REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.29[2] -0.43[3] -0.39[4] -0.36[5] -0.19[6] 0.06[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.15[16] 0.32[17] -0.03[18] 0.49[19] 0.19[20] 0.52[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.59[23] 2.56[24] 3.48[25] 1.89[26] 2.42[27] 1.29[28]
5 UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 [29] -1.97[30] -2.09[31] -2.07[32] -1.47[33] -2.41[34] -3.07[35]
6 IRAK1 Interleukin-1 receptor-associated kinase 1 [36] 3.33[37] 2.78[38] 1.65[39] 3.22[40] 3.30[41] 1.26[42]
7 UBE2N Ubiquitin-conjugating enzyme E2 N [43] 2.60[44] 3.14[45] 1.84[46] 2.74[47] 2.34[48] 1.22[49]
8 MYD88 Myeloid differentiation primary response protein MyD88 [50] 1.72[51] 1.84[52] 1.16[53] 1.39[54] 1.39[55] 2.74[56]
9 IRF7 Interferon regulatory factor 7 [57] -7.32[58] -6.26[59] -5.27[60] -0.73[61] -1.27[62] 1.87[63]
10 IRAK4 Interleukin-1 receptor-associated kinase 4 [64] 2.17[65] 3.59[66] 3.76[67] 3.84[68] 3.31[69] 3.72[70]
11 TRAF6 TNF receptor-associated factor 6 [71] 3.00[72] 2.95[73] 3.40[74] 4.08[75] 3.25[76] 4.85[77]
12 TLR7 Toll-like receptor 7 [78] 1.08[79] 1.93[80] 2.12[81] 1.84[82] 1.12[83] 3.21[84]
13 TLR9 Toll-like receptor 9 [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte UBE2V1
Mean 30.9
Standard deviation 6.6
Values 41 25 33 29 27
[30]
HepG2 UBE2V1
Mean 4.65
Standard deviation 0.14
Values 4.6 4.7
[31]
HepG2.C3A UBE2V1
Mean 3.63
Standard deviation 0.17
Values 3.8 3.5
[32]
HuH.7 UBE2V1
Mean 3.85
Standard deviation 0.39
Values 4.3 3.8 3.5
[33]
SNU475 UBE2V1
Mean 3.83
Standard deviation 0.48
Values 4.2 3.5
[34]
THLE UBE2V1
Mean 2.74
Standard deviation 0.61
Values 2.3 3.2
[35]
liver UBE2V1
Mean 1.36
Standard deviation 0.64
Values 1.9 0.84 2 0.78
[36]
ref_hepatocyte IRAK1
Mean 21.3
Standard deviation 13
Values 18 30 38 16 5
[37]
HepG2 IRAK1
Mean 126
Standard deviation 40
Values 1.5e+02 97
[38]
HepG2.C3A IRAK1
Mean 73.4
Standard deviation 2.1
Values 72 75
[39]
HuH.7 IRAK1
Mean 34.7
Standard deviation 4.6
Values 40 31 34
[40]
SNU475 IRAK1
Mean 67.9
Standard deviation 14
Values 58 78
[41]
THLE IRAK1
Mean 98.2
Standard deviation 12
Values 90 1.1e+02
[42]
liver IRAK1
Mean 18.8
Standard deviation 3.7
Values 17 19 15 24
[43]
ref_hepatocyte UBE2N
Mean 19.2
Standard deviation 7.8
Values 19 28 25 11 12
[44]
HepG2 UBE2N
Mean 68.4
Standard deviation 19
Values 55 82
[45]
HepG2.C3A UBE2N
Mean 84.8
Standard deviation 36
Values 60 1.1e+02
[46]
HuH.7 UBE2N
Mean 36
Standard deviation 8.3
Values 38 27 43
[47]
SNU475 UBE2N
Mean 44
Standard deviation 3.7
Values 47 41
[48]
THLE UBE2N
Mean 45.7
Standard deviation 8
Values 40 51
[49]
liver UBE2N
Mean 16.6
Standard deviation 11
Values 25 8.3 27 5.9
[50]
ref_hepatocyte MYD88
Mean 12.3
Standard deviation 6.2
Values 5.4 6 14 19 17
[51]
HepG2 MYD88
