REACTOME_BIOLOGICAL_OXIDATIONS |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
CYP2E1 |
Cytochrome P450 2E1 |
[1] |
-12.08[2] |
-12.40[3] |
-9.18[4] |
-13.94[5] |
-11.60[6] |
-0.13[7] |
2 |
CES1 |
Liver carboxylesterase 1 |
[8] |
-1.14[9] |
-8.04[10] |
-8.96[11] |
-1.28[12] |
-8.35[13] |
-1.23[14] |
3 |
MGST1 |
Microsomal glutathione S-transferase 1 |
[15] |
-1.84[16] |
-2.35[17] |
-1.49[18] |
-1.74[19] |
-0.26[20] |
-0.61[21] |
4 |
NNMT |
Nicotinamide N-methyltransferase |
[22] |
-10.91[23] |
-12.41[24] |
-5.15[25] |
-3.28[26] |
0.13[27] |
-0.05[28] |
5 |
ADH1B |
Alcohol dehydrogenase 1B |
[29] |
-11.26[30] |
[31] |
-7.72[32] |
[33] |
[34] |
0.33[35] |
6 |
HSP90AB1 |
Heat shock protein HSP 90-beta |
[36] |
2.65[37] |
2.57[38] |
1.73[39] |
1.94[40] |
2.10[41] |
-1.83[42] |
7 |
GSTA1 |
Glutathione S-transferase A1 |
[43] |
-3.22[44] |
-7.17[45] |
-0.99[46] |
-5.54[47] |
-9.58[48] |
-3.35[49] |
8 |
ALDH2 |
Aldehyde dehydrogenase, mitochondrial |
[50] |
-0.49[51] |
-1.54[52] |
-1.24[53] |
-1.96[54] |
-1.16[55] |
-0.18[56] |
9 |
ADH4 |
Alcohol dehydrogenase 4 |
[57] |
-4.04[58] |
-4.73[59] |
-8.95[60] |
-12.43[61] |
-9.69[62] |
-2.20[63] |
10 |
ALDH1A1 |
Retinal dehydrogenase 1 |
[64] |
0.92[65] |
-0.10[66] |
2.90[67] |
2.62[68] |
-4.98[69] |
-1.12[70] |
11 |
ADH1A |
Alcohol dehydrogenase 1A |
[71] |
-12.67[72] |
[73] |
-8.31[74] |
-15.51[75] |
[76] |
-1.66[77] |
12 |
CYP2C8 |
Cytochrome P450 2C8 |
[78] |
-14.07[79] |
-9.51[80] |
-7.34[81] |
-11.03[82] |
[83] |
0.79[84] |
13 |
EPHX1 |
Epoxide hydrolase 1 |
[85] |
-0.63[86] |
-2.28[87] |
-3.16[88] |
1.30[89] |
-1.20[90] |
-0.68[91] |
14 |
CYP2C9 |
Cytochrome P450 2C9 |
[92] |
[93] |
-14.43[94] |
-7.56[95] |
-13.71[96] |
-12.13[97] |
1.29[98] |
15 |
SULT2A1 |
Bile salt sulfotransferase |
[99] |
-0.85[100] |
-0.10[101] |
-1.39[102] |
-10.12[103] |
-9.14[104] |
0.56[105] |
16 |
CYP3A4 |
Cytochrome P450 3A4 |
[106] |
-9.33[107] |
-9.63[108] |
-11.37[109] |
-14.03[110] |
-11.70[111] |
1.00[112] |
17 |
UGT1A6 |
UDP-glucuronosyltransferase 1-6 |
[113] |
-6.42[114] |
-14.33[115] |
-8.47[116] |
-5.38[117] |
-10.44[118] |
-3.62[119] |
18 |
CYP2A6 |
Cytochrome P450 2A6 |
[120] |
-15.44[121] |
[122] |
-7.80[123] |
-10.79[124] |
-12.44[125] |
-1.34[126] |
19 |
TRMT112 |
Multifunctional methyltransferase subunit TRM112-like protein |
[127] |
-0.66[128] |
-0.61[129] |
-1.06[130] |
-0.80[131] |
-0.27[132] |
-3.63[133] |
20 |
MAT1A |
S-adenosylmethionine synthase isoform type-1 |
[134] |
-1.10[135] |
0.61[136] |
-1.34[137] |
-7.95[138] |
-9.69[139] |
1.21[140] |
21 |
UGT2B4 |
UDP-glucuronosyltransferase 2B4 |
[141] |
-7.03[142] |
-7.38[143] |
-2.16[144] |
-8.62[145] |
-11.33[146] |
1.04[147] |
22 |
GSTA2 |
Glutathione S-transferase A2 |
[148] |
-4.33[149] |
-7.00[150] |
-2.63[151] |
-6.96[152] |
-9.72[153] |
-3.16[154] |
23 |
UGDH |
UDP-glucose 6-dehydrogenase |
[155] |
1.38[156] |
1.12[157] |
0.02[158] |
1.08[159] |
-1.29[160] |
-0.31[161] |
24 |
GSTO1 |
Glutathione S-transferase omega-1 |
[162] |
0.48[163] |
1.02[164] |
0.46[165] |
-1.69[166] |
1.28[167] |
-0.94[168] |
25 |
UGP2 |
UTP--glucose-1-phosphate uridylyltransferase |
[169] |
0.23[170] |
0.67[171] |
0.07[172] |
0.69[173] |
0.99[174] |
0.02[175] |
26 |
PTGES3 |
Prostaglandin E synthase 3 |
[176] |
1.64[177] |
1.81[178] |
2.12[179] |
1.81[180] |
2.54[181] |
-1.80[182] |
27 |
CYP3A5 |
Cytochrome P450 3A5 |
[183] |
-4.39[184] |
-2.34[185] |
-5.12[186] |
-6.60[187] |
-8.04[188] |
1.37[189] |
28 |
CYP27A1 |
Sterol 26-hydroxylase, mitochondrial |
[190] |
0.34[191] |
0.95[192] |
-2.17[193] |
-2.07[194] |
-2.85[195] |
