REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IRF7 Interferon regulatory factor 7 [1] -10.20[2] -9.23[3] -8.18[4] -3.95[5] -4.16[6] -1.17[7]
2 IRF3 Interferon regulatory factor 3 [8] -0.67[9] -0.52[10] 0.14[11] -0.45[12] -0.81[13] -2.28[14]
3 TANK TRAF family member-associated NF-kappa-B activator [15] -2.10[16] -0.15[17] -0.58[18] -0.67[19] -1.40[20] -0.56[21]
4 TRIM4 E3 ubiquitin-protein ligase TRIM4 [22] -1.25[23] -1.09[24] -0.96[25] -2.12[26] -1.46[27] -0.69[28]
5 TBK1 Serine/threonine-protein kinase TBK1 [29] -1.60[30] 0.05[31] -0.87[32] -0.31[33] -0.18[34] -0.62[35]
6 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 [36] 1.17[37] 0.78[38] 0.55[39] 0.08[40] 0.78[41] 0.72[42]
7 TRAF2 TNF receptor-associated factor 2 [43] -0.74[44] -0.70[45] -1.03[46] -0.68[47] -0.63[48] -1.89[49]
8 IFIH1 Interferon-induced helicase C domain-containing protein 1 [50] -2.93[51] -2.87[52] -7.05[53] -2.03[54] -1.75[55] -0.84[56]
9 DDX58 Probable ATP-dependent RNA helicase DDX58 [57] -1.67[58] -1.71[59] -2.59[60] -1.59[61] -0.98[62] 0.02[63]
10 SIKE1 Suppressor of IKBKE 1 [64] -0.19[65] 0.89[66] 1.45[67] 0.94[68] 0.90[69] 0.69[70]
11 EP300 Histone acetyltransferase p300 [71] 1.76[72] 1.32[73] 2.16[74] 1.77[75] 1.87[76] 1.66[77]
12 MAVS Mitochondrial antiviral-signaling protein [78] 3.31[79] 2.89[80] 2.44[81] 2.93[82] 2.57[83] 2.25[84]
13 CREBBP CREB-binding protein [85] 1.93[86] 1.12[87] 1.67[88] 1.95[89] 2.01[90] 2.14[91]
14 TRAF6 TNF receptor-associated factor 6 [92] 0.13[93] -0.02[94] 0.49[95] 0.86[96] 0.36[97] 1.81[98]
15 RNF135 E3 ubiquitin-protein ligase RNF135 [99] -8.27[100] -7.91[101] -6.69[102] -8.28[103] 0.68[104] -0.23[105]
16 IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon [106] 0.75[107] 0.60[108] -0.57[109] 1.76[110] 1.36[111] -1.33[112]
17 IFNA13 [113] [114] [115] [116] [117] [118] [119]
18 IFNA8 Interferon alpha-8 [120] [121] [122] [123] [124] [125] [126]
19 IFNB1 Interferon beta [127] [128] [129] [130] [131] [132] [133]
20 IFNA4 Interferon alpha-4 [134] [135] [136] [137] [138] [139] [140]
21 IFNA6 Interferon alpha-6 [141] [142] [143] [144] [145] [146] [147]
22 IFNA7 Interferon alpha-7 [148] [149] [150] [151] [152] [153] [154]
23 IFNA5 Interferon alpha-5 [155] [156] [157] [158] [159] [160] [161]
24 IFNA14 Interferon alpha-14 [162] [163] [164] [165] [166] [167] [168]
25 IFNA16 Interferon alpha-16 [169] [170] [171] [172] [173] [174] [175]
26 IFNA21 Interferon alpha-21 [176] [177] [178] [179] [180] [181] [182]
27 IFNA17 Interferon alpha-17 [183] [184] [185] [186] [187] [188] [189]
28 IFNA10 Interferon alpha-10 [190] [191] [192] [193] [194] [195] [196]
29 IFNA1 Interferon alpha-1/13 [197] [198] [199] [200] [201] [202] [203]
30 IFNA2 Interferon alpha-2 [204] [205] [206] [207] [208] [209] [210]
[1]
ref_hepatocyte IRF7
Mean 11.7
Standard deviation 10
Values 0 3.4 11 20 24
[2]
HepG2 IRF7
Mean 0.0429
Standard deviation 0.012
Values 0.034 0.051
[3]
HepG2.C3A IRF7
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[4]
HuH.7 IRF7
Mean 0.158
Standard deviation 0.13
Values 0.16 0.29 0.028
[5]
SNU475 IRF7
Mean 2.42
Standard deviation 0.34
Values 2.2 2.7
[6]
THLE IRF7
Mean 2.27
Standard deviation 0.44
Values 2 2.6
[7]
liver IRF7
Mean 15.8
Standard deviation 4.5
Values 16 9.6 20 18
[8]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[9]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[10]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[11]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[12]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[13]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[14]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[15]