Mean 23.8
Standard deviation 12
Values 16 32
[52]
HepG2.C3A MYD88
Mean 22.1
Standard deviation 5.1
Values 18 26
[53]
HuH.7 MYD88
Mean 14.3
Standard deviation 1.1
Values 15 13 15
[54]
SNU475 MYD88
Mean 11
Standard deviation 1.1
Values 12 10
[55]
THLE MYD88
Mean 15.1
Standard deviation 1.7
Values 14 16
[56]
liver MYD88
Mean 30.3
Standard deviation 21
Values 47 9.8 51 14
[57]
ref_hepatocyte IRF7
Mean 11.7
Standard deviation 10
Values 0 3.4 11 20 24
[58]
HepG2 IRF7
Mean 0.0429
Standard deviation 0.012
Values 0.034 0.051
[59]
HepG2.C3A IRF7
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[60]
HuH.7 IRF7
Mean 0.158
Standard deviation 0.13
Values 0.16 0.29 0.028
[61]
SNU475 IRF7
Mean 2.42
Standard deviation 0.34
Values 2.2 2.7
[62]
THLE IRF7
Mean 2.27
Standard deviation 0.44
Values 2 2.6
[63]
liver IRF7
Mean 15.8
Standard deviation 4.5
Values 16 9.6 20 18
[64]
ref_hepatocyte IRAK4
Mean 1.45
Standard deviation 0.56
Values 1.6 0.94 0.79 2.1 1.9
[65]
HepG2 IRAK4
Mean 3.82
Standard deviation 0.94
Values 3.2 4.5
[66]
HepG2.C3A IRAK4
Mean 8.76
Standard deviation 1.5
Values 7.7 9.8
[67]
HuH.7 IRAK4
Mean 10.2
Standard deviation 0.57
Values 9.9 11 9.8
[68]
SNU475 IRAK4
Mean 7.11
Standard deviation 2.2
Values 8.7 5.5
[69]
THLE IRAK4
Mean 6.73
Standard deviation 0.64
Values 6.3 7.2
[70]
liver IRAK4
Mean 7.06
Standard deviation 1.8
Values 5.4 9.3 6 7.5
[71]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[72]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[73]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[74]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[75]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[76]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[77]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[78]
ref_hepatocyte TLR7
Mean 0.103
Standard deviation 0.13
Values 0 0.31 0.03 0.043 0.13
[79]
HepG2 TLR7
Mean 0.127
Standard deviation 0.026
Values 0.11 0.15
[80]
HepG2.C3A TLR7
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[81]
HuH.7 TLR7
Mean 0.233
Standard deviation 0.072
Values 0.21 0.31 0.18
[82]
SNU475 TLR7
Mean 0.126
Standard deviation 0.0079
Values 0.12 0.13
[83]
THLE TLR7
Mean 0.105
Standard deviation 0.028
Values 0.12 0.085
[84]
liver TLR7
Mean 0.352
Standard deviation 0.11
Values 0.24 0.49 0.39 0.3
[85]
ref_hepatocyte TLR9
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 TLR9
Mean 0.0229
Standard deviation 0.032
Values 0.046 0
[87]
HepG2.C3A TLR9
Mean 0.197
Standard deviation 0.2
Values 0.34 0.054
[88]
HuH.7 TLR9
Mean 1.11
Standard deviation 1.2
Values 0.44 2.5 0.37
[89]
SNU475 TLR9
Mean 0.0454
Standard deviation 0.021
Values 0.06 0.03
[90]
THLE TLR9
Mean 0.22
Standard deviation 0.12
Values 0.3 0.14
[91]
liver TLR9
Mean 0.227
Standard deviation 0.11
Values 0.12 0.23 0.18 0.38