REACTOME_BIOSYNTHESIS_OF_MARESINS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -5.18[2] -7.06[3] -5.17[4] -4.72[5] -3.30[6] -0.57[7]
2 CYP2C8 Cytochrome P450 2C8 [8] -7.18[9] -4.18[10] -3.33[11] -1.81[12] [13] 0.35[14]
3 CYP2C9 Cytochrome P450 2C9 [15] [16] -9.09[17] -3.55[18] -4.49[19] -3.83[20] 0.85[21]
4 CYP3A4 Cytochrome P450 3A4 [22] -2.43[23] -4.29[24] -7.36[25] -4.81[26] -3.41[27] 0.56[28]
5 CYP1A2 Cytochrome P450 1A2 [29] -1.61[30] -2.04[31] -4.05[32] 1.62[33] 1.06[34] -1.82[35]
6 CYP2D6 Cytochrome P450 2D6 [36] 1.41[37] 2.16[38] -1.73[39] 2.13[40] 1.47[41] 1.05[42]
7 EPHX2 Bifunctional epoxide hydrolase 2 [43] 6.03[44] 6.10[45] 6.19[46] 5.85[47] 5.94[48] 0.77[49]
8 ALOX5 Arachidonate 5-lipoxygenase [50] 8.44[51] 1.36[52] 0.08[53] 4.57[54] 5.69[55] 2.65[56]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 0 4.6 90 2.7e+03 4.1e+03
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.21 0.06
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0.21 0
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.67 1.3 0.99
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.032 0.025
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 2.6e+03 1e+03 1.7e+03 6.9e+02
[8]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 0 1.2 19 7.1e+02 9.1e+02
[9]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[10]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.14 0.24
[11]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.16 2 0.3
[12]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.037 0.066
[13]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[14]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 6.8e+02 6.2e+02 1.2e+03 2e+02
[15]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 0.064 20 21 4.7e+02 9.2e+02
[16]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[17]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[18]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[19]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[20]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[21]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 8.6e+02 6.1e+02 1.5e+03 2.9e+02
[22]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 11 3.2e+02 9.6e+02
[23]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[24]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[25]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[26]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[27]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[28]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 4.3e+02 6.4e+02 1.3e+03 49
[29]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 0.97 71 3e+02
[30]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[31]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[32]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[33]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[34]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[35]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 55 12 58 19
[36]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 0.24 0.47 3.7 1.1e+02 87
[37]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.36 0.4
[38]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 2.6 1.2
[39]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.23 0.4 0.31
[40]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.1 0.096
[41]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[42]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 3.1e+02 53 1.3e+02 57
[43]
ref_hepatocyte EPHX2
Mean 31.5
Standard deviation 40
Values 6.6 5.1 2.2 51 93
[44]
HepG2 EPHX2
Mean 7.16
Standard deviation 2
Values 5.8 8.5
[45]
HepG2.C3A EPHX2
Mean 22.2
Standard deviation 4
Values 25 19
[46]
HuH.7 EPHX2
Mean 58
Standard deviation 2.7
Values 58 55 61
[47]
SNU475 EPHX2
Mean 0.995
Standard deviation 0.55
Values 1.4 0.61
[48]
THLE EPHX2
Mean 1.31
Standard deviation 0.13
Values 1.4 1.2
[49]
liver EPHX2
Mean 85.8
Standard deviation 57
Values 1.6e+02 42 1e+02 40
[50]
ref_hepatocyte ALOX5
Mean 0.387
Standard deviation 0.51
Values 0 0.18 0 0.53 1.2
[51]
HepG2 ALOX5
Mean 0.467
Standard deviation 0.66
Values 0.93 0
[52]
HepG2.C3A ALOX5
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[53]
HuH.7 ALOX5
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[54]
SNU475 ALOX5
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[55]
THLE ALOX5
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[56]
liver ALOX5
Mean 3.87
Standard deviation 1.4
Values 2.2 4.4 3.4 5.5