ref_hepatocyte TANK
Mean 8.63
Standard deviation 3.4
Values 7.4 6.5 5.3 10 14
[16]
HepG2 TANK
Mean 8.65
Standard deviation 2.2
Values 7.1 10
[17]
HepG2.C3A TANK
Mean 30.5
Standard deviation 0.31
Values 31 30
[18]
HuH.7 TANK
Mean 22.6
Standard deviation 1.7
Values 22 21 25
[19]
SNU475 TANK
Mean 17.3
Standard deviation 2.1
Values 19 16
[20]
THLE TANK
Mean 11.4
Standard deviation 0.54
Values 12 11
[21]
liver TANK
Mean 17.8
Standard deviation 10
Values 32 10 20 9.7
[22]
ref_hepatocyte TRIM4
Mean 7
Standard deviation 3.2
Values 13 4.2 5.9 5.7 6.7
[23]
HepG2 TRIM4
Mean 12.7
Standard deviation 1.4
Values 12 14
[24]
HepG2.C3A TRIM4
Mean 12.9
Standard deviation 5.9
Values 17 8.8
[25]
HuH.7 TRIM4
Mean 14.1
Standard deviation 1.8
Values 14 16 12
[26]
SNU475 TRIM4
Mean 5.17
Standard deviation 0.5
Values 5.5 4.8
[27]
THLE TRIM4
Mean 8.85
Standard deviation 0.71
Values 8.3 9.4
[28]
liver TRIM4
Mean 13.1
Standard deviation 2.9
Values 17 12 13 10
[29]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[30]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[31]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[32]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[33]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[34]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[35]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[36]
ref_hepatocyte TRIM25
Mean 6.54
Standard deviation 4.3
Values 10 11 7.2 2.2 1.9
[37]
HepG2 TRIM25
Mean 63.4
Standard deviation 2.6
Values 65 62
[38]
HepG2.C3A TRIM25
Mean 43.9
Standard deviation 3.5
Values 41 46
[39]
HuH.7 TRIM25
Mean 37.6
Standard deviation 5.8
Values 42 39 31
[40]
SNU475 TRIM25
Mean 22.1
Standard deviation 1.8
Values 23 21
[41]
THLE TRIM25
Mean 39
Standard deviation 5.5
Values 35 43
[42]
liver TRIM25
Mean 32.7
Standard deviation 17
Values 20 44 16 51
[43]
ref_hepatocyte TRAF2
Mean 5.07
Standard deviation 4.4
Values 1.1 5.1 12 4.2 2.5
[44]
HepG2 TRAF2
Mean 13.1
Standard deviation 2.2
Values 15 12
[45]
HepG2.C3A TRAF2
Mean 12.2
Standard deviation 1.2
Values 13 11
[46]
HuH.7 TRAF2
Mean 9.75
Standard deviation 2.3
Values 9.4 7.6 12
[47]
SNU475 TRAF2
Mean 10.1
Standard deviation 0.75
Values 9.6 11
[48]
THLE TRAF2
Mean 11.4
Standard deviation 2.7
Values 9.5 13
[49]
liver TRAF2
Mean 4.15
Standard deviation 1.4
Values 4 2.6 6 4.1
[50]
ref_hepatocyte IFIH1
Mean 4.45
Standard deviation 2
Values 7.6 4.6 2.9 2.5 4.6
[51]
HepG2 IFIH1
Mean 2.51
Standard deviation 0.64
Values 2.1 3
[52]
HepG2.C3A IFIH1
Mean 2.38
Standard deviation 0.31
Values 2.6 2.2
[53]
HuH.7 IFIH1
Mean 0.132
Standard deviation 0.058
Values 0.16 0.17 0.066
[54]
SNU475 IFIH1
Mean 3.48
Standard deviation 0.87
Values 4.1 2.9
[55]
THLE IFIH1
Mean 4.58
Standard deviation 1.1
Values 5.3 3.8
[56]
liver IFIH1
Mean 7.55
Standard deviation 1.8
Values 10 7.5 5.9 6.7
[57]
ref_hepatocyte DDX58
Mean 3.45
Standard deviation 3
Values 1.2 7.5 5.8 1.2 1.7
[58]
HepG2 DDX58
Mean 4.68
Standard deviation 1.6
Values 3.5 5.8
[59]
HepG2.C3A DDX58
Mean 4.13
Standard deviation 1.1
Values 3.4 4.9
[60]
HuH.7 DDX58
Mean 2.24
Standard deviation 0.73
Values 1.8 3.1 1.9
[61]
SNU475 DDX58
Mean 3.67
Standard deviation 0.0023
Values 3.7 3.7
[62]
THLE DDX58
Mean 6.07
Standard deviation 0.0034
Values 6.1 6.1
[63]
liver DDX58
Mean 10.6
Standard deviation 2.3
Values 13 12 10 7.7
[64]
ref_hepatocyte SIKE1
Mean 2.92
Standard deviation 0.19
Values 3.1 3 3 2.6 2.9
