REACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SAA1 Serum amyloid A-1 protein [1] -13.07[2] -13.04[3] -8.27[4] -11.47[5] -2.92[6] -0.11[7]
2 HMGB1 High mobility group protein B1 [8] 5.78[9] 6.59[10] 6.34[11] 6.55[12] 5.75[13] 2.18[14]
3 NFKBIA NF-kappa-B inhibitor alpha [15] 5.02[16] 3.30[17] 2.94[18] 2.57[19] 4.17[20] 1.60[21]
4 APP Amyloid-beta A4 protein [22] 6.46[23] 5.97[24] 6.65[25] 6.86[26] 7.00[27] 2.87[28]
5 IKBKG NF-kappa-B essential modulator [29] 5.19[30] 5.40[31] 3.17[32] 5.24[33] 3.75[34] 2.13[35]
6 NFKB2 Nuclear factor NF-kappa-B p100 subunit [36] 5.31[37] 5.68[38] 6.15[39] 4.70[40] 5.28[41] -0.29[42]
7 RELA Transcription factor p65 [43] 6.21[44] 5.77[45] 5.93[46] 6.03[47] 5.66[48] 1.85[49]
8 NFKBIB NF-kappa-B inhibitor beta [50] 4.92[51] 4.81[52] 5.16[53] 4.27[54] 4.34[55] 1.01[56]
9 NKIRAS2 NF-kappa-B inhibitor-interacting Ras-like protein 2 [57] 6.83[58] 5.65[59] 6.73[60] 6.67[61] 6.19[62] 2.93[63]
10 TRIM4 E3 ubiquitin-protein ligase TRIM4 [64] 5.79[65] 6.05[66] 6.26[67] 4.77[68] 5.10[69] 3.13[70]
11 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 [71] 8.21[72] 7.92[73] 7.77[74] 6.97[75] 7.34[76] 4.55[77]
12 NFKB1 Nuclear factor NF-kappa-B p105 subunit [78] 6.75[79] 6.49[80] 6.30[81] 5.84[82] 6.47[83] 3.18[84]
13 NKIRAS1 NF-kappa-B inhibitor-interacting Ras-like protein 1 [85] 4.71[86] 4.57[87] 5.81[88] 5.54[89] 5.55[90] 2.51[91]
14 TRAF2 TNF receptor-associated factor 2 [92] 6.31[93] 6.44[94] 6.19[95] 6.21[96] 5.94[97] 1.94[98]
15 IFIH1 Interferon-induced helicase C domain-containing protein 1 [99] 4.11[100] 4.27[101] 0.17[102] 4.85[103] 4.81[104] 2.99[105]
16 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [106] 6.98[107] 8.27[108] 8.25[109] 6.74[110] 7.27[111] 4.25[112]
17 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [113] 6.60[114] 6.73[115] 6.85[116] 6.34[117] 6.16[118] 3.91[119]
18 DDX58 Probable ATP-dependent RNA helicase DDX58 [120] 5.37[121] 5.43[122] 4.62[123] 5.30[124] 5.58[125] 3.85[126]
19 MAVS Mitochondrial antiviral-signaling protein [127] 10.35[128] 10.03[129] 9.66[130] 9.82[131] 9.13[132] 6.08[133]
20 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 [134] 8.73[135] 8.51[136] 8.26[137] 8.41[138] 7.01[139] 5.53[140]
21 TRAF6 TNF receptor-associated factor 6 [141] 7.17[142] 7.12[143] 7.71[144] 7.75[145] 6.92[146] 5.64[147]
22 RNF135 E3 ubiquitin-protein ligase RNF135 [148] -1.23[149] -0.77[150] 0.53[151] -1.40[152] 7.25[153] 3.60[154]
23 S100A12 Protein S100-A12 [155] [156] [157] [158] [159] [160] 3.02[161]
24 AGER Advanced glycosylation end product-specific receptor [162] 5.03[163] 8.27[164] 7.22[165] 6.73[166] 6.21[167] 2.63[168]
25 S100B Protein S100-B [169] 2.22[170] 1.31[171] [172] 4.33[173] 0.04[174] 3.88[175]
[1]
ref_hepatocyte SAA1
Mean 2.5e+04
Standard deviation 3.8e+04
Values 0 1.6e+02 1.4e+04 9.1e+04 1.9e+04
[2]
HepG2 SAA1
Mean 0.0952
Standard deviation 0.019
Values 0.11 0.082
[3]
HepG2.C3A SAA1
Mean 0.0823
Standard deviation 0.02
