REACTOME_TRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | TRMT112 | Multifunctional methyltransferase subunit TRM112-like protein | [1] | -2.02[2] | -2.06[3] | -2.20[4] | -2.12[5] | -2.39[6] | -2.76[7] |
2 | NSUN2 | tRNA (cytosine(34)-C(5))-methyltransferase | [8] | 0.78[9] | 0.16[10] | 0.41[11] | 0.66[12] | 1.47[13] | 0.72[14] |
3 | URM1 | Ubiquitin-related modifier 1 | [15] | 0.35[16] | 0.18[17] | -0.29[18] | 0.36[19] | 0.49[20] | -0.36[21] |
4 | TRMT1 | tRNA (guanine(26)-N(2))-dimethyltransferase | [22] | 1.13[23] | 1.19[24] | 1.73[25] | 0.03[26] | 0.98[27] | 0.21[28] |
5 | FTSJ1 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase | [29] | 0.69[30] | 0.45[31] | 1.13[32] | 1.13[33] | 1.41[34] | 0.39[35] |
6 | QTRT1 | Queuine tRNA-ribosyltransferase catalytic subunit 1 | [36] | 0.55[37] | 0.83[38] | 1.04[39] | -0.76[40] | -0.18[41] | 0.14[42] |
7 | TRMT11 | tRNA (guanine(10)-N2)-methyltransferase homolog | [43] | -0.30[44] | 0.86[45] | 0.01[46] | -0.46[47] | -0.10[48] | 1.48[49] |
8 | PUS1 | tRNA pseudouridine synthase A | [50] | 0.64[51] | 0.72[52] | 0.74[53] | -0.44[54] | -0.31[55] | -0.82[56] |
9 | NSUN6 | Putative methyltransferase NSUN6 | [57] | -1.09[58] | 0.61[59] | 0.00[60] | -0.43[61] | -1.59[62] | 1.94[63] |
10 | OSGEP | Probable tRNA N6-adenosine threonylcarbamoyltransferase | [64] | 0.22[65] | -0.09[66] | 0.24[67] | -0.49[68] | -0.05[69] | 0.28[70] |
11 | TPRKB | EKC/KEOPS complex subunit TPRKB | [71] | -0.02[72] | 0.22[73] | 0.70[74] | 0.72[75] | 0.49[76] | -0.18[77] |
12 | PUS3 | tRNA pseudouridine(38/39) synthase | [78] | -0.53[79] | -0.71[80] | -0.10[81] | -0.47[82] | -0.67[83] | 1.18[84] |
13 | TYW3 | tRNA wybutosine-synthesizing protein 3 homolog | [85] | 0.92[86] | 1.74[87] | 1.48[88] | 0.97[89] | 0.22[90] | 1.11[91] |
14 | TRMT6 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 | 1.62[92] | 1.26[93] | 1.01[94] | 1.52[95] | 1.32[96] | -0.17[97] | |
15 | METTL1 | tRNA (guanine-N(7)-)-methyltransferase | [98] | 0.62[99] | 0.88[100] | 0.86[101] | 0.33[102] | 0.17[103] | -0.34[104] |
16 | CTU2 | Cytoplasmic tRNA 2-thiolation protein 2 | [105] | 0.95[106] | 1.06[107] | 1.03[108] | 0.28[109] | 0.42[110] | -0.08[111] |
17 | THG1L | Probable tRNA(His) guanylyltransferase | [112] | 0.09[113] | 0.46[114] | -1.03[115] | 0.05[116] | -0.41[117] | -0.61[118] |
18 | TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A | 1.93[119] | 1.12[120] | 0.13[121] | 1.57[122] | 0.90[123] | 0.88[124] | |
19 | TRIT1 | tRNA dimethylallyltransferase | [125] | 0.72[126] | 0.56[127] | 1.14[128] | 1.42[129] | 1.35[130] | 0.36[131] |
20 | TP53RK | TP53-regulating kinase | [132] | 2.27[133] | 2.01[134] | 0.28[135] | 1.64[136] | 1.38[137] | 1.06[138] |
21 | THADA | Thyroid adenoma-associated protein | [139] | 1.97[140] | 1.72[141] | 2.06[142] | 1.80[143] | 1.53[144] | 3.06[145] |
