REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX2 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.44[2] | -1.48[3] | -1.30[4] | -1.84[5] | -1.47[6] | -0.78[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.00[16] | -0.72[17] | -0.93[18] | -0.98[19] | -1.09[20] | -0.33[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.77[23] | -2.31[24] | -1.90[25] | -1.70[26] | -2.31[27] | -1.28[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.59[30] | -1.94[31] | -1.99[32] | -1.49[33] | -1.85[34] | -0.91[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.37[37] | 0.53[38] | -0.74[39] | 0.14[40] | -0.37[41] | 0.12[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | -0.08[44] | 0.08[45] | -0.94[46] | -1.11[47] | -0.41[48] | -0.05[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.57[51] | -1.30[52] | -0.21[53] | -1.13[54] | -1.31[55] | -0.34[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.32[58] | -0.10[59] | 0.08[60] | 0.30[61] | 0.23[62] | -0.67[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.27[65] | -1.20[66] | -1.01[67] | -1.47[68] | -1.10[69] | -1.11[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.13[72] | -0.24[73] | -0.26[74] | -0.75[75] | -0.54[76] | -0.64[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.26[79] | 0.04[80] | 0.03[81] | -0.22[82] | -0.27[83] | -0.55[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.67[86] | 0.06[87] | -0.10[88] | 0.08[89] | -0.16[90] | -0.63[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.22[93] | 0.34[94] | -0.51[95] | 0.44[96] | 0.57[97] | 0.40[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.70[100] | -0.71[101] | -0.03[102] | -1.12[103] | -0.99[104] | -0.16[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.29[107] | -0.22[108] | -0.85[109] | -0.37[110] | -0.89[111] | -0.39[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.74[114] | -0.53[115] | -0.33[116] | -0.92[117] | -1.25[118] | -0.23[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.82[121] | 0.20[122] | 0.58[123] | -0.42[124] | -0.11[125] | 0.00[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.31[128] | -0.23[129] | 0.02[130] | 0.28[131] | -0.32[132] | -0.33[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.39[135] | 0.05[136] | -0.04[137] | -0.80[138] | -0.40[139] | -0.50[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.22[142] | 0.08[143] | 0.27[144] | -0.53[145] | 0.17[146] | -0.48[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.31[149] | 0.55[150] | 0.68[151] | 0.58[152] | 1.81[153] | 0.56[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | -0.37[156] | -0.24[157] | -0.84[158] | 0.76[159] | 0.22[160] | -0.28[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | -0.19[163] | 0.27[164] | 0.38[165] | 0.34[166] | -0.22[167] | 0.21[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.44[170] | 1.51[171] | 2.58[172] | 0.41[173] | 1.14[174] | 0.44[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.13[177] | 0.09[178] | 0.22[179] | -0.25[180] | 0.10[181] | -0.03[182] |
27 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [183] | -1.30[184] | -0.70[185] | -0.79[186] | -1.76[187] | -1.42[188] | -1.01[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.53[191] | 0.09[192] | 0.73[193] | 0.28[194] | 0.44[195] | -0.31[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.87[198] | -2.39[199] | -9.56[200] | 0.25[201] | -1.12[202] | -1.00[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | -0.29[205] | 0.38[206] | 0.69[207] | 0.14[208] | 0.11[209] | -0.45[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.13[212] | 0.23[213] | 0.22[214] | -0.23[215] | -0.18[216] | 0.02[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -1.02[219] | -0.47[220] | -1.51[221] | -0.85[222] | -0.11[223] | -0.57[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.18[226] | 0.35[227] | 0.90[228] | 0.20[229] | -0.35[230] | -0.38[231] |
