REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -1.30[2] -1.56[3] -1.20[4] -1.45[5] -2.00[6] -0.65[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.86[16] -0.81[17] -0.83[18] -0.60[19] -1.62[20] -0.20[21]
4 SERPINE1 Plasminogen activator inhibitor 1 [22] 2.03[23] 2.19[24] -4.33[25] -2.48[26] 3.19[27] -2.65[28]
5 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 [29] 0.07[30] 0.33[31] 0.78[32] 0.59[33] 0.06[34] 1.08[35]
6 UBA52 Ubiquitin-60S ribosomal protein L40 [36] 1.57[37] 1.43[38] 2.68[39] 0.80[40] 0.61[41] 0.57[42]
7 JUNB Transcription factor jun-B [43] -1.06[44] -1.98[45] -1.06[46] -0.84[47] -1.00[48] -0.16[49]
8 PARP1 Poly [ADP-ribose] polymerase 1 [50] 1.02[51] 0.72[52] 1.67[53] 1.85[54] 0.37[55] 0.81[56]
9 MYC Myc proto-oncogene protein [57] 1.32[58] 0.93[59] -0.89[60] -1.46[61] -0.09[62] -0.77[63]
10 CCNC Cyclin-C [64] -0.03[65] 1.30[66] 1.02[67] 0.24[68] -0.53[69] 1.12[70]
11 SNW1 SNW domain-containing protein 1 [71] -0.11[72] 0.01[73] 0.24[74] 1.19[75] -0.06[76] -0.41[77]
12 HDAC1 Histone deacetylase 1 [78] 1.40[79] 1.36[80] 2.26[81] 1.97[82] 0.75[83] 0.76[84]
13 TGIF1 Homeobox protein TGIF1 [85] 0.59[86] -0.11[87] 0.94[88] 0.94[89] -0.42[90] -0.63[91]
14 TFDP1 Transcription factor Dp-1 [92] 1.56[93] 0.84[94] 1.11[95] 1.93[96] 1.51[97] 0.08[98]
15 CDK9 Cyclin-dependent kinase 9 [99] 0.52[100] 0.10[101] 0.39[102] 1.17[103] -0.13[104] 1.38[105]
16 CCNK Cyclin-K [106] 1.05[107] 0.03[108] 0.43[109] 1.73[110] 0.22[111] -0.83[112]
17 MAPK1 Mitogen-activated protein kinase 1 [113] 2.60[114] 2.69[115] 2.72[116] 3.18[117] 1.82[118] 3.00[119]
18 E2F4 Transcription factor E2F4 [120] 2.03[121] 2.08[122] 1.32[123] 1.75[124] 0.74[125] 0.98[126]
19 NCOR1 Nuclear receptor corepressor 1 [127] 1.98[128] 2.42[129] 3.28[130] 2.90[131] 1.94[132] 4.02[133]
20 SMAD3 Mothers against decapentaplegic homolog 3 [134] 2.82[135] 2.17[136] 2.60[137] 3.13[138] 3.00[139] 1.44[140]
21 MEN1 Menin [141] 1.72[142] 1.56[143] 1.85[144] 1.20[145] 0.59[146] 0.82[147]
22 TGIF2 Homeobox protein TGIF2 [148] 2.14[149] 2.51[150] 2.10[151] -0.95[152] -0.52[153] 0.34[154]
23 CDK8 Cyclin-dependent kinase 8 [155] 0.05[156] 0.54[157] -0.18[158] 0.83[159] -0.57[160] -0.53[161]
24 WWTR1 WW domain-containing transcription regulator protein 1 [162] 2.79[163] 2.32[164] 1.54[165] 3.64[166] 1.95[167] 1.96[168]
25 NEDD4L E3 ubiquitin-protein ligase NEDD4-like [169] 3.42[170] 3.28[171] 3.31[172] 1.40[173] 1.31[174] 1.96[175]
26 PPM1A Protein phosphatase 1A [176] 1.22[177] 2.11[178] 2.29[179] 2.55[180] 1.61[181] 3.42[182]
27 MAPK3 Mitogen-activated protein kinase 3 [183] 2.74[184] 2.74[185] 2.99[186] 1.75[187] 0.77[188] 0.18[189]
28 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X [190] 2.74[191] 3.40[192] 4.44[193] 5.05[194] 3.96[195] 5.42[196]
29 SMAD7 Mothers against decapentaplegic homolog 7 [197] 2.75[198] 0.81[199] 0.01[200] 1.91[201] 0.61[202] 1.22[203]
30 SP1 Transcription factor Sp1 [204] 2.71[205] 2.90[206] 4.18[207] 4.00[208] 2.68[209] 3.38[210]
31 CCNT1 Cyclin-T1 [211] 1.93[212] 2.82[213] 2.99[214] 3.24[215] 2.20[216] 2.85[217]
32 SKI Ski oncogene [218] 3.37[219] 3.01[220] 2.69[221] 3.49[222] 2.84[223] 2.25[224]