22 | TYW1 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase | 0.33[146] | -0.03[147] | 1.37[148] | 0.95[149] | 0.46[150] | 1.62[151] | |
23 | LAGE3 | EKC/KEOPS complex subunit LAGE3 | [152] | 0.92[153] | 0.25[154] | 1.23[155] | 1.72[156] | 1.21[157] | 0.33[158] |
24 | PUS7 | Pseudouridylate synthase 7 homolog | [159] | 1.95[160] | 1.83[161] | 1.96[162] | 1.82[163] | 1.57[164] | 1.46[165] |
25 | ADAT1 | tRNA-specific adenosine deaminase 1 | [166] | 1.13[167] | 0.57[168] | 0.54[169] | 1.78[170] | 1.63[171] | 1.98[172] |
26 | TRMT12 | tRNA wybutosine-synthesizing protein 2 homolog | [173] | -1.04[174] | -4.56[175] | 0.46[176] | 0.84[177] | 1.03[178] | 0.77[179] |
27 | WDR4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | 1.52[180] | 1.07[181] | -0.52[182] | 1.35[183] | 1.09[184] | 1.00[185] | |
28 | CDKAL1 | Threonylcarbamoyladenosine tRNA methylthiotransferase | [186] | 1.50[187] | 1.07[188] | 0.98[189] | 1.81[190] | 1.26[191] | 1.90[192] |
29 | LCMT2 | tRNA wybutosine-synthesizing protein 4 | [193] | 1.13[194] | 0.48[195] | 0.63[196] | 1.31[197] | 1.55[198] | 1.53[199] |
30 | ALKBH8 | Alkylated DNA repair protein alkB homolog 8 | [200] | 1.16[201] | 1.21[202] | 1.00[203] | 2.47[204] | 1.73[205] | 1.91[206] |
31 | TRMT5 | tRNA (guanine(37)-N1)-methyltransferase | [207] | 1.99[208] | 2.12[209] | 2.82[210] | 2.84[211] | 2.87[212] | 2.17[213] |
32 | TYW5 | tRNA wybutosine-synthesizing protein 5 | [214] | 1.73[215] | 3.01[216] | 2.81[217] | 1.88[218] | 2.31[219] | 2.39[220] |
33 | CTU1 | Cytoplasmic tRNA 2-thiolation protein 1 | [221] | 0.65[222] | 0.48[223] | 0.56[224] | 0.44[225] | 1.05[226] | -0.04[227] |
34 | ADAT2 | tRNA-specific adenosine deaminase 2 | [228] | 2.72[229] | 3.37[230] | 2.54[231] | 2.19[232] | 2.07[233] | 2.52[234] |
35 | ADAT3 | Probable inactive tRNA-specific adenosine deaminase-like protein 3 | 1.71[235] | 1.52[236] | 1.04[237] | -0.20[238] | 1.61[239] | 1.10[240] | |
36 | TRDMT1 | tRNA (cytosine(38)-C(5))-methyltransferase | [241] | 3.17[242] | 3.09[243] | 1.58[244] | 5.94[245] | 4.74[246] | 3.62[247] |
37 | DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like | [248] | [249] | [250] | [251] | [252] | [253] | [254] |
38 | QTRT2 | Queuine tRNA-ribosyltransferase accessory subunit 2 | [255] | [256] | [257] | [258] | [259] | [260] | [261] |
39 | EPRS1 | [262] | [263] | [264] | [265] | [266] | [267] | [268] | |
40 | TRMT13 | tRNA:m(4)X modification enzyme TRM13 homolog | [269] | [270] | [271] | [272] | [273] | [274] | [275] |
41 | TRMT10A | tRNA methyltransferase 10 homolog A | [276] | [277] | [278] | [279] | [280] | [281] | [282] |
42 | TRMT44 | Probable tRNA (uracil-O(2)-)-methyltransferase | [283] | [284] | [285] | [286] | [287] | [288] | [289] |
43 | TRMT9B | [290] | [291] | [292] | [293] | [294] | [295] | [296] |