0.36[196] |
29 |
ADH1C |
Alcohol dehydrogenase 1C |
[197] |
-13.05[198] |
-11.05[199] |
-9.70[200] |
-9.33[201] |
-10.89[202] |
-0.85[203] |
30 |
FMO3 |
Dimethylaniline monooxygenase [N-oxide-forming] 3 |
[204] |
[205] |
-13.29[206] |
-6.47[207] |
-6.29[208] |
-12.34[209] |
-0.83[210] |
31 |
UGT2B7 |
UDP-glucuronosyltransferase 2B7 |
[211] |
-0.92[212] |
-0.95[213] |
-6.45[214] |
-9.83[215] |
-10.62[216] |
-0.25[217] |
32 |
CYP4A11 |
Cytochrome P450 4A11 |
[218] |
-12.25[219] |
-9.80[220] |
-11.69[221] |
-9.84[222] |
-10.08[223] |
1.15[224] |
33 |
SULT1A1 |
Sulfotransferase 1A1 |
[225] |
0.91[226] |
1.38[227] |
-2.13[228] |
-1.11[229] |
-0.26[230] |
-1.88[231] |
34 |
POR |
NADPH--cytochrome P450 reductase |
[232] |
1.49[233] |
1.89[234] |
0.64[235] |
0.71[236] |
0.47[237] |
1.63[238] |
35 |
GSTK1 |
Glutathione S-transferase kappa 1 |
[239] |
-0.61[240] |
-0.21[241] |
0.01[242] |
-0.64[243] |
-0.43[244] |
-0.76[245] |
36 |
UGT2B10 |
UDP-glucuronosyltransferase 2B10 |
[246] |
-1.35[247] |
1.10[248] |
-6.58[249] |
-9.96[250] |
-12.65[251] |
-1.33[252] |
37 |
CYP1A2 |
Cytochrome P450 1A2 |
[253] |
-8.50[254] |
-7.38[255] |
-8.07[256] |
-7.60[257] |
-7.24[258] |
-1.38[259] |
38 |
AADAC |
Arylacetamide deacetylase |
[260] |
-6.60[261] |
-4.21[262] |
-0.17[263] |
-6.56[264] |
-5.55[265] |
0.61[266] |
39 |
MGST2 |
Microsomal glutathione S-transferase 2 |
[267] |
0.34[268] |
1.55[269] |
-0.17[270] |
-1.49[271] |
-0.73[272] |
-1.65[273] |
40 |
ADH6 |
Alcohol dehydrogenase 6 |
[274] |
-1.13[275] |
-0.54[276] |
-0.48[277] |
-8.33[278] |
-7.73[279] |
-0.43[280] |
41 |
UGT2B15 |
UDP-glucuronosyltransferase 2B15 |
[281] |
-9.26[282] |
-7.88[283] |
-7.20[284] |
-9.70[285] |
-9.46[286] |
-0.71[287] |
42 |
ACY1 |
Aminoacylase-1 |
[288] |
-3.62[289] |
-3.10[290] |
-2.55[291] |
-6.14[292] |
-4.89[293] |
-4.95[294] |
43 |
AHCY |
Adenosylhomocysteinase |
[295] |
3.41[296] |
3.66[297] |
3.86[298] |
1.71[299] |
2.06[300] |
-0.74[301] |
44 |
ACSM2B |
Acyl-coenzyme A synthetase ACSM2B, mitochondrial |
[302] |
-4.64[303] |
-4.53[304] |
0.18[305] |
-10.69[306] |
-8.70[307] |
1.10[308] |
45 |
ACSM2A |
Acyl-coenzyme A synthetase ACSM2A, mitochondrial |
[309] |
-5.90[310] |
-6.43[311] |
-0.85[312] |
-13.22[313] |
-10.33[314] |
1.10[315] |
46 |
UGT1A1 |
UDP-glucuronosyltransferase 1-1 |
[316] |
-3.95[317] |
-10.38[318] |
-5.25[319] |
0.14[320] |
-9.08[321] |
0.22[322] |
47 |
ADH5 |
Alcohol dehydrogenase class-3 |
[323] |
2.13[324] |
1.93[325] |
2.43[326] |
1.41[327] |
2.46[328] |
-0.09[329] |
48 |
AKR1A1 |
Alcohol dehydrogenase [NADP(+)] |
[330] |
1.22[331] |
1.22[332] |
1.90[333] |
-0.07[334] |
0.42[335] |
-0.05[336] |
49 |
CYP51A1 |
Lanosterol 14-alpha demethylase |
[337] |
-0.30[338] |
1.93[339] |
1.84[340] |
0.06[341] |
0.50[342] |
1.07[343] |
50 |
UGT1A4 |
UDP-glucuronosyltransferase 1-4 |
[344] |
-11.32[345] |
[346] |
-11.15[347] |
-9.13[348] |
[349] |
0.41[350] |
51 |
GSTT1 |
Glutathione S-transferase theta-1 |
[351] |
0.38[352] |
0.39[353] |
-9.92[354] |
-10.52[355] |
-1.35[356] |
-0.73[357] |
52 |
CYP2B6 |
Cytochrome P450 2B6 |
[358] |
-7.22[359] |
-3.97[360] |
-2.63[361] |
-8.58[362] |
-8.81[363] |
2.67[364] |
53 |
CES2 |
Cocaine esterase |
[365] |
1.41[366] |
1.81[367] |
-0.43[368] |
0.08[369] |
0.49[370] |
1.56[371] |
54 |
GLYATL1 |
Glycine N-acyltransferase-like protein 1 |
[372] |
-6.50[373] |
-8.58[374] |
-4.77[375] |
-7.61[376] |
-6.07[377] |
0.68[378] |
55 |
GLYAT |
Glycine N-acyltransferase |
[379] |
-10.64[380] |
-11.83[381] |
[382] |
[383] |
-10.30[384] |
-0.27[385] |
56 |
ALDH1B1 |
Aldehyde dehydrogenase X, mitochondrial |