33 SMAD4 Mothers against decapentaplegic homolog 4 [225] 2.29[226] 2.86[227] 3.04[228] 3.24[229] 2.60[230] 4.01[231]
34 TRIM33 E3 ubiquitin-protein ligase TRIM33 [232] 2.76[233] 3.16[234] 3.23[235] 3.38[236] 2.29[237] 3.57[238]
35 NCOR2 Nuclear receptor corepressor 2 [239] 4.24[240] 2.58[241] 2.89[242] 5.48[243] 3.97[244] 3.11[245]
36 SMAD2 Mothers against decapentaplegic homolog 2 [246] 2.91[247] 3.12[248] 2.83[249] 3.71[250] 2.90[251] 3.79[252]
37 UBE2D1 Ubiquitin-conjugating enzyme E2 D1 [253] 1.69[254] 2.50[255] 3.05[256] 2.85[257] 1.61[258] 1.73[259]
38 CDKN2B Cyclin-dependent kinase 4 inhibitor B [260] 1.26[261] -3.26[262] 0.80[263] 2.49[264] 1.79[265] -0.86[266]
39 SKIL Ski-like protein [267] 2.56[268] 2.54[269] 4.20[270] 3.96[271] 2.98[272] 4.38[273]
40 SMURF2 E3 ubiquitin-protein ligase SMURF2 [274] 2.61[275] 2.58[276] 1.30[277] 2.52[278] 1.96[279] 1.36[280]
41 CCNT2 Cyclin-T2 [281] 2.16[282] 3.95[283] 3.64[284] 3.78[285] 2.38[286] 4.12[287]
42 TFDP2 Transcription factor Dp-2 [288] 2.80[289] 3.44[290] 3.66[291] 3.71[292] 2.94[293] 3.58[294]
43 RNF111 E3 ubiquitin-protein ligase Arkadia [295] 2.50[296] 2.27[297] 3.03[298] 3.75[299] 2.44[300] 3.52[301]
44 E2F5 Transcription factor E2F5 [302] 2.42[303] 3.33[304] 3.94[305] 1.35[306] -1.19[307] -0.46[308]
45 RBL1 Retinoblastoma-like protein 1 [309] 2.67[310] 3.49[311] 2.32[312] 4.14[313] 3.47[314] 1.90[315]
46 ATP1B4 Protein ATP1B4 [316] 0.64[317] 1.91[318] 1.47[319] 1.48[320] 0.84[321] -0.02[322]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte SERPINE1
Mean 117
Standard deviation 1.5e+02
Values 3.2 2.4e+02 3.2e+02 27 2.1
[23]
HepG2 SERPINE1
Mean 569
Standard deviation 1.9e+02
Values 7.1e+02 4.3e+02
[24]
HepG2.C3A SERPINE1
Mean 590
Standard deviation 4.9e+02
Values 9.4e+02 2.5e+02
[25]
HuH.7 SERPINE1
Mean 5.32
Standard deviation 1.3
Values 5.2 6.6 4.1
[26]
SNU475 SERPINE1
Mean 15.4
Standard deviation 11
Values 7.3 24
[27]
THLE SERPINE1
Mean 1.76e+03
Standard deviation 4.3e+02
Values 1.5e+03 2.1e+03
[28]
liver SERPINE1
Mean 11.3
Standard deviation 5.1
Values 9 11 18 6.6
[29]
ref_hepatocyte UBE2D3
Mean 65.1
Standard deviation 16
Values 40 57 79 77 72
[30]
HepG2 UBE2D3
Mean 81.2
Standard deviation 7.1
Values 76 86
[31]
HepG2.C3A UBE2D3
Mean 90.2
Standard deviation 5
Values 87 94
[32]
HuH.7 UBE2D3
Mean 102
Standard deviation 3.4
Values 99 1.1e+02 1e+02
[33]
SNU475 UBE2D3
Mean 71.5
Standard deviation 4.7
Values 75 68
[34]
THLE UBE2D3
Mean 111
Standard deviation 12
Values 1e+02 1.2e+02
[35]
liver UBE2D3
Mean 83.8
Standard deviation 35
Values 1.1e+02 56 1.1e+02 51
[36]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[37]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[38]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[39]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[40]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[41]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[42]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[43]
ref_hepatocyte JUNB
Mean 38
Standard deviation 34
Values 4.3 9.7 61 84 31
[44]
HepG2 JUNB
Mean 21.6
Standard deviation 12
Values 30 13
[45]
HepG2.C3A JUNB
Mean 10.6
Standard deviation 6.5
