REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.62[2] | -1.47[3] | -1.25[4] | -1.79[5] | -1.29[6] | -0.67[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.18[16] | -0.72[17] | -0.89[18] | -0.94[19] | -0.91[20] | -0.22[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.95[23] | -2.31[24] | -1.86[25] | -1.66[26] | -2.13[27] | -1.17[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.77[30] | -1.93[31] | -1.95[32] | -1.44[33] | -1.67[34] | -0.79[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.19[37] | 0.54[38] | -0.70[39] | 0.18[40] | -0.19[41] | 0.23[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | -0.27[44] | 0.09[45] | -0.90[46] | -1.06[47] | -0.23[48] | 0.07[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.75[51] | -1.29[52] | -0.17[53] | -1.08[54] | -1.13[55] | -0.23[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.50[58] | -0.09[59] | 0.12[60] | 0.35[61] | 0.41[62] | -0.56[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.45[65] | -1.19[66] | -0.97[67] | -1.43[68] | -0.92[69] | -1.00[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 0.95[72] | -0.23[73] | -0.22[74] | -0.71[75] | -0.36[76] | -0.52[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.08[79] | 0.05[80] | 0.07[81] | -0.18[82] | -0.09[83] | -0.44[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.85[86] | 0.06[87] | -0.06[88] | 0.12[89] | 0.02[90] | -0.52[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.88[93] | -0.70[94] | 0.01[95] | -1.07[96] | -0.80[97] | -0.05[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -1.47[100] | -0.22[101] | -0.81[102] | -0.33[103] | -0.70[104] | -0.27[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.92[107] | -0.52[108] | -0.29[109] | -0.88[110] | -1.07[111] | -0.11[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -1.01[114] | 0.20[115] | 0.62[116] | -0.38[117] | 0.07[118] | 0.11[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | -0.49[121] | -0.22[122] | 0.06[123] | 0.32[124] | -0.14[125] | -0.21[126] |
19 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [127] | -0.57[128] | 0.05[129] | 0.00[130] | -0.76[131] | -0.22[132] | -0.39[133] |
20 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [134] | -0.40[135] | 0.09[136] | 0.31[137] | -0.49[138] | 0.35[139] | -0.36[140] |
21 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [141] | 1.13[142] | 0.56[143] | 0.72[144] | 0.62[145] | 1.99[146] | 0.67[147] |
22 | PSMC1 | 26S proteasome regulatory subunit 4 | [148] | -0.55[149] | -0.23[150] | -0.80[151] | 0.81[152] | 0.40[153] | -0.17[154] |
23 | PSMA1 | Proteasome subunit alpha type-1 | [155] | -0.37[156] | 0.28[157] | 0.43[158] | 0.38[159] | -0.04[160] | 0.32[161] |
24 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [162] | 1.26[163] | 1.52[164] | 2.62[165] | 0.46[166] | 1.32[167] | 0.55[168] |
25 | PSMC5 | 26S proteasome regulatory subunit 8 | [169] | -0.05[170] | 0.10[171] | 0.26[172] | -0.21[173] | 0.28[174] | 0.09[175] |