Values 0.068 0.097
[4]
HuH.7 SAA1
Mean 2.13
Standard deviation 1
Values 1.3 3.3 1.8
[5]
SNU475 SAA1
Mean 0.238
Standard deviation 0.015
Values 0.23 0.25
[6]
THLE SAA1
Mean 121
Standard deviation 20
Values 1.4e+02 1.1e+02
[7]
liver SAA1
Mean 4.95e+03
Standard deviation 4.5e+03
Values 7.5e+03 6.8e+02 1e+04 1.6e+03
[8]
ref_hepatocyte HMGB1
Mean 96.9
Standard deviation 78
Values 1.5e+02 2.1e+02 24 42 63
[9]
HepG2 HMGB1
Mean 174
Standard deviation 48
Values 1.4e+02 2.1e+02
[10]
HepG2.C3A HMGB1
Mean 259
Standard deviation 1.5e+02
Values 1.5e+02 3.7e+02
[11]
HuH.7 HMGB1
Mean 207
Standard deviation 1.1e+02
Values 2.5e+02 85 2.9e+02
[12]
SNU475 HMGB1
Mean 245
Standard deviation 23
Values 2.6e+02 2.3e+02
[13]
THLE HMGB1
Mean 191
Standard deviation 52
Values 1.5e+02 2.3e+02
[14]
liver HMGB1
Mean 93.7
Standard deviation 62
Values 1.7e+02 50 1.3e+02 34
[15]
ref_hepatocyte NFKBIA
Mean 84.3
Standard deviation 48
Values 83 48 1.6e+02 90 40
[16]
HepG2 NFKBIA
Mean 89.6
Standard deviation 1.2
Values 89 90
[17]
HepG2.C3A NFKBIA
Mean 23
Standard deviation 1.2
Values 24 22
[18]
HuH.7 NFKBIA
Mean 17
Standard deviation 7.2
Values 11 25 15
[19]
SNU475 NFKBIA
Mean 13.5
Standard deviation 0.67
Values 13 14
[20]
THLE NFKBIA
Mean 55.8
Standard deviation 6.4
Values 51 60
[21]
liver NFKBIA
Mean 54.5
Standard deviation 46
Values 1.2e+02 19 55 24
[22]
ref_hepatocyte APP
Mean 58.3
Standard deviation 28
Values 31 1e+02 46 51 59
[23]
HepG2 APP
Mean 167
Standard deviation 49
Values 2e+02 1.3e+02
[24]
HepG2.C3A APP
Mean 102
Standard deviation 27
Values 1.2e+02 83
[25]
HuH.7 APP
Mean 154
Standard deviation 13
Values 1.6e+02 1.7e+02 1.4e+02
[26]
SNU475 APP
Mean 184
Standard deviation 28
Values 2e+02 1.6e+02
[27]
THLE APP
Mean 273
Standard deviation 68
Values 2.3e+02 3.2e+02
[28]
liver APP
Mean 91
Standard deviation 73
Values 32 1.7e+02 28 1.3e+02
[29]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[30]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[31]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[32]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[33]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[34]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[35]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[36]
ref_hepatocyte NFKB2
Mean 16.8
Standard deviation 20
Values 3.6 24 49 4.1 3
[37]
HepG2 NFKB2
Mean 21.8
Standard deviation 8.1
Values 28 16
[38]
HepG2.C3A NFKB2
Mean 23.9
Standard deviation 12
Values 32 16
[39]
HuH.7 NFKB2
Mean 31.3
Standard deviation 3.8
Values 29 36 29
[40]
SNU475 NFKB2
Mean 11.9
Standard deviation 3
Values 9.7 14
[41]
THLE NFKB2
Mean 24
Standard deviation 2.2
Values 22 26
[42]
liver NFKB2
Mean 2.95
Standard deviation 1.2
Values 2.1 3.3 1.8 4.5
[43]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 9.8 12 35 15 8.1
[44]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 42 35
[45]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 29 20
[46]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 29 25 23