[386] |
1.76[387] |
1.54[388] |
-0.37[389] |
0.35[390] |
0.61[391] |
0.03[392] |
57 |
MAOB |
Amine oxidase [flavin-containing] B |
[393] |
0.05[394] |
-0.53[395] |
0.11[396] |
0.27[397] |
-6.67[398] |
0.27[399] |
58 |
GSTZ1 |
Maleylacetoacetate isomerase |
[400] |
-1.55[401] |
-0.94[402] |
-1.36[403] |
-1.88[404] |
-1.06[405] |
-1.54[406] |
59 |
ESD |
S-formylglutathione hydrolase |
[407] |
1.29[408] |
1.55[409] |
1.87[410] |
0.54[411] |
1.76[412] |
-0.43[413] |
60 |
CYP1A1 |
Cytochrome P450 1A1 |
[414] |
-2.05[415] |
-3.81[416] |
-0.18[417] |
-3.00[418] |
-2.76[419] |
-5.53[420] |
61 |
CYP2C18 |
Cytochrome P450 2C18 |
[421] |
-9.05[422] |
-10.70[423] |
-4.88[424] |
-10.86[425] |
-8.14[426] |
-0.19[427] |
62 |
CYB5R3 |
NADH-cytochrome b5 reductase 3 |
[428] |
3.06[429] |
3.16[430] |
2.61[431] |
2.09[432] |
3.24[433] |
0.90[434] |
63 |
COMT |
Catechol O-methyltransferase |
[435] |
1.78[436] |
2.21[437] |
0.01[438] |
0.75[439] |
1.58[440] |
0.64[441] |
64 |
CYP2D6 |
Cytochrome P450 2D6 |
[442] |
-5.48[443] |
-3.18[444] |
-5.74[445] |
-7.09[446] |
-6.83[447] |
1.49[448] |
65 |
AKR7A3 |
Aflatoxin B1 aldehyde reductase member 3 |
[449] |
-6.82[450] |
-4.52[451] |
-7.38[452] |
-6.48[453] |
-5.90[454] |
-0.56[455] |
66 |
NQO2 |
Ribosyldihydronicotinamide dehydrogenase [quinone] |
[456] |
-0.23[457] |
0.23[458] |
0.35[459] |
0.88[460] |
0.67[461] |
-0.50[462] |
67 |
CYP8B1 |
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
[463] |
-5.80[464] |
-3.43[465] |
-7.39[466] |
-7.49[467] |
-8.54[468] |
2.72[469] |
68 |
ABHD14B |
Protein ABHD14B |
[470] |
1.57[471] |
1.65[472] |
0.48[473] |
0.04[474] |
1.47[475] |
0.26[476] |
69 |
CYP4F2 |
Phylloquinone omega-hydroxylase CYP4F2 |
[477] |
-4.21[478] |
-0.76[479] |
-12.49[480] |
-11.06[481] |
-8.39[482] |
1.09[483] |
70 |
MGST3 |
Microsomal glutathione S-transferase 3 |
[484] |
0.23[485] |
0.09[486] |
0.79[487] |
1.64[488] |
2.39[489] |
0.06[490] |
71 |
CYP3A7 |
Cytochrome P450 3A7 |
[491] |
-4.51[492] |
-2.42[493] |
-7.17[494] |
[495] |
-9.50[496] |
-1.40[497] |
72 |
ACSM5 |
Acyl-coenzyme A synthetase ACSM5, mitochondrial |
[498] |
-3.13[499] |
-4.12[500] |
-4.79[501] |
-4.02[502] |
-11.07[503] |
1.92[504] |
73 |
CNDP2 |
Cytosolic non-specific dipeptidase |
[505] |
2.18[506] |
2.00[507] |
0.67[508] |
1.01[509] |
1.41[510] |
1.35[511] |
74 |
ACSS2 |
Acetyl-coenzyme A synthetase, cytoplasmic |
[512] |
0.74[513] |
2.23[514] |
1.91[515] |
0.80[516] |
1.19[517] |
0.28[518] |
75 |
GCLC |
Glutamate--cysteine ligase catalytic subunit |
[519] |
2.06[520] |
2.25[521] |
1.00[522] |
3.44[523] |
1.50[524] |
0.69[525] |
76 |
TPST2 |
Protein-tyrosine sulfotransferase 2 |
[526] |
0.00[527] |
-0.09[528] |
0.48[529] |
1.15[530] |
0.17[531] |
0.78[532] |
77 |
TPMT |
Thiopurine S-methyltransferase |
[533] |
0.79[534] |
1.40[535] |
-0.11[536] |
1.09[537] |
1.47[538] |
0.13[539] |
78 |
MAT2A |
S-adenosylmethionine synthase isoform type-2 |
[540] |
2.93[541] |
3.09[542] |
2.86[543] |
3.31[544] |
4.32[545] |
1.15[546] |
79 |
CYP2J2 |
Cytochrome P450 2J2 |
[547] |
-2.99[548] |
-3.16[549] |
-0.07[550] |
-5.69[551] |
-3.45[552] |
0.54[553] |
80 |
GGCT |
Gamma-glutamylcyclotransferase |
[554] |
0.46[555] |
1.07[556] |
2.10[557] |
1.04[558] |
1.84[559] |
-1.89[560] |
81 |
MAOA |
Amine oxidase [flavin-containing] A |
[561] |
-0.78[562] |
-0.17[563] |
2.06[564] |
-2.16[565] |
3.81[566] |
1.77[567] |
82 |
PAPSS2 |
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
[568] |
-3.23[569] |
-5.32[570] |
1.89[571] |
2.35[572] |
3.56[573] |
1.78[574] |
83 |
SULT1A2 |
Sulfotransferase 1A2 |
