REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -9.67[2] -10.04[3] -7.45[4] -11.97[5] -9.69[6] -0.30[7]
2 PTGR1 Prostaglandin reductase 1 [8] -0.03[9] -5.84[10] -0.72[11] 1.85[12] 0.89[13] -1.19[14]
3 CYP2C8 Cytochrome P450 2C8 [15] -11.67[16] -7.16[17] -5.61[18] -9.05[19] [20] 0.62[21]
4 CYP2C9 Cytochrome P450 2C9 [22] [23] -12.08[24] -5.83[25] -11.74[26] -10.22[27] 1.12[28]
5 CYP3A4 Cytochrome P450 3A4 [29] -6.92[30] -7.27[31] -9.64[32] -12.05[33] -9.79[34] 0.83[35]
6 GPX4 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [36] 3.01[37] 3.19[38] 2.23[39] 1.81[40] 2.12[41] -1.69[42]
7 CYP1A2 Cytochrome P450 1A2 [43] -6.10[44] -5.03[45] -6.34[46] -5.62[47] -5.32[48] -1.55[49]
8 CYP1A1 Cytochrome P450 1A1 [50] 0.35[51] -1.46[52] 1.55[53] -1.02[54] -0.85[55] -5.69[56]
9 CYP2D6 Cytochrome P450 2D6 [57] -3.08[58] -0.82[59] -4.01[60] -5.11[61] -4.92[62] 1.32[63]
10 EPHX2 Bifunctional epoxide hydrolase 2 [64] 1.54[65] 3.12[66] 3.91[67] -1.40[68] -0.45[69] 1.04[70]
11 HPGD 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [71] -3.33[72] -3.80[73] 4.68[74] -2.33[75] -2.16[76] 0.72[77]
12 LTA4H Leukotriene A-4 hydrolase [78] 4.84[79] 5.25[80] 4.39[81] 3.85[82] 5.05[83] -1.42[84]
13 GSTM4 Glutathione S-transferase Mu 4 [85] 4.01[86] 3.24[87] 2.77[88] 4.23[89] 1.77[90] -0.14[91]
14 ALOX5AP Arachidonate 5-lipoxygenase-activating protein [92] 2.80[93] 0.74[94] 1.48[95] 4.32[96] 4.49[97] -0.23[98]
15 ALOX5 Arachidonate 5-lipoxygenase [99] 3.95[100] -1.62[101] -2.20[102] -2.67[103] -0.69[104] 2.92[105]
16 LTC4S Leukotriene C4 synthase [106] 1.90[107] 3.17[108] 1.15[109] -1.35[110] 2.70[111] 0.64[112]
17 ALOX12 Arachidonate 12-lipoxygenase, 12S-type [113] 5.44[114] 5.16[115] 3.48[116] 5.30[117] 5.42[118] 0.92[119]
18 PTGS2 Prostaglandin G/H synthase 2 [120] [121] 1.98[122] 1.58[123] 7.33[124] 13.86[125] 2.94[126]
19 ALOX15 Arachidonate 15-lipoxygenase [127] 6.43[128] 2.14[129] 6.07[130] 2.71[131] 3.87[132] -0.84[133]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 0 4.6 90 2.7e+03 4.1e+03
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.21 0.06
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0.21 0
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.67 1.3 0.99
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.032 0.025
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 2.6e+03 1e+03 1.7e+03 6.9e+02
[8]
ref_hepatocyte PTGR1
Mean 540
Standard deviation 7.3e+02
Values 73 1.8e+03 1.5e+02 4.2e+02 2.3e+02
[9]
HepG2 PTGR1
Mean 41.5
Standard deviation 32
Values 64 19
[10]
HepG2.C3A PTGR1
Mean 0.764
Standard deviation 0.27
Values 0.57 0.95
[11]
HuH.7 PTGR1
Mean 40.3
Standard deviation 6.4
Values 35 47 39
[12]
SNU475 PTGR1
Mean 161
Standard deviation 14
Values 1.5e+02 1.7e+02
[13]
THLE PTGR1
Mean 56.8
Standard deviation 6.8
Values 62 52
[14]
liver PTGR1
Mean 313
Standard deviation 2.3e+02
Values 3.1e+02 2.6e+02 6.2e+02 56
[15]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 0 1.2 19 7.1e+02 9.1e+02
[16]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[17]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.14 0.24
[18]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.16 2 0.3
[19]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.037 0.066
[20]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[21]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 6.8e+02 6.2e+02 1.2e+03 2e+02
[22]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 0.064 20 21 4.7e+02 9.2e+02
[23]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[24]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[25]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[26]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[27]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[28]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 8.6e+02 6.1e+02 1.5e+03 2.9e+02