[65]
HepG2 SIKE1
Mean 11.1
Standard deviation 3.6
Values 8.5 14
[66]
HepG2.C3A SIKE1
Mean 21.2
Standard deviation 1.5
Values 20 22
[67]
HuH.7 SIKE1
Mean 31.3
Standard deviation 5
Values 36 26 32
[68]
SNU475 SIKE1
Mean 18
Standard deviation 2.2
Values 19 16
[69]
THLE SIKE1
Mean 19
Standard deviation 2.5
Values 21 17
[70]
liver SIKE1
Mean 14.3
Standard deviation 1.9
Values 13 16 16 12
[71]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[72]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[73]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[74]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[75]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[76]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[77]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[78]
ref_hepatocyte MAVS
Mean 2.3
Standard deviation 1.1
Values 4.3 1.9 1.7 1.8 1.9
[79]
HepG2 MAVS
Mean 98.5
Standard deviation 2.4
Values 97 1e+02
[80]
HepG2.C3A MAVS
Mean 66.9
Standard deviation 0.12
Values 67 67
[81]
HuH.7 MAVS
Mean 48.8
Standard deviation 7.5
Values 56 50 41
[82]
SNU475 MAVS
Mean 56.1
Standard deviation 14
Values 66 46
[83]
THLE MAVS
Mean 47.4
Standard deviation 9.4
Values 41 54
[84]
liver MAVS
Mean 33.3
Standard deviation 8
Values 26 34 29 44
[85]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[86]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[87]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[88]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[89]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[90]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[91]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[92]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[93]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[94]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[95]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[96]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[97]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[98]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[99]
ref_hepatocyte RNF135
Mean 0.925
Standard deviation 0.88
Values 0 1.1 0.45 0.78 2.3
[100]
HepG2 RNF135
Mean 0.0129
Standard deviation 0.0061
Values 0.017 0.0086
[101]
HepG2.C3A RNF135
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[102]
HuH.7 RNF135
Mean 0.0351
Standard deviation 0.018
Values 0.016 0.051 0.037
[103]
SNU475 RNF135
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[104]
THLE RNF135
Mean 5.16
Standard deviation 0.15
Values 5.1 5.3
[105]
liver RNF135
Mean 2.39
Standard deviation 0.75
Values 3.2 1.6 2.8 1.9
[106]
ref_hepatocyte IKBKE
Mean 0.818
Standard deviation 0.8
Values 0.91 2.2 0.36 0.25 0.39
[107]
HepG2 IKBKE
Mean 5.94
Standard deviation 0.2
Values 5.8 6.1
[108]
HepG2.C3A IKBKE
Mean 4.84
Standard deviation 0.7
Values 4.3 5.3
[109]
HuH.7 IKBKE
Mean 2.16
Standard deviation 0.28
Values 2.3 1.8 2.3
[110]
SNU475 IKBKE
Mean 8.87
Standard deviation 0.19
Values 8.7 9
[111]
THLE IKBKE
Mean 7.27
Standard deviation 2.9
Values 5.2 9.3
[112]
liver IKBKE
Mean 0.988
Standard deviation 0.21
Values 1.2 0.98 1.1 0.69
[113]
ref_hepatocyte IFNA13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 IFNA13
Missing
[115]
HepG2.C3A IFNA13
Missing
[116]
HuH.7 IFNA13
Missing
[117]
SNU475 IFNA13
Missing
[118]
THLE IFNA13
Missing
[119]
liver IFNA13
Missing
[120]
ref_hepatocyte IFNA8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 IFNA8
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A IFNA8
