REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
SOD2 |
Superoxide dismutase [Mn], mitochondrial |
[1] |
-3.46[2] |
-3.25[3] |
-4.09[4] |
-4.44[5] |
-2.31[6] |
-2.58[7] |
2 |
IDH2 |
Isocitrate dehydrogenase [NADP], mitochondrial |
[8] |
-0.56[9] |
-1.36[10] |
-0.94[11] |
-1.27[12] |
-2.59[13] |
-0.06[14] |
3 |
GLUD1 |
Glutamate dehydrogenase 1, mitochondrial |
[15] |
0.62[16] |
1.59[17] |
0.33[18] |
-1.86[19] |
-0.98[20] |
1.29[21] |
4 |
SSBP1 |
Single-stranded DNA-binding protein, mitochondrial |
[22] |
-0.48[23] |
-1.25[24] |
-0.80[25] |
-0.49[26] |
-0.52[27] |
-1.67[28] |
5 |
ALAS1 |
5-aminolevulinate synthase, nonspecific, mitochondrial |
[29] |
-0.23[30] |
-1.06[31] |
-0.36[32] |
-0.34[33] |
-0.05[34] |
1.33[35] |
6 |
CALM1 |
Calmodulin-1 |
[36] |
1.54[37] |
1.13[38] |
1.57[39] |
3.14[40] |
2.42[41] |
1.87[42] |
7 |
ACSS2 |
Acetyl-coenzyme A synthetase, cytoplasmic |
[43] |
-0.21[44] |
1.00[45] |
0.69[46] |
-0.13[47] |
-0.51[48] |
0.26[49] |
8 |
RXRA |
Retinoic acid receptor RXR-alpha |
[50] |
1.41[51] |
0.77[52] |
1.59[53] |
1.57[54] |
1.25[55] |
2.40[56] |
9 |
CYCS |
Cytochrome c |
[57] |
2.80[58] |
2.55[59] |
2.60[60] |
2.89[61] |
3.30[62] |
1.57[63] |
10 |
ESRRA |
Steroid hormone receptor ERR1 |
[64] |
1.25[65] |
1.62[66] |
1.05[67] |
0.72[68] |
0.70[69] |
0.28[70] |
11 |
TFAM |
Transcription factor A, mitochondrial |
[71] |
1.34[72] |
2.06[73] |
1.44[74] |
1.75[75] |
1.48[76] |
-0.01[77] |
12 |
HDAC3 |
Histone deacetylase 3 |
[78] |
1.95[79] |
1.55[80] |
1.34[81] |
1.50[82] |
1.68[83] |
-0.15[84] |
13 |
POLRMT |
DNA-directed RNA polymerase, mitochondrial |
[85] |
2.32[86] |
1.88[87] |
1.81[88] |
0.83[89] |
1.18[90] |
0.45[91] |
14 |
TFB2M |
Dimethyladenosine transferase 2, mitochondrial |
[92] |
0.57[93] |
0.66[94] |
0.48[95] |
1.06[96] |
0.01[97] |
0.38[98] |
15 |
CARM1 |
Histone-arginine methyltransferase CARM1 |
[99] |
2.92[100] |
1.92[101] |
2.23[102] |
1.31[103] |
2.11[104] |
-0.77[105] |
16 |
ATF2 |
Cyclic AMP-dependent transcription factor ATF-2 |
[106] |
2.11[107] |
2.71[108] |
2.91[109] |
2.34[110] |
2.12[111] |
1.27[112] |
17 |
CRTC2 |
CREB-regulated transcription coactivator 2 |
[113] |
0.83[114] |
0.53[115] |
1.56[116] |
2.03[117] |
2.04[118] |
-0.82[119] |
18 |
NCOR1 |
Nuclear receptor corepressor 1 |
[120] |
2.55[121] |
2.60[122] |
3.23[123] |
3.12[124] |
3.18[125] |
3.05[126] |
19 |
NR1D1 |
Nuclear receptor subfamily 1 group D member 1 |
[127] |
0.19[128] |
-0.58[129] |
-0.09[130] |
0.44[131] |
-0.15[132] |
-0.71[133] |
20 |
GABPB1 |
GA-binding protein subunit beta-1 |
[134] |
0.91[135] |
1.04[136] |
0.53[137] |
1.26[138] |
1.38[139] |
-0.40[140] |
21 |
SIRT3 |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
[141] |
0.81[142] |
0.90[143] |
0.92[144] |
0.47[145] |
-0.44[146] |
0.28[147] |
22 |
TBL1XR1 |
F-box-like/WD repeat-containing protein TBL1XR1 |
[148] |
2.55[149] |
2.64[150] |
3.26[151] |
3.96[152] |
3.54[153] |
3.12[154] |
23 |
TBL1X |
F-box-like/WD repeat-containing protein TBL1X |
[155] |
2.81[156] |
2.76[157] |
4.30[158] |
-2.85[159] |
2.66[160] |
1.99[161] |
24 |
PPARA |
Peroxisome proliferator-activated receptor alpha |
[162] |
2.14[163] |
2.67[164] |
3.50[165] |
1.59[166] |
0.77[167] |
4.40[168] |
25 |
SIRT5 |
NAD-dependent protein deacylase sirtuin-5, mitochondrial |
[169] |
2.07[170] |
2.25[171] |
1.69[172] |
1.62[173] |
0.60[174] |
1.41[175] |
26 |
PPRC1 |
Peroxisome proliferator-activated
receptor gamma coactivator-related protein 1 |
3.52[176] |
3.02[177] |
3.38[178] |
2.45[179] |
3.29[180] |
0.99[181] |
27 |
MED1 |
Mediator of RNA polymerase II transcription subunit 1 |
[182] |
4.01[183] |
2.89[184] |
3.77[185] |
3.75[186] |
3.92[187] |
1.53[188] |
28 |
TFB1M |