[575] |
0.87[576] |
1.38[577] |
-3.41[578] |
-0.95[579] |
-3.42[580] |
-1.71[581] |
84 |
NR1H4 |
Bile acid receptor |
[582] |
0.82[583] |
1.23[584] |
2.99[585] |
-5.56[586] |
-4.81[587] |
0.79[588] |
85 |
GCLM |
Glutamate--cysteine ligase regulatory subunit |
[589] |
1.44[590] |
0.50[591] |
0.94[592] |
3.34[593] |
2.29[594] |
-0.57[595] |
86 |
CYB5B |
Cytochrome b5 type B |
[596] |
3.50[597] |
3.91[598] |
3.50[599] |
2.42[600] |
3.44[601] |
-0.06[602] |
87 |
CMBL |
Carboxymethylenebutenolidase homolog |
[603] |
2.04[604] |
0.83[605] |
0.45[606] |
2.46[607] |
1.52[608] |
0.29[609] |
88 |
CYP2C19 |
Cytochrome P450 2C19 |
[610] |
[611] |
[612] |
-4.70[613] |
-11.40[614] |
-10.43[615] |
1.85[616] |
89 |
AIP |
AH receptor-interacting protein |
[617] |
1.90[618] |
1.79[619] |
2.95[620] |
3.10[621] |
2.45[622] |
-1.43[623] |
90 |
GSS |
Glutathione synthetase |
[624] |
3.12[625] |
2.65[626] |
1.96[627] |
2.82[628] |
2.99[629] |
0.03[630] |
91 |
BPHL |
Valacyclovir hydrolase |
[631] |
0.81[632] |
1.73[633] |
1.97[634] |
0.77[635] |
-0.31[636] |
0.27[637] |
92 |
UGT1A9 |
UDP-glucuronosyltransferase 1-9 |
[638] |
-5.29[639] |
-10.34[640] |
-6.56[641] |
-4.19[642] |
-8.67[643] |
-0.36[644] |
93 |
GGT1 |
Glutathione hydrolase 1 proenzyme |
[645] |
1.74[646] |
1.30[647] |
1.05[648] |
0.30[649] |
-3.46[650] |
0.99[651] |
94 |
CYP2A7 |
Cytochrome P450 2A7 |
[652] |
[653] |
[654] |
-3.21[655] |
-9.39[656] |
[657] |
-1.50[658] |
95 |
NAT2 |
Arylamine N-acetyltransferase 2 |
[659] |
-5.54[660] |
-5.26[661] |
-3.73[662] |
-7.12[663] |
-6.40[664] |
0.41[665] |
96 |
CYP4F11 |
Phylloquinone omega-hydroxylase CYP4F11 |
[666] |
-0.11[667] |
-0.71[668] |
-8.03[669] |
1.38[670] |
-7.89[671] |
1.02[672] |
97 |
SMOX |
Spermine oxidase |
[673] |
2.60[674] |
1.18[675] |
1.04[676] |
1.32[677] |
2.76[678] |
-3.87[679] |
98 |
RXRA |
Retinoic acid receptor RXR-alpha |
[680] |
2.36[681] |
1.99[682] |
2.80[683] |
2.50[684] |
2.95[685] |
2.42[686] |
99 |
TPST1 |
Protein-tyrosine sulfotransferase 1 |
[687] |
0.67[688] |
1.12[689] |
1.49[690] |
1.92[691] |
2.35[692] |
0.41[693] |
100 |
CYP4F3 |
Docosahexaenoic acid omega-hydroxylase CYP4F3 |
[694] |
-1.04[695] |
-0.31[696] |
0.93[697] |
-2.03[698] |
-7.40[699] |
2.45[700] |
101 |
AS3MT |
Arsenite methyltransferase |
[701] |
-3.74[702] |
-3.46[703] |
-2.32[704] |
-5.30[705] |
-3.56[706] |
-5.49[707] |
102 |
MAT2B |
Methionine adenosyltransferase 2 subunit beta |
[708] |
2.33[709] |
2.24[710] |
2.41[711] |
2.95[712] |
3.63[713] |
0.29[714] |
103 |
PAPSS1 |
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
[715] |
3.14[716] |
3.43[717] |
2.68[718] |
2.69[719] |
3.55[720] |
-1.22[721] |
104 |
AKR7A2 |
Aflatoxin B1 aldehyde reductase member 2 |
[722] |
2.76[723] |
3.41[724] |
1.15[725] |
2.11[726] |
3.06[727] |
0.79[728] |
105 |
GSTA4 |
Glutathione S-transferase A4 |
[729] |
1.24[730] |
1.34[731] |
2.49[732] |
2.56[733] |
1.48[734] |
-1.20[735] |
106 |
FDX1 |
Adrenodoxin, mitochondrial |
[736] |
1.72[737] |
1.10[738] |
-0.45[739] |
2.19[740] |
2.89[741] |
1.08[742] |
107 |
CYP4V2 |
Cytochrome P450 4V2 |
[743] |
-0.82[744] |
0.75[745] |
-1.22[746] |
-1.38[747] |
-0.06[748] |
2.03[749] |
108 |
UGT2B17 |
UDP-glucuronosyltransferase 2B17 |
[750] |
-8.61[751] |
-8.17[752] |
-11.01[753] |
[754] |
[755] |
-1.09[756] |
109 |
CBR3 |
Carbonyl reductase [NADPH] 3 |
[757] |
-8.25[758] |
-6.73[759] |
-5.40[760] |
0.22[761] |
1.33[762] |
-5.97[763] |
110 |
SULT1A4 |
Sulfotransferase 1A4 |
[764] |
[765] |
[766] |
[767] |
[768] |
[769] |
[770] |
111 |
SULT1A3 |
Sulfotransferase 1A3 |
[771] |
[772] |
[773] |