[47]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[48]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[49]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 19 4.1 20 5.7
[50]
ref_hepatocyte NFKBIB
Mean 13.2
Standard deviation 9.2
Values 3.7 6.2 27 17 12
[51]
HepG2 NFKBIB
Mean 13
Standard deviation 3.4
Values 15 11
[52]
HepG2.C3A NFKBIB
Mean 10.3
Standard deviation 1.5
Values 11 9.2
[53]
HuH.7 NFKBIB
Mean 12.4
Standard deviation 1.7
Values 11 12 14
[54]
SNU475 NFKBIB
Mean 6.88
Standard deviation 1.6
Values 5.7 8
[55]
THLE NFKBIB
Mean 9.79
Standard deviation 0.9
Values 9.1 10
[56]
liver NFKBIB
Mean 5.65
Standard deviation 1
Values 6.1 4.3 5.5 6.8
[57]
ref_hepatocyte NKIRAS2
Mean 7.22
Standard deviation 5.2
Values 4.7 3.4 16 7.2 4.6
[58]
HepG2 NKIRAS2
Mean 26.9
Standard deviation 4.4
Values 30 24
[59]
HepG2.C3A NKIRAS2
Mean 10
Standard deviation 1.8
Values 11 8.8
[60]
HuH.7 NKIRAS2
Mean 20.2
Standard deviation 2.6
Values 22 17 21
[61]
SNU475 NKIRAS2
Mean 19.8
Standard deviation 1.9
Values 21 18
[62]
THLE NKIRAS2
Mean 19.3
Standard deviation 1.3
Values 18 20
[63]
liver NKIRAS2
Mean 11.8
Standard deviation 7.8
Values 19 4.9 18 5.2
[64]
ref_hepatocyte TRIM4
Mean 7
Standard deviation 3.2
Values 13 4.2 5.9 5.7 6.7
[65]
HepG2 TRIM4
Mean 12.7
Standard deviation 1.4
Values 12 14
[66]
HepG2.C3A TRIM4
Mean 12.9
Standard deviation 5.9
Values 17 8.8
[67]
HuH.7 TRIM4
Mean 14.1
Standard deviation 1.8
Values 14 16 12
[68]
SNU475 TRIM4
Mean 5.17
Standard deviation 0.5
Values 5.5 4.8
[69]
THLE TRIM4
Mean 8.85
Standard deviation 0.71
Values 8.3 9.4
[70]
liver TRIM4
Mean 13.1
Standard deviation 2.9
Values 17 12 13 10
[71]
ref_hepatocyte TRIM25
Mean 6.54
Standard deviation 4.3
Values 10 11 7.2 2.2 1.9
[72]
HepG2 TRIM25
Mean 63.4
Standard deviation 2.6
Values 65 62
[73]
HepG2.C3A TRIM25
Mean 43.9
Standard deviation 3.5
Values 41 46
[74]
HuH.7 TRIM25
Mean 37.6
Standard deviation 5.8
Values 42 39 31
[75]
SNU475 TRIM25
Mean 22.1
Standard deviation 1.8
Values 23 21
[76]
THLE TRIM25
Mean 39
Standard deviation 5.5
Values 35 43
[77]
liver TRIM25
Mean 32.7
Standard deviation 17
Values 20 44 16 51
[78]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 3 6.7 12 5.3 4.7
[79]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 18 26
[80]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 15 17
[81]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 14 12 13
[82]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 9.6 10
[83]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[84]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 9.7 15 7.2 17
[85]
ref_hepatocyte NKIRAS1
Mean 5.36
Standard deviation 2.8
Values 3.2 10 4.7 5.4 3.4
[86]
HepG2 NKIRAS1
Mean 4.58
Standard deviation 0.0091
Values 4.6 4.6
[87]
HepG2.C3A NKIRAS1
Mean 3.54
Standard deviation 0.22
Values 3.4 3.7
[88]
HuH.7 NKIRAS1
Mean 7.9
Standard deviation 2.6
Values 6.2 11 6.6
[89]
SNU475 NKIRAS1
Mean 6.75
Standard deviation 0.8