26 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [176] | 0.35[177] | 0.09[178] | 0.77[179] | 0.32[180] | 0.62[181] | -0.20[182] |
27 | PSMB8 | Proteasome subunit beta type-8 | [183] | -2.05[184] | -2.39[185] | -9.51[186] | 0.30[187] | -0.94[188] | -0.88[189] |
28 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [190] | -0.47[191] | 0.38[192] | 0.73[193] | 0.19[194] | 0.29[195] | -0.34[196] |
29 | PSMC4 | 26S proteasome regulatory subunit 6B | [197] | -0.05[198] | 0.23[199] | 0.26[200] | -0.18[201] | 0.00[202] | 0.14[203] |
30 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [204] | -1.20[205] | -0.47[206] | -1.47[207] | -0.81[208] | 0.07[209] | -0.45[210] |
31 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [211] | 0.00[212] | 0.36[213] | 0.95[214] | 0.25[215] | -0.17[216] | -0.26[217] |
32 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [218] | 1.42[219] | 0.38[220] | -2.25[221] | -1.00[222] | 1.60[223] | -0.63[224] |
33 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [225] | -0.82[226] | -0.49[227] | -0.71[228] | -0.13[229] | 0.01[230] | -0.34[231] |
34 | CTNNB1 | Catenin beta-1 | [232] | 2.20[233] | 2.04[234] | 3.00[235] | 1.74[236] | 2.02[237] | 2.32[238] |
35 | PSMC6 | 26S proteasome regulatory subunit 10B | [239] | -0.53[240] | 1.30[241] | 0.21[242] | 0.23[243] | 0.23[244] | 0.31[245] |
36 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [246] | 0.35[247] | 0.22[248] | 0.90[249] | 0.63[250] | 0.86[251] | 1.14[252] |
37 | PSMC2 | 26S proteasome regulatory subunit 7 | [253] | 0.11[254] | 0.76[255] | 0.63[256] | 1.03[257] | 0.93[258] | 1.19[259] |
38 | MYC | Myc proto-oncogene protein | [260] | 1.01[261] | 1.02[262] | -0.94[263] | -1.80[264] | 0.62[265] | -0.79[266] |
39 | PSME3 | Proteasome activator complex subunit 3 | [267] | 1.34[268] | 1.31[269] | 1.08[270] | 1.05[271] | 1.39[272] | 0.75[273] |
40 | SPP1 | Osteopontin | [274] | 3.75[275] | 2.87[276] | -5.56[277] | 2.89[278] | -5.13[279] | 0.13[280] |
41 | BRD2 | Bromodomain-containing protein 2 | [281] | 1.03[282] | 1.67[283] | 1.20[284] | 2.21[285] | 1.42[286] | 1.30[287] |
42 | SNW1 | SNW domain-containing protein 1 | [288] | -0.42[289] | 0.10[290] | 0.19[291] | 0.85[292] | 0.66[293] | -0.42[294] |
43 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [295] | 1.10[296] | 1.67[297] | 1.63[298] | 1.86[299] | 1.94[300] | 1.94[301] |
44 | CCND1 | G1/S-specific cyclin-D1 | [302] | 3.63[303] | 1.48[304] | 2.37[305] | 2.87[306] | 1.44[307] | 2.26[308] |
45 | PSMB10 | Proteasome subunit beta type-10 | [309] | -1.63[310] | -0.78[311] | -2.58[312] | -0.35[313] | -1.44[314] | -0.21[315] |
46 | PSMA5 | Proteasome subunit alpha type-5 | [316] | 1.42[317] | 2.10[318] | 1.75[319] | 1.91[320] | 1.55[321] | 1.78[322] |
47 | PSMF1 | Proteasome inhibitor PI31 subunit | [323] | 1.80[324] | 2.10[325] | 0.99[326] | 0.92[327] | 0.75[328] | 1.72[329] |
48 | PSMB2 | Proteasome subunit beta type-2 | [330] | 1.58[331] | 1.57[332] | 2.04[333] | 2.22[334] | 2.27[335] | 2.27[336] |