[774] |
[775] |
[776] |
[777] |
112 |
SLC35B2 |
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 |
[778] |
4.14[779] |
4.11[780] |
2.36[781] |
3.91[782] |
4.19[783] |
0.25[784] |
113 |
GSTM4 |
Glutathione S-transferase Mu 4 |
[785] |
1.61[786] |
0.88[787] |
1.04[788] |
2.26[789] |
-0.14[790] |
0.03[791] |
114 |
SLC35D1 |
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter |
[792] |
3.08[793] |
3.23[794] |
3.39[795] |
1.64[796] |
3.04[797] |
3.23[798] |
115 |
UGT2A3 |
UDP-glucuronosyltransferase 2A3 |
[799] |
3.70[800] |
5.38[801] |
-2.05[802] |
-4.56[803] |
-6.62[804] |
1.77[805] |
116 |
CYP4F12 |
Cytochrome P450 4F12 |
[806] |
-0.28[807] |
0.88[808] |
2.02[809] |
-2.45[810] |
-5.73[811] |
0.47[812] |
117 |
CHAC1 |
Glutathione-specific gamma-glutamylcyclotransferase 1 |
[813] |
-2.98[814] |
-0.80[815] |
1.64[816] |
-1.24[817] |
2.43[818] |
-3.40[819] |
118 |
FDXR |
NADPH:adrenodoxin oxidoreductase, mitochondrial |
[820] |
5.02[821] |
4.17[822] |
1.00[823] |
0.59[824] |
2.45[825] |
-1.65[826] |
119 |
CYP39A1 |
24-hydroxycholesterol 7-alpha-hydroxylase |
[827] |
-2.65[828] |
-3.00[829] |
1.61[830] |
-2.45[831] |
0.29[832] |
0.74[833] |
120 |
ABHD10 |
Mycophenolic acid acyl-glucuronide esterase, mitochondrial |
[834] |
2.16[835] |
2.77[836] |
3.09[837] |
2.56[838] |
3.65[839] |
0.86[840] |
121 |
UGT3A1 |
UDP-glucuronosyltransferase 3A1 |
[841] |
[842] |
-8.01[843] |
[844] |
[845] |
-9.06[846] |
2.07[847] |
122 |
CES3 |
Carboxylesterase 3 |
[848] |
1.17[849] |
2.26[850] |
-0.56[851] |
-1.24[852] |
-1.10[853] |
0.49[854] |
123 |
GSTP1 |
Glutathione S-transferase P |
[855] |
-1.55[856] |
-0.84[857] |
6.82[858] |
8.20[859] |
6.74[860] |
0.21[861] |
124 |
SLC35B3 |
Adenosine 3'-phospho 5'-phosphosulfate transporter 2 |
[862] |
1.92[863] |
2.22[864] |
1.91[865] |
2.43[866] |
2.59[867] |
0.18[868] |
125 |
BPNT1 |
3'(2'),5'-bisphosphate nucleotidase 1 |
[869] |
3.28[870] |
3.65[871] |
4.18[872] |
3.76[873] |
3.23[874] |
0.09[875] |
126 |
MTRR |
Methionine synthase reductase |
[876] |
2.65[877] |
3.14[878] |
3.84[879] |
3.04[880] |
4.50[881] |
1.49[882] |
127 |
ARNT |
Aryl hydrocarbon receptor nuclear translocator |
[883] |
2.83[884] |
2.45[885] |
3.29[886] |
3.85[887] |
4.40[888] |
1.80[889] |
128 |
CYP21A2 |
Steroid 21-hydroxylase |
[890] |
-3.44[891] |
-1.69[892] |
-6.09[893] |
-1.74[894] |
-6.27[895] |
0.00[896] |
129 |
AHR |
Aryl hydrocarbon receptor |
[897] |
3.54[898] |
3.66[899] |
4.65[900] |
3.03[901] |
4.73[902] |
2.86[903] |
130 |
OPLAH |
5-oxoprolinase |
[904] |
3.36[905] |
3.23[906] |
1.68[907] |
2.07[908] |
0.81[909] |
1.94[910] |
131 |
ACY3 |
N-acyl-aromatic-L-amino acid
amidohydrolase (carboxylate-forming) |
-0.03[911] |
-0.14[912] |
1.22[913] |
0.50[914] |
-6.12[915] |
-0.41[916] |
132 |
UGT1A3 |
UDP-glucuronosyltransferase 1-3 |
[917] |
-0.54[918] |
[919] |
-7.41[920] |
-3.93[921] |
-8.26[922] |
1.51[923] |
133 |
CYP7A1 |
Cholesterol 7-alpha-monooxygenase |
[924] |
-1.93[925] |
-4.43[926] |
-8.00[927] |
-7.48[928] |
[929] |
-2.69[930] |
134 |
GSTT2 |
Glutathione S-transferase theta-2 |
[931] |
-4.91[932] |
-7.03[933] |
-7.91[934] |
-2.48[935] |
-0.04[936] |
-3.31[937] |
135 |
N6AMT1 |
HemK methyltransferase family member 2 |
[938] |
0.89[939] |
0.95[940] |
-1.19[941] |
1.06[942] |
1.76[943] |
-1.47[944] |
136 |
PAOX |
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase |
[945] |
-1.80[946] |
0.40[947] |
0.05[948] |
-0.08[949] |
0.01[950] |
0.80[951] |
137 |
CYP4A22 |
Cytochrome P450 4A22 |
[952] |
[953] |
[954] |
[955] |
[956] |
[957] |
2.53[958] |
138 |
CHAC2 |