34 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [232] | 1.60[233] | 0.37[234] | -2.29[235] | -1.04[236] | 1.42[237] | -0.74[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.64[240] | -0.50[241] | -0.76[242] | -0.18[243] | -0.17[244] | -0.46[245] |
36 | AKT1 | RAC-alpha serine/threonine-protein kinase | [246] | 0.84[247] | 0.77[248] | -0.28[249] | 0.89[250] | 0.83[251] | 0.85[252] |
37 | STUB1 | E3 ubiquitin-protein ligase CHIP | [253] | -1.22[254] | -1.04[255] | -1.67[256] | -1.72[257] | -1.48[258] | -1.16[259] |
38 | PSMC6 | 26S proteasome regulatory subunit 10B | [260] | -0.35[261] | 1.29[262] | 0.17[263] | 0.18[264] | 0.05[265] | 0.20[266] |
39 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [267] | 0.54[268] | 0.21[269] | 0.86[270] | 0.59[271] | 0.68[272] | 1.02[273] |
40 | PSMC2 | 26S proteasome regulatory subunit 7 | [274] | 0.29[275] | 0.76[276] | 0.58[277] | 0.98[278] | 0.75[279] | 1.07[280] |
41 | PSME3 | Proteasome activator complex subunit 3 | [281] | 1.52[282] | 1.30[283] | 1.03[284] | 1.01[285] | 1.21[286] | 0.64[287] |
42 | BAX | Apoptosis regulator BAX | [288] | 1.09[289] | 0.46[290] | 0.03[291] | -0.66[292] | -0.36[293] | -2.86[294] |
43 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [295] | 1.28[296] | 1.66[297] | 1.59[298] | 1.82[299] | 1.76[300] | 1.83[301] |
44 | CCND1 | G1/S-specific cyclin-D1 | [302] | 3.81[303] | 1.47[304] | 2.33[305] | 2.82[306] | 1.26[307] | 2.15[308] |
45 | PSMB10 | Proteasome subunit beta type-10 | [309] | -1.45[310] | -0.79[311] | -2.62[312] | -0.40[313] | -1.62[314] | -0.32[315] |
46 | YES1 | Tyrosine-protein kinase Yes | [316] | -0.10[317] | 1.55[318] | 1.80[319] | 1.39[320] | 0.77[321] | 1.22[322] |
47 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [323] | 0.68[324] | -0.07[325] | 1.07[326] | 3.47[327] | 1.12[328] | 2.04[329] |
48 | PSMA5 | Proteasome subunit alpha type-5 | [330] | 1.61[331] | 2.10[332] | 1.71[333] | 1.87[334] | 1.37[335] | 1.67[336] |
49 | PSMF1 | Proteasome inhibitor PI31 subunit | [337] | 1.99[338] | 2.09[339] | 0.95[340] | 0.88[341] | 0.57[342] | 1.61[343] |
50 | CDK4 | Cyclin-dependent kinase 4 | [344] | 2.09[345] | 2.84[346] | 2.50[347] | 1.12[348] | 1.69[349] | 0.26[350] |
51 | PSMB2 | Proteasome subunit beta type-2 | [351] | 1.77[352] | 1.56[353] | 2.00[354] | 2.17[355] | 2.09[356] | 2.15[357] |
52 | PSMB9 | Proteasome subunit beta type-9 | [358] | -2.24[359] | -4.80[360] | -7.05[361] | 1.42[362] | -0.91[363] | -0.74[364] |
53 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [365] | 0.14[366] | 0.70[367] | -0.24[368] | 0.05[369] | 0.42[370] | 0.48[371] |
54 | CUL1 | Cullin-1 | [372] | 0.37[373] | 1.22[374] | 0.80[375] | 1.53[376] | 1.09[377] | 1.84[378] |
55 | ESRRA | Steroid hormone receptor ERR1 | [379] | 0.54[380] | 1.53[381] | 1.00[382] | 0.11[383] | -0.01[384] | 1.13[385] |
56 | HDAC3 | Histone deacetylase 3 | [386] | 1.24[387] | 1.46[388] | 1.29[389] | 0.89[390] | 0.96[391] | 0.69[392] |
57 | ITGA5 | Integrin alpha-5 | [393] | -0.46[394] | -6.72[395] | 0.50[396] | 3.67[397] | 4.21[398] | 2.23[399] |
58 | YAP1 | Transcriptional coactivator YAP1 | [400] | 2.72[401] | 2.35[402] | 2.00[403] | 3.23[404] | 2.55[405] | 1.45[406] |
59 | WWP1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | [407] | 0.76[408] | 1.96[409] | 2.37[410] | 0.72[411] | 0.23[412] | 3.26[413] |
60 | MAPK1 | Mitogen-activated protein kinase 1 | [414] | 2.47[415] | 2.77[416] | 2.63[417] | 2.79[418] | 2.35[419] | 2.87[420] |