Values 15 6
[46]
HuH.7 JUNB
Mean 16.6
Standard deviation 6.7
Values 12 24 14
[47]
SNU475 JUNB
Mean 15.5
Standard deviation 3.7
Values 13 18
[48]
THLE JUNB
Mean 31.2
Standard deviation 6
Values 27 35
[49]
liver JUNB
Mean 20.6
Standard deviation 9
Values 28 18 9.1 28
[50]
ref_hepatocyte PARP1
Mean 36.6
Standard deviation 31
Values 26 91 33 17 16
[51]
HepG2 PARP1
Mean 88.3
Standard deviation 6.6
Values 84 93
[52]
HepG2.C3A PARP1
Mean 66.3
Standard deviation 14
Values 56 76
[53]
HuH.7 PARP1
Mean 106
Standard deviation 38
Values 1.3e+02 62 1.3e+02
[54]
SNU475 PARP1
Mean 96.8
Standard deviation 5.2
Values 1e+02 93
[55]
THLE PARP1
Mean 77.5
Standard deviation 13
Values 68 87
[56]
liver PARP1
Mean 39.1
Standard deviation 10
Values 31 44 51 31
[57]
ref_hepatocyte MYC
Mean 29.9
Standard deviation 34
Values 15 20 89 23 1.4
[58]
HepG2 MYC
Mean 88.8
Standard deviation 53
Values 1.3e+02 52
[59]
HepG2.C3A MYC
Mean 62.6
Standard deviation 15
Values 73 52
[60]
HuH.7 MYC
Mean 14.7
Standard deviation 2.6
Values 13 18 14
[61]
SNU475 MYC
Mean 7.93
Standard deviation 1.4
Values 6.9 8.9
[62]
THLE MYC
Mean 46
Standard deviation 10
Values 39 53
[63]
liver MYC
Mean 10.6
Standard deviation 6
Values 18 5.9 13 5.5
[64]
ref_hepatocyte CCNC
Mean 27
Standard deviation 9
Values 33 36 16 19 32
[65]
HepG2 CCNC
Mean 31.4
Standard deviation 8.2
Values 26 37
[66]
HepG2.C3A CCNC
Mean 73.2
Standard deviation 17
Values 61 85
[67]
HuH.7 CCNC
Mean 50
Standard deviation 1.4
Values 51 50 48
[68]
SNU475 CCNC
Mean 23.4
Standard deviation 2.1
Values 25 22
[69]
THLE CCNC
Mean 30.9
Standard deviation 0.57
Values 30 31
[70]
liver CCNC
Mean 35.7
Standard deviation 16
Values 45 26 54 19
[71]
ref_hepatocyte SNW1
Mean 24.9
Standard deviation 12
Values 34 38 27 15 9.7
[72]
HepG2 SNW1
Mean 27.5
Standard deviation 2.9
Values 25 29
[73]
HepG2.C3A SNW1
Mean 27.5
Standard deviation 0.76
Values 27 28
[74]
HuH.7 SNW1
Mean 26.8
Standard deviation 1.3
Values 26 26 28
[75]
SNU475 SNW1
Mean 41.5
Standard deviation 3.1
Values 39 44
[76]
THLE SNW1
Mean 39.4
Standard deviation 2.3
Values 38 41
[77]
liver SNW1
Mean 11.4
Standard deviation 4.1
Values 14 9.2 15 6.8
[78]
ref_hepatocyte HDAC1
Mean 20.8
Standard deviation 4.1
Values 22 28 19 18 18
[79]
HepG2 HDAC1
Mean 65.4
Standard deviation 11
Values 73 58
[80]
HepG2.C3A HDAC1
Mean 58.9
Standard deviation 2.3
Values 57 60
[81]
HuH.7 HDAC1
Mean 90.9
Standard deviation 22
Values 94 68 1.1e+02
[82]
SNU475 HDAC1
Mean 59.8
Standard deviation 8
Values 65 54
[83]
THLE HDAC1
Mean 57.8
Standard deviation 6.8
Values 53 63
[84]
liver HDAC1
Mean 21.5
Standard deviation 6.8
Values 25 18 29 14
[85]
ref_hepatocyte TGIF1
Mean 16.4
Standard deviation 7.1
Values 18 22 23 12 6.4
[86]
HepG2 TGIF1
Mean 29.4
Standard deviation 8.9
Values 36 23
[87]
HepG2.C3A TGIF1
Mean 16.8
Standard deviation 4.7
Values 20 13
[88]
HuH.7 TGIF1
Mean 28.6
Standard deviation 4.6
Values 25 34 28
[89]
SNU475 TGIF1
Mean 23.1
Standard deviation 0.016
Values 23 23
[90]
THLE TGIF1
Mean 20.1
Standard deviation 0.36
Values 20 20
[91]
liver TGIF1
Mean 6.47
Standard deviation 2.5
Values 8.7 4.4 8.6 4.2
[92]
ref_hepatocyte TFDP1
Mean 14.3
Standard deviation 8.3