Glutathione-specific gamma-glutamylcyclotransferase 2 |
[959] |
1.31[960] |
1.62[961] |
0.72[962] |
1.88[963] |
2.77[964] |
-0.88[965] |
139 |
ACSS1 |
Acetyl-coenzyme A synthetase 2-like, mitochondrial |
[966] |
5.12[967] |
3.54[968] |
-5.59[969] |
-0.62[970] |
0.79[971] |
2.36[972] |
140 |
CYP2R1 |
Vitamin D 25-hydroxylase |
[973] |
-1.56[974] |
0.05[975] |
2.24[976] |
1.16[977] |
1.43[978] |
-0.61[979] |
141 |
GSTM3 |
Glutathione S-transferase Mu 3 |
[980] |
4.79[981] |
3.96[982] |
1.61[983] |
5.35[984] |
5.97[985] |
1.79[986] |
142 |
CYP4F22 |
Cytochrome P450 4F22 |
[987] |
-3.46[988] |
[989] |
-8.67[990] |
-7.47[991] |
-4.89[992] |
-0.70[993] |
143 |
SULT1E1 |
Estrogen sulfotransferase |
[994] |
-0.44[995] |
2.05[996] |
2.50[997] |
-5.71[998] |
3.78[999] |
1.35[1000] |
144 |
CYP1B1 |
Cytochrome P450 1B1 |
[1001] |
-4.63[1002] |
-4.24[1003] |
-0.16[1004] |
3.99[1005] |
7.38[1006] |
1.28[1007] |
145 |
ALDH3A1 |
Aldehyde dehydrogenase, dimeric NADP-preferring |
[1008] |
-0.09[1009] |
-4.39[1010] |
-1.83[1011] |
0.72[1012] |
-1.55[1013] |
-2.30[1014] |
146 |
SLC26A1 |
Sulfate anion transporter 1 |
[1015] |
2.88[1016] |
3.22[1017] |
3.26[1018] |
1.50[1019] |
0.63[1020] |
2.46[1021] |
147 |
NCOA1 |
Nuclear receptor coactivator 1 |
[1022] |
2.88[1023] |
3.28[1024] |
3.44[1025] |
4.28[1026] |
4.51[1027] |
2.92[1028] |
148 |
NAT1 |
Arylamine N-acetyltransferase 1 |
[1029] |
1.11[1030] |
1.54[1031] |
2.76[1032] |
1.08[1033] |
2.47[1034] |
1.04[1035] |
149 |
SULT1C2 |
Sulfotransferase 1C2 |
[1036] |
1.09[1037] |
0.94[1038] |
1.01[1039] |
1.29[1040] |
-3.11[1041] |
-2.43[1042] |
150 |
GGT7 |
Glutathione hydrolase 7 |
[1043] |
4.20[1044] |
4.35[1045] |
3.87[1046] |
4.45[1047] |
4.35[1048] |
0.63[1049] |
151 |
DPEP1 |
Dipeptidase 1 |
[1050] |
4.30[1051] |
2.41[1052] |
-4.32[1053] |
-4.57[1054] |
-5.98[1055] |
-3.86[1056] |
152 |
PODXL2 |
Podocalyxin-like protein 2 |
[1057] |
5.91[1058] |
-0.18[1059] |
5.44[1060] |
4.27[1061] |
1.91[1062] |
-2.38[1063] |
153 |
CYP3A43 |
Cytochrome P450 3A43 |
[1064] |
-2.44[1065] |
0.28[1066] |
0.07[1067] |
[1068] |
-6.87[1069] |
1.65[1070] |
154 |
CYP7B1 |
25-hydroxycholesterol 7-alpha-hydroxylase |
[1071] |
-5.61[1072] |
-4.51[1073] |
[1074] |
-6.54[1075] |
-2.03[1076] |
2.54[1077] |
155 |
MTR |
Methionine synthase |
[1078] |
4.68[1079] |
5.20[1080] |
5.31[1081] |
5.64[1082] |
5.75[1083] |
3.63[1084] |
156 |
GSTO2 |
Glutathione S-transferase omega-2 |
[1085] |
1.18[1086] |
3.67[1087] |
1.21[1088] |
-2.35[1089] |
0.61[1090] |
-0.97[1091] |
157 |
SLC26A2 |
Sulfate transporter |
[1092] |
3.71[1093] |
3.89[1094] |
3.58[1095] |
5.13[1096] |
7.18[1097] |
1.29[1098] |
158 |
NCOA2 |
Nuclear receptor coactivator 2 |
[1099] |
3.99[1100] |
4.64[1101] |
6.44[1102] |
5.69[1103] |
4.76[1104] |
4.87[1105] |
159 |
CYP19A1 |
Aromatase |
[1106] |
4.35[1107] |
5.19[1108] |
-1.29[1109] |
0.83[1110] |
-0.83[1111] |
-6.07[1112] |
160 |
CYP2U1 |
Cytochrome P450 2U1 |
[1113] |
2.59[1114] |
-1.39[1115] |
-1.22[1116] |
3.72[1117] |
5.29[1118] |
2.34[1119] |
161 |
GSTM2 |
Glutathione S-transferase Mu 2 |
[1120] |
2.81[1121] |
1.38[1122] |
3.14[1123] |
3.96[1124] |
4.09[1125] |
0.28[1126] |
162 |
AOC3 |
Membrane primary amine oxidase |
[1127] |
4.30[1128] |
6.52[1129] |
3.19[1130] |
1.07[1131] |
1.79[1132] |
2.40[1133] |
163 |
POMC |
Pro-opiomelanocortin |
[1134] |
[1135] |
-6.12[1136] |
[1137] |
[1138] |
-3.85[1139] |
-1.92[1140] |
164 |
TBXAS1 |
Thromboxane-A synthase |
[1141] |
-0.55[1142] |
1.33[1143] |
-1.89[1144] |
3.13[1145] |
2.46[1146] |
1.92[1147] |
165 |
GSTT2B |
Glutathione S-transferase theta-2B |
[1148] |
[1149] |
