REACTOME_TRANSLESION_SYNTHESIS_BY_Y_FAMILY_DNA_POLYMERASES_BYPASSES_LESI | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.83[2] | -1.06[3] | -1.00[4] | -1.19[5] | -0.91[6] | -0.45[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.38[16] | -0.31[17] | -0.63[18] | -0.33[19] | -0.53[20] | 0.00[21] |
4 | VCP | Transitional endoplasmic reticulum ATPase | [22] | 1.61[23] | 1.31[24] | 1.15[25] | 1.09[26] | 1.47[27] | 1.67[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 2.05[30] | 1.93[31] | 2.88[32] | 1.06[33] | 1.69[34] | 0.77[35] |
6 | ISG15 | Ubiquitin-like protein ISG15 | [36] | -0.79[37] | -0.57[38] | -1.77[39] | -1.71[40] | -3.03[41] | -0.97[42] |
7 | UBE2L6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | [43] | -0.38[44] | -2.90[45] | -1.33[46] | 0.54[47] | -0.21[48] | 0.74[49] |
8 | PCNA | Proliferating cell nuclear antigen | [50] | 2.26[51] | 2.21[52] | 0.71[53] | 1.37[54] | 1.47[55] | -1.65[56] |
9 | POLD2 | DNA polymerase delta subunit 2 | [57] | 0.77[58] | 0.91[59] | 1.33[60] | 0.72[61] | 0.91[62] | 1.31[63] |
10 | POLD4 | DNA polymerase delta subunit 4 | [64] | -0.76[65] | -1.14[66] | 0.85[67] | 3.03[68] | -0.74[69] | 0.95[70] |
11 | POLE3 | DNA polymerase epsilon subunit 3 | [71] | 0.59[72] | 0.41[73] | 0.62[74] | 0.53[75] | 1.39[76] | -0.14[77] |
12 | POLE4 | DNA polymerase epsilon subunit 4 | [78] | 0.33[79] | 1.03[80] | -2.51[81] | -0.04[82] | -0.69[83] | -0.38[84] |
13 | RPA2 | Replication protein A 32 kDa subunit | [85] | -0.09[86] | -0.04[87] | 0.43[88] | 0.85[89] | 0.74[90] | -0.97[91] |
14 | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B | [92] | -0.16[93] | 1.22[94] | -0.15[95] | -0.08[96] | -0.05[97] | 0.01[98] |
15 | NPLOC4 | Nuclear protein localization protein 4 homolog | [99] | 3.12[100] | 2.66[101] | 2.41[102] | 3.06[103] | 3.10[104] | 2.72[105] |
16 | RFC4 | Replication factor C subunit 4 | [106] | 0.40[107] | 1.00[108] | 1.49[109] | 0.62[110] | 1.77[111] | -1.32[112] |
17 | USP10 | Ubiquitin carboxyl-terminal hydrolase 10 | [113] | 2.23[114] | 2.19[115] | 2.42[116] | 2.24[117] | 2.37[118] | 2.36[119] |
18 | RFC1 | Replication factor C subunit 1 | [120] | 1.51[121] | 2.77[122] | 3.06[123] | 1.91[124] | 2.57[125] | 2.21[126] |
19 | RFC2 | Replication factor C subunit 2 | [127] | 1.11[128] | 0.93[129] | 0.89[130] | 1.77[131] | 2.05[132] | 0.65[133] |
20 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [134] | 2.68[135] | 2.39[136] | 2.57[137] | 3.44[138] | 3.28[139] | 1.43[140] |
21 | RPA3 | Replication protein A 14 kDa subunit | [141] | 1.00[142] | 1.77[143] | 2.40[144] | 0.69[145] | 0.79[146] | 0.74[147] |
22 | TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 | [148] | 3.51[149] | 3.11[150] | 2.86[151] | 2.47[152] | 2.94[153] | 3.24[154] |
23 | RFC5 | Replication factor C subunit 5 | [155] | 1.50[156] | 1.93[157] | 2.04[158] | 1.86[159] | 2.20[160] | 0.55[161] |
24 | RFC3 | Replication factor C subunit 3 | [162] | 2.55[163] | 3.38[164] | 3.43[165] | 2.84[166] | 3.26[167] | 0.56[168] |
25 | UBA7 | Ubiquitin-like modifier-activating enzyme 7 | [169] | 1.13[170] | 0.83[171] | -4.02[172] | 2.66[173] | 2.03[174] | 2.81[175] |
26 | RCHY1 | RING finger and CHY zinc finger domain-containing protein 1 | [176] | 2.06[177] | 2.59[178] | 1.90[179] | 1.83[180] | 2.38[181] | 3.08[182] |
27 | POLD1 | DNA polymerase delta catalytic subunit | [183] | 3.23[184] | 3.42[185] | 4.15[186] | 3.41[187] | 3.99[188] | 2.10[189] |
28 | REV1 | DNA repair protein REV1 | [190] | 2.81[191] | 3.98[192] | 3.18[193] | 3.43[194] | 3.21[195] | 3.24[196] |
29 | POLK | DNA polymerase kappa | [197] | 0.53[198] | 1.97[199] | 2.14[200] | 3.42[201] | 2.97[202] | 3.52[203] |
30 | POLH | DNA polymerase eta | [204] | 3.48[205] | 2.95[206] | 1.42[207] | 3.59[208] | 3.20[209] | 2.76[210] |
31 | POLD3 | DNA polymerase delta subunit 3 | [211] | 2.54[212] | 2.39[213] | 3.27[214] | 3.70[215] | 4.01[216] | 2.41[217] |
32 | POLE | DNA polymerase epsilon catalytic subunit A | [218] | 4.41[219] | 5.01[220] | 4.97[221] | 4.33[222] | 5.16[223] | 4.36[224] |
33 | USP43 | Ubiquitin carboxyl-terminal hydrolase 43 | [225] | 0.33[226] | 1.20[227] | -3.57[228] | 1.42[229] | -2.09[230] | 1.70[231] |
34 | POLE2 | DNA polymerase epsilon subunit 2 | [232] | 2.07[233] | 2.84[234] | 3.74[235] | 2.74[236] | 3.10[237] | 0.27[238] |
35 | REV3L | DNA polymerase zeta catalytic subunit | [239] | 3.78[240] | 5.31[241] | 3.84[242] | 4.59[243] | 4.55[244] | 5.89[245] |
36 | POLI | DNA polymerase iota | [246] | 2.95[247] | 4.30[248] | 4.13[249] | 3.86[250] | 3.46[251] | 4.31[252] |
37 | SPRTN | SprT-like domain-containing protein Spartan | [253] | [254] | [255] | [256] | [257] | [258] | [259] |
38 | PCLAF | PCNA-associated factor | [260] | [261] | [262] | [263] | [264] | [265] | [266] |
39 | UFD1 | Ubiquitin recognition factor in ER-associated degradation protein 1 | [267] | [268] | [269] | [270] | [271] | [272] | [273] |