61 | AKT2 | RAC-beta serine/threonine-protein kinase | [421] | 1.72[422] | 2.16[423] | 2.32[424] | 1.80[425] | 1.50[426] | 2.22[427] |
62 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [428] | 0.70[429] | 1.08[430] | 1.16[431] | 1.72[432] | 0.98[433] | 0.47[434] |
63 | LGALS3 | Galectin-3 | [435] | 2.00[436] | 2.93[437] | 2.08[438] | 2.01[439] | 0.98[440] | -0.92[441] |
64 | CCNB1 | G2/mitotic-specific cyclin-B1 | [442] | 2.60[443] | 3.01[444] | 3.21[445] | 2.55[446] | 3.44[447] | -1.25[448] |
65 | PSME4 | Proteasome activator complex subunit 4 | [449] | 2.22[450] | 3.20[451] | 3.25[452] | 2.28[453] | 2.18[454] | 2.73[455] |
66 | CBFB | Core-binding factor subunit beta | [456] | 1.30[457] | 2.08[458] | 1.14[459] | 1.78[460] | 2.11[461] | 0.71[462] |
67 | NR3C1 | Glucocorticoid receptor | [463] | 0.79[464] | 0.54[465] | 0.87[466] | 2.42[467] | 2.44[468] | 2.86[469] |
68 | HES1 | Transcription factor HES-1 | [470] | 0.32[471] | -2.01[472] | 0.27[473] | -0.33[474] | -1.25[475] | -0.30[476] |
69 | HDAC6 | Histone deacetylase 6 | [477] | 1.41[478] | 2.53[479] | 2.65[480] | 1.23[481] | 0.61[482] | 3.25[483] |
70 | SOX9 | Transcription factor SOX-9 | [484] | 3.12[485] | 3.42[486] | 3.29[487] | 0.01[488] | -0.82[489] | -2.04[490] |
71 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [491] | 1.12[492] | 0.73[493] | 2.35[494] | 2.11[495] | 2.12[496] | 1.91[497] |
72 | CDK1 | Cyclin-dependent kinase 1 | [498] | 2.01[499] | 4.24[500] | 3.00[501] | 3.21[502] | 3.94[503] | -1.38[504] |
73 | BMP2 | Bone morphogenetic protein 2 | [505] | -4.22[506] | -7.19[507] | 1.94[508] | -0.94[509] | -0.79[510] | -1.09[511] |
74 | SMAD1 | Mothers against decapentaplegic homolog 1 | [512] | -0.29[513] | 0.13[514] | 0.45[515] | 0.22[516] | 0.68[517] | 1.72[518] |
75 | WWTR1 | WW domain-containing transcription regulator protein 1 | [519] | 2.65[520] | 2.40[521] | 1.44[522] | 3.25[523] | 2.48[524] | 1.83[525] |
76 | AR | Androgen receptor | [526] | -9.70[527] | -8.85[528] | -10.66[529] | -0.80[530] | -3.93[531] | 4.74[532] |
77 | MAPK3 | Mitogen-activated protein kinase 3 | [533] | 2.61[534] | 2.82[535] | 2.89[536] | 1.37[537] | 1.30[538] | 0.05[539] |
78 | GSK3B | Glycogen synthase kinase-3 beta | [540] | 2.02[541] | 1.83[542] | 2.43[543] | 2.76[544] | 2.50[545] | 2.26[546] |
79 | RBM14 | RNA-binding protein 14 | [547] | 2.32[548] | 2.05[549] | 2.67[550] | 2.40[551] | 2.18[552] | 2.36[553] |
80 | ABL1 | Tyrosine-protein kinase ABL1 | [554] | 2.99[555] | 2.55[556] | 3.37[557] | 3.01[558] | 3.61[559] | 2.03[560] |
81 | SRC | Proto-oncogene tyrosine-protein kinase Src | [561] | 3.78[562] | 3.93[563] | 2.96[564] | 3.34[565] | 2.43[566] | 0.24[567] |
82 | SKP2 | S-phase kinase-associated protein 2 | [568] | 2.07[569] | 2.70[570] | 3.86[571] | 2.20[572] | 2.20[573] | 2.17[574] |
83 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [575] | 2.20[576] | 1.81[577] | 2.75[578] | 2.16[579] | 1.96[580] | 2.48[581] |
84 | FBXW7 | F-box/WD repeat-containing protein 7 | [582] | 0.02[583] | 0.86[584] | 0.87[585] | 0.04[586] | 0.97[587] | 2.24[588] |
85 | SMAD4 | Mothers against decapentaplegic homolog 4 | [589] | 2.15[590] | 2.95[591] | 2.94[592] | 2.85[593] | 3.13[594] | 3.88[595] |
86 | RB1 | Retinoblastoma-associated protein | [596] | 1.98[597] | 2.64[598] | 3.23[599] | 3.22[600] | 3.46[601] | 2.57[602] |
87 | PPM1D | Protein phosphatase 1D | [603] | 2.01[604] | 2.41[605] | 1.65[606] | 0.45[607] | 1.43[608] | 1.20[609] |
88 | MAF | Transcription factor Maf | [610] | -2.13[611] | -5.01[612] | 2.15[613] | 1.09[614] | 0.07[615] | 3.50[616] |
89 | RUNX1 | Runt-related transcription factor 1 | [617] | 1.96[618] | 0.92[619] | 1.05[620] | 3.13[621] | 2.74[622] | 0.45[623] |