Dimethyladenosine transferase 1, mitochondrial |
[189] |
3.49[190] |
3.07[191] |
1.96[192] |
1.02[193] |
1.06[194] |
0.37[195] |
29 |
HCFC1 |
Host cell factor 1 |
[196] |
4.21[197] |
3.31[198] |
3.55[199] |
4.11[200] |
4.02[201] |
2.31[202] |
30 |
GABPA |
GA-binding protein alpha chain |
[203] |
1.70[204] |
2.59[205] |
2.54[206] |
3.56[207] |
2.63[208] |
2.11[209] |
31 |
NCOA6 |
Nuclear receptor coactivator 6 |
[210] |
3.67[211] |
3.07[212] |
3.26[213] |
4.12[214] |
3.38[215] |
1.66[216] |
32 |
MEF2D |
Myocyte-specific enhancer factor 2D |
[217] |
2.21[218] |
1.63[219] |
2.32[220] |
4.13[221] |
3.73[222] |
1.10[223] |
33 |
TGS1 |
Trimethylguanosine synthase |
[224] |
2.06[225] |
2.05[226] |
2.57[227] |
3.27[228] |
3.11[229] |
1.23[230] |
34 |
NCOA1 |
Nuclear receptor coactivator 1 |
[231] |
1.93[232] |
2.05[233] |
2.23[234] |
3.35[235] |
2.81[236] |
2.90[237] |
35 |
POLG2 |
DNA polymerase subunit gamma-2, mitochondrial |
[238] |
1.52[239] |
1.68[240] |
1.71[241] |
1.36[242] |
1.32[243] |
-0.27[244] |
36 |
PPARGC1A |
Peroxisome proliferator-activated
receptor gamma coactivator 1-alpha |
0.38[245] |
2.82[246] |
-7.98[247] |
2.32[248] |
-0.97[249] |
3.68[250] |
37 |
CREB1 |
Cyclic AMP-responsive element-binding protein 1 |
[251] |
3.19[252] |
3.90[253] |
4.37[254] |
4.10[255] |
4.05[256] |
2.59[257] |
38 |
CREBBP |
CREB-binding protein |
[258] |
4.37[259] |
3.14[260] |
3.72[261] |
4.31[262] |
4.33[263] |
3.48[264] |
39 |
GLUD2 |
Glutamate dehydrogenase 2, mitochondrial |
[265] |
-6.56[266] |
-5.40[267] |
1.41[268] |
-6.26[269] |
-3.79[270] |
0.35[271] |
40 |
CRTC3 |
CREB-regulated transcription coactivator 3 |
[272] |
2.85[273] |
2.04[274] |
2.41[275] |
3.65[276] |
3.57[277] |
1.54[278] |
41 |
SIRT4 |
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
[279] |
-0.79[280] |
-1.01[281] |
-0.21[282] |
-0.81[283] |
-0.79[284] |
-0.90[285] |
42 |
NRF1 |
Nuclear respiratory factor 1 |
[286] |
2.48[287] |
2.25[288] |
2.22[289] |
2.56[290] |
2.53[291] |
0.73[292] |
43 |
CHD9 |
Chromodomain-helicase-DNA-binding protein 9 |
[293] |
2.79[294] |
4.44[295] |
3.66[296] |
3.93[297] |
4.96[298] |
5.18[299] |
44 |
NCOA2 |
Nuclear receptor coactivator 2 |
[300] |
3.05[301] |
3.41[302] |
5.22[303] |
4.75[304] |
3.06[305] |
4.85[306] |
45 |
USP46 |
Ubiquitin carboxyl-terminal hydrolase 46 |
[307] |
3.69[308] |
3.07[309] |
4.56[310] |
3.74[311] |
4.26[312] |
2.37[313] |
46 |
CRTC1 |
CREB-regulated transcription coactivator 1 |
[314] |
4.16[315] |
4.23[316] |
5.26[317] |
3.95[318] |
3.72[319] |
2.20[320] |
47 |
SMARCD3 |
SWI/SNF-related matrix-associated
actin-dependent regulator of chromatin subfamily D
member 3 |
2.94[321] |
0.82[322] |
2.85[323] |
4.82[324] |
5.02[325] |
1.61[326] |
48 |
PPARGC1B |
Peroxisome proliferator-activated
receptor gamma coactivator 1-beta |
3.83[327] |
-0.54[328] |
5.21[329] |
4.22[330] |
4.60[331] |
5.19[332] |
49 |
MEF2C |
Myocyte-specific enhancer factor 2C |
[333] |
-1.64[334] |
-0.96[335] |
3.98[336] |
7.17[337] |
3.16[338] |
5.54[339] |
50 |
CAMK4 |
Calcium/calmodulin-dependent protein kinase type IV |
[340] |
[341] |
-0.74[342] |
-1.43[343] |
3.00[344] |
5.08[345] |
4.49[346] |
51 |
TWNK |
Twinkle protein, mitochondrial |
[347] |
[348] |
[349] |
[350] |
[351] |
[352] |
[353] |
52 |
ATP5F1B |
|
[354] |
[355] |
[356] |
[357] |
[358] |
[359] |
[360] |
53 |
HELZ2 |
Helicase with zinc finger domain 2 |
[361] |
[362] |
[363] |
[364] |
[365] |
[366] |
[367] |
54 |
PERM1 |
PGC-1 and ERR-induced regulator in muscle protein 1 |
[368] |
[369] |
[370] |
[371] |
[372] |
[373] |
[374] |
55 |
MTERF1 |
Transcription termination factor 1, mitochondrial |
[375] |
[376] |
[377] |
[378] |
[379] |
[380] |
[381] |
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