49 | PSMB9 | Proteasome subunit beta type-9 | [337] | -2.42[338] | -4.79[339] | -7.01[340] | 1.47[341] | -0.73[342] | -0.63[343] |
50 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [344] | -0.04[345] | 0.70[346] | -0.19[347] | 0.09[348] | 0.60[349] | 0.60[350] |
51 | YAP1 | Transcriptional coactivator YAP1 | [351] | 2.54[352] | 2.35[353] | 2.05[354] | 3.27[355] | 2.73[356] | 1.56[357] |
52 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [358] | 0.52[359] | 1.09[360] | 1.20[361] | 1.76[362] | 1.16[363] | 0.58[364] |
53 | KRAS | GTPase KRas | [365] | 0.06[366] | 0.39[367] | 2.06[368] | 1.79[369] | 1.49[370] | 1.88[371] |
54 | RORC | Nuclear receptor ROR-gamma | [372] | -0.75[373] | 0.29[374] | -9.65[375] | -3.51[376] | -5.47[377] | 1.42[378] |
55 | CBFB | Core-binding factor subunit beta | [379] | 1.12[380] | 2.08[381] | 1.18[382] | 1.82[383] | 2.29[384] | 0.83[385] |
56 | HES1 | Transcription factor HES-1 | [386] | 0.14[387] | -2.01[388] | 0.31[389] | -0.29[390] | -1.07[391] | -0.19[392] |
57 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [393] | 2.68[394] | 4.46[395] | 1.76[396] | 1.50[397] | 2.42[398] | 3.37[399] |
58 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [400] | 0.94[401] | 0.74[402] | 2.39[403] | 2.15[404] | 2.30[405] | 2.03[406] |
59 | SMAD3 | Mothers against decapentaplegic homolog 3 | [407] | 2.51[408] | 2.25[409] | 2.55[410] | 2.79[411] | 3.71[412] | 1.42[413] |
60 | TP53 | Cellular tumor antigen p53 | [414] | 2.21[415] | 2.13[416] | 2.95[417] | 2.28[418] | 1.99[419] | 1.17[420] |
61 | WWTR1 | WW domain-containing transcription regulator protein 1 | [421] | 2.47[422] | 2.41[423] | 1.48[424] | 3.30[425] | 2.66[426] | 1.94[427] |
62 | KAT2A | Histone acetyltransferase KAT2A | [428] | 2.60[429] | 2.82[430] | 2.00[431] | 2.12[432] | 2.01[433] | 1.49[434] |
63 | SRC | Proto-oncogene tyrosine-protein kinase Src | [435] | 3.60[436] | 3.94[437] | 3.00[438] | 3.39[439] | 2.61[440] | 0.36[441] |
64 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [442] | 2.02[443] | 1.81[444] | 2.79[445] | 2.20[446] | 2.14[447] | 2.59[448] |
65 | RBPJ | Recombining binding protein suppressor of hairless | [449] | 1.92[450] | 2.84[451] | 3.91[452] | 3.01[453] | 2.99[454] | 3.06[455] |
66 | SMAD4 | Mothers against decapentaplegic homolog 4 | [456] | 1.97[457] | 2.95[458] | 2.98[459] | 2.90[460] | 3.31[461] | 4.00[462] |
67 | KAT2B | Histone acetyltransferase KAT2B | [463] | -1.47[464] | -2.24[465] | 0.19[466] | 0.92[467] | 1.39[468] | 3.00[469] |
68 | TEAD2 | Transcriptional enhancer factor TEF-4 | [470] | 1.62[471] | 0.91[472] | 2.52[473] | 3.00[474] | 1.90[475] | 0.80[476] |
69 | FOXO3 | Forkhead box protein O3 | [477] | 1.03[478] | 1.47[479] | 2.18[480] | 1.39[481] | 2.67[482] | 3.54[483] |
70 | TEAD4 | Transcriptional enhancer factor TEF-3 | [484] | 2.86[485] | 2.62[486] | 1.72[487] | 0.62[488] | 0.98[489] | -1.32[490] |
71 | TEAD3 | Transcriptional enhancer factor TEF-5 | [491] | 2.44[492] | 2.82[493] | 1.24[494] | 1.98[495] | 2.05[496] | 1.04[497] |