Values 23 24 5.8 10 9.4
[93]
HepG2 TFDP1
Mean 50.2
Standard deviation 7.6
Values 45 56
[94]
HepG2.C3A TFDP1
Mean 28.1
Standard deviation 13
Values 19 38
[95]
HuH.7 TFDP1
Mean 28.3
Standard deviation 13
Values 35 13 37
[96]
SNU475 TFDP1
Mean 40
Standard deviation 3.2
Values 42 38
[97]
THLE TFDP1
Mean 67
Standard deviation 13
Values 58 76
[98]
liver TFDP1
Mean 9.23
Standard deviation 0.4
Values 9.3 9.6 8.7 9.3
[99]
ref_hepatocyte CDK9
Mean 12.2
Standard deviation 3.1
Values 8.9 17 11 14 10
[100]
HepG2 CDK9
Mean 20.8
Standard deviation 3.7
Values 23 18
[101]
HepG2.C3A CDK9
Mean 14.3
Standard deviation 1.4
Values 15 13
[102]
HuH.7 CDK9
Mean 14.6
Standard deviation 2.2
Values 16 12 16
[103]
SNU475 CDK9
Mean 20.1
Standard deviation 0.34
Values 20 20
[104]
THLE CDK9
Mean 18.3
Standard deviation 4.1
Values 15 21
[105]
liver CDK9
Mean 19.2
Standard deviation 2.9
Values 21 18 22 16
[106]
ref_hepatocyte CCNK
Mean 11.2
Standard deviation 8.8
Values 9.1 9.8 26 7 3.8
[107]
HepG2 CCNK
Mean 27.6
Standard deviation 1.4
Values 29 27
[108]
HepG2.C3A CCNK
Mean 12.6
Standard deviation 0.61
Values 12 13
[109]
HuH.7 CCNK
Mean 13.8
Standard deviation 2.2
Values 16 12 13
[110]
SNU475 CCNK
Mean 27.2
Standard deviation 2.4
Values 29 26
[111]
THLE CCNK
Mean 21.5
Standard deviation 2.7
Values 20 23
[112]
liver CCNK
Mean 3.85
Standard deviation 0.87
Values 5 2.9 3.5 4
[113]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[114]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[115]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[116]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[117]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[118]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[119]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[120]
ref_hepatocyte E2F4
Mean 10.4
Standard deviation 9.6
Values 7.5 5.1 27 7.8 4.3
[121]
HepG2 E2F4
Mean 50.4
Standard deviation 3
Values 48 53
[122]
HepG2.C3A E2F4
Mean 48.5
Standard deviation 4.6
Values 45 52
[123]
HuH.7 E2F4
Mean 23.7
Standard deviation 7.6
Values 26 15 30
[124]
SNU475 E2F4
Mean 25.6
Standard deviation 0.41
Values 26 25
[125]
THLE E2F4
Mean 28.5
Standard deviation 3.3
Values 31 26
[126]
liver E2F4
Mean 12.5
Standard deviation 3.7
Values 14 8.5 17 11
[127]
ref_hepatocyte NCOR1
Mean 7.02
Standard deviation 2.9
Values 10 10 5.5 4.3 5.1
[128]
HepG2 NCOR1
Mean 32.8
Standard deviation 11
Values 25 41
[129]
HepG2.C3A NCOR1
Mean 41.3
Standard deviation 1.3
Values 40 42
[130]
HuH.7 NCOR1
Mean 62.2
Standard deviation 16
Values 78 63 46
[131]
SNU475 NCOR1
Mean 38.2
Standard deviation 4.6
Values 42 35
[132]
THLE NCOR1
Mean 44.2
Standard deviation 1.4
Values 43 45
[133]
liver NCOR1
Mean 69.4
Standard deviation 14
Values 87 68 52 70
[134]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[135]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[136]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[137]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[138]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[139]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[140]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[141]
ref_hepatocyte MEN1