90 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | -0.33[624] | 2.72[625] | -8.02[626] | 1.71[627] | -1.69[628] | 4.53[629] | |
91 | ESR1 | Estrogen receptor | [630] | -6.55[631] | [632] | -4.83[633] | -3.22[634] | -5.57[635] | 3.49[636] |
92 | SMAD6 | Mothers against decapentaplegic homolog 6 | [637] | 2.17[638] | 0.60[639] | 1.04[640] | 2.40[641] | 0.76[642] | 1.95[643] |
93 | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 | [644] | 2.40[645] | 1.02[646] | 1.12[647] | 0.45[648] | -0.84[649] | 1.14[650] |
94 | SATB2 | DNA-binding protein SATB2 | [651] | 1.97[652] | 3.61[653] | 3.24[654] | 2.04[655] | 2.97[656] | 1.96[657] |
95 | HEY2 | Hairy/enhancer-of-split related with YRPW motif protein 2 | [658] | -2.96[659] | -4.59[660] | -4.66[661] | -2.92[662] | -5.83[663] | 1.85[664] |
96 | HDAC4 | Histone deacetylase 4 | [665] | 4.22[666] | 4.22[667] | 4.03[668] | 3.64[669] | 3.88[670] | 4.48[671] |
97 | COL1A1 | Collagen alpha-1(I) chain | [672] | 5.49[673] | -1.85[674] | 0.00[675] | 7.95[676] | 9.40[677] | 7.45[678] |
98 | AKT3 | RAC-gamma serine/threonine-protein kinase | [679] | -1.09[680] | -3.48[681] | -2.76[682] | 6.79[683] | 5.65[684] | 4.70[685] |
99 | IHH | Indian hedgehog protein | [686] | 1.81[687] | 0.03[688] | 5.87[689] | -3.35[690] | -4.30[691] | 1.19[692] |
100 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-beta | 3.12[693] | -0.63[694] | 5.17[695] | 3.61[696] | 3.89[697] | 6.03[698] | |
101 | ITGBL1 | Integrin beta-like protein 1 | [699] | -0.72[700] | [701] | -3.45[702] | 1.82[703] | 5.67[704] | 4.56[705] |
102 | HIVEP3 | Transcription factor HIVEP3 | [706] | 0.30[707] | -2.13[708] | -0.50[709] | 5.97[710] | 6.28[711] | 5.55[712] |
103 | HAND2 | Heart- and neural crest derivatives-expressed protein 2 | [713] | -2.82[714] | -2.73[715] | -3.47[716] | 0.65[717] | 8.17[718] | 6.26[719] |
104 | RUNX2 | Runt-related transcription factor 2 | [720] | -0.09[721] | -0.28[722] | 4.81[723] | 8.07[724] | 9.94[725] | 4.72[726] |
105 | GLI2 | Zinc finger protein GLI2 | [727] | 1.40[728] | -1.98[729] | -0.21[730] | 9.41[731] | 8.50[732] | 3.98[733] |
106 | GLI3 | Transcriptional activator GLI3 | [734] | -0.47[735] | [736] | 0.68[737] | 9.88[738] | 8.16[739] | 5.25[740] |
107 | ZNF521 | Zinc finger protein 521 | [741] | 1.07[742] | [743] | [744] | 5.24[745] | 1.95[746] | 7.53[747] |
108 | TWIST2 | Twist-related protein 2 | [748] | 2.44[749] | [750] | [751] | 7.26[752] | 7.82[753] | 0.08[754] |
109 | DLX6 | Homeobox protein DLX-6 | [755] | 6.92[756] | 6.85[757] | 7.26[758] | 7.03[759] | [760] | [761] |
110 | SEM1 | Putative protein SEM1, isoform 2 | [762] | [763] | [764] | [765] | [766] | [767] | [768] |
111 | PSMA8 | Proteasome subunit alpha type-7-like | [769] | [770] | [771] | [772] | [773] | [774] | [775] |
112 | PSMB11 | Proteasome subunit beta type-11 | [776] | [777] | [778] | [779] | [780] | [781] | [782] |
113 | SP7 | Transcription factor Sp7 | [783] | [784] | [785] | [786] | [787] | [788] | [789] |
114 | UCMA | Unique cartilage matrix-associated protein | [790] | [791] | [792] | [793] | [794] | [795] | [796] |
115 | NKX3-2 | Homeobox protein Nkx-3.2 | [797] | [798] | [799] | [800] | [801] | [802] | [803] |
116 | DLX5 | Homeobox protein DLX-5 | [804] | [805] | [806] | [807] | [808] | [809] | [810] |
117 | MSX2 | Homeobox protein MSX-2 | [811] | [812] | [813] | [814] | [815] | [816] | [817] |
118 | MMP13 | Collagenase 3 | [818] | [819] | [820] | [821] | [822] | [823] | [824] |
119 | TWIST1 | Twist-related protein 1 | [825] | [826] | [827] | [828] | [829] | [830] | [831] |
120 | BGLAP | Osteocalcin | [832] | [833] | [834] | [835] | [836] | [837] | [838] |