72 | JAG1 | Protein jagged-1 | [498] | 5.35[499] | 4.29[500] | 3.83[501] | 2.50[502] | 1.19[503] | 2.26[504] |
73 | EP300 | Histone acetyltransferase p300 | [505] | 3.30[506] | 3.24[507] | 4.20[508] | 3.56[509] | 3.66[510] | 3.96[511] |
74 | TEAD1 | Transcriptional enhancer factor TEF-1 | [512] | 2.31[513] | 2.99[514] | 3.36[515] | 5.46[516] | 4.43[517] | 4.43[518] |
75 | TCF7L2 | Transcription factor 7-like 2 | [519] | 1.44[520] | 2.56[521] | 2.83[522] | 1.68[523] | 1.71[524] | 2.93[525] |
76 | RUNX1 | Runt-related transcription factor 1 | [526] | 1.78[527] | 0.92[528] | 1.10[529] | 3.17[530] | 2.92[531] | 0.56[532] |
77 | TGFB1 | Transforming growth factor beta-1 | [533] | 4.05[534] | 3.36[535] | 0.68[536] | 4.83[537] | 4.10[538] | -0.02[539] |
78 | MAML1 | Mastermind-like protein 1 | [540] | 2.69[541] | 3.01[542] | 3.61[543] | 3.23[544] | 3.41[545] | 2.29[546] |
79 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [547] | 2.29[548] | 2.67[549] | 1.25[550] | 2.18[551] | 2.67[552] | 1.35[553] |
80 | TCF7L1 | Transcription factor 7-like 1 | [554] | -2.48[555] | -0.32[556] | 1.94[557] | -0.83[558] | -0.66[559] | 1.50[560] |
81 | CREBBP | CREB-binding protein | [561] | 3.48[562] | 3.04[563] | 3.72[564] | 3.74[565] | 3.80[566] | 4.44[567] |
82 | TCF7 | Transcription factor 7 | [568] | 3.01[569] | 2.02[570] | 1.14[571] | 1.15[572] | 0.89[573] | 0.84[574] |
83 | BCL2L11 | Bcl-2-like protein 11 | [575] | 2.08[576] | 2.44[577] | 2.83[578] | 2.85[579] | 1.88[580] | 3.19[581] |
84 | ITGAL | Integrin alpha-L | [582] | -0.05[583] | 2.16[584] | 3.90[585] | -3.31[586] | -3.16[587] | 3.35[588] |
85 | MAMLD1 | Mastermind-like domain-containing protein 1 | [589] | -1.32[590] | -7.47[591] | -1.15[592] | 2.04[593] | 1.91[594] | 0.88[595] |
86 | ZFHX3 | Zinc finger homeobox protein 3 | [596] | 3.73[597] | 4.55[598] | 4.15[599] | 4.55[600] | 3.66[601] | 5.02[602] |
87 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [603] | 2.48[604] | 1.67[605] | 3.07[606] | 3.57[607] | 3.97[608] | 5.84[609] |
88 | HDAC4 | Histone deacetylase 4 | [610] | 4.04[611] | 4.23[612] | 4.07[613] | 3.69[614] | 4.06[615] | 4.59[616] |
89 | MAML3 | Mastermind-like protein 3 | [617] | 0.20[618] | 1.29[619] | 4.38[620] | 2.39[621] | 1.06[622] | 4.71[623] |
90 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [624] | 4.66[625] | 2.78[626] | 6.25[627] | 6.20[628] | 8.03[629] | -0.95[630] |
91 | MAML2 | Mastermind-like protein 2 | [631] | 4.06[632] | 5.04[633] | -1.46[634] | 5.76[635] | 4.68[636] | 3.57[637] |
92 | ITGA4 | Integrin alpha-4 | [638] | -3.07[639] | [640] | -0.17[641] | 8.58[642] | 5.27[643] | 4.64[644] |
93 | RUNX3 | Runt-related transcription factor 3 | [645] | 1.34[646] | 0.71[647] | 3.76[648] | 4.55[649] | -0.59[650] | 2.57[651] |
94 | LEF1 | Lymphoid enhancer-binding factor 1 | [652] | 3.23[653] | -3.34[654] | 4.64[655] | 2.07[656] | 0.41[657] | 2.29[658] |
95 | CCN2 | [659] | [660] | [661] | [662] | [663] | [664] | [665] | |
96 | SEM1 | Putative protein SEM1, isoform 2 | [666] | [667] | [668] | [669] | [670] | [671] | [672] |