Mean 5.94
Standard deviation 1.6
Values 5.1 3.9 5.6 7.4 7.7
[142]
HepG2 MEN1
Mean 23.3
Standard deviation 0.94
Values 24 23
[143]
HepG2.C3A MEN1
Mean 19.3
Standard deviation 4.2
Values 22 16
[144]
HuH.7 MEN1
Mean 19.5
Standard deviation 4.4
Values 22 14 22
[145]
SNU475 MEN1
Mean 10
Standard deviation 0.56
Values 10 9.6
[146]
THLE MEN1
Mean 14.7
Standard deviation 2.6
Values 13 17
[147]
liver MEN1
Mean 6.36
Standard deviation 2.6
Values 10 4.3 5 6
[148]
ref_hepatocyte TGIF2
Mean 5.52
Standard deviation 6.3
Values 16 5.5 2.3 2.1 1.2
[149]
HepG2 TGIF2
Mean 28.8
Standard deviation 4.1
Values 32 26
[150]
HepG2.C3A TGIF2
Mean 34.7
Standard deviation 11
Values 42 27
[151]
HuH.7 TGIF2
Mean 21.6
Standard deviation 5.1
Values 23 16 26
[152]
SNU475 TGIF2
Mean 2.09
Standard deviation 0.75
Values 2.6 1.6
[153]
THLE TGIF2
Mean 6.33
Standard deviation 0.15
Values 6.2 6.4
[154]
liver TGIF2
Mean 4.24
Standard deviation 1.8
Values 5.1 2.5 6.4 3
[155]
ref_hepatocyte CDK8
Mean 5.05
Standard deviation 2.5
Values 6.5 7.7 6.4 2.5 2.1
[156]
HepG2 CDK8
Mean 6.2
Standard deviation 1.5
Values 5.1 7.3
[157]
HepG2.C3A CDK8
Mean 8.08
Standard deviation 0.79
Values 8.6 7.5
[158]
HuH.7 CDK8
Mean 4.06
Standard deviation 0.63
Values 3.9 3.5 4.8
[159]
SNU475 CDK8
Mean 6.55
Standard deviation 0.87
Values 5.9 7.2
[160]
THLE CDK8
Mean 5.6
Standard deviation 0.087
Values 5.5 5.7
[161]
liver CDK8
Mean 2.12
Standard deviation 1.3
Values 1.1 3.9 1.2 2.3
[162]
ref_hepatocyte WWTR1
Mean 5.02
Standard deviation 4.3
Values 12 3.8 5.4 1.2 2.6
[163]
HepG2 WWTR1
Mean 41.2
Standard deviation 0.072
Values 41 41
[164]
HepG2.C3A WWTR1
Mean 27.5
Standard deviation 7.8
Values 33 22
[165]
HuH.7 WWTR1
Mean 13.3
Standard deviation 1.5
Values 13 15 12
[166]
SNU475 WWTR1
Mean 45.7
Standard deviation 8.3
Values 52 40
[167]
THLE WWTR1
Mean 31.8
Standard deviation 6
Values 28 36
[168]
liver WWTR1
Mean 11.9
Standard deviation 2.9
Values 14 11 15 8.4
[169]
ref_hepatocyte NEDD4L
Mean 4.96
Standard deviation 4.4
Values 12 5.6 4.9 1.7 0.72
[170]
HepG2 NEDD4L
Mean 63.2
Standard deviation 5
Values 60 67
[171]
HepG2.C3A NEDD4L
Mean 53.1
Standard deviation 11
Values 61 45
[172]
HuH.7 NEDD4L
Mean 44.8
Standard deviation 8.9
Values 44 54 36
[173]
SNU475 NEDD4L
Mean 9.57
Standard deviation 0.3
Values 9.4 9.8
[174]
THLE NEDD4L
Mean 20.2
Standard deviation 2.2
Values 19 22
[175]
liver NEDD4L
Mean 11.8
Standard deviation 9.5
Values 26 8.9 7.8 4.7
[176]
ref_hepatocyte PPM1A
Mean 4.55
Standard deviation 0.9
Values 3.8 5.5 3.5 4.5 5.3
[177]
HepG2 PPM1A
Mean 12.6
Standard deviation 0.86
Values 12 13
[178]
HepG2.C3A PPM1A
Mean 21.6
Standard deviation 1.1
Values 22 21
[179]
HuH.7 PPM1A
Mean 20.3
Standard deviation 6.7
Values 18 28 15
[180]
SNU475 PPM1A
Mean 19.5
Standard deviation 2.8
Values 21 18
[181]
THLE PPM1A
Mean 22.9
Standard deviation 0.86
Values 23 22
[182]
liver PPM1A
Mean 29.7
Standard deviation 7.1
Values 29 34 20 35
[183]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[184]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[185]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[186]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[187]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[188]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[189]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[190]