Values 6.2 7.3
[90]
THLE NKIRAS1
Mean 9.2
Standard deviation 0.3
Values 9 9.4
[91]
liver NKIRAS1
Mean 6.52
Standard deviation 2.2
Values 9.3 4.4 7.1 5.3
[92]
ref_hepatocyte TRAF2
Mean 5.07
Standard deviation 4.4
Values 1.1 5.1 12 4.2 2.5
[93]
HepG2 TRAF2
Mean 13.1
Standard deviation 2.2
Values 15 12
[94]
HepG2.C3A TRAF2
Mean 12.2
Standard deviation 1.2
Values 13 11
[95]
HuH.7 TRAF2
Mean 9.75
Standard deviation 2.3
Values 9.4 7.6 12
[96]
SNU475 TRAF2
Mean 10.1
Standard deviation 0.75
Values 9.6 11
[97]
THLE TRAF2
Mean 11.4
Standard deviation 2.7
Values 9.5 13
[98]
liver TRAF2
Mean 4.15
Standard deviation 1.4
Values 4 2.6 6 4.1
[99]
ref_hepatocyte IFIH1
Mean 4.45
Standard deviation 2
Values 7.6 4.6 2.9 2.5 4.6
[100]
HepG2 IFIH1
Mean 2.51
Standard deviation 0.64
Values 2.1 3
[101]
HepG2.C3A IFIH1
Mean 2.38
Standard deviation 0.31
Values 2.6 2.2
[102]
HuH.7 IFIH1
Mean 0.132
Standard deviation 0.058
Values 0.16 0.17 0.066
[103]
SNU475 IFIH1
Mean 3.48
Standard deviation 0.87
Values 4.1 2.9
[104]
THLE IFIH1
Mean 4.58
Standard deviation 1.1
Values 5.3 3.8
[105]
liver IFIH1
Mean 7.55
Standard deviation 1.8
Values 10 7.5 5.9 6.7
[106]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[107]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[108]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[109]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[110]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[111]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[112]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[113]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 2.9 4.3 4.2 3.5 2.5
[114]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[115]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 11 9.5
[116]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 11 8.4 12
[117]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 8.9 6.4
[118]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[119]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 11 11 11 12
[120]
ref_hepatocyte DDX58
Mean 3.45
Standard deviation 3
Values 1.2 7.5 5.8 1.2 1.7
[121]
HepG2 DDX58
Mean 4.68
Standard deviation 1.6
Values 3.5 5.8
[122]
HepG2.C3A DDX58
Mean 4.13
Standard deviation 1.1
Values 3.4 4.9
[123]
HuH.7 DDX58
Mean 2.24
Standard deviation 0.73
Values 1.8 3.1 1.9
[124]
SNU475 DDX58
Mean 3.67
Standard deviation 0.0023
Values 3.7 3.7
[125]
THLE DDX58
Mean 6.07
Standard deviation 0.0034
Values 6.1 6.1
[126]
liver DDX58
Mean 10.6
Standard deviation 2.3
Values 13 12 10 7.7
[127]
ref_hepatocyte MAVS
Mean 2.3
Standard deviation 1.1
Values 4.3 1.9 1.7 1.8 1.9
[128]
HepG2 MAVS
Mean 98.5
Standard deviation 2.4
Values 97 1e+02
[129]
HepG2.C3A MAVS
Mean 66.9
Standard deviation 0.12
Values 67 67
[130]
HuH.7 MAVS
Mean 48.8
Standard deviation 7.5
Values 56 50 41
[131]
SNU475 MAVS
Mean 56.1
Standard deviation 14
Values 66 46
[132]
THLE MAVS
Mean 47.4
Standard deviation 9.4
Values 41 54
[133]
liver MAVS
Mean 33.3
Standard deviation 8