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 IFNA8
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 IFNA8
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[125]
THLE IFNA8
Mean 0
Standard deviation 0
Values 0 0
[126]
liver IFNA8
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte IFNB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 IFNB1
Missing
[129]
HepG2.C3A IFNB1
Missing
[130]
HuH.7 IFNB1
Missing
[131]
SNU475 IFNB1
Missing
[132]
THLE IFNB1
Missing
[133]
liver IFNB1
Missing
[134]
ref_hepatocyte IFNA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 IFNA4
Missing
[136]
HepG2.C3A IFNA4
Missing
[137]
HuH.7 IFNA4
Missing
[138]
SNU475 IFNA4
Missing
[139]
THLE IFNA4
Missing
[140]
liver IFNA4
Missing
[141]
ref_hepatocyte IFNA6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 IFNA6
Missing
[143]
HepG2.C3A IFNA6
Missing
[144]
HuH.7 IFNA6
Missing
[145]
SNU475 IFNA6
Missing
[146]
THLE IFNA6
Missing
[147]
liver IFNA6
Missing
[148]
ref_hepatocyte IFNA7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 IFNA7
Missing
[150]
HepG2.C3A IFNA7
Missing
[151]
HuH.7 IFNA7
Missing
[152]
SNU475 IFNA7
Missing
[153]
THLE IFNA7
Missing
[154]
liver IFNA7
Missing
[155]
ref_hepatocyte IFNA5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 IFNA5
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A IFNA5
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 IFNA5
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 IFNA5
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[160]
THLE IFNA5
Mean 0
Standard deviation 0
Values 0 0
[161]
liver IFNA5
Mean 0.00688
Standard deviation 0.008
Values 0 0.014 0 0.013
[162]
ref_hepatocyte IFNA14
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 IFNA14
Missing
[164]
HepG2.C3A IFNA14
Missing
[165]
HuH.7 IFNA14
Missing
[166]
SNU475 IFNA14
Missing
[167]
THLE IFNA14
Missing
[168]
liver IFNA14
Missing
[169]
ref_hepatocyte IFNA16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 IFNA16
Missing
[171]
HepG2.C3A IFNA16
Missing
[172]
HuH.7 IFNA16
Missing
[173]
SNU475 IFNA16
Missing
[174]
THLE IFNA16
Missing
[175]
liver IFNA16
Missing
[176]
ref_hepatocyte IFNA21
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 IFNA21
Missing
[178]
HepG2.C3A IFNA21
Missing
[179]
HuH.7 IFNA21
Missing
[180]
SNU475 IFNA21
Missing
[181]
THLE IFNA21
Missing
[182]
liver IFNA21
Missing
[183]
ref_hepatocyte IFNA17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[184]
HepG2 IFNA17
Missing
[185]
HepG2.C3A IFNA17
Missing
[186]
HuH.7 IFNA17
Missing
[187]
SNU475 IFNA17
Missing
[188]
THLE IFNA17
Missing
[189]
liver IFNA17
Missing
[190]
ref_hepatocyte IFNA10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[191]
HepG2 IFNA10
Missing
[192]
HepG2.C3A IFNA10
Missing
[193]
HuH.7 IFNA10
Missing
[194]
SNU475 IFNA10
Missing
[195]
THLE IFNA10
Missing
[196]
liver IFNA10
Missing
[197]
ref_hepatocyte IFNA1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[198]
HepG2 IFNA1
Mean 0
Standard deviation 0
Values 0 0
[199]
HepG2.C3A IFNA1
Mean 0
Standard deviation 0
Values 0 0
[200]
HuH.7 IFNA1
Mean 0
Standard deviation 0
Values 0 0 0
[201]
SNU475 IFNA1
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[202]
THLE IFNA1
Mean 0
Standard deviation 0
Values 0 0
[203]
liver IFNA1
Mean 0
Standard deviation 0
Values 0 0 0 0
[204]
ref_hepatocyte IFNA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[205]
HepG2 IFNA2
Missing
[206]
HepG2.C3A IFNA2
Missing
[207]
HuH.7 IFNA2
Missing
[208]
SNU475 IFNA2
Missing
[209]
THLE IFNA2
Missing
[210]
liver IFNA2
Missing