ref_hepatocyte USP9X
Mean 4.1
Standard deviation 1.1
Values 3 5.1 2.9 4.2 5.3
[191]
HepG2 USP9X
Mean 32.5
Standard deviation 10
Values 25 40
[192]
HepG2.C3A USP9X
Mean 47.5
Standard deviation 6
Values 52 43
[193]
HuH.7 USP9X
Mean 81.4
Standard deviation 21
Values 92 95 57
[194]
SNU475 USP9X
Mean 99.8
Standard deviation 10
Values 1.1e+02 92
[195]
THLE USP9X
Mean 105
Standard deviation 1.7
Values 1e+02 1.1e+02
[196]
liver USP9X
Mean 107
Standard deviation 61
Values 63 1.6e+02 46 1.5e+02
[197]
ref_hepatocyte SMAD7
Mean 3.77
Standard deviation 2.9
Values 5.6 7.9 2.4 1.7 1.3
[198]
HepG2 SMAD7
Mean 30.1
Standard deviation 6.8
Values 35 25
[199]
HepG2.C3A SMAD7
Mean 7.28
Standard deviation 2.6
Values 5.5 9.1
[200]
HuH.7 SMAD7
Mean 3.45
Standard deviation 0.58
Values 3.1 4.1 3.1
[201]
SNU475 SMAD7
Mean 10.4
Standard deviation 2.4
Values 12 8.7
[202]
THLE SMAD7
Mean 9.45
Standard deviation 1.3
Values 8.6 10
[203]
liver SMAD7
Mean 5.35
Standard deviation 1.1
Values 4.2 6.5 6 4.8
[204]
ref_hepatocyte SP1
Mean 3.57
Standard deviation 0.42
Values 3.2 3.3 4.3 3.5 3.6
[205]
HepG2 SP1
Mean 27.8
Standard deviation 1
Values 27 29
[206]
HepG2.C3A SP1
Mean 29.3
Standard deviation 0.25
Values 29 29
[207]
HuH.7 SP1
Mean 58.8
Standard deviation 12
Values 71 59 46
[208]
SNU475 SP1
Mean 41.7
Standard deviation 2.6
Values 44 40
[209]
THLE SP1
Mean 37.5
Standard deviation 7.4
Values 32 43
[210]
liver SP1
Mean 22.6
Standard deviation 13
Values 14 31 9.1 36
[211]
ref_hepatocyte CCNT1
Mean 3.29
Standard deviation 2.6
Values 6.4 5.7 2.7 0.92 0.79
[212]
HepG2 CCNT1
Mean 14.9
Standard deviation 4
Values 12 18
[213]
HepG2.C3A CCNT1
Mean 25.6
Standard deviation 2
Values 24 27
[214]
HuH.7 CCNT1
Mean 23.8
Standard deviation 3.1
Values 26 25 20
[215]
SNU475 CCNT1
Mean 22.7
Standard deviation 2.3
Values 21 24
[216]
THLE CCNT1
Mean 24.9
Standard deviation 0.71
Values 24 25
[217]
liver CCNT1
Mean 14.4
Standard deviation 5.7
Values 9.1 19 9.7 19
[218]
ref_hepatocyte SKI
Mean 3.28
Standard deviation 1.6
Values 5.4 1.7 4.6 2.4 2.3
[219]
HepG2 SKI
Mean 40.2
Standard deviation 3.3
Values 43 38
[220]
HepG2.C3A SKI
Mean 29
Standard deviation 6
Values 33 25
[221]
HuH.7 SKI
Mean 19.3
Standard deviation 4.4
Values 24 16 18
[222]
SNU475 SKI
Mean 27
Standard deviation 2
Values 28 26
[223]
THLE SKI
Mean 38.5
Standard deviation 8.8
Values 32 45
[224]
liver SKI
Mean 9.51
Standard deviation 6.6
Values 6.9 11 2.3 18
[225]
ref_hepatocyte SMAD4
Mean 3.16
Standard deviation 0.71
Values 2.9 2.8 4.2 2.4 3.4
[226]
HepG2 SMAD4
Mean 18.3
Standard deviation 3.2
Values 16 21
[227]
HepG2.C3A SMAD4
Mean 25.2
Standard deviation 3
Values 27 23
[228]
HuH.7 SMAD4
Mean 23.6
Standard deviation 3.4
Values 24 27 20
[229]
SNU475 SMAD4
Mean 21.8
Standard deviation 2.7
Values 24 20
[230]
THLE SMAD4
Mean 31.4
Standard deviation 1.4
Values 30 32
[231]
liver SMAD4
Mean 31
Standard deviation 13
Values 23 40 16 44
[232]
ref_hepatocyte TRIM33
Mean 2.76
Standard deviation 2.5
Values 7.1 2 2 1.1 1.6
[233]
HepG2 TRIM33
