02
[45]
HepG2.C3A SLC7A5
Mean 125
Standard deviation 38
Values 1.5e+02 98
[46]
HuH.7 SLC7A5
Mean 56.1
Standard deviation 23
Values 76 31 61
[47]
SNU475 SLC7A5
Mean 34.2
Standard deviation 11
Values 42 26
[48]
THLE SLC7A5
Mean 65.6
Standard deviation 9.3
Values 72 59
[49]
liver SLC7A5
Mean 8.45
Standard deviation 2.5
Values 8.8 5.7 12 7.6
[50]
ref_hepatocyte AADAT
Mean 6.3
Standard deviation 9.1
Values 1.3 1.3 0.67 6.3 22
[51]
HepG2 AADAT
Mean 3.81
Standard deviation 2.5
Values 2 5.6
[52]
HepG2.C3A AADAT
Mean 3.96
Standard deviation 1.1
Values 3.2 4.7
[53]
HuH.7 AADAT
Mean 1.15
Standard deviation 0.46
Values 1.4 0.62 1.5
[54]
SNU475 AADAT
Mean 1.43
Standard deviation 0.11
Values 1.5 1.3
[55]
THLE AADAT
Mean 2.12
Standard deviation 0.11
Values 2 2.2
[56]
liver AADAT
Mean 10.5
Standard deviation 4.6
Values 16 7.2 13 6
[57]
ref_hepatocyte KMO
Mean 3.63
Standard deviation 4.2
Values 0.026 0.95 0.79 7.5 8.8
[58]
HepG2 KMO
Mean 0.0165
Standard deviation 0.0071
Values 0.011 0.021
[59]
HepG2.C3A KMO
Mean 0.0452
Standard deviation 0.018
Values 0.058 0.032
[60]
HuH.7 KMO
Mean 0.212
Standard deviation 0.072
Values 0.17 0.3 0.17
[61]
SNU475 KMO
Mean 0.629
Standard deviation 0.51
Values 0.27 0.99
[62]
THLE KMO
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[63]
liver KMO
Mean 16.3
Standard deviation 7.3
Values 27 14 15 9.6
[64]
ref_hepatocyte SLC36A4
Mean 2.42
Standard deviation 0.74
Values 2.2 3.1 3 2.6 1.2
[65]
HepG2 SLC36A4
Mean 4.34
Standard deviation 0.4
Values 4.1 4.6
[66]
HepG2.C3A SLC36A4
Mean 1.35
Standard deviation 0.32
Values 1.1 1.6
[67]
HuH.7 SLC36A4
Mean 3.2
Standard deviation 0.57
Values 3.8 3.2 2.6
[68]
SNU475 SLC36A4
Mean 4.71
Standard deviation 1.3
Values 3.8 5.6
[69]
THLE SLC36A4
Mean 5.24
Standard deviation 0.51
Values 5.6 4.9
[70]
liver SLC36A4
Mean 4.85
Standard deviation 1.8
Values 6.1 4 6.5 2.7
[71]
ref_hepatocyte IDO1
Mean 0.512
Standard deviation 0.3
Values 0.8 0.86 0.35 0.22 0.33
[72]
HepG2 IDO1
Mean 0.438
Standard deviation 0.012
Values 0.43 0.45
[73]
HepG2.C3A IDO1
Mean 0.68
Standard deviation 0.23
Values 0.85 0.51
[74]
HuH.7 IDO1
Mean 0.343
Standard deviation 0.071
Values 0.37 0.4 0.26
[75]
SNU475 IDO1
Mean 3.13
Standard deviation 1.9
Values 4.4 1.8
[76]
THLE IDO1
Mean 0.339
Standard deviation 0.014
Values 0.35 0.33
[77]
liver IDO1
Mean 0.937
Standard deviation 0.19
Values 0.85 1.1 0.72 1.1
[78]
ref_hepatocyte IDO2
Mean 0.384
Standard deviation 0.62
Values 0 0 0 0.49 1.4
[79]
HepG2 IDO2
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A IDO2
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 IDO2
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 IDO2
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[83]
THLE IDO2
Mean 0
Standard deviation 0
Values 0 0
[84]
liver IDO2
Mean 0.511
Standard deviation 0.4
Values 0.12 0.7 0.98 0.25
[85]
ref_hepatocyte KYAT1
Missing
[86]
HepG2 KYAT1
Missing
[87]
HepG2.C3A KYAT1
Missing
[88]
HuH.7 KYAT1
Missing
[89]
SNU475 KYAT1
Missing
[90]
THLE KYAT1
Missing
[91]
liver KYAT1
Missing
[92]
ref_hepatocyte KYAT3
Missing
[93]
HepG2 KYAT3
Missing
[94]
HepG2.C3A KYAT3
Missing
[95]
HuH.7 KYAT3
Missing
[96]
SNU475 KYAT3
Missing
[97]
THLE KYAT3
Missing
[98]
liver KYAT3
Missing