[1150] |
[1151] |
[1152] |
[1153] |
[1154] |
166 |
SULT1B1 |
Sulfotransferase family cytosolic 1B member 1 |
[1155] |
-2.45[1156] |
-1.32[1157] |
-2.15[1158] |
[1159] |
1.53[1160] |
3.23[1161] |
167 |
CYP11A1 |
Cholesterol side-chain cleavage enzyme, mitochondrial |
[1162] |
1.76[1163] |
-0.93[1164] |
[1165] |
-0.77[1166] |
4.06[1167] |
0.74[1168] |
168 |
CYP2W1 |
Cytochrome P450 2W1 |
[1169] |
6.11[1170] |
7.85[1171] |
1.73[1172] |
-0.94[1173] |
-0.57[1174] |
-3.75[1175] |
169 |
CYP2S1 |
Cytochrome P450 2S1 |
[1176] |
5.33[1177] |
4.02[1178] |
3.18[1179] |
3.67[1180] |
4.53[1181] |
-0.38[1182] |
170 |
UGT2A2 |
|
[1183] |
[1184] |
[1185] |
[1186] |
[1187] |
[1188] |
[1189] |
171 |
AOC2 |
Retina-specific copper amine oxidase |
[1190] |
2.73[1191] |
3.35[1192] |
4.75[1193] |
3.33[1194] |
4.19[1195] |
0.74[1196] |
172 |
GSTM1 |
Glutathione S-transferase Mu 1 |
[1197] |
0.10[1198] |
-1.35[1199] |
4.77[1200] |
6.58[1201] |
-1.05[1202] |
6.83[1203] |
173 |
UGT1A5 |
UDP-glucuronosyltransferase 1-5 |
[1204] |
-3.83[1205] |
[1206] |
-5.23[1207] |
-0.79[1208] |
[1209] |
1.58[1210] |
174 |
UGT2B11 |
UDP-glucuronosyltransferase 2B11 |
[1211] |
2.63[1212] |
1.10[1213] |
2.32[1214] |
-3.79[1215] |
[1216] |
1.09[1217] |
175 |
CYP24A1 |
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
[1218] |
10.56[1219] |
5.52[1220] |
-0.15[1221] |
6.59[1222] |
0.57[1223] |
-6.83[1224] |
176 |
GGT6 |
Glutathione hydrolase 6 |
[1225] |
2.74[1226] |
3.11[1227] |
1.34[1228] |
1.50[1229] |
1.56[1230] |
0.26[1231] |
177 |
UGT2B28 |
UDP-glucuronosyltransferase 2B28 |
[1232] |
2.40[1233] |
2.74[1234] |
-1.54[1235] |
-4.38[1236] |
[1237] |
1.04[1238] |
178 |
UGT3A2 |
UDP-glucuronosyltransferase 3A2 |
[1239] |
-2.32[1240] |
[1241] |
[1242] |
-2.03[1243] |
0.49[1244] |
-0.76[1245] |
179 |
CYP26A1 |
Cytochrome P450 26A1 |
[1246] |
5.58[1247] |
-0.43[1248] |
3.08[1249] |
2.64[1250] |
-2.27[1251] |
1.27[1252] |
180 |
ACSM1 |
Acyl-coenzyme A synthetase ACSM1, mitochondrial |
[1253] |
2.57[1254] |
0.16[1255] |
0.76[1256] |
-2.65[1257] |
-2.13[1258] |
0.29[1259] |
181 |
PTGIS |
Prostacyclin synthase |
[1260] |
0.86[1261] |
1.81[1262] |
5.75[1263] |
3.61[1264] |
10.33[1265] |
5.11[1266] |
182 |
DPEP2 |
Dipeptidase 2 |
[1267] |
-0.78[1268] |
0.16[1269] |
-1.89[1270] |
[1271] |
[1272] |
1.30[1273] |
183 |
SULT1C4 |
Sulfotransferase 1C4 |
[1274] |
3.29[1275] |
3.03[1276] |
1.84[1277] |
-4.85[1278] |
-4.04[1279] |
0.90[1280] |
184 |
GGT5 |
Glutathione hydrolase 5 proenzyme |
[1281] |
6.99[1282] |
4.20[1283] |
-0.71[1284] |
6.40[1285] |
7.31[1286] |
5.90[1287] |
185 |
GSTA5 |
Glutathione S-transferase A5 |
[1288] |
-4.65[1289] |
[1290] |
-4.28[1291] |
[1292] |
[1293] |
[1294] |
186 |
AHRR |
Aryl hydrocarbon receptor repressor |
[1295] |
3.81[1296] |
2.75[1297] |
3.02[1298] |
7.28[1299] |
6.44[1300] |
1.00[1301] |
187 |
PTGS1 |
Prostaglandin G/H synthase 1 |
[1302] |
3.77[1303] |
-3.32[1304] |
-1.61[1305] |
5.17[1306] |
8.78[1307] |
3.25[1308] |
188 |
ACSM4 |
Acyl-coenzyme A synthetase ACSM4, mitochondrial |
[1309] |
-0.09[1310] |
1.48[1311] |
-4.36[1312] |
[1313] |
-2.97[1314] |
-2.95[1315] |
189 |
DPEP3 |
Dipeptidase 3 |
[1316] |
[1317] |
[1318] |
-4.00[1319] |
-3.44[1320] |
[1321] |
-0.59[1322] |
190 |
HPGDS |
Hematopoietic prostaglandin D synthase |
[1323] |
[1324] |
[1325] |
[1326] |
-3.55[1327] |
-0.61[1328] |
0.23[1329] |
191 |
GSTA3 |
Glutathione S-transferase A3 |
[1330] |
-3.91[1331] |
[1332] |
-1.39[1333] |
0.49[1334] |
[1335] |
[1336] |
192 |
FMO1 |
Dimethylaniline monooxygenase [N-oxide-forming] 1 |
[1337] |
-2.73[1338] |
-1.41[1339] |