Mean 22.2
Standard deviation 6.9
Values 17 27
[234]
HepG2.C3A TRIM33
Mean 27.1
Standard deviation 2.8
Values 25 29
[235]
HuH.7 TRIM33
Mean 23.5
Standard deviation 4
Values 27 24 19
[236]
SNU475 TRIM33
Mean 20.9
Standard deviation 1.2
Values 20 22
[237]
THLE TRIM33
Mean 22.1
Standard deviation 0.14
Values 22 22
[238]
liver TRIM33
Mean 20
Standard deviation 6.6
Values 18 28 12 22
[239]
ref_hepatocyte NCOR2
Mean 2.59
Standard deviation 0.92
Values 2.5 2.2 4.1 2.4 1.7
[240]
HepG2 NCOR2
Mean 58.1
Standard deviation 18
Values 71 46
[241]
HepG2.C3A NCOR2
Mean 17
Standard deviation 4.1
Values 20 14
[242]
HuH.7 NCOR2
Mean 17.5
Standard deviation 6.7
Values 25 14 13
[243]
SNU475 NCOR2
Mean 84.3
Standard deviation 15
Values 95 73
[244]
THLE NCOR2
Mean 66.6
Standard deviation 7.4
Values 61 72
[245]
liver NCOR2
Mean 13.6
Standard deviation 4.9
Values 11 14 8.8 20
[246]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 4.5 2.8 1.9 1.9 1.6
[247]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 21 24
[248]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 25 23
[249]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 17 18 15
[250]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 27 22
[251]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[252]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 17 29 15 25
[253]
ref_hepatocyte UBE2D1
Mean 2.43
Standard deviation 1.1
Values 2.2 1.2 4.1 1.7 2.8
[254]
HepG2 UBE2D1
Mean 9.29
Standard deviation 2.7
Values 7.4 11
[255]
HepG2.C3A UBE2D1
Mean 15.1
Standard deviation 2.9
Values 13 17
[256]
HuH.7 UBE2D1
Mean 18.4
Standard deviation 3.8
Values 21 14 20
[257]
SNU475 UBE2D1
Mean 12.8
Standard deviation 0.14
Values 13 13
[258]
THLE UBE2D1
Mean 12.2
Standard deviation 0.065
Values 12 12
[259]
liver UBE2D1
Mean 4.88
Standard deviation 2.6
Values 6.8 2.9 7.4 2.4
[260]
ref_hepatocyte CDKN2B
Mean 2.34
Standard deviation 3.2
Values 0.3 7.5 3.5 0.4 0.081
[261]
HepG2 CDKN2B
Mean 6.66
Standard deviation 0.64
Values 7.1 6.2
[262]
HepG2.C3A CDKN2B
Mean 0.268
Standard deviation 0.076
Values 0.21 0.32
[263]
HuH.7 CDKN2B
Mean 3.7
Standard deviation 0.34
Values 4 3.3 3.8
[264]
SNU475 CDKN2B
Mean 9.59
Standard deviation 3.2
Values 12 7.3
[265]
THLE CDKN2B
Mean 13.3
Standard deviation 2
Values 15 12
[266]
liver CDKN2B
Mean 0.784
Standard deviation 0.26
Values 0.52 0.66 1.1 0.83
[267]
ref_hepatocyte SKIL
Mean 2.1
Standard deviation 0.9
Values 1.8 3.4 1.8 1 2.5
[268]
HepG2 SKIL
Mean 14.7
Standard deviation 2.2
Values 13 16
[269]
HepG2.C3A SKIL
Mean 13.4
Standard deviation 2.5
Values 12 15
[270]
HuH.7 SKIL
Mean 35.2
Standard deviation 4.3
Values 39 36 30
[271]
SNU475 SKIL
Mean 24
Standard deviation 4.2
Values 27 21
[272]
THLE SKIL
Mean 27.3
Standard deviation 5.3
Values 31 24
[273]
liver SKIL
Mean 26.6
Standard deviation 8.2
Values 24 24 20 38
[274]
ref_hepatocyte SMURF2
Mean 2.04
Standard deviation 1.5
Values 4 2.4 2.7 0.61 0.48
[275]
HepG2 SMURF2
Mean 14.8
Standard deviation 1.9
Values 13 16
[276]
HepG2.C3A SMURF2
Mean 13.4
Standard deviation 0.28
Values 13 14
[277]
HuH.7 SMURF2
Mean 4.58
Standard deviation 0.75
Values 4.3 5.4 4
[278]
SNU475 SMURF2
Mean 8.55