Values 26 34 29 44
[134]
ref_hepatocyte MAP3K1
Mean 1.15
Standard deviation 0.91
Values 2.7 0.56 1.1 0.47 0.9
[135]
HepG2 MAP3K1
Mean 16
Standard deviation 5.2
Values 12 20
[136]
HepG2.C3A MAP3K1
Mean 11.7
Standard deviation 2.9
Values 9.6 14
[137]
HuH.7 MAP3K1
Mean 9.28
Standard deviation 2.5
Values 10 11 6.5
[138]
SNU475 MAP3K1
Mean 10.6
Standard deviation 2.4
Values 12 8.9
[139]
THLE MAP3K1
Mean 5.47
Standard deviation 0.12
Values 5.5 5.4
[140]
liver MAP3K1
Mean 11.4
Standard deviation 4.8
Values 7.7 17 7 14
[141]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[142]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[143]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[144]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[145]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[146]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[147]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[148]
ref_hepatocyte RNF135
Mean 0.925
Standard deviation 0.88
Values 0 1.1 0.45 0.78 2.3
[149]
HepG2 RNF135
Mean 0.0129
Standard deviation 0.0061
Values 0.017 0.0086
[150]
HepG2.C3A RNF135
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[151]
HuH.7 RNF135
Mean 0.0351
Standard deviation 0.018
Values 0.016 0.051 0.037
[152]
SNU475 RNF135
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[153]
THLE RNF135
Mean 5.16
Standard deviation 0.15
Values 5.1 5.3
[154]
liver RNF135
Mean 2.39
Standard deviation 0.75
Values 3.2 1.6 2.8 1.9
[155]
ref_hepatocyte S100A12
Mean 0.497
Standard deviation 0.84
Values 0 0 0 1.9 0.55
[156]
HepG2 S100A12
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A S100A12
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 S100A12
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 S100A12
Mean 0
Standard deviation 0
Values 0 0
[160]
THLE S100A12
Mean 0
Standard deviation 0
Values 0 0
[161]
liver S100A12
Mean 0.858
Standard deviation 0.61
Values 0.61 0.19 1.6 1
[162]
ref_hepatocyte AGER
Mean 0.428
Standard deviation 0.33
Values 0.64 0.18 0 0.53 0.79
[163]
HepG2 AGER
Mean 0.458
Standard deviation 0.017
Values 0.47 0.45
[164]
HepG2.C3A AGER
Mean 3.68
Standard deviation 1.8
Values 5 2.4
[165]
HuH.7 AGER
Mean 1.68
Standard deviation 0.57
Values 1.2 1.5 2.3
[166]
SNU475 AGER
Mean 1.23
Standard deviation 0.34
Values 1.5 0.98
[167]
THLE AGER
Mean 1.17
Standard deviation 0.6
Values 1.6 0.74
[168]
liver AGER
Mean 0.565
Standard deviation 0.23
Values 0.42 0.5 0.44 0.9
[169]
ref_hepatocyte S100B
Mean 0.0705
Standard deviation 0.1
Values 0 0 0.14 0 0.21
[170]
HepG2 S100B
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[171]
HepG2.C3A S100B
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[172]
HuH.7 S100B
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 S100B
Mean 0.0384
Standard deviation 0.011
Values 0.046 0.03
[174]
THLE S100B
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[175]
liver S100B
Mean 0.222
Standard deviation 0.098
Values 0.31 0.14 0.31 0.13