5.34[1340] |
-1.61[1341] |
[1342] |
1.68[1343] |
193 |
CYP2A13 |
Cytochrome P450 2A13 |
[1344] |
[1345] |
[1346] |
[1347] |
[1348] |
[1349] |
-0.25[1350] |
194 |
CYP27B1 |
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
[1351] |
5.10[1352] |
6.36[1353] |
5.72[1354] |
3.68[1355] |
5.19[1356] |
1.94[1357] |
195 |
GLYATL3 |
Glycine N-acyltransferase-like protein 3 |
[1358] |
-1.74[1359] |
0.85[1360] |
-1.16[1361] |
[1362] |
-0.15[1363] |
-1.46[1364] |
196 |
CYP46A1 |
Cholesterol 24-hydroxylase |
[1365] |
-1.37[1366] |
-0.21[1367] |
-1.26[1368] |
-0.07[1369] |
1.91[1370] |
2.52[1371] |
197 |
UGT1A7 |
UDP-glucuronosyltransferase 1-7 |
[1372] |
1.59[1373] |
[1374] |
0.66[1375] |
7.19[1376] |
2.59[1377] |
3.52[1378] |
198 |
ADH7 |
Alcohol dehydrogenase class 4 mu/sigma chain |
[1379] |
[1380] |
[1381] |
[1382] |
[1383] |
[1384] |
-2.74[1385] |
199 |
CYP2F1 |
Cytochrome P450 2F1 |
[1386] |
1.64[1387] |
-0.15[1388] |
4.13[1389] |
3.92[1390] |
3.60[1391] |
1.24[1392] |
200 |
ARNT2 |
Aryl hydrocarbon receptor nuclear translocator 2 |
[1393] |
7.80[1394] |
-0.38[1395] |
0.92[1396] |
8.91[1397] |
11.46[1398] |
5.22[1399] |
201 |
CYP26B1 |
Cytochrome P450 26B1 |
[1400] |
7.31[1401] |
4.08[1402] |
11.26[1403] |
9.19[1404] |
9.21[1405] |
5.80[1406] |
202 |
SULT4A1 |
Sulfotransferase 4A1 |
[1407] |
2.55[1408] |
[1409] |
[1410] |
[1411] |
8.98[1412] |
0.41[1413] |
203 |
AKR7L |
Aflatoxin B1 aldehyde reductase member 4 |
[1414] |
[1415] |
[1416] |
[1417] |
[1418] |
[1419] |
[1420] |
204 |
SULT6B1 |
Sulfotransferase 6B1 |
[1421] |
[1422] |
[1423] |
[1424] |
[1425] |
[1426] |
[1427] |
205 |
FMO2 |
Dimethylaniline monooxygenase [N-oxide-forming] 2 |
[1428] |
[1429] |
[1430] |
[1431] |
[1432] |
[1433] |
[1434] |
206 |
BPNT2 |
|
[1435] |
[1436] |
[1437] |
[1438] |
[1439] |
[1440] |
[1441] |
207 |
CYP11B2 |
Cytochrome P450 11B2, mitochondrial |
[1442] |
[1443] |
[1444] |
[1445] |
[1446] |
[1447] |
[1448] |
208 |
GLYATL2 |
Glycine N-acyltransferase-like protein 2 |
[1449] |
[1450] |
[1451] |
[1452] |
[1453] |
[1454] |
[1455] |
209 |
CYP11B1 |
Cytochrome P450 11B1, mitochondrial |
[1456] |
[1457] |
[1458] |
[1459] |
[1460] |
[1461] |
[1462] |
210 |
SULT2B1 |
Sulfotransferase family cytosolic 2B member 1 |
[1463] |
[1464] |
[1465] |
[1466] |
[1467] |
[1468] |
[1469] |
211 |
UGT1A10 |
UDP-glucuronosyltransferase 1-10 |
[1470] |
[1471] |
[1472] |
[1473] |
[1474] |
[1475] |
[1476] |
212 |
CYP4B1 |
Cytochrome P450 4B1 |
[1477] |
[1478] |
[1479] |
[1480] |
[1481] |
[1482] |
[1483] |
213 |
UGT1A8 |
UDP-glucuronosyltransferase 1-8 |
[1484] |
[1485] |
[1486] |
[1487] |
[1488] |
[1489] |
[1490] |
214 |
AOC1 |
Amiloride-sensitive amine oxidase [copper-containing] |
[1491] |
[1492] |
[1493] |
[1494] |
[1495] |
[1496] |
[1497] |
215 |
CYP4F8 |
Cytochrome P450 4F8 |
[1498] |
[1499] |
[1500] |
[1501] |
[1502] |
[1503] |
[1504] |
216 |
MTARC2 |
|
[1505] |
[1506] |
[1507] |
[1508] |
[1509] |
[1510] |
[1511] |
217 |
MTARC1 |
|
[1512] |
[1513] |
[1514] |
[1515] |
[1516] |
[1517] |
[1518] |
218 |
PDCD6-AHRR |
[1519] |
[1520] |
[1521] |
[1522] |
[1523] |
[1524] |
[1525] |
219 |
GSTM5 |
Glutathione S-transferase Mu 5 |
[1526] |
[1527] |
[1528] |
[1529] |
[1530] |
[1531] |
[1532] |
220 |
UGT2A1 |
UDP-glucuronosyltransferase 2A1 |
[1533] |
[1534] |
[1535] |
[1536] |
[1537] |
[1538] |
[1539] |
221 |
CYP26C1 |
Cytochrome P450 26C1 |
[1540] |
[1541] |
[1542] |
[1543] |
[1544] |
[1545] |
[1546] |
222 |
FDX2 |
Ferredoxin-2, mitochondrial |
[1547] |
[1548] |
[1549] |
[1550] |
[1551] |
[1552] |
[1553] |
|
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