Standard deviation 1
Values 7.8 9.3
[279]
THLE SMURF2
Mean 13
Standard deviation 1.5
Values 12 14
[280]
liver SMURF2
Mean 3.18
Standard deviation 1.7
Values 1.8 5.1 1.8 4
[281]
ref_hepatocyte CCNT2
Mean 2.02
Standard deviation 0.79
Values 3.3 1.9 2 1.2 1.7
[282]
HepG2 CCNT2
Mean 10.8
Standard deviation 4.3
Values 7.8 14
[283]
HepG2.C3A CCNT2
Mean 34.3
Standard deviation 5
Values 31 38
[284]
HuH.7 CCNT2
Mean 22.9
Standard deviation 1.8
Values 25 22 22
[285]
SNU475 CCNT2
Mean 20.3
Standard deviation 0.81
Values 21 20
[286]
THLE CCNT2
Mean 17.3
Standard deviation 1.8
Values 19 16
[287]
liver CCNT2
Mean 21.4
Standard deviation 5.6
Values 19 29 16 22
[288]
ref_hepatocyte TFDP2
Mean 1.97
Standard deviation 0.83
Values 3.4 2.1 1.3 1.4 1.7
[289]
HepG2 TFDP2
Mean 16.3
Standard deviation 2.5
Values 15 18
[290]
HepG2.C3A TFDP2
Mean 23.5
Standard deviation 2.1
Values 22 25
[291]
HuH.7 TFDP2
Mean 22.8
Standard deviation 3.1
Values 26 20 22
[292]
SNU475 TFDP2
Mean 18.9
Standard deviation 4.1
Values 22 16
[293]
THLE TFDP2
Mean 24.9
Standard deviation 1.2
Values 24 26
[294]
liver TFDP2
Mean 14.3
Standard deviation 3.4
Values 17 14 9.6 16
[295]
ref_hepatocyte RNF111
Mean 1.67
Standard deviation 0.68
Values 1.4 1.5 2.8 1 1.6
[296]
HepG2 RNF111
Mean 11.3
Standard deviation 3.4
Values 8.9 14
[297]
HepG2.C3A RNF111
Mean 8.85
Standard deviation 0.44
Values 8.5 9.2
[298]
HuH.7 RNF111
Mean 12.5
Standard deviation 1.7
Values 13 14 11
[299]
SNU475 RNF111
Mean 16.5
Standard deviation 1.4
Values 17 15
[300]
THLE RNF111
Mean 14.9
Standard deviation 1.7
Values 14 16
[301]
liver RNF111
Mean 11.6
Standard deviation 1.1
Values 12 12 13 10
[302]
ref_hepatocyte E2F5
Mean 1
Standard deviation 0.88
Values 1.9 0.45 0 1.9 0.74
[303]
HepG2 E2F5
Mean 6.38
Standard deviation 0.95
Values 7.1 5.7
[304]
HepG2.C3A E2F5
Mean 11.1
Standard deviation 0.8
Values 11 12
[305]
HuH.7 E2F5
Mean 14
Standard deviation 0.82
Values 13 14 15
[306]
SNU475 E2F5
Mean 1.88
Standard deviation 0.29
Values 2.1 1.7
[307]
THLE E2F5
Mean 0.724
Standard deviation 0.11
Values 0.8 0.65
[308]
liver E2F5
Mean 0.444
Standard deviation 0.12
Values 0.54 0.54 0.31 0.38
[309]
ref_hepatocyte RBL1
Mean 0.836
Standard deviation 0.94
Values 2.4 0.96 0.44 0.14 0.22
[310]
HepG2 RBL1
Mean 6.34
Standard deviation 2.4
Values 4.6 8
[311]
HepG2.C3A RBL1
Mean 10.3
Standard deviation 8.7
Values 4.2 16
[312]
HuH.7 RBL1
Mean 3.82
Standard deviation 1.7
Values 5.6 2.2 3.6
[313]
SNU475 RBL1
Mean 10.8
Standard deviation 2.6
Values 8.9 13
[314]
THLE RBL1
Mean 15.2
Standard deviation 0.62
Values 15 16
[315]
liver RBL1
Mean 1.9
Standard deviation 0.74
Values 1.3 2.9 1.5 2
[316]
ref_hepatocyte ATP1B4
Mean 0.081
Standard deviation 0.086
Values 0 0.028 0.035 0.14 0.2
[317]
HepG2 ATP1B4
Mean 0.15
Standard deviation 0.00081
Values 0.15 0.15
[318]
HepG2.C3A ATP1B4
Mean 0.333
Standard deviation 0.059
Values 0.29 0.38
[319]
HuH.7 ATP1B4
Mean 0.205
Standard deviation 0.04
Values 0.24 0.16 0.22
[320]
SNU475 ATP1B4
Mean 0.165
Standard deviation 0.024
Values 0.15 0.18
[321]
THLE ATP1B4
Mean 0.239
Standard deviation 0.045
Values 0.21 0.27
[322]
liver ATP1B4
Mean 0.0487
Standard deviation 0.062
Values 0 0.13 0 0.066