[29]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 11 3.2e+02 9.6e+02
[30]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[31]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[32]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[33]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[34]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[35]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 4.3e+02 6.4e+02 1.3e+03 49
[36]
ref_hepatocyte GPX4
Mean 223
Standard deviation 63
Values 3.1e+02 1.4e+02 2.2e+02 2e+02 2.5e+02
[37]
HepG2 GPX4
Mean 141
Standard deviation 10
Values 1.5e+02 1.3e+02
[38]
HepG2.C3A GPX4
Mean 164
Standard deviation 3.3
Values 1.7e+02 1.6e+02
[39]
HuH.7 GPX4
Mean 128
Standard deviation 29
Values 1.1e+02 1.1e+02 1.6e+02
[40]
SNU475 GPX4
Mean 64.8
Standard deviation 11
Values 73 57
[41]
THLE GPX4
Mean 54.8
Standard deviation 1.7
Values 54 56
[42]
liver GPX4
Mean 91.2
Standard deviation 88
Values 1.7e+02 18 1.6e+02 12
[43]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 0.97 71 3e+02
[44]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[45]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[46]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[47]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[48]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[49]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 55 12 58 19
[50]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 77 43 0.06 17 82
[51]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 6.2 2.6
[52]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.4 1.2
[53]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 14 17 17
[54]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 0.49 3.1
[55]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[56]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 1.2 0.47 0.92 1.8
[57]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 0.24 0.47 3.7 1.1e+02 87
[58]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.36 0.4
[59]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 2.6 1.2
[60]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.23 0.4 0.31
[61]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.1 0.096
[62]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[63]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 3.1e+02 53 1.3e+02 57
[64]
ref_hepatocyte EPHX2
Mean 31.5
Standard deviation 40
Values 6.6 5.1 2.2 51 93
[65]
HepG2 EPHX2
Mean 7.16
Standard deviation 2
Values 5.8 8.5
[66]
HepG2.C3A EPHX2
Mean 22.2
Standard deviation 4
Values 25 19
[67]
HuH.7 EPHX2
Mean 58
Standard deviation 2.7
Values 58 55 61
[68]
SNU475 EPHX2
Mean 0.995
Standard deviation 0.55
Values 1.4 0.61
[69]
THLE EPHX2
Mean 1.31
Standard deviation 0.13
Values 1.4 1.2
[70]
liver EPHX2
Mean 85.8
Standard deviation 57
Values 1.6e+02 42 1e+02 40
[71]
ref_hepatocyte HPGD
Mean 29.5
Standard deviation 45
Values 0.17 5.7 1.8 35 1.1e+02
[72]
HepG2 HPGD
Mean 0.23
Standard deviation 0.13
Values 0.14 0.32
[73]
HepG2.C3A HPGD
Mean 0.172
Standard deviation 0.12
Values 0.087 0.26
[74]
HuH.7 HPGD
Mean 92.8
Standard deviation 79
Values 46 1.8e+02 48
[75]
SNU475 HPGD
Mean 0.487
Standard deviation 0.29
Values 0.7 0.28
[76]
THLE HPGD
Mean 0.376
Standard deviation 0.08
Values 0.43 0.32
[77]
liver HPGD
Mean 64.5
Standard deviation 48
Values 25 68 1.3e+02 35
[78]
ref_hepatocyte LTA4H
Mean 21.8
Standard deviation 17
Values 50 24 8.9 13 13
[79]
HepG2 LTA4H
Mean 48.8
Standard deviation 6.4
Values 53 44
[80]
HepG2.C3A LTA4H
Mean 67.1
Standard deviation 27
Values 86 48
[81]
HuH.7 LTA4H
Mean 55.9
Standard deviation 9.7
Values 48 67 53
[82]
SNU475 LTA4H
Mean 26
Standard deviation 1.8
Values 27 25
[83]
THLE LTA4H
Mean 40.9
Standard deviation 1.6
Values 40 42
[84]
liver LTA4H
Mean 10.7
Standard deviation 1.4
Values 11 11 13 9
[85]
ref_hepatocyte GSTM4
Mean 9.44
Standard deviation 5.5
Values 11 5.2 2.4 14 15
[86]
HepG2 GSTM4
Mean 11.9
Standard deviation 5
Values 8.4 15
[87]
HepG2.C3A GSTM4
Mean 7.23
Standard deviation 1
Values 8 6.5
[88]
HuH.7 GSTM4
Mean 7.9
Standard deviation 0.7
Values 8.4 7.1 8.2
[89]
SNU475 GSTM4
Mean 14.8
Standard deviation 7.9
Values 20 9.2
[90]
THLE GSTM4
Mean 1.82
Standard deviation 0.44
Values 2.1 1.5
[91]
liver GSTM4
Mean 11.3
Standard deviation 5.6
Values 18 5.7 14 7.7
[92]
ref_hepatocyte ALOX5AP
Mean 0.929
Standard deviation 0.85
Values 0.13 0 1.2 1.3 2
[93]
HepG2 ALOX5AP
Mean 0.507
Standard deviation 0.0044
Values 0.5 0.51
[94]
HepG2.C3A ALOX5AP
Mean 0.126
Standard deviation 0.095
Values 0.058 0.19
[95]
HuH.7 ALOX5AP
Mean 0.318
Standard deviation 0.44
Values 0.049 0.82 0.084
[96]
SNU475 ALOX5AP
Mean 1.54
Standard deviation 0.32
Values 1.8 1.3
[97]
THLE ALOX5AP
Mean 1.18
Standard deviation 0.56
Values 0.79 1.6
[98]
liver ALOX5AP
Mean 1.05
Standard deviation 0.72
Values 1.5 0.46 1.8 0.41
[99]
ref_hepatocyte ALOX5
Mean 0.387
Standard deviation 0.51
Values 0 0.18 0 0.53 1.2
[100]
HepG2 ALOX5
Mean 0.467
Standard deviation 0.66
Values 0.93 0
[101]
HepG2.C3A ALOX5
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[102]
HuH.7 ALOX5
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[103]
SNU475 ALOX5
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[104]
THLE ALOX5
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[105]
liver ALOX5
Mean 3.87
Standard deviation 1.4
Values 2.2 4.4 3.4 5.5
[106]
ref_hepatocyte LTC4S
Mean 0.22
Standard deviation 0.38
Values 0 0 0 0.22 0.88
[107]
HepG2 LTC4S
Mean 0.0644
Standard deviation 0.055
Values 0.1 0.026
[108]
HepG2.C3A LTC4S
Mean 0.162
Standard deviation 0.046
Values 0.19 0.13
[109]
HuH.7 LTC4S
Mean 0.0599
Standard deviation 0.031
Values 0.025 0.071 0.084
[110]
SNU475 LTC4S
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[111]
THLE LTC4S
Mean 0.081
Standard deviation 0.0058
Values 0.077 0.085
[112]
liver LTC4S
Mean 0.455
Standard deviation 0.39
Values 0.89 0.13 0.67 0.13
[113]
ref_hepatocyte ALOX12
Mean 0.117
Standard deviation 0.11
Values 0 0 0.18 0.17 0.24
[114]
HepG2 ALOX12
Mean 0.399
Standard deviation 0.13
Values 0.49 0.3
[115]
HepG2.C3A ALOX12
Mean 0.34
Standard deviation 0.041
Values 0.37 0.31
[116]
HuH.7 ALOX12
Mean 0.159
Standard deviation 0.066
Values 0.19 0.21 0.084
[117]
SNU475 ALOX12
Mean 0.384
Standard deviation 0.19
Values 0.52 0.25
[118]
THLE ALOX12
Mean 0.284
Standard deviation 0.025
Values 0.3 0.27
[119]
liver ALOX12
Mean 0.294
Standard deviation 0.18
Values 0.14 0.43 0.13 0.48
[120]
ref_hepatocyte PTGS2
Mean 0.032
Standard deviation 0.045
Values 0 0 0 0.095 0.065
[121]
HepG2 PTGS2
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A PTGS2
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[123]
HuH.7 PTGS2
Mean 0.0117
Standard deviation 0.013
Values 0 0.026 0.0094
[124]
SNU475 PTGS2
Mean 0.428
Standard deviation 0.51
Values 0.07 0.79
[125]
THLE PTGS2
Mean 27
Standard deviation 7.8
Values 33 22
[126]
liver PTGS2
Mean 0.325
Standard deviation 0.24
Values 0.24 0.67 0.13 0.26
[127]
ref_hepatocyte ALOX15
Mean 0.0272
Standard deviation 0.03
Values 0 0 0.019 0.052 0.065
[128]
HepG2 ALOX15
Mean 0.183
Standard deviation 0.19
Values 0.32 0.051
[129]
HepG2.C3A ALOX15
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[130]
HuH.7 ALOX15
Mean 0.223
Standard deviation 0.099
Values 0.27 0.11 0.29
[131]
SNU475 ALOX15
Mean 0.0148
Standard deviation 0.0078
Values 0.0093 0.02
[132]
THLE ALOX15
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[133]
liver ALOX15
Mean 0.0201
Standard deviation 0.031
Values 0 0.014 0 0.066